Risk factors and outcome of bacterial infections in cirrhosis.

Abstract:

:Viable and non-viable pathological bacterial translocation promote a self-perpetuating circle of dysfunctional immune activation and systemic inflammation facilitating infections and organ failure in advanced cirrhosis. Bacterial infections and sepsis are now recognized as a distinct stage in the natural progression of chronic liver disease as they accelerate organ failure and contribute to the high mortality observed in decompensated cirrhosis. The increasing knowledge of structural, immunological and hemodynamic pathophysiology in advanced cirrhosis has not yet translated into significantly improved outcomes of bacterial infections over the last decades. Therefore, early identification of patients at the highest risk for developing infections and infection-related complications is required to tailor the currently available measures of surveillance, prophylaxis and therapy to the patients in need in order to improve the detrimental outcome of bacterial infections in cirrhosis.

journal_name

World J Gastroenterol

authors

Bruns T,Zimmermann HW,Stallmach A

doi

10.3748/wjg.v20.i10.2542

subject

Has Abstract

pub_date

2014-03-14 00:00:00

pages

2542-54

issue

10

eissn

1007-9327

issn

2219-2840

journal_volume

20

pub_type

杂志文章,评审
  • Advances in the management of acute liver failure.

    abstract::Acute liver failure (ALF) is an uncommon but dramatic clinical syndrome characterized by hepatic encephalopathy and a bleeding tendency due to abrupt loss of liver function caused by massive or submassive liver necrosis in a patient with a previously healthy liver. The causes of ALF encompass a wide variety of toxic, ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v19.i41.7069

    authors: Wang DW,Yin YM,Yao YM

    更新日期:2013-11-07 00:00:00

  • Endoscopic management of intragastric penetrated adjustable gastric band for morbid obesity.

    abstract::This report describes a case of successful endoscopic management of intragastric penetrated adjustable gastric band in a patient with morbid obesity. The favorable course of the case described here demonstrates that adjustable gastric bands in the process of migration need not be removed surgically in patients who are...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v12.i25.4098

    authors: De Palma GD,Formato A,Pilone V,Rega M,Giuliano ME,Simeoli I,Forestieri P

    更新日期:2006-07-07 00:00:00

  • Pre-treatment urea breath test results predict the efficacy of Helicobacter pylori eradication therapy in patients with active duodenal ulcers.

    abstract:AIM:To evaluate the association of pre-treatment (13)C-urea breath test (UBT) results with H pylori density and efficacy of eradication therapy in patients with active duodenal ulcers. METHODS:One hundred and seventeen consecutive outpatients with active duodenal ulcer and H pylori infection were recruited. H pylori d...

    journal_title:World journal of gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.3748/wjg.v10.i7.991

    authors: Lai YC,Yang JC,Huang SH

    更新日期:2004-04-01 00:00:00

  • Target genes discovery through copy number alteration analysis in human hepatocellular carcinoma.

    abstract::High-throughput short-read sequencing of exomes and whole cancer genomes in multiple human hepatocellular carcinoma (HCC) cohorts confirmed previously identified frequently mutated somatic genes, such as TP53, CTNNB1 and AXIN1, and identified several novel genes with moderate mutation frequencies, including ARID1A, AR...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v19.i47.8873

    authors: Gu DL,Chen YH,Shih JH,Lin CH,Jou YS,Chen CF

    更新日期:2013-12-21 00:00:00

  • Proliferation of intestinal crypt cells by gastrin-induced ornithine decarboxylase.

    abstract:AIM:To determine whether the gastrin stimulated intestinal crypt cell (IEC-6) proliferation by induction of ornithine decarboxylase (ODC). METHODS:IEC-6 cells were grown in DMEM containing 50 mL x L(-1) dialyzed fetal bovine serum for 24h and then were treated with gastrin. The proliferative capability of the cells wa...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v8.i1.183

    authors: Zhang ZL,Chen WW

    更新日期:2002-02-01 00:00:00

  • Targeted medical therapy of biliary tract cancer: recent advances and future perspectives.

    abstract::The limited efficacy of cytotoxic therapy for advanced biliary tract and gallbladder cancers emphasizes the need for novel and more effective medical treatment options. A better understanding of the specific biological features of these neoplasms led to the development of new targeted therapies, which take the abundan...

    journal_title:World journal of gastroenterology

    pub_type: 社论,评审

    doi:10.3748/wjg.14.7021

    authors: Hopfner M,Schuppan D,Scherubl H

    更新日期:2008-12-14 00:00:00

  • Hepatogenic differentiation of human mesenchymal stem cells from adipose tissue in comparison with bone marrow mesenchymal stem cells.

    abstract:AIM:To investigate and compare the hepatogenic transdifferentiation of adipose tissue-derived stem cells (ADSC) and bone marrow-derived mesenchymal stem cells (BMSC) in vitro. Transdifferentiation of BMSC into hepatic cells in vivo has been described. Adipose tissue represents an accessible source of ADSC, with similar...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v12.i36.5834

    authors: Taléns-Visconti R,Bonora A,Jover R,Mirabet V,Carbonell F,Castell JV,Gómez-Lechón MJ

    更新日期:2006-09-28 00:00:00

  • Liuweiwuling tablets attenuate acetaminophen-induced acute liver injury and promote liver regeneration in mice.

    abstract:AIM:To explore the mechanism of protection against acetaminophen-induced acute liver injury by Liuweiwuling tablets. METHODS:Intraperitoneal injections of acetaminophen (250 mg/kg) were used to induce acute liver injury in male C57BL/6 mice. A total of 24 healthy mice were randomly assigned to two groups: an acute liv...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v21.i26.8089

    authors: Lei YC,Li W,Luo P

    更新日期:2015-07-14 00:00:00

  • Prognostic implication of isolated tumor cells and micrometastases in regional lymph nodes of gastric cancer.

    abstract:AIM:To determine the prognostic significance of isolated tumor cells (ITCs) and lymph node micrometastases in gastric cancer. METHODS:Hematoxylin and eosin-stained slides of lymph node dissections of 632 consecutive gastric cancers were reviewed. Cytokeratin immunostaining was performed in 280 node-negative cases and ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i38.5920

    authors: Lee HS,Kim MA,Yang HK,Lee BL,Kim WH

    更新日期:2005-10-14 00:00:00

  • Hepatic failure caused by plasma cell infiltration in multiple myeloma.

    abstract::Although plasma cell infiltration is not rare in autopsy of patients with multiple myeloma (MM), it is very rarely detected in living patients. This is because MM rarely causes significant liver dysfunction that requires further evaluation. A 49-year-old man presented with acute renal failure and was diagnosed with ka...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.15.2038

    authors: Rahhal FE,Schade RR,Nayak A,Coleman TA

    更新日期:2009-04-28 00:00:00

  • Air leak syndrome after endoscopic retrograde cholangiopancreatography: a rare and fatal complication.

    abstract::Endoscopic retrograde cholangiopancreatography (ERCP) is a state of the art diagnostic and therapeutic procedure for various pancreatic and biliary problems. In spite of the well-established safety of the procedure, there is still a risk of complications such as pancreatitis, cholangitis, bleeding and perforation. Air...

    journal_title:World journal of gastroenterology

    pub_type: 信件

    doi:10.3748/wjg.v21.i15.4770

    authors: Yilmaz B,Roach EC,Koklu S,Aydin O,Unlu O,Kilic YA

    更新日期:2015-04-21 00:00:00

  • Prognosis and feasibility of en-bloc vascular resection in stage II pancreatic adenocarcinoma.

    abstract:AIM:To establish the prognosis and feasibility of en-bloc vascular resection of stage II pancreatic adenocarcinoma of the head and uncinate process. METHODS:We retrospectively analyzed 87 patients with stage II pancreatic adenocarcinoma, who were subjected to pancreaticoduodenectomy (PD) and pylorus-preserving PD (PPP...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v16.i8.997

    authors: Chakravarty KD,Hsu JT,Liu KH,Yeh CN,Yeh TS,Hwang TL,Jan YY,Chen MF

    更新日期:2010-02-28 00:00:00

  • Antiviral therapy delays esophageal variceal bleeding in hepatitis B virus-related cirrhosis.

    abstract:AIM:To investigate the effect of antiviral therapy with nucleoside analogs in hepatitis B virus (HBV)-related cirrhosis and esophageal varices. METHODS:Eligible patients with HBV-related cirrhosis and esophageal varices who consulted two tertiary hospitals in Beijing, China, the Chinese Second Artillery General Hospit...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,多中心研究

    doi:10.3748/wjg.v19.i40.6849

    authors: Li CZ,Cheng LF,Li QS,Wang ZQ,Yan JH

    更新日期:2013-10-28 00:00:00

  • Thermo-chemo-radiotherapy for advanced bile duct carcinoma.

    abstract:AIM:Complete resection of the bile duct carcinoma is sometimes difficult by subepithelial spread in the duct wall or direct invasion of adjacent blood vessels. Nonresected extrahepatic bile duct carcinoma has a dismal prognosis, with a life expectancy of about 6 mo to 1 year. To improve the treatment results of locally...

    journal_title:World journal of gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.3748/wjg.v11.i27.4206

    authors: Kamisawa T,Tu Y,Egawa N,Karasawa K,Matsuda T,Tsuruta K,Okamoto A

    更新日期:2005-07-21 00:00:00

  • Efflux pump gene hefA of Helicobacter pylori plays an important role in multidrug resistance.

    abstract:AIM:To determine whether efflux systems contribute to multidrug resistance of H pylori. METHODS:A chloramphenicol-induced multidrug resistance model of six susceptible H pylori strains (5 isolates and H pylori NCTC11637) was developed. Multidrug-resistant (MDR) strains were selected and the minimal inhibitory concentr...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.14.5217

    authors: Liu ZQ,Zheng PY,Yang PC

    更新日期:2008-09-07 00:00:00

  • Association between pepsinogen C gene polymorphism and genetic predisposition to gastric cancer.

    abstract:AIM:To identify a molecular marker for gastric cancer, and to investigate the relationship between the polymorphism of pepsinogen C (PGC) gene and the genetic predisposition to gastric cancer. METHODS:A total of 289 cases were involved in this study. 115 cases came from Shenyang area, a low risk area of gastric cancer...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v9.i1.50

    authors: Liu HJ,Guo XL,Dong M,Wang L,Yuan Y

    更新日期:2003-01-01 00:00:00

  • Management of parastomal ulcers.

    abstract::Management of surgically placed ostomies is an important aspect of any general surgical or colon and rectal surgery practice. Complications with surgically placed ostomies are common and their causes are multifactorial. Parastomal ulceration, although rare, is a particularly difficult management problem. We conducted ...

    journal_title:World journal of gastroenterology

    pub_type: 社论,评审

    doi:10.3748/wjg.v12.i20.3133

    authors: Yeo H,Abir F,Longo WE

    更新日期:2006-05-28 00:00:00

  • Helicobacter pylori: management in 2013.

    abstract::Helicobacter pylori (H. pylori) is a prevalent, worldwide, chronic infection. Choice of treatment can be modified according to antibiotic-resistance rates of H. pylori. The ideal therapeutic regimen for H. pylori infection should achieve an eradication rate of ≥ 80%. In some countries, triple therapy with a proton-pum...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v20.i18.5302

    authors: Alahdab YO,Kalayci C

    更新日期:2014-05-14 00:00:00

  • Hepatoma with cardiac metastasis: an advanced cancer requiring advanced treatment.

    abstract:AIM:To investigate the clinical and pathologic findings, and to discuss the pathophysiology of hepatocellular carcinoma with cardiac metastasis. METHODS:Eight hepatoma patients with cardiac metastasis, who were treated by surgical excision from 1993 to 2006, were retrospectively studied. Detailed clinical parameters w...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v13.i25.3513

    authors: Lin YS,Jung SM,Tsai FC,Yeh CN,Shiu TF,Wu HH,Lin PJ,Chu PH

    更新日期:2007-07-07 00:00:00

  • Hyperhomocysteinemia, endoplasmic reticulum stress, and alcoholic liver injury.

    abstract::Deficiencies in vitamins or other factors (B6, B12, folic acid, betaine) and genetic disorders for the metabolism of the non-protein amino acid-homocysteine (Hcy) lead to hyperhomocysteinemia (HHcy). HHcy is an integral component of several disorders including cardiovascular disease, neurodegeneration, diabetes and al...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v10.i12.1699

    authors: Ji C,Kaplowitz N

    更新日期:2004-06-15 00:00:00

  • Differences in endoscopic classification of early colorectal carcinoma between China and Japan: a comparative study.

    abstract:AIM:To compare the differences in the endoscopic classification of early colorectal carcinoma (CRC) between Japan and China. METHODS:Ten cases of early CRC were included in the study. After reviewing the color pictures of these cases, 5 Japanese endoscopists and 5 Chinese endoscopists made their classificatory diagnos...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v9.i9.1985

    authors: Zhu RM,Wang FY,Hirata I,Katsu K,Xiao SD,Yu ZL,Zhang ZH,Xu ZM

    更新日期:2003-09-01 00:00:00

  • Comparison of two different laparotomy methods for modeling rabbit VX2 hepatocarcinoma.

    abstract:AIM:To compare two different laparotomy methods for modeling rabbit VX2 hepatocarcinoma. METHODS:Thirty New Zealand rabbits were randomly divided into two groups: A and B. Group A was assigned a traditional laparotomy method (embedding tumor fragments directly into the liver with tweezers). Group B was subjected to an...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v21.i16.4875

    authors: Chen Z,Kang Z,Xiao EH,Tong M,Xiao YD,Li HB

    更新日期:2015-04-28 00:00:00

  • Pretreatment with intestinal trefoil factor alleviates stress-induced gastric mucosal damage via Akt signaling.

    abstract:BACKGROUND:Stress-related gastric mucosal damage or ulcer remains an unsolved issue for critically ill patients. Stress ulcer prophylaxis has been part of routine intensive care, but uncertainty and controversy still exist. Co-secreted with mucins, intestinal trefoil factor (ITF) is reported to promote restitution and ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v26.i48.7619

    authors: Huang Y,Wang MM,Yang ZZ,Ren Y,Zhang W,Sun ZR,Nie SN

    更新日期:2020-12-28 00:00:00

  • Restraint stress induces and exacerbates intestinal inflammation in interleukin-10 deficient mice.

    abstract:AIM:To investigate the effects of restraint stress on chronic colitis in interleukin (IL)-10 deficient (IL-10(-/-)) mice. METHODS:The first experiment compared the effect of restraint stress on the development of intestinal inflammation in wild-type and IL-10(-/-) mice. Both wild-type and IL-10(-/-) mice were physical...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v21.i28.8580

    authors: Koh SJ,Kim JW,Kim BG,Lee KL,Kim JS

    更新日期:2015-07-28 00:00:00

  • Linker phosphorylation of Smad3 promotes fibro-carcinogenesis in chronic viral hepatitis of hepatocellular carcinoma.

    abstract::Epidemiological and clinical data point to a close association between chronic hepatitis B virus infection or chronic hepatitis C virus infection and development of hepatocellular carcinoma (HCC). HCC develops over several decades and is associated with fibrosis. This sequence suggests that persistent viral infection ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v20.i41.15018

    authors: Murata M,Yoshida K,Yamaguchi T,Matsuzaki K

    更新日期:2014-11-07 00:00:00

  • Real-world disease activity and sociodemographic, clinical and treatment characteristics of moderate-to-severe inflammatory bowel disease in Brazil.

    abstract:BACKGROUND:Understanding the treatment landscape of inflammatory bowel diseases (IBD) is essential for improving disease management and patient outcomes. Brazil is the largest Latin American country, and it presents socioeconomic and health care differences across its geographical regions. This country has the highest ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v27.i2.208

    authors: Zaltman C,Parra RS,Sassaki LY,Santana GO,Ferrari MLA,Miszputen SJ,Amarante HMBS,Kaiser Junior RL,Flores C,Catapani WR,Parente JML,Bafutto M,Ramos O,Gonçalves CD,Guimaraes IM,da Rocha JJR,Feitosa MR,Feres O,Saad-Hossne

    更新日期:2021-01-14 00:00:00

  • Dilemma of first line regimens in metastatic pancreatic adenocarcinoma.

    abstract::Pancreatic cancer is one of the deadliest cancers, ranking fourth among cancer-related deaths. Despite all the major molecular advances and treatment breakthroughs, mainly targeted therapies, the cornerstone treatment of metastatic pancreatic cancer (mPC) remains cytotoxic chemotherapy. In 2016, more than 40 years aft...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v22.i46.10124

    authors: Ghosn M,Ibrahim T,Assi T,El Rassy E,Kourie HR,Kattan J

    更新日期:2016-12-14 00:00:00

  • Effects of ciglitazone and troglitazone on the proliferation of human stomach cancer cells.

    abstract:AIM:To determine the cytological and molecular effects of peroxisome proliferation-activated receptor (PPAR)-gamma and PPAR-gamma agonists on stomach cancer cells. METHODS:To determine the proliferation-suppressive effects of troglitazone and ciglitazone, SNU-216 and SNU-668 stomach cancer cells were plated in media c...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.15.310

    authors: Cheon CW,Kim DH,Kim DH,Cho YH,Kim JH

    更新日期:2009-01-21 00:00:00

  • Relationship between tumor necrosis factor-alphaand liver fibrosis.

    abstract::INTRODUCTION:To intrestigate the relationship between tumor necrosis factor-alphaand liver fibrosis in patients with chronic liver disease.METHODS:Radioimmunoassay was made in 20 patients with mild chronic hepatitis(CMH),20 patients with severe chronic hepatitis(CSH),51 patients with liver cirrhosis(LC)and 32-normal p...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v4.i1.18

    authors: Wang X,Chen YX,Xu CF,Zhao GN,Huang YX,Wang QL

    更新日期:1998-02-01 00:00:00

  • Prospective randomized controlled trial investigating the type of sutures used during hepatectomy.

    abstract:AIM:To determine whether absorbable sutures or non-absorbable sutures are better in preventing surgical site infection (SSI), in this paper we discuss the results of a randomized clinical trial which examined the type of sutures used during hepatectomy. METHODS:All hepatic resections performed from January 2007 to Nov...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,随机对照试验

    doi:10.3748/wjg.v17.i18.2338

    authors: Harimoto N,Shirabe K,Abe T,Yukaya T,Tsujita E,Gion T,Kajiyama K,Nagaie T

    更新日期:2011-05-14 00:00:00