Abstract:
:AIM:To investigate the expression of somatostatin mRNA in various differentiated types of gastric carcinoma.METHODS: By using in situ hybridization and immunohistochemical techniques, the expression of somatostatin mRNA and somatostatin immunoreactivity in the normal gastric mucosa, the poorly, moderately and well-differentiated gastric carcinomas, and various clinical stages of carcinoma were observed.RESULTS: In comparison with the normal gastric mucosa, the significantly increased expression of somatostatin mRNA positive cells was displayed in gastric carcinoma (t = 2.681, P < 0.01). The positive signal cells were distributed in a scattered form or aggregated as a mass or a cord, and the positive cells were more significantly enhanced in poorly differentiated carcinomas than those in well and moderately differentiated carcinomas (t = 2.962, P < 0.01). The somatostatin mRNA hybridization signals in stages III and IV of gastric carcinoma were significantly higher than those in stages I and II. The results of somatostatin immunoreactivity were consistent with those of in situhybridization.CONCLUSION: The alteration of the expression of somatostatin mRNA was associated with the development of gastric carcinoma and may play an important role in theprocess of tumor differentiation.
journal_name
World J Gastroenteroljournal_title
World journal of gastroenterologyauthors
Zhang QX,Dou YL,Shi XY,Ding Ydoi
10.3748/wjg.v4.i1.48keywords:
subject
Has Abstractpub_date
1998-02-01 00:00:00pages
48-51issue
1eissn
1007-9327issn
2219-2840journal_volume
4pub_type
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
doi:10.3748/wjg.v10.i18.2637
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abstract::As the incidence of acute pancreatitis continues to rise, establishing the etiology in order to prevent recurrence is important. Although the etiology of acute pancreatitis is not difficult in the majority of patients, almost a quarter of patients are initially labeled as having idiopathic acute pancreatitis. When con...
journal_title:World journal of gastroenterology
pub_type: 杂志文章
doi:10.3748/wjg.v20.i44.16529
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pub_type: 杂志文章
doi:10.3748/wjg.v11.i4.529
更新日期:2005-01-28 00:00:00
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pub_type: 杂志文章
doi:10.3748/wjg.v9.i5.1028
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journal_title:World journal of gastroenterology
pub_type: 信件
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更新日期:2008-05-14 00:00:00
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journal_title:World journal of gastroenterology
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pub_type: 杂志文章
doi:10.3748/wjg.v26.i33.4933
更新日期:2020-09-07 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章,meta分析,评审
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更新日期:2014-10-28 00:00:00
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doi:10.3748/wjg.v23.i15.2731
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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更新日期:2014-03-14 00:00:00
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pub_type: 杂志文章
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更新日期:2004-04-15 00:00:00
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pub_type: 杂志文章
doi:10.3748/wjg.v21.i34.9957
更新日期:2015-09-14 00:00:00
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pub_type: 杂志文章
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更新日期:1997-06-15 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2004-08-15 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
doi:10.3748/wjg.v12.i18.2923
更新日期:2006-05-14 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章,评审
doi:10.3748/wjg.v25.i38.5732
更新日期:2019-10-14 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 社论
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更新日期:2009-05-28 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章,评审
doi:10.3748/wjg.v19.i35.5925
更新日期:2013-09-21 00:00:00
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pub_type: 杂志文章
doi:10.3748/wjg.v11.i47.7536
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
doi:10.3748/wjg.v12.i4.568
更新日期:2006-01-28 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
doi:10.3748/wjg.v23.i46.8128
更新日期:2017-12-14 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
doi:10.3748/wjg.v18.i9.915
更新日期:2012-03-07 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
doi:10.3748/wjg.v19.i23.3665
更新日期:2013-06-21 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
doi:10.3748/wjg.v10.i13.1890
更新日期:2004-07-01 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
doi:10.3748/wjg.v11.i42.6593
更新日期:2005-11-14 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章,meta分析,评审
doi:10.3748/wjg.v21.i12.3711
更新日期:2015-03-28 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章,多中心研究
doi:10.3748/wjg.v20.i17.4987
更新日期:2014-05-07 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
doi:10.3748/wjg.15.5592
更新日期:2009-11-28 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
doi:10.3748/wjg.v18.i30.4069
更新日期:2012-08-14 00:00:00