Huge undifferentiated carcinoma of the pancreas with osteoclast-like giant cells.

Abstract:

:Undifferentiated carcinoma of the pancreas with osteoclast-like giant cells (OGCs) is very rare, less than 1% of all pancreatic malignancies, and shows worse prognosis than that of invasive ductal adenocarcinoma of the pancreas. We present a case of en bloc resection for a huge undifferentiated carcinoma with OGCs that invaded the stomach and transverse mesocolon. A 67-year female was admitted for left upper quadrant pain and computed tomography demonstrated a mass occupying the lesser sac and abutting the stomach and pancreas. There were no distant metastases and the patient underwent subtotal pancreatectomy with splenectomy, total gastrectomy, and segmental resection of the transverse colon. Histopathological examination confirmed an 11 cm-sized undifferentiated carcinoma of the pancreas with OGCs. Immunohistochemical staining revealed reactivity with pan-cytokeratin in adenocarcinoma component, with vimentin in neoplastic multi-nucleated cells, with CD45/CD68 in OGCs, and with p53 in tumor cells, respectively. The patient had suffered from multiple bone metastases and survived 9 mo after surgery. This case supports the ductal epithelial origin of undifferentiated carcinoma with OGCs and early diagnosis could result in favorable surgical outcomes. Investigations on the surgical role and prognostic factors need to be warranted in this tumor.

journal_name

World J Gastroenterol

authors

Jo S

doi

10.3748/wjg.v20.i10.2725

subject

Has Abstract

pub_date

2014-03-14 00:00:00

pages

2725-30

issue

10

eissn

1007-9327

issn

2219-2840

journal_volume

20

pub_type

杂志文章,评审
  • Reduced antioxidant level and increased oxidative damage in intact liver lobes during ischaemia-reperfusion.

    abstract:AIM:To determine whether increased blood flow of the liver can cause oxidative stress and hepatocyte damage, and to elaborate methods suitable for measuring the antioxidant defence during hepatic surgery on rat model. METHODS:In nembutal narcosis, the left lateral and the medial lobes of the liver were clipped for 45 ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v12.i7.1086

    authors: Váli L,Taba G,Szentmihályi K,Fébel H,Kurucz T,Pallai Z,Kupcsulik P,Blázovics A

    更新日期:2006-02-21 00:00:00

  • Effects of short-term application of low-dose growth hormone on trace element metabolism and blood glucose in surgical patients.

    abstract:AIM:To investigate the effects of short-term application of low-dose growth hormone on trace element metabolism and blood glucose in surgical patients. METHODS:A total of 48 consecutive patients undergoing abdominal operations were randomized to receive either subcutaneous rhGH (0.15 IU/kg) or placebo (menstruum) inje...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,随机对照试验

    doi:10.3748/wjg.v13.i46.6259

    authors: Qian K,Wan Z,Hao LS,Zhang MM,Zhou Y,Wu XT

    更新日期:2007-12-14 00:00:00

  • Vascular tumors and malformations of the colon.

    abstract::The term "hemangioma" refers to the common tumor of infancy that exhibits rapid postnatal growth and slow regression during childhood. It may cause confusion with venous malformations that are often incorrectly called "cavernous hemangioma". Venous malformations comprise abnormally formed channels that are lined by qu...

    journal_title:World journal of gastroenterology

    pub_type: 评论,信件

    doi:10.3748/wjg.15.5242

    authors: Fernandez-Pineda I

    更新日期:2009-11-07 00:00:00

  • Emodin and baicalein inhibit sodium taurocholate-induced vacuole formation in pancreatic acinar cells.

    abstract:AIM:To investigate the effects of combined use of emodin and baicalein (CEB) at the cellular and organism levels in severe acute pancreatitis (SAP) and explore the underlying mechanism. METHODS:SAP was induced by retrograde infusion of 5% sodium taurocholate into the pancreatic duct in 48 male SD rats. Pancreatic hist...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v24.i1.35

    authors: Li J,Zhou R,Bie BB,Huang N,Guo Y,Chen HY,Shi MJ,Yang J,Zhang J,Li ZF

    更新日期:2018-01-07 00:00:00

  • Incidence of gallstone disease in Italy: results from a multicenter, population-based Italian study (the MICOL project).

    abstract:AIM:To evaluate gallstone incidence and risk factors in a large population-based study. METHODS:Gallstone incidence and risk factors, were evaluated by structured questionnaire and physical examination, respectively, in 9611 of 11 109 (86.5%) subjects who were gallstone-free at the cross-sectional study. RESULTS:Six ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,多中心研究

    doi:10.3748/wjg.14.5282

    authors: Festi D,Dormi A,Capodicasa S,Staniscia T,Attili AF,Loria P,Pazzi P,Mazzella G,Sama C,Roda E,Colecchia A

    更新日期:2008-09-14 00:00:00

  • Diet and microbiota in inflammatory bowel disease: The gut in disharmony.

    abstract::Bacterial colonization of the gut shapes both the local and the systemic immune response and is implicated in the modulation of immunity in both healthy and disease states. Recently, quantitative and qualitative changes in the composition of the gut microbiota have been detected in Crohn's disease and ulcerative colit...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v23.i12.2124

    authors: Rapozo DC,Bernardazzi C,de Souza HS

    更新日期:2017-03-28 00:00:00

  • Comprehensive screening for reg1alpha gene rules out association with tropical calcific pancreatitis.

    abstract:AIM:To investigate the allelic and haplotypic association of reg1alpha gene with tropical calcific pancreatitis (TCP). Since TCP is known to have a variable genetic basis, we investigated the interaction between mutations in the susceptibility genes, SPINK1 and CTSB with reg1alpha polymorphisms. METHODS:We analyzed th...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v13.i44.5938

    authors: Mahurkar S,Bhaskar S,Reddy DN,Rao GV,Chandak GR

    更新日期:2007-11-28 00:00:00

  • Prediction of risk factors for lymph node metastasis in early gastric cancer.

    abstract:AIM:To explore risk factors for lymph node metastases in early gastric cancer (EGC) and to confirm the appropriate range of lymph node dissection. METHODS:A total of 202 patients with EGC who underwent curative gastrectomy with lymphadenectomy in the Department of Surgery, Xinhua Hospital and Ruijin Hospital of Shangh...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v19.i20.3096

    authors: Ren G,Cai R,Zhang WJ,Ou JM,Jin YN,Li WH

    更新日期:2013-05-28 00:00:00

  • Liver-related effects of chronic hepatitis C antiviral treatment.

    abstract::More than five years ago, the treatment of hepatitis C virus infection was revolutionized with the introduction of all-oral direct-acting antiviral (DAA) drugs. They proved highly efficient in curing patients with chronic hepatitis C (CHC), including patients with cirrhosis. The new DAA treatments were alleged to indu...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v26.i22.2931

    authors: Laursen TL,Sandahl TD,Kazankov K,George J,Grønbæk H

    更新日期:2020-06-14 00:00:00

  • Different behaviour of BK-virus infection in liver transplant recipients.

    abstract::Polyomavirus BK (BKV) infects up to 90% of the general population. After primary infection, occurring early during childhood, a state of non-replicative infection is established in the reno-urinary tract, without complications for immunocompetent hosts. In immunocompromised individuals, particularly transplanted patie...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v22.i4.1532

    authors: Umbro I,Tinti F,Muiesan P,Mitterhofer AP

    更新日期:2016-01-28 00:00:00

  • Hypoxia inducible factor-1alpha mediates protective effects of ischemic preconditioning on ECV-304 endothelial cells.

    abstract:AIM:To investigate whether hypoxia inducible factor-1alpha (HIF-1alpha) is linked to the protective effects of ischemic preconditioning (IP) on sinusoidal endothelial cells against ischemia/reperfusion injury. METHODS:Sinusoidal endothelial cell lines ECV-304 were cultured and divided into four groups: control group, ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v13.i16.2369

    authors: Shi LB,Huang JH,Han BS

    更新日期:2007-04-28 00:00:00

  • Antifibrotic effects of green tea on in vitro and in vivo models of liver fibrosis.

    abstract:AIM:To examine the protective effect of green tea extract (GT) on hepatic fibrosis in vitro and in vivo in dimethylnitrosamine (DMN)-induced rats. METHODS:HSC-T6, a rat hepatic stellate cell line, was used as an in vitro assay system. Cell proliferation, collagen content, and type 1 collagen expression were examined i...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.15.5200

    authors: Kim HK,Yang TH,Cho HY

    更新日期:2009-11-07 00:00:00

  • Association of core promoter mutations of hepatitis B virus and viral load is different in HBeAg(+) and HBeAg(-) patients.

    abstract:AIM:To identify the prevalence of hepatitis B e antigen (HBeAg) and to assess the association of hepatitis B virus (HBV) core promoter mutations and viral load in Indonesian patients. METHODS:Sixty-four patients with chronic hepatitis, 65 with liver cirrhosis and 50 with hepatocellular carcinoma were included in this ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v17.i6.708

    authors: Utama A,Siburian MD,Purwantomo S,Intan MD,Kurniasih TS,Gani RA,Achwan WA,Arnelis,Lelosutan SA,Lukito B,Harmono T,Zubir N,Julius,Soemohardjo S,Lesmana LA,Sulaiman A,Tai S

    更新日期:2011-02-14 00:00:00

  • Resection of the uncinate process of the pancreas due to a ganglioneuroma.

    abstract::A 33-year-old woman who presented with epigastric discomfort and diarrhea underwent an abdominal ultrasound (US). This investigation and subsequent contrast-enhanced computed tomography, magnetic resonance imaging and endoscopic US with fine needle aspiration (FNA) revealed a 40 mm well-circumscribed mass in the uncin...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.15.4334

    authors: Poves I,Burdío F,Iglesias M,Martínez-Serrano Mde L,Aguilar G,Grande L

    更新日期:2009-09-14 00:00:00

  • Protective effects of panax notoginseng saponin on dextran sulfate sodium-induced colitis in rats through phosphoinositide-3-kinase protein kinase B signaling pathway inhibition.

    abstract:BACKGROUND:Intestinal inflammation is a common digestive tract disease, which is usually treated with hormone medicines. Hormone medicines are effective to some extent, but long-term use of them may bring about many complications. AIM:To explore the protective effects of panax notoginseng saponin (PNS) against dextran...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v26.i11.1156

    authors: Lu QG,Zeng L,Li XH,Liu Y,Du XF,Bai GM,Yan X

    更新日期:2020-03-21 00:00:00

  • Nasogastric tube syndrome induced by an indwelling long intestinal tube.

    abstract::The nasogastric tube (NGT) has become a frequently used device to alleviate gastrointestinal symptoms. Nasogastric tube syndrome (NTS) is an uncommon but potentially life-threatening complication of an indwelling NGT. NTS is characterized by acute upper airway obstruction due to bilateral vocal cord paralysis. We repo...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v22.i15.4057

    authors: Sano N,Yamamoto M,Nagai K,Yamada K,Ohkohchi N

    更新日期:2016-04-21 00:00:00

  • Evaluation of endoscopic biliary stenting for obstructive jaundice caused by hepatocellular carcinoma.

    abstract:AIM:To review the usefulness of endoscopic biliary stenting for obstructive jaundice caused by hepatocellular carcinoma and identify problems that may need to be addressed. METHODS:The study population consisted of 36 patients with obstructive jaundice caused by hepatocellular carcinoma (HCC) who underwent endoscopic ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v20.i22.6968

    authors: Sugiyama G,Okabe Y,Ishida Y,Saitou F,Kawahara R,Ishikawa H,Horiuchi H,Kinoshita H,Tsuruta O,Sata M

    更新日期:2014-06-14 00:00:00

  • Endoscopic occlusion with silicone spigots for the closure of refractory esophago-bronchiole fistula after esophagectomy.

    abstract::A 65-year-old man with cT1bN0M0 stage I middle thoracic esophageal cancer underwent subtotal esophagectomy and gastric tube reconstruction through the posterior mediastinal route after preoperative carbon-ion radiotherapy and chemotherapy in a clinical trial. Anastomotic leakage occurred, but it spontaneously improved...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v23.i28.5253

    authors: Uesato M,Kono T,Akutsu Y,Murakami K,Kagaya A,Muto Y,Nakano A,Aikawa M,Tamachi T,Amagai H,Arasawa T,Muto Y,Matsubara H

    更新日期:2017-07-28 00:00:00

  • Characteristics of upper digestive tract diseases in Bohai Bay fishermen.

    abstract:AIM:To study the characteristics of upper digestive tract diseases (UDTDs) in fishermen who live in Bohai Bay. METHODS:An investigation was carried out in 1488 fishermen with symptoms of UDTDs (aside from liver, biliary and pancreatic diseases) during the time period between December 1991 and February 1995. This inves...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v3.i3.171

    authors: Wang YB,Wang YP,Zou J,Bai BJ,Ren GC,Cai BQ

    更新日期:1997-09-15 00:00:00

  • Failure of interferon-γ pre-treated mesenchymal stem cell treatment in a patient with Crohn's disease.

    abstract::Mesenchymal stem cells (MSC) are cells of stromal origin which exhibit unlimited self-renewal capacity and pluripotency in vitro. It has recently been observed that MSC may also exert a profound immunosuppressive and anti-inflammatory effect both in vitro and in vivo with consequent potential use in autoimmune disorde...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v21.i14.4379

    authors: Taddio A,Tommasini A,Valencic E,Biagi E,Decorti G,De Iudicibus S,Cuzzoni E,Gaipa G,Badolato R,Prandini A,Biondi A,Ventura A

    更新日期:2015-04-14 00:00:00

  • Detection of hepatitis B virus genotypes using oligonucleotide chip among hepatitis B virus carriers in Eastern China.

    abstract:AIM:To determine the genotype distribution of hepatitis B virus (HBV) with a newly oligonucleotide chip assay among the HBV carriers in Eastern China. METHODS:An assay using oligonucleotide chip was developed for detection of HBV genotypes in serum samples from HBV DNA-positive patients in Eastern China. This method i...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,多中心研究

    doi:10.3748/wjg.v13.i13.1975

    authors: Tang XR,Zhang JS,Zhao H,Gong YH,Wang YZ,Zhao JL

    更新日期:2007-04-07 00:00:00

  • MiR-451 inhibits proliferation of esophageal carcinoma cell line EC9706 by targeting CDKN2D and MAP3K1.

    abstract:AIM:To investigate the underlying molecular mechanisms of miR-451 to inhibit proliferation of esophageal carcinoma cell line EC9706. METHODS:Assays for cell growth, apoptosis and invasion were used to evaluate the effects of miR-451 expression on EC cells. Luciferase reporter and Western blot assays were used to test ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v21.i19.5867

    authors: Zang WQ,Yang X,Wang T,Wang YY,Du YW,Chen XN,Li M,Zhao GQ

    更新日期:2015-05-21 00:00:00

  • Recent advances in pharmacological treatment of irritable bowel syndrome.

    abstract::Irritable bowel syndrome (IBS) is a highly prevalent functional disorder that reduces patients' quality of life. It is a chronic disorder characterized by abdominal pain or discomfort associated with disordered defecation in the absence of identifiable structural or biochemical abnormalities. IBS imposes a significant...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v20.i27.8867

    authors: Lazaraki G,Chatzimavroudis G,Katsinelos P

    更新日期:2014-07-21 00:00:00

  • Clinical relevance of endoscopic assessment of inflammation in ulcerative colitis: Can endoscopic evaluation predict outcomes?

    abstract::Ulcerative colitis (UC) is a chronic inflammatory bowel condition characterised by a relapsing and remitting course. Symptom control has been the traditional mainstay of medical treatment. It is well known that histological inflammatory activity persists despite adequate symptom control and absence of endoscopic infla...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v22.i42.9324

    authors: Mohammed N,Subramanian V

    更新日期:2016-11-14 00:00:00

  • Smoking, alcohol consumption, and the risk of extrahepatic cholangiocarcinoma: a meta-analysis.

    abstract:AIM:To assess the association between smoking and alcohol consumption and extrahepatic cholangiocarcinoma (ECC) through a meta-analysis of clinical observational studies. METHODS:A literature search was conducted using Embase and MEDLINE databases from inception to 31 May 2013 without language limitations, and by manu...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,meta分析,评审

    doi:10.3748/wjg.v19.i46.8780

    authors: Ye XH,Huai JP,Ding J,Chen YP,Sun XC

    更新日期:2013-12-14 00:00:00

  • Objective assessment of the antispasmodic effect of shakuyaku-kanzo-to (TJ-68), a Chinese herbal medicine, on the colonic wall by direct spraying during colonoscopy.

    abstract:AIM:To objectively evaluate the effect of TJ-68 on colonic spasms during colonoscopy. METHODS:One hundred and one patients subjected to screening colonoscopy were randomly assigned to two groups: TJ-68 in 51 subjects and saline as the control in 50. The endoscope was inserted into the sigmoid colon, then a spastic reg...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,随机对照试验

    doi:10.3748/wjg.v12.i5.760

    authors: Ai M,Yamaguchi T,Odaka T,Mitsuhashi K,Shishido T,Yan J,Seza A,Saisho H

    更新日期:2006-02-07 00:00:00

  • Relationship between tumor necrosis factor-alphaand liver fibrosis.

    abstract::INTRODUCTION:To intrestigate the relationship between tumor necrosis factor-alphaand liver fibrosis in patients with chronic liver disease.METHODS:Radioimmunoassay was made in 20 patients with mild chronic hepatitis(CMH),20 patients with severe chronic hepatitis(CSH),51 patients with liver cirrhosis(LC)and 32-normal p...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v4.i1.18

    authors: Wang X,Chen YX,Xu CF,Zhao GN,Huang YX,Wang QL

    更新日期:1998-02-01 00:00:00

  • Successful combination of direct antiviral agents in liver-transplanted patients with recurrent hepatitis C virus.

    abstract:AIM:To analyze the safety and efficiency of direct-acting antiviral (DAA) regimens in liver-transplanted patients with hepatitis C virus (HCV) reinfection. METHODS:Between January 2014 and December 2016, 39 patients with HCV reinfection after liver transplantation were treated at our tertiary referral center with sofo...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v24.i12.1353

    authors: Rupp C,Hippchen T,Neuberger M,Sauer P,Pfeiffenberger J,Stremmel W,Gotthardt DN,Mehrabi A,Weiss KH

    更新日期:2018-03-28 00:00:00

  • Expression of pituitary homeobox 1 gene in human gastric carcinogenesis and its clinicopathological significance.

    abstract:AIM:To investigate the effect of pituitary homeobox 1 (PITX1) expression in cases of human gastric cancer on cancer differentiation and progression, and carcinogenesis. METHODS:Using polyclonal PITX1 antibodies, we studied the expression of PITX1 in normal gastric mucosa, atypical hyperplasia, intestinal metaplasia, a...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.14.292

    authors: Chen YN,Chen H,Xu Y,Zhang X,Luo Y

    更新日期:2008-01-14 00:00:00

  • Hepatic perfusion disorders: etiopathogenesis and related diseases.

    abstract::In this article, we have reviewed the hepatic perfusion disorder (HPD), etiopathogenesis of HPD and corresponding diseases. Review of the literature was based on computer searches (PubMed, Index Medicus) and personal experiences. We considered HPD reflects perfusion differences due to redistribution of arterial blood ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v12.i20.3265

    authors: Tian JL,Zhang JS

    更新日期:2006-05-28 00:00:00