Elderly patients with inflammatory bowel disease: Updated review of the therapeutic landscape.

abstract：:Despite advancements in medical therapy of Crohn's disease (CD), majority of patients with CD will eventually require surgical intervention, with at least a third of patients requiring multiple surgeries. It is important to understand the role and timing of surgery, with the goals of therapy to reduce the need for sur...

journal_title：World journal of gastroenterology

authors： Toh JW,Stewart P,Rickard MJ,Leong R,Wang N,Young CJ

更新日期：2016-10-28 00:00:00

abstract：AIM:To investigate the post-colonoscopy colorectal cancer (PCCRC) rate for high-definition (HD) colonoscopy compared with that for standard-definition colonoscopy reported previously. METHODS:Using medical records at Sano Hospital (SH) and Dokkyo Medical University Koshigaya Hospital (DMUKH), we retrospectively obtain...

journal_title：World journal of gastroenterology

authors： Iwatate M,Kitagawa T,Katayama Y,Tokutomi N,Ban S,Hattori S,Hasuike N,Sano W,Sano Y,Tamano M

更新日期：2017-11-14 00:00:00

abstract：:To review the inhibitory effect of preventive approaches on recurrence after operation in patients with hepatocellular carcinoma (HCC), we summarized all available publications reporting randomized control trial indexed in PubMed. The treatment approaches presented above included pre-operative transcatheter arterial c...

journal_title：World journal of gastroenterology

authors： Sun HC,Tang ZY

更新日期：2003-04-01 00:00:00

abstract：:We report a case of duodenal varix bleeding as a long term complication of balloon occluded retrograde transvenous obliteration (BRTO), which was successfully treated with a transjugular intrahepatic portosystemic shunt (TIPS). A 57-year-old man was admitted to the emergency room suffering from melena. He had undergon...

journal_title：World journal of gastroenterology

authors： Kim MJ,Jang BK,Chung WJ,Hwang JS,Kim YH

更新日期：2012-06-14 00:00:00

abstract：AIM:To investigate omeprazole-induced transepithelial gastric leak and its effects on the permeability of the peptides bradykinin and oxytocin. METHODS:Rat gastric corpus tissue was isolated and mounted in an Ussing chamber apparatus to evaluate the permeability of (3)H-bradykinin, (3)H-oxytocin, and (14)C-EDTA in the...

journal_title：World journal of gastroenterology

authors： Gabello M,Valenzano MC,Zurbach EP,Mullin JM

更新日期：2010-03-07 00:00:00

abstract：AIM:To retrospectively analyze factors affecting the long-term survival of patients with pancreatic cancer who underwent pancreatic resection. METHODS:From January 2000 to December 2011, 195 patients underwent pancreatic resection in our hospital. The prognostic factors after pancreatic resection were analyzed in all ...

journal_title：World journal of gastroenterology

authors： Yamamoto T,Yagi S,Kinoshita H,Sakamoto Y,Okada K,Uryuhara K,Morimoto T,Kaihara S,Hosotani R

更新日期：2015-01-07 00:00:00

abstract：AIM:To study the expression levels of E- selectin, integrin beta1 and immunoglobulin superfamily member-intercellular adhesion molecule-1 (ICAM-1) in human gastric carcinoma cells, and to explore the relationship between these three kinds of cell adhesion molecules and gastric carcinoma. METHODS:The serum contents of ...

journal_title：World journal of gastroenterology

authors： Ke JJ,Shao QS,Ling ZQ

更新日期：2006-06-14 00:00:00

abstract：AIM:To clarify the relationship between circumferential resection margin status and local and distant recurrence as well as survival of patients with middle and lower rectal carcinoma. The relationship between circumferential resection margin status and clinicopathologic characteristics of middle and lower rectal carci...

journal_title：World journal of gastroenterology

authors： Wu ZY,Wan J,Li JH,Zhao G,Peng L,Yao Y,Du JL,Liu QF,Wang ZD,Huang ZM,Lin HH

更新日期：2007-06-28 00:00:00

abstract：:Crohn's disease is a chronic inflammatory granulomatous process that usually involves different sites in the intestinal tract. Genetic and environmental factors are thought to play a role in its etiology and pathogenesis. The disorder has a heterogeneous clinical expression and data from tertiary care settings have do...

journal_title：World journal of gastroenterology

authors： Freeman HJ

更新日期：2009-03-21 00:00:00

abstract：AIM:To investigate the effect of pituitary homeobox 1 (PITX1) expression in cases of human gastric cancer on cancer differentiation and progression, and carcinogenesis. METHODS:Using polyclonal PITX1 antibodies, we studied the expression of PITX1 in normal gastric mucosa, atypical hyperplasia, intestinal metaplasia, a...

journal_title：World journal of gastroenterology

authors： Chen YN,Chen H,Xu Y,Zhang X,Luo Y

更新日期：2008-01-14 00:00:00

abstract：AIM:To improve anti-inflammatory activity while reducing drug doses, we developed a nanoformulation carrying dexamethasone and butyrate. METHODS:Dexamethasone cholesteryl butyrate-solid lipid nanoparticles (DxCb-SLN) were obtained with the warm microemulsion method. The anti-inflammatory activity of this novel nanofor...

journal_title：World journal of gastroenterology

authors： Dianzani C,Foglietta F,Ferrara B,Rosa AC,Muntoni E,Gasco P,Della Pepa C,Canaparo R,Serpe L

更新日期：2017-06-21 00:00:00

abstract：:In 2018, the pan-Janus kinase (JAK) inhibitor tofacitinib was launched for the treatment of ulcerative colitis (UC). Although tofacitinib has proven efficacious in patients with active UC, it failed in patients with Crohn's disease (CD). This finding strongly hints at a different contribution of JAK signaling in both ...

journal_title：World journal of gastroenterology

authors： Cordes F,Foell D,Ding JN,Varga G,Bettenworth D

更新日期：2020-07-28 00:00:00

abstract：:Multiple robotic flexible endoscope platforms have been developed based on cross specialty collaboration between engineers and medical doctors. However, significant number of these platforms have been developed for the natural orifice transluminal endoscopic surgery paradigm. Increasing amount of evidence suggest the ...

journal_title：World journal of gastroenterology

authors： Yeung BP,Chiu PW

更新日期：2016-02-07 00:00:00

abstract：AIM:To investigate the inhibitory effects of sinomenine (SIN) combined with 5-fluorouracil (5-FU) on esophageal carcinoma in vitro and in vivo. METHODS:Esophageal carcinoma (Eca-109) cells were cultured in DMEM. The single or combined growth inhibition effects of SIN and 5-FU on the Eca-109 cells were examined by meas...

journal_title：World journal of gastroenterology

authors： Wang J,Yang ZR,Dong WG,Zhang JX,Guo XF,Song J,Qiu S

更新日期：2013-12-07 00:00:00

abstract：:An estimated 300 million people worldwide suffer from chronic hepatitis C with a prevalence of 0.8%-1.0% of the general population in Canada. An increasing pool of evidence exists supporting the use of pegylated- interferon (pegIFN) and ribavirin combination therapy for hepatitis C. We report a 49-year old male of Nor...

journal_title：World journal of gastroenterology

authors： Zandieh I,Adenwalla M,Cheong-Lee C,Ma PE,Yoshida EM

更新日期：2006-08-14 00:00:00

abstract：AIM:To study the clinical outcome of antiviral therapy in hepatitis B-related decompensated cirrhotic patients. METHODS:Three hundred and twelve patients with decompensated hepatitis B cirrhosis were evaluated in a prospective cohort. With two years of follow-up, 198 patients in the group receiving antiviral therapy w...

journal_title：World journal of gastroenterology

authors： Li L,Liu W,Chen YH,Fan CL,Dong PL,Wei FL,Li B,Chen DX,Ding HG

更新日期：2013-12-07 00:00:00

abstract：:Although primary gastrointestinal lymphoma is a rare malignancy, it can cause an intussusception in adults and can be a clinically challenging condition to manage. Intussusception could progress to life-threatening complications if left untreated or could delay chemotherapy if inappropriate surgical management is used...

journal_title：World journal of gastroenterology

authors： Yang TW,Lin YY,Tsuei YW,Chen YL,Huang CY,Hsu SD

更新日期：2016-05-21 00:00:00

abstract：AIM:To compare the effect of intravenous and oral omeprazole in patients with bleeding peptic ulcers without high-risk stigmata. METHODS:This randomized study included 211 patients [112 receiving iv omeprazole protocol (Group 1), 99 receiving po omeprazole 40 mg every 12 h (Group 2)] with a mean age of 52.7. In 144 pa...

journal_title：World journal of gastroenterology

authors： Yilmaz S,Bayan K,Tüzün Y,Dursun M,Canoruç F

更新日期：2006-12-28 00:00:00

abstract：AIM:To study the therapeutic effectiveness of intra-tumor injection of Xiao-Zhi-Ling(XZL) on transplanted hepatoma in rats. METHODS:Sixty rats were divided into 3 groups (groups S, X and E), 20 in each. Different drugs were injected into the implanted hepatoma (Group S with 0.2 ml saline as control, group X with 0.2 m...

journal_title：World journal of gastroenterology

authors： Lu Y,Wu LQ

更新日期：2003-09-01 00:00:00

abstract：AIM:To develop a conditionally replicative gene-viral vector system called CNHK500-p53, which contains dual promoters within the E1 region, and combines the advantages of oncolytic virus and gene therapies for hepatocellular carcinoma (HCC). METHODS:CNHK500-p53 was constructed by using human telomerase reverse transcr...

journal_title：World journal of gastroenterology

authors： Zhao HC,Zhang Q,Yang Y,Lu MQ,Li H,Xu C,Chen GH

更新日期：2007-02-07 00:00:00

abstract：AIM:To investigate the role of reactive oxygen species (ROS) in ethanol-mediated cell death of polarized hepatic (WIF-B) cells. METHODS:In this work, WIF-B cultures were treated with pyrazole (inducer of cytochrome P4502E1, CYP2E1) and/or L-buthionine sulfoximine (BSO), a known inhibitor of hepatic glutathione (GSH), ...

journal_title：World journal of gastroenterology

authors： McVicker BL,Tuma PL,Kharbanda KK,Lee SM,Tuma DJ

更新日期：2009-06-07 00:00:00

abstract：BACKGROUND:End-stage liver disease caused by non-alcoholic steatohepatitis (NASH) is the second leading indication for liver transplantation. To date, only moderately effective pharmacotherapies exist to treat NASH. Understanding the pathogenesis of NASH is therefore crucial for the development of new therapies. The in...

journal_title：World journal of gastroenterology

authors： Bluemel S,Wang Y,Lee S,Schnabl B

更新日期：2020-09-07 00:00:00

abstract：AIM:To study the interactive relationship of gallbladder motor function, plasma cholecystokinin (CCK) and cholecystokinin A receptor (CCK-R) of gallbladder in patients with cholesterol stone disease. METHODS:Gallbladder motility was studied by ultrasonography in 33 patients with gallbladder stone and 10 health subject...

journal_title：World journal of gastroenterology

authors： Zhu J,Han TQ,Chen S,Jiang Y,Zhang SD

更新日期：2005-03-21 00:00:00

abstract：AIM:To explore the impact of prolonged fraction dose-delivery time modeling intensity-modulated radiation therapy (IMRT) on cell killing of human hepatocellular carcinoma (HCC) HepG2 and Hep3B cell lines. METHODS:The radiobiological characteristics of human HCC HepG2 and Hep3b cell lines were studied with standard clo...

journal_title：World journal of gastroenterology

authors： Zheng XK,Chen LH,Yan X,Wang HM

更新日期：2005-03-14 00:00:00

abstract：AIM:To investigate the possible mechanism by which hepatitis B virus X protein (HBx) mediates apoptosis of HepG2 cells. METHODS:HBx expression vector pcDNA3.1-X was transfected into HepG2 cells to establish an HBx high-expression cellular model as pcDNA3.1-X transfected group. The pcDNA3.1-X and pSilencer3.1-shHBX (HB...

journal_title：World journal of gastroenterology

authors： Tang RX,Kong FY,Fan BF,Liu XM,You HJ,Zhang P,Zheng KY

更新日期：2012-04-07 00:00:00

abstract：AIM:To investigate the safety and efficacy of adding bevacizumab to first-line chemotherapy in metastatic colorectal cancer patients with peritoneal disease. METHODS:We compared rates of gastrointestinal perforation in patients with metastatic colorectal cancer and peritoneal disease receiving first-line chemotherapy ...

journal_title：World journal of gastroenterology

authors： Roohullah A,Wong HL,Sjoquist KM,Gibbs P,Field K,Tran B,Shapiro J,Mckendrick J,Yip D,Nott L,Gebski V,Ng W,Chua W,Price T,Tebbutt N,Chantrill L

更新日期：2015-05-07 00:00:00

abstract：AIM:To determine the maximum tolerated dose (MTD) and dose-limiting toxicity (DLT) of capecitabine combined with postoperative radiotherapy for gastric cancer. METHODS:We enrolled patients with any T stage and node-positive gastroesophageal or gastric adenocarcinoma after complete resection with negative margins (R0) ...

journal_title：World journal of gastroenterology

authors： Wang X,Jin J,Li YX,Ren H,Fang H,Wang SL,Liu YP,Wang WH,Yu ZH,Song YW,Liu XF

更新日期：2014-01-28 00:00:00

abstract：AIM:To evaluate the effects of combined radiofrequency ablation and transcatheter arterial embolization with iodized oil on ablation time, maximum output, coagulation diameter, and portal angiography in a porcine liver model. METHODS:Radiofrequency ablation (RFA) was applied to in vivo livers of 10 normal pigs using a...

journal_title：World journal of gastroenterology

authors： Nakai M,Sato M,Sahara S,Kawai N,Tanihata H,Kimura M,Terada M

更新日期：2007-05-28 00:00:00

abstract：AIM:To study the effect of nicotine on the migration and invasion of human esophageal squamous carcinoma cells and to investigate whether nimesulide can inhibit the effect of nicotine. METHODS:The esophageal squamous carcinoma cell line (TE-13) was treated with different concentrations of nicotine (100 microg/mL and 2...

journal_title：World journal of gastroenterology

authors： Zong Y,Zhang ST,Zhu ST

更新日期：2009-05-28 00:00:00

abstract：AIM:To study the effect of hepatitis C virus nonstructural protein 3 c-terminal deleted protein (HCV NS3-5') on hepatocyte transformation and tumor development. METHODS:QSG7701 cells were transfected with plasmid pRcHCNS3-5' (expressing HCV NS3 c-terminal deleted protein) by lipofectamine and selected in G418. The exp...

journal_title：World journal of gastroenterology

authors： He QQ,Cheng RX,Sun Y,Feng DY,Chen ZC,Zheng H

更新日期：2003-03-01 00:00:00