Abstract:
:Perfusion of individual tissues is a basic physiological process that is necessary to sustain oxygenation and nutrition at a cellular level. Ischemia, or the insufficiency of perfusion, is a common mechanism for tissue death or degeneration, and at a lower threshold, a mechanism for the generation of sensory signalling including pain. It is of considerable interest to study perfusion of peripheral abdominal tissues in a variety of circumstances. Microvascular disease of the abdominal organs has been implicated in the pathogenesis of a variety of disorders, including peptic ulcer disease, inflammatory bowel disease and chest pain. The basic principle of laser Doppler perfusion monitoring (LDPM) is to analyze changes in the spectrum of light reflected from tissues as a response to a beam of monochromatic laser light emitted. It reflects the total local microcirculatory blood perfusion, including perfusion in capillaries, arterioles, venules and shunts. During the last 20-25 years, numerous studies have been performed in different parts of the gastrointestinal (GI) tract using LDPM. In recent years we have developed a multi-modal catheter device which includes a laser Doppler probe, with the intent primarily to investigate patients suffering from functional chest pain of presumed oesophageal origin. Preliminary studies show the feasibility of incorporating LDPM into such catheters for performing physiological studies in the GI tract. LDPM has emerged as a research and clinical tool in preference to other methods; but, it is important to be aware of its limitations and account for them when reporting results.
journal_name
World J Gastroenteroljournal_title
World journal of gastroenterologyauthors
Hoff DA,Gregersen H,Hatlebakk JGdoi
10.3748/wjg.15.198subject
Has Abstractpub_date
2009-01-14 00:00:00pages
198-203issue
2eissn
1007-9327issn
2219-2840journal_volume
15pub_type
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journal_title:World journal of gastroenterology
pub_type: 杂志文章,meta分析,评审
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更新日期:2013-07-14 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.3748/wjg.v11.i6.797
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journal_title:World journal of gastroenterology
pub_type: 杂志文章,评审
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pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章,评审
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pub_type: 评论,信件
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journal_title:World journal of gastroenterology
pub_type: 杂志文章,随机对照试验
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
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更新日期:1998-02-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2014-08-14 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
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更新日期:2013-08-21 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
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更新日期:2011-06-28 00:00:00
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pub_type: 杂志文章,meta分析,评审
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更新日期:2015-03-14 00:00:00
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pub_type: 杂志文章
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更新日期:2006-01-14 00:00:00