Effect of Helicobacter pylori eradication on gastric hyperplastic polyposis in Cowden's disease.

Abstract:

:A 21-year-old woman with complaints of hematochezia was diagnosed as having Cowden's disease (CD), an autosomal dominant condition characterized by multiple hamartomas, since facial papules and gingival papillomas were identified. On endoscopy, multiple hyperplastic polyps were seen in the rectum and left-side colon. There were also esophageal glycogenic acanthosis and hyperplastic polyposis in the antrum accompanied by Helicobacter pylori-related gastritis. Although gastric hyperplastic polyposis had by no means regressed with unsuccessful first-line eradication therapy for H pylori, following cure of the infection with salvage therapy consisting of rabeprazole, amoxicillin and metronidazole, the polyposis lesions almost disappeared. Follow-up gastroscopy 2 and 3 years after cessation of the second-line eradication therapy revealed almost complete regression of the polyposis lesions with no evidence of H pylori infection. We recommend eradication treatment for CD patients with gastric hyperplastic polyps and the infection, as the occurrence of gastric carcinoma among hyperplastic polyps has been described.

journal_name

World J Gastroenterol

authors

Isomoto H,Furusu H,Ohnita K,Takehara Y,Wen CY,Kohno S

doi

10.3748/wjg.v11.i10.1567

keywords:

subject

Has Abstract

pub_date

2005-03-14 00:00:00

pages

1567-9

issue

10

eissn

1007-9327

issn

2219-2840

journal_volume

11

pub_type

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