Pretreatment with intestinal trefoil factor alleviates stress-induced gastric mucosal damage via Akt signaling.

Abstract:

BACKGROUND:Stress-related gastric mucosal damage or ulcer remains an unsolved issue for critically ill patients. Stress ulcer prophylaxis has been part of routine intensive care, but uncertainty and controversy still exist. Co-secreted with mucins, intestinal trefoil factor (ITF) is reported to promote restitution and regeneration of intestinal mucosal epithelium, although the mechanism remains unknown. AIM:To elucidate the protective effects of ITF on gastric mucosa and explore the possible mechanisms. METHODS:We used a rat model of gastric mucosal damage induced by water immersion restraint stress and lipopolysaccharide-treated human gastric epithelial cell line to investigate the potential effects of ITF on damaged gastric mucosa both in vivo and in vitro. RESULTS:ITF promoted the proliferation and migration and inhibited necrosis of gastric mucosal epithelia in vitro. It also preserved the integrity of gastric mucosa by upregulating expressions of occludin and zonula occludens-1. In the rat model, pretreatment with ITF ameliorated the gastric mucosal epithelial damage and facilitated mucosal repair. The protective effects of ITF were confirmed to be exerted via activation of Akt signaling, and the specific inhibitor of Akt signaling LY249002 reversed the protective effects. CONCLUSION:ITF might be a promising candidate for prevention and treatment of stress-induced gastric mucosal damage, and further studies should be undertaken to verify its clinical feasibility.

journal_name

World J Gastroenterol

authors

Huang Y,Wang MM,Yang ZZ,Ren Y,Zhang W,Sun ZR,Nie SN

doi

10.3748/wjg.v26.i48.7619

subject

Has Abstract

pub_date

2020-12-28 00:00:00

pages

7619-7632

issue

48

eissn

1007-9327

issn

2219-2840

journal_volume

26

pub_type

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