Abstract:
:Irritable bowel syndrome (IBS) is a highly prevalent functional disorder that reduces patients' quality of life. It is a chronic disorder characterized by abdominal pain or discomfort associated with disordered defecation in the absence of identifiable structural or biochemical abnormalities. IBS imposes a significant economic burden to the healthcare system. Alteration in neurohumoral mechanisms and psychological factors, bacterial overgrowth, genetic factors, gut motility, visceral hypersensitivity, and immune system factors are currently believed to influence the pathogenesis of IBS. It is possible that there is an interaction of one or more of these etiologic factors leading to heterogeneous symptoms of IBS. IBS treatment is predicated upon the patient's most bothersome symptoms. Despite the wide range of medications and the high prevalence of the disease, to date no completely effective remedy is available. This article reviews the literature from January 2008 to July 2013 on the subject of IBS peripherally acting pharmacological treatment. Drugs are categorized according to their administration for IBS-C, IBS-D or abdominal pain predominant IBS.
journal_name
World J Gastroenteroljournal_title
World journal of gastroenterologyauthors
Lazaraki G,Chatzimavroudis G,Katsinelos Pdoi
10.3748/wjg.v20.i27.8867subject
Has Abstractpub_date
2014-07-21 00:00:00pages
8867-85issue
27eissn
1007-9327issn
2219-2840journal_volume
20pub_type
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pub_type: 临床试验,杂志文章,随机对照试验
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