Clinical significance of molecular diagnosis for gastric cancer lymph node micrometastasis.

Abstract:

:Advances in molecular diagnostic tools have allowed the identification of lymph node micrometastasis (LNM), including isolated tumor cells, in cancer patients. While immunohistochemistry and reverse transcription-polymerase chain reaction have been used to identify LNM in patients with gastric cancer, the clinical significance of this finding remains unclear. Recently, minimally invasive treatments, such as endoscopic submucosal dissection and laparoscopic surgery, are widely performed to help improve postsurgical quality of life (QOL). However, it is important to maintain the balance between QOL and curability when making treatments decision for patients with gastric cancer. If minimally invasive surgery based on accurate intraoperative LNM diagnosis was established, it could be performed safely. Therefore, we reviewed the clinical significance of LNM detected by molecular techniques as an important target for treatment decision making with gastric cancer patients.

journal_name

World J Gastroenterol

authors

Sonoda H,Tani T

doi

10.3748/wjg.v20.i38.13728

subject

Has Abstract

pub_date

2014-10-14 00:00:00

pages

13728-33

issue

38

eissn

1007-9327

issn

2219-2840

journal_volume

20

pub_type

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