Recent advances in pharmacological treatment of irritable bowel syndrome.

Abstract:

:Irritable bowel syndrome (IBS) is a highly prevalent functional disorder that reduces patients' quality of life. It is a chronic disorder characterized by abdominal pain or discomfort associated with disordered defecation in the absence of identifiable structural or biochemical abnormalities. IBS imposes a significant economic burden to the healthcare system. Alteration in neurohumoral mechanisms and psychological factors, bacterial overgrowth, genetic factors, gut motility, visceral hypersensitivity, and immune system factors are currently believed to influence the pathogenesis of IBS. It is possible that there is an interaction of one or more of these etiologic factors leading to heterogeneous symptoms of IBS. IBS treatment is predicated upon the patient's most bothersome symptoms. Despite the wide range of medications and the high prevalence of the disease, to date no completely effective remedy is available. This article reviews the literature from January 2008 to July 2013 on the subject of IBS peripherally acting pharmacological treatment. Drugs are categorized according to their administration for IBS-C, IBS-D or abdominal pain predominant IBS.

journal_name

World J Gastroenterol

authors

Lazaraki G,Chatzimavroudis G,Katsinelos P

doi

10.3748/wjg.v20.i27.8867

subject

Has Abstract

pub_date

2014-07-21 00:00:00

pages

8867-85

issue

27

eissn

1007-9327

issn

2219-2840

journal_volume

20

pub_type

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