Risk factors and outcome of bacterial infections in cirrhosis.


:Viable and non-viable pathological bacterial translocation promote a self-perpetuating circle of dysfunctional immune activation and systemic inflammation facilitating infections and organ failure in advanced cirrhosis. Bacterial infections and sepsis are now recognized as a distinct stage in the natural progression of chronic liver disease as they accelerate organ failure and contribute to the high mortality observed in decompensated cirrhosis. The increasing knowledge of structural, immunological and hemodynamic pathophysiology in advanced cirrhosis has not yet translated into significantly improved outcomes of bacterial infections over the last decades. Therefore, early identification of patients at the highest risk for developing infections and infection-related complications is required to tailor the currently available measures of surveillance, prophylaxis and therapy to the patients in need in order to improve the detrimental outcome of bacterial infections in cirrhosis.


World J Gastroenterol


Bruns T,Zimmermann HW,Stallmach A




Has Abstract


2014-03-14 00:00:00












  • Bacterial flora concurrent with Helicobacter pylori in the stomach of patients with upper gastrointestinal diseases.

    abstract:AIM:To investigate the non-Helicobacter pylori (H. pylori) bacterial flora concurrent with H. pylori infection. METHODS:A total of 103 gastric biopsy specimens from H. pylori positive patients were selected for bacterial culture. All the non-H. pylori bacterial isolates were identified by matrix-assisted laser desorpt...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Hu Y,He LH,Xiao D,Liu GD,Gu YX,Tao XX,Zhang JZ

    更新日期:2012-03-21 00:00:00

  • Clinicopathological features and prognosis assessment of extranodal follicular dendritic cell sarcoma.

    abstract:AIM:To establish a model for prognosis assessment of extranodal follicular dendritic cell (FDC) sarcoma. METHODS:Nine lesions were examined by routine and molecular approaches. Clinicopathological factors from the new cases and 97 reported cases were analyzed for their prognostic values. RESULTS:The current lesions w...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Li L,Shi YH,Guo ZJ,Qiu T,Guo L,Yang HY,Zhang X,Zhao XM,Su Q

    更新日期:2010-05-28 00:00:00

  • Multidetector CT in evaluating blood supply of hepatocellular carcinoma after transcatheter arterial chemoembolization.

    abstract:AIM:To assess the value of multidetector-row computed tomography (MDCT) in choosing retreatment methods of hepatocellular carcinoma (HCC) through evaluating the blood supply of low-density area of HCC after transcatheter arterial chemoembolization (TACE). METHODS:Thirty-two patients with HCC after TACE treatment were ...

    journal_title:World journal of gastroenterology

    pub_type: 临床试验,杂志文章


    authors: Guan YS,Zheng XH,Zhou XP,Huang J,Sun L,Chen X,Li X,He Q

    更新日期:2004-07-15 00:00:00

  • Metastatic breast cancer to the gastrointestinal tract: a case series and review of the literature.

    abstract::Metastatic breast cancer involving the hepatobiliary tract or ascites secondary to peritoneal carcinomatosis has been well described. Luminal gastrointestinal tract involvement is less common and recognition of the range of possible presentations is important for early and accurate diagnosis and treatment. We report 6...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Nazareno J,Taves D,Preiksaitis HG

    更新日期:2006-10-14 00:00:00

  • Muscle fatigue in women with primary biliary cirrhosis: Spectral analysis of surface electromyography.

    abstract:AIM:To evaluate the myoelectric manifestations of peripheral fatigability in patients with primary biliary cirrhosis in comparison to healthy subjects. METHODS:Sixteen women with primary biliary cirrhosis without comorbidity and 13 healthy women matched for age and body mass index (BMI) completed the self-reported que...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Biagini MR,Tozzi A,Grippo A,Galli A,Milani S,Amantini A

    更新日期:2006-08-28 00:00:00

  • High throughput RNA sequencing utility for diagnosis and prognosis in colon diseases.

    abstract::RNA sequencing is the use of high throughput next generation sequencing technology to survey, characterize, and quantify the transcriptome of a genome. RNA sequencing has been used to analyze the pathogenesis of several malignancies such melanoma, lung cancer, and colorectal cancer. RNA sequencing can identify differe...

    journal_title:World journal of gastroenterology

    pub_type: 社论,评审


    authors: Gao M,Zhong A,Patel N,Alur C,Vyas D

    更新日期:2017-04-28 00:00:00

  • Role of HSP-90 for increased nNOS-mediated vasodilation in mesenteric arteries in portal hypertension.

    abstract:AIM:To explore the role of heat shock protein-90 (HSP-90) for nitrergic vasorelaxation in the splanchnic circulation in rats with and without portal hypertension. METHODS:Neuronal nitric oxide synthase (nNOS) and HSP-90 were analyzed by immunofluorescence, western blotting and co-immunoprecipitation in the mesenteric ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Moleda L,Jurzik L,Froh M,Gäbele E,Hellerbrand C,Straub RH,Schölmerich J,Wiest R

    更新日期:2010-04-21 00:00:00

  • Pernicious anemia: new insights from a gastroenterological point of view.

    abstract::Pernicious anemia (PA) is a macrocytic anemia that is caused by vitamin B(12) deficiency, as a result of intrinsic factor deficiency. PA is associated with atrophic body gastritis (ABG), whose diagnosis is based on histological confirmation of gastric body atrophy. Serological markers that suggest oxyntic mucosa damag...

    journal_title:World journal of gastroenterology

    pub_type: 社论,评审


    authors: Lahner E,Annibale B

    更新日期:2009-11-07 00:00:00

  • Endoscopic papillectomy of minor papillar adenoma associated with pancreas divisum.

    abstract::Tumors of the minor papilla of the duodenum are quite rare. We successfully and safely treated an 18-mm adenoma of the minor papilla associated with pancreas divisum using endoscopic papillectomy. A 64-year-old man was admitted to our hospital for treatment of an asymptomatic mass in the minor papilla detected by uppe...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Kanamori A,Kumada T,Kiriyama S,Sone Y,Tanikawa M,Hisanaga Y,Toyoda H,Kawashima H,Itoh A,Hirooka Y,Goto H

    更新日期:2009-03-07 00:00:00

  • Furazolidone-based triple and quadruple eradication therapy for Helicobacter pylori infection.

    abstract:AIM:To evaluate the efficacy of furazolidone-based triple and quadruple therapy in eradicating Helicobacter pylori (H. pylori) in a multi-center randomized controlled trial. METHODS:A total of 720 H. pylori positive patients with duodenal ulcer disease were enrolled at 10 different hospitals in Jiangxi province in Chi...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Xie Y,Zhu Y,Zhou H,Lu ZF,Yang Z,Shu X,Guo XB,Fan HZ,Tang JH,Zeng XP,Wen JB,Li XQ,He XX,Ma JH,Liu DS,Huang CB,Xu NJ,Wang NR,Lu NH

    更新日期:2014-08-28 00:00:00

  • Effects of Linomide on growth and metastasis of implanted human gastric cancer in nude mice.

    abstract:AIM:To elucidate the effect of angiogenesis inhibitor, Linomide, on tumor growth and metastasis in nude mice implanted with human gastric cancer. METHODS:A metastatic model of gastric cancer was established using orthotopic implantation of histologically intact tumor tissues into the gastric wall of nude mice. Linomid...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Tao HQ,Lin YZ,Yin HR,Gu QL,Zhu ZG,Yao M

    更新日期:1997-09-15 00:00:00

  • Improving outcomes in pancreatic cancer: key points in perioperative management.

    abstract::This review focused in the perioperative management of patients with pancreatic cancer in order to improve the outcome of the disease. We consider that the most controversial points in pancreatic cancer management are jaundice management, vascular resection and neo-adjuvant therapy. Preoperative biliary drainage is re...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Alamo JM,Marín LM,Suarez G,Bernal C,Serrano J,Barrera L,Gómez MA,Muntané J,Padillo FJ

    更新日期:2014-10-21 00:00:00

  • Expression of mucins and E-cadherin in gastric carcinoma and their clinical significance.

    abstract:AIM:To investigate the expression of three types of mucin (MUC1, MUC2, MUC5AC) and E-cadherin in human gastric carcinomas and their clinical significance. METHODS:Ninety-four gastric cancer specimens were classified according to WHO criteria and detected by immunohistochemical assay of expression of mucins and E-cadhe...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Zhang HK,Zhang QM,Zhao TH,Li YY,Yi YF

    更新日期:2004-10-15 00:00:00

  • Estrogens and the pathophysiology of the biliary tree.

    abstract::The scientific framework concerning estrogen effects on different tissues has expanded enormously during the last decades, when estrogen receptor (ER) subtypes were identified. Estrogens are not only essential for the female reproductive system, but they also control fundamental functions in other tissues including th...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Alvaro D,Mancino MG,Onori P,Franchitto A,Alpini G,Francis H,Glaser S,Gaudio E

    更新日期:2006-06-14 00:00:00

  • Combined detection of plasma GATA5 and SFRP2 methylation is a valid noninvasive biomarker for colorectal cancer and adenomas.

    abstract:AIM:To investigate GATA5, SFRP2, and ITGA4 methylation in plasma DNA as noninvasive biomarkers for colorectal cancer (CRC) or adenomas. METHODS:There were 57 CRC patients, 30 adenomas patients, and 47 control patients enrolled in this study. Methylation-specific polymerase chain reaction was used to determine the prom...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Zhang X,Song YF,Lu HN,Wang DP,Zhang XS,Huang SL,Sun BL,Huang ZG

    更新日期:2015-03-07 00:00:00

  • Clinical significance of granuloma in Crohn's disease.

    abstract:AIM:Granuloma is considered the hallmark of microscopic diagnosis in Crohn's disease (CD), but granulomas can be detected in only 21-60% of CD patients. The aim of this study was to evaluate the frequency of granulomas by multiple endoscopic biopsies in patients with CD and to examine whether group of patients with or ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Molnár T,Tiszlavicz L,Gyulai C,Nagy F,Lonovics J

    更新日期:2005-05-28 00:00:00

  • hsa-miR-29c and hsa-miR-135b differential expression as potential biomarker of gastric carcinogenesis.

    abstract:AIM:To investigate the expression profiles of hsa-miR-29c and hsa-miR-135b in gastric mucosal samples and their values as gastric carcinogenesis biomarkers. METHODS:The expression levels of hsa-miR-29c and hsa-miR-135b in normal gastric mucosa, non-atrophic chronic gastritis, intestinal metaplasia and intestinal-type ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Vidal AF,Cruz AM,Magalhães L,Pereira AL,Anaissi AK,Alves NC,Albuquerque PJ,Burbano RM,Demachki S,Ribeiro-dos-Santos Â

    更新日期:2016-02-14 00:00:00

  • Juvenile ferric iron prevents microbiota dysbiosis and colitis in adult rodents.

    abstract:AIM:To assess whether juvenile chronic ferric iron ingestion limit colitis and dysbiosis at adulthood in rats and mice. METHODS:Two sets of experiments were designed. In the first set, recently weaned mice were either orally administered ferrous (Fe²⁺) iron salt or ferric (Fe³⁺) microencapsulated iron for 6 wk. The la...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Ettreiki C,Gadonna-Widehem P,Mangin I,Coëffier M,Delayre-Orthez C,Anton PM

    更新日期:2012-06-07 00:00:00

  • Prediction of the indication criteria for endoscopic resection of early gastric cancer.

    abstract:AIM:To find risk factors of lymph node metastasis (LNM) in early gastric cancer (EGC) and to find proper endoscopic therapy indication in EGC. METHODS:We retrospectively reviewed the 2270 patients who underwent curative operation for EGC from January 2001 to December 2008. EGC was defined as malignant lesions that do ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Park JH,Lee SH,Park JM,Park CS,Park KS,Kim ES,Cho KB

    更新日期:2015-10-21 00:00:00

  • Effect of mutant p27(kipl) gene on human cholangiocarcinoma cell line, QBC(939).

    abstract:AIM:To investigate the effects of exogenously mutated p27(kipl) (p27) on proliferation and apoptosis of human cholangiocarcinoma cell line, QBC(939)in vivo. METHODS:Adenviral vectors were used to transfect mutated p27 cDNA into human QBC(939)cell line. Expression of p27 was detected by RT-PCR. Western blot. Cell growt...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Luo J,Chen YJ,Wang WY,Zou SQ

    更新日期:2008-09-14 00:00:00

  • Advanced imaging techniques in the therapeutic response of transarterial chemoembolization for hepatocellular carcinoma.

    abstract::Hepatocellular carcinoma (HCC) is one of the major causes of morbidity and mortality in patients with chronic liver disease. Transarterial chemoembolization (TACE) can significantly improve the survival rate of patients with HCC and is the first treatment choice for patients who are not suitable for surgical resection...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Yang K,Zhang XM,Yang L,Xu H,Peng J

    更新日期:2016-05-28 00:00:00

  • Expression of insulin-like growth factor binding protein-2 in gastric carcinoma and its relationship with cell proliferation.

    abstract:AIM:To investigate the expression of insulin-like growth factor binding protein-2 (IGFBP-2) in gastric carcinoma and its clinical significance and to explore its relationship with cell proliferation. METHODS:Expressions of IGFBP-2 and Ki-67 in 118 cases of gastric carcinoma and 40 cases of normal gastric mucosa were d...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Shi LH,Zhu XQ,Zhao GH,Xia YB,Zhang YS

    更新日期:2006-10-21 00:00:00

  • Gastric ulcer penetrating to liver diagnosed by endoscopic biopsy.

    abstract::Liver penetration is a rare but serious complication of peptic ulcer disease. Usually the diagnosis is made by operation or autopsy. Clinical and laboratory data were no specific. A 64-year-old man was admitted with upper gastrointestinal bleeding. Hepatic penetration was diagnosed as the cause of bleeding. Endoscopy ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Kayacetin E,Kayacetin S

    更新日期:2004-06-15 00:00:00

  • Induction of clinical response and remission of inflammatory bowel disease by use of herbal medicines: a meta-analysis.

    abstract:AIM:To evaluate the efficacy and tolerability of herbal medicines in inflammatory bowel disease (IBD) by conducting a meta-analysis. METHODS:Electronic databases were searched for studies investigating efficacy and/or tolerability of herbal medicines in the management of different types of IBD. The search terms were: ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,meta分析


    authors: Rahimi R,Nikfar S,Abdollahi M

    更新日期:2013-09-14 00:00:00

  • Topical negative pressure in managing severe peritonitis: a positive contribution?

    abstract:AIM:To assess the use of topical negative pressure (TNP) in the management of severe peritonitis. METHODS:This is a four-year prospective analysis from January 2005 to December 2008 of 20 patients requiring TNP following laparotomy for severe peritonitis. RESULTS:There were 11 males with an average age of (59.3 +/- 3...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Amin AI,Shaikh IA

    更新日期:2009-07-21 00:00:00

  • NF-kappaB and ERK-signaling pathways contribute to the gene expression induced by cag PAI-positive-Helicobacter pylori infection.

    abstract:AIM:To elucidate the sequential gene expression profile in AGS cells co-cultured with wild-type Helicobacter pylori (H pylori) as a model of H pylori-infected gastric epithelium, and to further examine the contribution of cag-pathogenicity islands (cagPAI)-coding type IV secretion system and the two pathways, nuclear f...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Shibata W,Hirata Y,Yoshida H,Otsuka M,Hoshida Y,Ogura K,Maeda S,Ohmae T,Yanai A,Mitsuno Y,Seki N,Kawabe T,Omata M

    更新日期:2005-10-21 00:00:00

  • Addition of senna improves quality of colonoscopy preparation with magnesium citrate.

    abstract:AIM:To prospectively investigate the effectiveness and patient's tolerance of two low-cost bowel cleansing preparation protocols based on magnesium citrate only or the combination of magnesium citrate and senna. METHODS:A total of 342 patients who were referred for colonoscopy underwent a colon cleansing protocol with...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Vradelis S,Kalaitzakis E,Sharifi Y,Buchel O,Keshav S,Chapman RW,Braden B

    更新日期:2009-04-14 00:00:00

  • Multifactorial analysis of recurrence of cholecy_stolithiasis in Shanghai area.

    abstract::AIM:To explore the risk factors of gallbladder stone recurrence.METHODS:A multifactorial analysis was made for 1058 patients in Shanghai area whose gallbladder stones disappeared after different kinds of nonsurgical therapy,including oral litholytic therapy, extracorporeal shock wave lithotripsy and percutaneous chole...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Chen P,Wang BS,He LQ

    更新日期:1999-02-01 00:00:00

  • Probiotics in hepatology.

    abstract::The paper provides a basic review of intestinal microflora and its importance in liver diseases. The intestinal microflora has many important functions, above all to maintain the microbial barrier against established as well as potential pathogens. Furthermore, it influences the motility and perfusion of the intestina...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Lata J,Jurankova J,Kopacova M,Vitek P

    更新日期:2011-06-28 00:00:00

  • Interstitial cells of Cajal in the gut--a gastroenterologist's point of view.

    abstract::Alterations of normal function of interstitial cells of Cajal (ICC) are reported in many intestinal disorders. Diagnosis of their involvement is rare (infrequent), but necessary to propose a specific treatment. This article reviews the place of ICC in the pathogenesis of achalasia, gastroesophageal reflux disease, inf...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Negreanu LM,Assor P,Mateescu B,Cirstoiu C

    更新日期:2008-11-07 00:00:00