Ste20-related proline/alanine-rich kinase: a novel regulator of intestinal inflammation.

Abstract:

:Recently, inflammatory bowel disease (IBD) has been the subject of considerable research, with increasing attention being paid to the loss of intestinal epithelial cell barrier function as a mechanism of pathogenesis. Ste20-related proline/alanine-rich kinase (SPAK) is involved in regulating barrier function. SPAK is known to interact with inflammation-related kinases (such as p38, JNK, NKCC1, PKCtheta, WNK and MLCK), and with transcription factor AP-1, resulting in diverse biological phenomena, including cell differentiation, cell transformation and proliferation, cytoskeleton rearrangement, and regulation of chloride transport. This review examines the involvement of Ste20-like kinases and downstream mitogen-activated protein kinases (MAPKs) pathways in the pathogenesis and control of intestinal inflammation. The primary focus will be on the molecular features of intestinal inflammation, with an emphasis on the interaction between SPAK and other molecules, and the effect of these interactions on homeostatic maintenance, cell volume regulation and increased cell permeability in intestinal inflammation.

journal_name

World J Gastroenterol

authors

Yan Y,Merlin D

doi

10.3748/wjg.14.6115

subject

Has Abstract

pub_date

2008-10-28 00:00:00

pages

6115-21

issue

40

eissn

1007-9327

issn

2219-2840

journal_volume

14

pub_type

杂志文章,评审
  • Genomic characterization of esophageal squamous cell carcinoma: Insights from next-generation sequencing.

    abstract::Two major types of cancer occur in the esophagus: squamous cell carcinoma, which is associated with chronic smoking and alcohol consumption, and adenocarcinoma, which typically arises in gastric reflux-associated Barrett's esophagus. Although there is increasing incidence of esophageal adenocarcinoma in Western counti...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v22.i7.2284

    authors: Sasaki Y,Tamura M,Koyama R,Nakagaki T,Adachi Y,Tokino T

    更新日期:2016-02-21 00:00:00

  • Short-term overlap lamivudine treatment with adefovir dipivoxil in patients with lamivudine-resistant chronic hepatitis B.

    abstract:AIM:To evaluate the efficacy of short-term overlap lamivudine therapy with adefovir in patients with lamivudine-resistant and naive chronic hepatitis B, we compared patients receiving overlap therapy with those receiving adefovir alone. METHODS:Eighty patients who had received lamivudine treatment for various periods ...

    journal_title:World journal of gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.3748/wjg.14.1781

    authors: Nam SW,Bae SH,Lee SW,Kim YS,Kang SB,Choi JY,Cho SH,Yoon SK,Han JY,Yang JM,Lee YS

    更新日期:2008-03-21 00:00:00

  • Hexahydrocurcumin enhances inhibitory effect of 5-fluorouracil on HT-29 human colon cancer cells.

    abstract:AIM:To investigate the ability of hexahydrocurcumin (HHC) to enhance 5-fluorouracil (5-FU) in inhibiting the growth of HT-29 cells by focusing on cyclooxygenase (COX)-2 expression. METHODS:Antiproliferative effects of HHC and 5-FU, alone and in combination, on growth of HT-29 human colon cancer cells were assessed usi...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v18.i19.2383

    authors: Srimuangwong K,Tocharus C,Yoysungnoen Chintana P,Suksamrarn A,Tocharus J

    更新日期:2012-05-21 00:00:00

  • A clinical evaluation of serological diagnosis for pancreatic cancer.

    abstract::AIM:To assess the diagnostic values of tumor markers for pancreatic cancer.METHODS:Pancreatic cancer-associated antigen from colonic mucosa (PCAAc), pancreas-specific antigen (PaA), pancreatic oncofetal antigen (POA) and minimolecular pancreatic antigen (mPOA) were detected by double antibodies Sandwich ELISA; CA19-9,...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v4.i2.147

    authors: Zhao XY,Yu SY,Da SP,Bai L,Guo XZ,Dai XJ,Wang YM

    更新日期:1998-04-01 00:00:00

  • Cloning and expression of core gene cDNA of Chinese hepatitis C virus in cosmid pTM3.

    abstract::AIM:To clone core gene cDNA of Chinese hepatitis C virus (HCV) into eukaryotic expression vector cosmid pTM3 and to express HCV core antigen in HepG2 cells.METHODS:Core gene cDNA of HCV was introduced into eukaryotic expression vector cosmid pTM3.Using vaccinia virus/bacteriophage T7 hybrid expression system, HepG2 ce...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v6.i2.220

    authors: Jiang RL,Lu QS,Luo KX

    更新日期:2000-04-01 00:00:00

  • Human intestinal capillariasis in Thailand.

    abstract::Intestinal capillariasis caused by Capillaria philippinensis appeared first in the Philippines and subsequently in Thailand, Japan, Iran, Egypt and Taiwan; major outbreaks have occurred in the Philippines and Thailand. This article reviews the epidemiology, history and sources of C. philippinensis infection in Thailan...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.14.506

    authors: Saichua P,Nithikathkul C,Kaewpitoon N

    更新日期:2008-01-28 00:00:00

  • Nonalcoholic fatty liver disease - A multisystem disease?

    abstract::Non-alcoholic fatty liver disease (NAFLD) is one of the most common comorbidities associated with overweight and metabolic syndrome (MetS). Importantly, NAFLD is one of its most dangerous complications because it can lead to severe liver pathologies, including fibrosis, cirrhosis and hepatic cellular carcinoma. Given ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v22.i43.9488

    authors: Mikolasevic I,Milic S,Turk Wensveen T,Grgic I,Jakopcic I,Stimac D,Wensveen F,Orlic L

    更新日期:2016-11-21 00:00:00

  • Different behaviour of BK-virus infection in liver transplant recipients.

    abstract::Polyomavirus BK (BKV) infects up to 90% of the general population. After primary infection, occurring early during childhood, a state of non-replicative infection is established in the reno-urinary tract, without complications for immunocompetent hosts. In immunocompromised individuals, particularly transplanted patie...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v22.i4.1532

    authors: Umbro I,Tinti F,Muiesan P,Mitterhofer AP

    更新日期:2016-01-28 00:00:00

  • Screening analysis of candidate gene mutations in a kindred with polycystic liver disease.

    abstract:AIM:To find potential mutable sites by detecting mutations of the candidate gene in a kindred with polycystic liver disease (PCLD). METHODS:First, we chose a kindred with PCLD and obtained five venous blood samples of this kindred after the family members signed the informed consent form. In the kindred two cases were...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v21.i8.2343

    authors: Jin S,Cui K,Sun ZQ,Shen YY,Li P,Wang ZD,Li FF,Gong KN,Li S

    更新日期:2015-02-28 00:00:00

  • Mutation of RET proto-oncogene in Hirschsprung's disease and intestinal neuronal dysplasia.

    abstract:AIM:To investigate the genetic relationship between Hirschsprung's disease (HD) and intestinal neuronal dysplasia (IND) in Chinese population. METHODS:Peripheral blood samples were obtained from 30 HD patients, 20 IND patients, 18 HD/IND combined patients and 20 normal individuals as control. Genomic DNA was extracted...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v12.i7.1136

    authors: Tou JF,Li MJ,Guan T,Li JC,Zhu XK,Feng ZG

    更新日期:2006-02-21 00:00:00

  • Post-colonoscopy colorectal cancer rate in the era of high-definition colonoscopy.

    abstract:AIM:To investigate the post-colonoscopy colorectal cancer (PCCRC) rate for high-definition (HD) colonoscopy compared with that for standard-definition colonoscopy reported previously. METHODS:Using medical records at Sano Hospital (SH) and Dokkyo Medical University Koshigaya Hospital (DMUKH), we retrospectively obtain...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v23.i42.7609

    authors: Iwatate M,Kitagawa T,Katayama Y,Tokutomi N,Ban S,Hattori S,Hasuike N,Sano W,Sano Y,Tamano M

    更新日期:2017-11-14 00:00:00

  • A critical role of gastric mucosal ascorbic acid in the progression of acute gastric mucosal lesions induced by compound 48/80 in rats.

    abstract:AIM:To study the role of gastric mucosal ascorbic acid (AA) in the progression of acute gastric mucosal lesions induced by compound 48/80 (C48/80), a mast cell degranulator, in rats. METHODS:C48/80 (0.75 mg/kg) was intraperitoneally injected to fasted Wistar rats. Oral administration of AA (10, 50 or 100 mg/kg) was pe...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i9.1324

    authors: Kamiya Y,Ohta Y,Imai Y,Arisawa T,Nakano H

    更新日期:2005-03-07 00:00:00

  • Laparoscopic cholecystectomy in situs inversus totalis with "inferior" cystic artery: a case report.

    abstract::A 76-year-old man with known situs inversus totalis presented with left-sided discomfort. Abdominal ultrasonography and CT scan confirmed the diagnosis of a gallstone, as well as, situs inversus; the liver and gallbladder on the left side and the spleen on the right. The biliary system was thought to be left-right rev...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i33.5232

    authors: Kamitani S,Tsutamoto Y,Hanasawa K,Tani T

    更新日期:2005-09-07 00:00:00

  • Expression of HIF-2alpha/EPAS1 in hepatocellular carcinoma.

    abstract:AIM:To investigate the expression of hypoxia-inducible factor (HIF)-2alpha/endothelial PAS domain protein1 (EPAS1) in hepatocellular carcinoma (HCC). METHODS:Expression of HIF-2alpha/EPAS1 was investigated immunohistochemically on paraffin-embedded sections from 97 patients with HCC. To further confirm that HIF-2alpha...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v10.i4.525

    authors: Bangoura G,Yang LY,Huang GW,Wang W

    更新日期:2004-02-15 00:00:00

  • Fractalkine and TGF-beta1 levels reflect the severity of chronic pancreatitis in humans.

    abstract:AIM:To clarify whether serum chemokine and cytokine levels can become useful biological and functional markers to assess the severity of chronic pancreatitis (CP). This study aimed at clarifying whether serum chemokine and cytokine levels can become useful biological and functional markers to assess the severity of CP....

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.14.6488

    authors: Yasuda M,Ito T,Oono T,Kawabe K,Kaku T,Igarashi H,Nakamura T,Takayanagi R

    更新日期:2008-11-14 00:00:00

  • Primary sclerosing cholangitis--what is the difference between east and west?

    abstract::Primary sclerosing cholangitis (PSC) is a chronic, progressive, cholestatic liver disease characterized by inflammation and fibrotic obliteration of the hepatic biliary tree. It is commonly associated with inflammatory bowel disease (IBD). A number of complications can occur which require special consideration, the mo...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.14.3974

    authors: Shorbagi A,Bayraktar Y

    更新日期:2008-07-07 00:00:00

  • Eradication of Helicobacter pylori infection: which regimen first?

    abstract::Helicobacter pylori (H. pylori) is a well-known human pathogen that plays an essential role in the pathogenesis of chronic gastritis, peptic ulcer disease, and gastric malignancies. Although H. pylori is susceptible to several antimicrobials, this infection has proven challenging to cure because of the increasing prev...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v20.i3.665

    authors: Federico A,Gravina AG,Miranda A,Loguercio C,Romano M

    更新日期:2014-01-21 00:00:00

  • Pre-hepatectomy type IV collagen 7S predicts post-hepatectomy liver failure and recovery.

    abstract:BACKGROUND:Liver resection is an effective treatment for benign and malignant liver tumors. However, a method for preoperative evaluation of hepatic reserve has not yet been established. Previously reported assessments of preoperative hepatic reserve focused only on liver failure in the early postoperative period and d...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v26.i7.725

    authors: Ishii M,Itano O,Shinoda M,Kitago M,Abe Y,Hibi T,Yagi H,Takeuchi A,Tsujikawa H,Abe T,Kitagawa Y

    更新日期:2020-02-21 00:00:00

  • Current status and prospects of clinical proteomics studies on detection of colorectal cancer: hopes and fears.

    abstract::Colorectal adenocarcinoma (CRC) is the third most common type of cancer and the fourth most frequent cause of death due to cancer worldwide. Given the natural history of CRC, early diagnosis appears to be the most appropriate tool to reduce disease-related mortality. A field of recent interest is clinical proteomics, ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v12.i41.6594

    authors: de Noo ME,Tollenaar RA,Deelder AM,Bouwman LH

    更新日期:2006-11-07 00:00:00

  • Expression of mucins and E-cadherin in gastric carcinoma and their clinical significance.

    abstract:AIM:To investigate the expression of three types of mucin (MUC1, MUC2, MUC5AC) and E-cadherin in human gastric carcinomas and their clinical significance. METHODS:Ninety-four gastric cancer specimens were classified according to WHO criteria and detected by immunohistochemical assay of expression of mucins and E-cadhe...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v10.i20.3044

    authors: Zhang HK,Zhang QM,Zhao TH,Li YY,Yi YF

    更新日期:2004-10-15 00:00:00

  • Sub-classification of intermediate-stage (Barcelona Clinic Liver Cancer stage-B) hepatocellular carcinomas.

    abstract::Hepatocellular carcinoma (HCC), the fifth most common cancer in the world, shows increasing incidence worldwide. Curative treatments such as hepatectomy, liver transplantation, and radiofrequency ablation are applied in only 30%-60% of cases. Most remaining patients receive transarterial chemoembolization (TACE). Pati...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v21.i37.10604

    authors: Yamakado K,Hirota S

    更新日期:2015-10-07 00:00:00

  • Relationship between antral distension and postprandial symptoms in functional dyspepsia.

    abstract:AIM:To investigate in patients with functional dyspepsia (FD) after an every-day meal whether (1) gastrointestinal (GI) and extra-GI symptoms had any relation with the degree of antral volume, (2) the onset of postprandial symptoms was associated with, and may predict, delayed gastric emptying. METHODS:In 94 symptomat...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v12.i43.6982

    authors: Pallotta N,Pezzotti P,Corazziari E

    更新日期:2006-11-21 00:00:00

  • Antitumor mechanism of antisense cantide targeting human telomerase reverse transcriptase.

    abstract:AIM:To investigate the anti-tumor mechanism of antisense oligodeoxynucleotide cantide against hTERT. METHODS:Tumor cells were cultured overnight and grown to 50-60 % confluence. HepG2 and SMMC-7721 were treated with cantide mixed with lipofectin, or lipofectin alone. After inducted for 6 h at 37 degrees, 10 % FCS in D...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v9.i9.2030

    authors: Du QY,Wang XB,Chen XJ,Zheng W,Wang SQ

    更新日期:2003-09-01 00:00:00

  • Comparison between tocotrienol and omeprazole on gastric growth factors in stress-exposed rats.

    abstract:AIM:To investigate and compare the effects of tocotrienol and omeprazole on gastric growth factors in rats exposed to water-immersion restraint stress (WIRS). METHODS:Twenty-eight male Wistar rats were randomly assigned to four groups of seven rats. The two control groups were administered vitamin-free palm oil (vehic...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v23.i32.5887

    authors: Nur Azlina MF,Qodriyah HMS,Chua KH,Kamisah Y

    更新日期:2017-08-28 00:00:00

  • Interleukin 28B-related polymorphisms: a pathway for understanding hepatitis C virus infection?

    abstract:AIM:To analyze the role of rs12979860 and rs8099917 polymorphisms in hepatitis C virus (HCV) genotype 1 infection of Brazilians. METHODS:A total of 145 adult patients diagnosed with genotype 1 chronic hepatitis C (CHC) who had completed a 48-wk regimen of pegylated-interferon α-2a or -2b plus ribavirin combination the...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,多中心研究

    doi:10.3748/wjg.v19.i42.7399

    authors: Garcia RF,Moreira S,de Araújo Ramos AL,Ferreira LE,de Mattos AA,Tovo CV,Nader LA,Ramos JA,Rondinelli E,de Jesus Dominici A,Garcia CE,de Souza Leite Pinho M,Brandão-Mello CE,Villela-Nogueira CA,de França PH

    更新日期:2013-11-14 00:00:00

  • Combined detection tumor markers for diagnosis and prognosis of gallbladder cancer.

    abstract:AIM:To clarify the value of combined use of markers for the diagnosis of gallbladder cancer and prediction of its prognosis. METHODS:Serum cancer antigens (CA)199, CA242, carcinoembryonic antigen (CEA), and CA125 levels were measured in 78 patients with gallbladder cancer (GBC), 78 patients with benign gallbladder dis...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v20.i14.4085

    authors: Wang YF,Feng FL,Zhao XH,Ye ZX,Zeng HP,Li Z,Jiang XQ,Peng ZH

    更新日期:2014-04-14 00:00:00

  • Omeprazole induces gastric transmucosal permeability to the peptide bradykinin.

    abstract:AIM:To investigate omeprazole-induced transepithelial gastric leak and its effects on the permeability of the peptides bradykinin and oxytocin. METHODS:Rat gastric corpus tissue was isolated and mounted in an Ussing chamber apparatus to evaluate the permeability of (3)H-bradykinin, (3)H-oxytocin, and (14)C-EDTA in the...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v16.i9.1097

    authors: Gabello M,Valenzano MC,Zurbach EP,Mullin JM

    更新日期:2010-03-07 00:00:00

  • Subtypes of functional dyspepsia.

    abstract::Functional dyspepsia is a common clinical condition characterised by chronic or recurrent upper abdominal pain or discomfort commonly associated with a variety of associated gastrointestinal symptoms and a normal endoscopy. To standardise research-based approaches, an initial categorisation of into sub groups was agre...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v12.i17.2667

    authors: Baker G,Fraser RJ,Young G

    更新日期:2006-05-07 00:00:00

  • Micronucleus analysis in patients with colorectal adenocarcinoma and colorectal polyps.

    abstract:AIM:To determine, by counting micronucleus (MN) frequencies, whether chromosomal or DNA damage have an effect on the pathogenesis of early colorectal adenocarcinoma (CRC). METHODS:We analyzed MN frequencies in 21 patients with CRC, 24 patients with colon polyps [10 neoplastic polyps (NP) and 14 non-neoplastic polyps (...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.14.6835

    authors: Karaman A,Binici DN,Kabalar ME,Calikuşu Z

    更新日期:2008-11-28 00:00:00

  • Molecular evolution of hepatitis A virus in a human diploid cell line.

    abstract:AIM:To investigate the hotspots, direction, and the time course of evolution of hepatitis A virus in the process of consecutive cell culture passage in human KMB17 diploid cells. METHODS:Wild type hepatitis A virus H2w was serially propagated in KMB17 cells until passage 30, and the full-length genomes of H2w and its ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v13.i34.4630

    authors: Tang CH,Mao JS,Chai SA,Chen Y,Zhuang FC

    更新日期:2007-09-14 00:00:00