Abstract:
AIM:To establish the prognosis and feasibility of en-bloc vascular resection of stage II pancreatic adenocarcinoma of the head and uncinate process. METHODS:We retrospectively analyzed 87 patients with stage II pancreatic adenocarcinoma, who were subjected to pancreaticoduodenectomy (PD) and pylorus-preserving PD (PPPD) between 1996 and 2006 in Chang Gung Memorial Hospital, Taiwan. Twelve and 75 patients underwent PD/PPPD with and without resection of portal vein/superior mesenteric vein (PV/SMV), respectively. RESULTS:The overall 1- and 3-year survival rates of patients undergoing PD/PPPD with and without vascular resection were 50.0% and 16.7%, and 44.4% and 12.2%, respectively. Morbidity and mortality rates in the PV/SMV resection vs non-resection group were 50.0% and 0.0%, and 40.0% and 2.7%, respectively. In multivariate analysis, serum bilirubin, histological differentiation and adjuvant chemotherapy were independent prognostic factors that influenced survival. CONCLUSION:In stage II adenocarcinoma of the pancreatic head and uncinate process, serum bilirubin, histological differentiation and adjuvant chemotherapy were independent prognostic factors, and en-bloc vascular resection is a feasible option in carefully selected patients.
journal_name
World J Gastroenteroljournal_title
World journal of gastroenterologyauthors
Chakravarty KD,Hsu JT,Liu KH,Yeh CN,Yeh TS,Hwang TL,Jan YY,Chen MFdoi
10.3748/wjg.v16.i8.997subject
Has Abstractpub_date
2010-02-28 00:00:00pages
997-1002issue
8eissn
1007-9327issn
2219-2840journal_volume
16pub_type
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更新日期:2014-09-14 00:00:00
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更新日期:2011-05-28 00:00:00
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更新日期:2014-06-14 00:00:00
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更新日期:2007-01-21 00:00:00