Current treatment for colorectal liver metastases.

Abstract:

:Surgical resection offers the best opportunity for survival in patients with colorectal cancer metastatic to the liver, with five-year survival rates up to 58% in selected cases. However, only a minority are resectable at the time of diagnosis. Continuous research in this field aims at increasing the percentage of patients eligible for resection, refining the indications and contraindications for surgery, and improving overall survival. The use of surgical innovations, such as staged resection, portal vein embolization, and repeat resection has allowed higher resection rates in patients with bilobar disease. The use of neoadjuvant chemotherapy allows up to 38% of patients previously considered unresectable to be significantly downstaged and eligible for hepatic resection. Ablative techniques have gained wide acceptance as an adjunct to surgical resection and in the management of patients who are not surgical candidates. Current management of colorectal liver metastases requires a multidisciplinary approach, which should be individualized in each case.

journal_name

World J Gastroenterol

authors

Misiakos EP,Karidis NP,Kouraklis G

doi

10.3748/wjg.v17.i36.4067

subject

Has Abstract

pub_date

2011-09-28 00:00:00

pages

4067-75

issue

36

eissn

1007-9327

issn

2219-2840

journal_volume

17

pub_type

杂志文章,评审
  • Genetic alterations in benign lesions: chronic gastritis and gastric ulcer.

    abstract:AIM:To investigate the occurrence of chromosome 3, 7, 8, 9, and 17 aneuploidies, TP53 gene deletion and p53 protein expression in chronic gastritis, atrophic gastritis and gastric ulcer, and their association with H pylori infection. METHODS:Gastric biopsies from normal mucosa (NM, n=10), chronic gastritis (CG, n=38),...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v12.i4.625

    authors: Gobbo César AC,de Freitas Calmon M,Cury PM,Caetano A,Borim AA,Silva AE

    更新日期:2006-01-28 00:00:00

  • Microbial metabolites in non-alcoholic fatty liver disease.

    abstract::The prevalence of non-alcoholic fatty liver disease (NAFLD) is rising exponentially worldwide. The spectrum of NAFLD includes non-alcoholic fatty liver, non-alcoholic steatohepatitis, liver cirrhosis, and even hepatocellular carcinoma. Evidence shows that microbial metabolites play pivotal roles in the onset and progr...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v25.i17.2019

    authors: Zhou D,Fan JG

    更新日期:2019-05-07 00:00:00

  • Retrospective analysis of extra-gastrointestinal stromal tumors.

    abstract:AIM:To investigate the clinicopathologic features of patients with extra-gastrointestinal stromal tumors (EGISTs) in South Korea. METHODS:A total of 51 patients with an EGIST were identified. The clinicopathologic features, including sex, age, location, tumor size, histology, mitotic rate, immunohistochemical features...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v21.i6.1845

    authors: Yi JH,Park BB,Kang JH,Hwang IG,Shin DB,Sym SJ,Ahn HK,Lee SI,Lim DH,Park KW,Won YW,Lim SH,Park SH

    更新日期:2015-02-14 00:00:00

  • Omeprazole induces gastric transmucosal permeability to the peptide bradykinin.

    abstract:AIM:To investigate omeprazole-induced transepithelial gastric leak and its effects on the permeability of the peptides bradykinin and oxytocin. METHODS:Rat gastric corpus tissue was isolated and mounted in an Ussing chamber apparatus to evaluate the permeability of (3)H-bradykinin, (3)H-oxytocin, and (14)C-EDTA in the...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v16.i9.1097

    authors: Gabello M,Valenzano MC,Zurbach EP,Mullin JM

    更新日期:2010-03-07 00:00:00

  • Primary sclerosing cholangitis--what is the difference between east and west?

    abstract::Primary sclerosing cholangitis (PSC) is a chronic, progressive, cholestatic liver disease characterized by inflammation and fibrotic obliteration of the hepatic biliary tree. It is commonly associated with inflammatory bowel disease (IBD). A number of complications can occur which require special consideration, the mo...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.14.3974

    authors: Shorbagi A,Bayraktar Y

    更新日期:2008-07-07 00:00:00

  • Z-line examination by the PillCam SB: prospective comparison of three ingestion protocols.

    abstract:AIM:To evaluate the Z-line visualization by the PillCam SB2 using three different ingestion protocols. METHODS:Ninety consecutive patients undergoing small bowel capsule endoscopy (SBCE) between January and May 2008 were included in the study. They swallowed the capsule in the standing (Group A = 30), supine (Group B ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,随机对照试验

    doi:10.3748/wjg.v16.i1.63

    authors: Fernandez-Urien I,Borobio E,Elizalde I,Irisarri R,Vila JJ,Urman JM,Jimenez J

    更新日期:2010-01-07 00:00:00

  • Predictive factors for lymph node metastasis in early gastric cancer.

    abstract:AIM:To analyze the predictive factors for lymph node metastasis (LNM) in early gastric cancer (EGC). METHODS:Data from patients surgically treated for gastric cancers between January 1994 and December 2007 were retrospectively collected. Clinicopathological factors were analyzed to identify predictive factors for LNM....

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v16.i41.5252

    authors: Sung CM,Hsu CM,Hsu JT,Yeh TS,Lin CJ,Chen TC,Su MY,Chiu CT

    更新日期:2010-11-07 00:00:00

  • Green tea and the risk of gastric cancer: epidemiological evidence.

    abstract::Gastric cancer (GC) is one of the leading causes of cancer death in the world. Numerous efforts are being made to find chemoprotective agents able to reduce its risk. Amongst these, green tea has been reported to have a protective effect against stomach cancer. This article aims to critically evaluate all epidemiologi...

    journal_title:World journal of gastroenterology

    pub_type: 社论,评审

    doi:10.3748/wjg.v19.i24.3713

    authors: Hou IC,Amarnani S,Chong MT,Bishayee A

    更新日期:2013-06-28 00:00:00

  • T cell responses to hepatitis B surface antigen are detectable in non-vaccinated individuals.

    abstract:AIM:To evaluate, whether humoral hepatitis-B-vaccine non-responders also fail to mount a T cell response and to compare these results to normal vaccinees. METHODS:Fourty-seven health care employees were enrolled in this study including all available non-responders (n = 13) with an anti-HBsAg titer < 10 kU/L and all av...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.14.2529

    authors: Weihrauch MR,von Bergwelt-Baildon M,Kandic M,Weskott M,Klamp W,Rosler J,Schultze JL

    更新日期:2008-04-28 00:00:00

  • A dose-up of ursodeoxycholic acid decreases transaminases in hepatitis C patients.

    abstract:AIM:To examine whether a dose-up to 900 mg of ursodeoxycholic acid (UDCA) decreases transaminases in hepatitis C patients. METHODS:From January to December 2007, patients with chronic hepatitis C or compensated liver cirrhosis with hepatitis C virus (HCV) (43-80 years old) showing positive serum HCV-RNA who had alread...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.15.2782

    authors: Sato S,Miyake T,Tobita H,Oshima N,Ishine J,Hanaoka T,Amano Y,Kinoshita Y

    更新日期:2009-06-14 00:00:00

  • Stable expression of human cytochrome P450 2D6*10 in HepG2 cells.

    abstract:AIM:Over 90% of drugs are metabolized by the cytochrome P-450 (CYP) family of liver isoenzymes. The most important enzymes are CYP1A2, 3A4, 2C9/19, 2D6 and 2E1. Although CYP2D6 accounts for <2% of the total CYP liver enzyme content, it mediates metabolism in almost 25% of drugs. In order to study its enzymatic activity...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v10.i2.234

    authors: Zhuge J,Yu YN,Wu XD

    更新日期:2004-01-15 00:00:00

  • Effects of autoantibodies against beta(1)-adrenoceptor in hepatitis virus myocarditis on action potential and L-type Ca(2+) currents.

    abstract:AIM:To investigate the effects of autoantibodies against beta(1)-adrenoceptor in hepatitis virus myocarditis on action potential and L-type Ca(2+) currents. METHODS:Fifteen samples of autoantibodies against beta(1)-adrenoceptor positive sera of patients with hepatitis virus myocarditis were obtained and IgGs were puri...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v10.i8.1171

    authors: Liu K,Liao YH,Wang ZH,Li SL,Wang M,Zeng LL,Tang M

    更新日期:2004-04-15 00:00:00

  • Jejunoileal bypass: a surgery of the past and a review of its complications.

    abstract::Jejunoileal bypass (JIB), popular in the 1960s and 1970s, had remarkable success in achieving weight loss by creating a surgical short bowel syndrome. Our patient had an unusual case of liver disease and provided no history of prior bariatric surgery. Later, it was recognized that he had a JIB in the 1970s, which was ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.15.2277

    authors: Singh D,Laya AS,Clarkston WK,Allen MJ

    更新日期:2009-05-14 00:00:00

  • Successful endoscopic treatment of biliary stricture following mesenteric tear caused by blunt abdominal trauma.

    abstract::Biliary duct injuries are frequently iatrogenic, being associated with surgery for gallbladder stones. However, blunt abdominal trauma such as a motor vehicle crash is a rare cause of extrahepatic biliary stricture. A few reports have been published on biliary strictures treated with endoscopic therapy. In the present...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.14.2277

    authors: Kang DO,Kim TH,You SS,Min HJ,Kim HJ,Jung WT,Lee OJ

    更新日期:2008-04-14 00:00:00

  • Esophageal intramural pseudodiverticulosis of the residual esophagus after esophagectomy for esophageal cancer.

    abstract::A 91-year-old man was referred to our hospital with intermittent dysphagia. He had undergone esophagectomy for esophageal cancer (T3N2M0 Stage III) 11 years earlier. Endoscopic examination revealed an anastomotic stricture; signs of inflammation, including redness, erosion, edema, bleeding, friability, and exudate wit...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v21.i30.9223

    authors: Takeshita N,Kanda N,Fukunaga T,Kimura M,Sugamoto Y,Tasaki K,Uesato M,Sazuka T,Maruyama T,Aida N,Tamachi T,Hosokawa T,Asai Y,Matsubara H

    更新日期:2015-08-14 00:00:00

  • New tight junction protein 2 variant causing progressive familial intrahepatic cholestasis type 4 in adults: A case report.

    abstract:BACKGROUND:Progressive familial intrahepatic cholestasis (PFIC) encompasses a group of autosomal recessive disorders with high morbidity and mortality. Variants in the gene encoding tight junction protein-2 (TJP2) have been linked to PFIC type 4 (PFIC4), which predominantly presents in childhood. However, there are onl...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v26.i5.550

    authors: Wei CS,Becher N,Friis JB,Ott P,Vogel I,Grønbæk H

    更新日期:2020-02-07 00:00:00

  • Mechanism of diarrhea in microscopic colitis.

    abstract:AIM:To search the pathophysiological mechanism of diarrhea based on daily stool weights, fecal electrolytes, osmotic gap and pH. METHODS:Seventy-six patients were included: 51 with microscopic colitis (MC) (40 with lymphocytic colitis (LC); 11 with collagenous colitis (CC)); 7 with MC without diarrhea and 18 as a cont...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i35.5535

    authors: Protic M,Jojic N,Bojic D,Milutinovic S,Necic D,Bojic B,Svorcan P,Krstic M,Popovic O

    更新日期:2005-09-21 00:00:00

  • Improving outcomes in pancreatic cancer: key points in perioperative management.

    abstract::This review focused in the perioperative management of patients with pancreatic cancer in order to improve the outcome of the disease. We consider that the most controversial points in pancreatic cancer management are jaundice management, vascular resection and neo-adjuvant therapy. Preoperative biliary drainage is re...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v20.i39.14237

    authors: Alamo JM,Marín LM,Suarez G,Bernal C,Serrano J,Barrera L,Gómez MA,Muntané J,Padillo FJ

    更新日期:2014-10-21 00:00:00

  • Differential mucin phenotypes and their significance in a variation of colorectal carcinoma.

    abstract:AIM:To investigate mucin expression profiles in colorectal carcinoma (CRC) histological subtypes with regard to clinicopathologic variables and prognosis. METHODS:Mucin (MUC)2 and MUC5AC expressions were assessed by immunohistochemistry for a total of 250 CRC cases that underwent surgical resection. CRCs included 63 w...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v19.i25.3957

    authors: Imai Y,Yamagishi H,Fukuda K,Ono Y,Inoue T,Ueda Y

    更新日期:2013-07-07 00:00:00

  • Effects of 7.5% hypertonic saline on fluid balance after radical surgery for gastrointestinal carcinoma.

    abstract:AIM:To investigate the effects of 7.5% hypertonic saline on positive fluid balance and negative fluid balance, after radical surgery for gastrointestinal carcinoma. METHODS:Fifty-two patients with gastrointestinal carcinoma undergoing radical surgery were studied. The patients were assigned to receive either Ringer la...

    journal_title:World journal of gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.3748/wjg.v11.i11.1577

    authors: Shao YS,Zhang YT,Peng KQ,Quan ZY

    更新日期:2005-03-21 00:00:00

  • Methodology for high-quality studies on course and prognosis of inflammatory bowel disease.

    abstract::Inflammatory bowel diseases (IBDs) are characterized by a chronic course with an alternation of relapses and remissions. Questions about prognosis are important for the patient who wants to know how the disease will affect his/her life and also for clinicians to make management decisions. Correct selection of the pati...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v18.i29.3800

    authors: Modesto I,Perricone G,Orlando A,Cottone M

    更新日期:2012-08-07 00:00:00

  • Successful esophagectomy in a patient with combined esophageal cancer and hemophilia B.

    abstract::Patients with esophageal cancer often require esophagectomy with esophagogastrostomy. However, the incidence of complications, such as hemorrhage, during operations for esophageal cancer is high, even with minimally invasive surgery. Without the appropriate interventions, the risk of major intraoperative and postopera...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v20.i35.12701

    authors: Zhang GF,Chai Y,Li WS,Huang LS,Shen G

    更新日期:2014-09-21 00:00:00

  • Abnormal expression of HMGB-3 is significantly associated with malignant transformation of hepatocytes.

    abstract:AIM:To explore the relationship between dynamic expression of high mobility group box-3 (HMGB3) and malignant transformation of hepatocytes. METHODS:Expression of HMGB family proteins were observed in rat hepatocarcinogenesis models induced with 2-acetylaminofluorene. Alterations of HMGB3 were analyzed at the mRNA lev...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v24.i32.3650

    authors: Zheng WJ,Yao M,Fang M,Wang L,Dong ZZ,Yao DF

    更新日期:2018-08-28 00:00:00

  • Aberrant expression of nuclear matrix proteins during HMBA-induced differentiation of gastric cancer cells.

    abstract:AIM:To investigate the aberrant expression of nuclear matrix proteins in human gastric cancer cells before and after hexamethylene bisacetamide (HMBA) treatment. METHODS:Proteomics analysis of differential nuclear matrix proteins was performed by two dimensional electrophoresis polyacrylamide gel electrophoresis and m...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v16.i17.2176

    authors: Jing GJ,Xu DH,Shi SL,Li QF,Wang SY,Wu FY,Kong HY

    更新日期:2010-05-07 00:00:00

  • Prognostic significance of preoperative circulating vascular endothelial growth factor messenger RNA expression in resectable hepatocellular carcinoma: a prospective study.

    abstract:AIM:To investigate the prognostic value of vascular endothelial growth factor messenger RNA (VEGF mRNA) in the peripheral blood (PB) of patients with hepatocellular carcinoma (HCC) undergoing curative resection. METHODS:Using a reverse-transcription polymerase chain reaction (RT-PCR)-based assay, VEGF mRNA in the PB w...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v10.i5.643

    authors: Jeng KS,Sheen IS,Wang YC,Gu SL,Chu CM,Shih SC,Wang PC,Chang WH,Wang HY

    更新日期:2004-03-01 00:00:00

  • Role of bacteria in the etiopathogenesis of inflammatory bowel disease.

    abstract::Increased numbers of mucosa-associated Escherichia coli are observed in both of the major inflammatory bowel diseases, Crohn d' disease (CD) and ulcerative colitis (UC). A potential pathophysiological link between the presence of pathogenic invasive bacteria and genetic host susceptibility of patients with ileal CD is...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v13.i42.5571

    authors: Barnich N,Darfeuille-Michaud A

    更新日期:2007-11-14 00:00:00

  • Effect of interleukin-10 and platelet-derived growth factor on expressions of matrix metalloproteinases-2 and tissue inhibitor of metalloproteinases-1 in rat fibrotic liver and cultured hepatic stellate cells.

    abstract:AIM:To examine the expressions of matrix metalloproteinases-2 (MMP-2) and tissue inhibitor of metalloproteinases-1 (TIMP-1) in rat fibrotic liver and in normal rat hepatic stellate cells, and to investigate the changes in their expressions in response to treatment with interleukin-10 (IL-10) and platelet-derived growth...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v10.i17.2574

    authors: Zhang LJ,Chen YX,Chen ZX,Huang YH,Yu JP,Wang XZ

    更新日期:2004-09-01 00:00:00

  • Impact of ribavirin dose on retreatment of chronic hepatitis C patients.

    abstract:AIM:To study the efficacy and factors associated with a sustained virological response (SVR) in chronic hepatitis C (CHC) relapsing patients. METHODS:Out of 1228 CHC patients treated with pegylated interferon (PEG-IFN) and ribavirin (RBV), 165 (13%) had a relapse. Among these, 62 patients were retreated with PEG-IFN-α...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v18.i23.2966

    authors: Stern C,Martinot-Peignoux M,Ripault MP,Boyer N,Castelnau C,Valla D,Marcellin P

    更新日期:2012-06-21 00:00:00

  • Post-cholecystectomy symptoms were caused by persistence of a functional gastrointestinal disorder.

    abstract:AIM:To classify gallstone disease as a basis for assessment of post-cholecystectomy symptoms. METHODS:One hundred and fifty three patients with a clinical and ultrasonographic diagnosis of gallstones filled out a structured questionnaire on abdominal pain symptoms and functional gastrointestinal disorder (FGID) before...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v18.i12.1365

    authors: Schmidt M,Søndenaa K,Dumot JA,Rosenblatt S,Hausken T,Ramnefjell M,Njølstad G,Eide GE

    更新日期:2012-03-28 00:00:00

  • Effectiveness of contrast-enhanced harmonic endoscopic ultrasound for the evaluation of solid pancreatic masses.

    abstract:AIM:To evaluate the usefulness of contrast-enhanced harmonic endoscopic ultrasound (CH-EUS) in differentiating between pancreatic adenocarcinomas and other pancreatic disease. METHODS:This retrospective cohort study evaluated 90 patients who were seen between November 2010 and May 2013. All these patients had solid pa...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v20.i2.518

    authors: Park JS,Kim HK,Bang BW,Kim SG,Jeong S,Lee DH

    更新日期:2014-01-14 00:00:00