Recent advances in hepatitis B virus research: a German point of view.

Abstract:

:More than 30 years after the discovery of human hepatitis B virus (HBV) this virus remains to be one of the major global health problems. In infected adolescents or adults, 5%-10% will lead to a chronic carrier state, whereas in infected neonates up to 90% develop chronicity. It is estimated that about 370 million people are chronic carriers of HBV worldwide. In many regions of the world, chronic HBV infection is still the major cause of liver cirrhosis and hepatocellular carcinoma. During the last 30 years, many steps of the viral life cycle have been unravelled, mainly due to cloning, sequencing and expression of the genomic DNA extracted from HBV virions. This has lead to the development of a safe and efficient vaccine and sensitive tests for HBV surface protein (HBsAg) allowing reliable diagnosis and screening of blood products. More recently, a growing number of reverse transcriptase inhibitors have been developed. However, together with these improvements new deficiencies in prevention and cure of HBV infections are becoming apparent. Although HBV is a DNA virus, it is highly variable under immunity or drug induced selection pressure, resulting in vaccine-related escape mutants and drug resistance. To overcome these challenging problems new antivirals and optimised vaccines have to be developed.

journal_name

World J Gastroenterol

authors

Glebe D

doi

10.3748/wjg.v13.i1.8

subject

Has Abstract

pub_date

2007-01-07 00:00:00

pages

8-13

issue

1

eissn

1007-9327

issn

2219-2840

journal_volume

13

pub_type

社论,评审
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    authors: Chen P,Wang BS,He LQ

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    authors: Zhang P,Wang CY,Li YX,Pan Y,Niu JQ,He SM

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    pub_type: 临床试验,杂志文章

    doi:10.3748/wjg.v11.i27.4206

    authors: Kamisawa T,Tu Y,Egawa N,Karasawa K,Matsuda T,Tsuruta K,Okamoto A

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    pub_type: 杂志文章

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    journal_title:World journal of gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

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    更新日期:2008-04-07 00:00:00

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    doi:10.3748/wjg.14.101

    authors: Yan G,Zhou XY,Cai SJ,Zhang GH,Peng JJ,Du X

    更新日期:2008-01-07 00:00:00

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    doi:10.3748/wjg.v23.i7.1203

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    journal_title:World journal of gastroenterology

    pub_type: 评论,信件

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    pub_type: 杂志文章,评审

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    pub_type: 临床试验,杂志文章

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    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v23.i10.1843

    authors: Zhou JQ,Tang XW,Ren YT,Wei ZJ,Huang SL,Gao QP,Zhang XF,Yang JF,Gong W,Jiang B

    更新日期:2017-03-14 00:00:00

  • Diet and microbiota in inflammatory bowel disease: The gut in disharmony.

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    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v23.i12.2124

    authors: Rapozo DC,Bernardazzi C,de Souza HS

    更新日期:2017-03-28 00:00:00

  • Analysis of ABC (D) stratification for screening patients with gastric cancer.

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    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v17.i43.4793

    authors: Kudo T,Kakizaki S,Sohara N,Onozato Y,Okamura S,Inui Y,Mori M

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    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.15.2927

    authors: Ohwada S,Kobayashi I,Harasawa N,Tsuda K,Inui Y

    更新日期:2009-06-21 00:00:00

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    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,meta分析,评审

    doi:10.3748/wjg.v21.i10.3093

    authors: Fan KX,Xu ZF,Wang MR,Li DT,Yang XS,Guo J

    更新日期:2015-03-14 00:00:00

  • Safety of lamivudine treatment for chronic hepatitis B in early pregnancy.

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    journal_title:World journal of gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.3748/wjg.v18.i45.6645

    authors: Yi W,Liu M,Cai HD

    更新日期:2012-12-07 00:00:00

  • Sodium alginate ameliorates indomethacin-induced gastrointestinal mucosal injury via inhibiting translocation in rats.

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    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v20.i10.2641

    authors: Yamamoto A,Itoh T,Nasu R,Nishida R

    更新日期:2014-03-14 00:00:00