Abstract:
BACKGROUND:Stress-related gastric mucosal damage or ulcer remains an unsolved issue for critically ill patients. Stress ulcer prophylaxis has been part of routine intensive care, but uncertainty and controversy still exist. Co-secreted with mucins, intestinal trefoil factor (ITF) is reported to promote restitution and regeneration of intestinal mucosal epithelium, although the mechanism remains unknown. AIM:To elucidate the protective effects of ITF on gastric mucosa and explore the possible mechanisms. METHODS:We used a rat model of gastric mucosal damage induced by water immersion restraint stress and lipopolysaccharide-treated human gastric epithelial cell line to investigate the potential effects of ITF on damaged gastric mucosa both in vivo and in vitro. RESULTS:ITF promoted the proliferation and migration and inhibited necrosis of gastric mucosal epithelia in vitro. It also preserved the integrity of gastric mucosa by upregulating expressions of occludin and zonula occludens-1. In the rat model, pretreatment with ITF ameliorated the gastric mucosal epithelial damage and facilitated mucosal repair. The protective effects of ITF were confirmed to be exerted via activation of Akt signaling, and the specific inhibitor of Akt signaling LY249002 reversed the protective effects. CONCLUSION:ITF might be a promising candidate for prevention and treatment of stress-induced gastric mucosal damage, and further studies should be undertaken to verify its clinical feasibility.
journal_name
World J Gastroenteroljournal_title
World journal of gastroenterologyauthors
Huang Y,Wang MM,Yang ZZ,Ren Y,Zhang W,Sun ZR,Nie SNdoi
10.3748/wjg.v26.i48.7619subject
Has Abstractpub_date
2020-12-28 00:00:00pages
7619-7632issue
48eissn
1007-9327issn
2219-2840journal_volume
26pub_type
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journal_title:World journal of gastroenterology
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pub_type: 杂志文章,meta分析
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
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更新日期:2013-07-21 00:00:00
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更新日期:2009-02-28 00:00:00