Stronger inhibition of gastric acid secretion by lafutidine, a novel H2 receptor antagonist, than by the proton pump inhibitor lansoprazole.

Abstract:

AIM:To compare the antisecretory activity and plasma drug concentrations of a single oral dose of 10 mg lafutidine, a novel H2 receptor antagonist, with those of the proton pump inhibitor lansoprazole (LPZ) 30 mg. METHODS:Ten volunteers without H pylori infection participated in this crossover study comparing lafutidine 10 mg with LPZ 30 mg. Intragastric pH was monitored for 6 h in all participants, and blood samples were collected from four randomly selected individuals after single-dose administration of each drug. RESULTS:The median intragastric pH was significantly higher in individuals who received lafutidine 10 mg than in those who received LPZ 30 mg 2, 3, 4, 5, and 6 h after administration. Maximal plasma drug concentration was reached more promptly with lafutidine 10 mg than with LPZ 30 mg. CONCLUSION:In H pylori-negative individuals, gastric acid secretion is more markedly inhibited by lafutidine than by LPZ.

journal_name

World J Gastroenterol

authors

Yamagishi H,Koike T,Ohara S,Horii T,Kikuchi R,Kobayashi S,Abe Y,Iijima K,Imatani A,Suzuki K,Hishinuma T,Goto J,Shimosegawa T

doi

10.3748/wjg.14.2406

subject

Has Abstract

pub_date

2008-04-21 00:00:00

pages

2406-10

issue

15

eissn

1007-9327

issn

2219-2840

journal_volume

14

pub_type

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