Leptin transiently antagonizes ghrelin and long-lastingly orexin in regulation of Ca2+ signaling in neuropeptide Y neurons of the arcuate nucleus.

abstract：AIM:To investigate the tumor-suppressive effect of the phosphatase and tensin homologue deleted from chromosome (PTEN) in human gastric cancer cells that were wild type for PTEN. METHODS:Adenoviruses expressing PTEN or luciferase as a control were introduced into gastric cancer cells. The effect of exogenous PTEN gene...

journal_title：World journal of gastroenterology

authors： Hang Y,Zheng YC,Cao Y,Li QS,Sui YJ

更新日期：2005-04-21 00:00:00

abstract：AIM:To discuss the expression of human leukocyte antigen (HLA) class I antigens in gastric cancer and correlate these with pathologic type and TNM stage. METHODS:The expression of HLA class I antigen was detected by immunohistochemistry in 185 specimens of gastric cancer, 20 gastric cancer specimens with lymphatic met...

journal_title：World journal of gastroenterology

authors： Shen YQ,Zhang JQ,Miao FQ,Zhang JM,Jiang Q,Chen H,Shan XN,Xie W

更新日期：2005-06-21 00:00:00

abstract：AIM:To investigate the role of Delta-like ligand 4 (DLL4) on tumour growth in hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC) in vivo. METHODS:We suppressed DLL4 expression in an HBV expressing HCC cell line, HepG2.2.15 and analysed the growth ability of cells as subcutaneous tumours in nude mice. Th...

journal_title：World journal of gastroenterology

authors： Kunanopparat A,Issara-Amphorn J,Leelahavanichkul A,Sanpavat A,Patumraj S,Tangkijvanich P,Palaga T,Hirankarn N

更新日期：2018-09-14 00:00:00

abstract：:Gastrin is the main hormone responsible for the stimulation of gastric acid secretion; in addition, gastrin and its derivatives exert proliferative and antiapoptotic effects on several cell types. Gastrin synthesis and secretion are increased in certain situations, for example, when proton pump inhibitors are used. Th...

journal_title：World journal of gastroenterology

authors： Chueca E,Lanas A,Piazuelo E

更新日期：2012-12-07 00:00:00

abstract：AIM:To compare outcome of stapled hemorrhoidopexy (SH) vs LigaSure hemorrhoidectomy (LH) by a meta-analysis of available randomized controlled trials (RCTs). METHODS:Databases, including PubMed, EMBASE, the Cochrane Library, and the Science Citation Index updated to December 2012, were searched. The main outcomes meas...

journal_title：World journal of gastroenterology

authors： Yang J,Cui PJ,Han HZ,Tong DN

更新日期：2013-08-07 00:00:00

abstract：AIM:To study and provide data on the evolution of medical procedures and outcomes of patients suffering from perforated midgut diverticulitis. METHODS:Three data sources were used: the Medline and Google search engines were searched for case reports on one or more patients treated for perforated midgut diverticulitis ...

journal_title：World journal of gastroenterology

authors： Spasojevic M,Naesgaard JM,Ignjatovic D

更新日期：2012-09-14 00:00:00

abstract：AIM:To determine the effect of chemotherapy on wound healing by giving early preoperative 5-fluorouracil (5-FU) to rats with colonic anastomoses. METHODS:Sixty Albino-Wistar male rats (median weight, 235 g) were used in this study. The rats were fed with standard laboratory food and given tap water ad libitum. The ani...

journal_title：World journal of gastroenterology

authors： Ozel L,Ozel MS,Toros AB,Kara M,Ozkan KS,Tellioglu G,Krand O,Koyuturk M,Berber I

更新日期：2009-09-07 00:00:00

abstract：:Portal hypertension, one of the vascular diseases, not only has lesions in liver, but also changes in vascular structures and functions of extrahepatic portal system, systemic system and pulmonary circulation. The pathological changes of vasculopathy in portal hypertension include remodeling of arterialized visceral v...

journal_title：World journal of gastroenterology

authors： Li T,Yang Z

更新日期：2005-10-21 00:00:00

abstract：:Many patients with Crohn's disease (CD) require surgery. Indications for surgery include failure of medical treatment, bowel obstruction, fistula or abscess formation. The most common surgical procedure is resection. In jejunoileal CD, strictureplasty is an accepted surgical technique that relieves the obstructive sym...

journal_title：World journal of gastroenterology

authors： Yamamoto T,Watanabe T

更新日期：2014-01-07 00:00:00

abstract：AIM:To study the relationship between anti-beta2-glycoprotein I (abeta2GPI) antibodies and platelet activation state in patients with ulcerative colitis (UC) and its significance. METHODS:Peripheral blood samples were collected from 56 UC patients (34 males and 22 females, aged 43.5 years, range 21-66 years), includin...

journal_title：World journal of gastroenterology

authors： Gao YH,Gao PJ,Wang CG,Wang XC,Piao YF

更新日期：2008-02-07 00:00:00

abstract：AIM:To identify whether chitinase 3-like 1 (CHI3L1) serves as a suitable biomarker for the prognosis of esophageal squamous cell carcinoma (ESCC) and to analyze this protein's cellular source. METHODS:An ELISA was conducted to detect the concentration of CHI3L1 in the serum of 150 ESCC patients diagnosed between Janua...

journal_title：World journal of gastroenterology

authors： Xing S,Zheng X,Zeng T,Zeng MS,Zhong Q,Cao YS,Pan KL,Wei C,Hou F,Liu WL

更新日期：2017-11-21 00:00:00

abstract：:Study of the effects of natural products, including traditional Chinese Medicines, on acetaminophen hepatotoxicity has gained considerable popularity in recent years, and some of them showed positive results and even promising therapeutic potentials. A recent report suggested that Liuweiwuling tablets protect against ...

journal_title：World journal of gastroenterology

authors： Du K,Jaeschke H

更新日期：2016-03-21 00:00:00

abstract：AIM:To analyze the current available evidence of Kudo's pit pattern classification for diagnosing colorectal neoplasms. METHODS:A search was performed on Pubmed/Embase to identify studies reporting the outcomes of the pit pattern classification in colorectal polyps. Retrieved records were evaluated and selected by two...

journal_title：World journal of gastroenterology

authors： Li M,Ali SM,Umm-a-OmarahGilani S,Liu J,Li YQ,Zuo XL

更新日期：2014-09-21 00:00:00

abstract：:Management of acute diarrhea remains a global challenge, particularly in resource-limiting countries. Oral rehydration solution (ORS), a passive rehydrating therapy developed approximately 40 years ago, remains the mainstay treatment. Although ORS is effective for hydration, since it does not inhibit enterotoxin-media...

journal_title：World journal of gastroenterology

authors： Cheng SX

更新日期：2016-03-07 00:00:00

abstract：AIM:To compare the differences in the endoscopic classification of early colorectal carcinoma (CRC) between Japan and China. METHODS:Ten cases of early CRC were included in the study. After reviewing the color pictures of these cases, 5 Japanese endoscopists and 5 Chinese endoscopists made their classificatory diagnos...

journal_title：World journal of gastroenterology

authors： Zhu RM,Wang FY,Hirata I,Katsu K,Xiao SD,Yu ZL,Zhang ZH,Xu ZM

更新日期：2003-09-01 00:00:00

abstract：:The incidence of obesity has dramatically increased in recent years. Consequently, obesity and associated disorders such as nonalcoholic fatty liver disease constitute a serious problem. Therefore, the contribution of adipose tissue to metabolic homeostasis has become a focus of interest. In this review, we discuss th...

journal_title：World journal of gastroenterology

authors： Tarantino G,Caputi A

更新日期：2011-09-07 00:00:00

abstract：AIM:To investigate the outcome of repeating endoscopic retrograde cholangiopancreaticography (ERCP) after initially failed precut sphincterotomy to achieve biliary cannulation. METHODS:In this retrospective study, consecutive ERCPs performed between January 2009 and September 2012 were included. Data from our endoscop...

journal_title：World journal of gastroenterology

authors： Pavlides M,Barnabas A,Fernandopulle N,Bailey AA,Collier J,Phillips-Hughes J,Ellis A,Chapman R,Braden B

更新日期：2014-09-28 00:00:00

abstract：:Unidimensional transient elastography (TE) is a noninvasive technique, which has been increasingly used in the assessment of diffuse liver diseases. This paper focuses on reviewing the existing data on the use of TE in the diagnosis of fibrosis and in monitoring disease progression in alcoholic liver disease, on the f...

journal_title：World journal of gastroenterology

authors： Lupsor-Platon M,Badea R

更新日期：2015-11-14 00:00:00

abstract：:Ischemic colitis is a rare complication of interferon administration. Only 9 cases in 6 reports have been described to-date. This report describes a case of ischemic colitis during pegylated interferon and ribavirin treatment for chronic hepatitis C, and includes a review of the relevant literature. A 48-year-old woma...

journal_title：World journal of gastroenterology

authors： Baik SJ,Kim TH,Yoo K,Moon IH,Cho MS

更新日期：2012-08-21 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is a highly invasive tumor that metastasizes hematogenously and lymphogenously to distant site. Frequent sites are lung, regional lymph node, bone, and adrenal gland. But metastasis to the gastrointestinal (GI) tract is rare, and most common site is stomach. Metastasis to the small intes...

journal_title：World journal of gastroenterology

authors： Kim HS,Shin JW,Kim GY,Kim YM,Cha HJ,Jeong YK,Jeong ID,Bang SJ,Kim DH,Park NH

更新日期：2006-03-28 00:00:00

abstract：AIM:To examine the extent of use of specific therapies in clinical practice, and their relationship to therapies validated in clinical trials. METHODS:The US National Cancer Institutes' Patterns of Care study was used to examine therapies and survival of patients diagnosed in 2001 with histologically-confirmed gastroe...

journal_title：World journal of gastroenterology

authors： Cronin-Fenton DP,Mooney MM,Clegg LX,Harlan LC

更新日期：2008-05-28 00:00:00

abstract：:Patients with advanced gastric cancer (AGC) can be treated with multiple lines of chemotherapy. Although several randomized trials have demonstrated the benefit of second-line chemotherapy compared with best supportive care, there is no evidence that further lines of chemotherapy will result in substantial prolongatio...

journal_title：World journal of gastroenterology

authors： Kim SM,Park SH

更新日期：2015-08-07 00:00:00

abstract：AIM:To determine the association of human antigen R (HuR) and inhibitors of apoptosis proteins (IAP1, IAP2) and prognosis in pancreatic cancer. METHODS:Protein and mRNA expression levels of IAP1, IAP2 and HuR in pancreatic ductal adenocarcinoma (PDAC) were compared with normal pancreatic tissue. The correlations among...

journal_title：World journal of gastroenterology

authors： Lukosiute-Urboniene A,Jasukaitiene A,Silkuniene G,Barauskas V,Gulbinas A,Dambrauskas Z

更新日期：2019-01-14 00:00:00

abstract：AIM:To study the viscoelastic properties of human hepatocytes and hepatocellular carcinoma (HCC) cells under cytoskeletal perturbation, and to further to study the viscoelastic properties and the adhesive properties of mouse hepatoma cells (HTC) in different cell cycle. METHODS:Micropipette aspiration technique was ad...

journal_title：World journal of gastroenterology

authors： Zhang G,Long M,Wu ZZ,Yu WQ

更新日期：2002-04-01 00:00:00

abstract：AIM:To explore the relationship among interferon-gamma (IFN-gamma) activity, fibrogenesis, T cell immune responses and hepatic inflammatory activity. METHODS:Peripheral blood samples from a total of 43 hepatitis B cirrhotic patients (LC) and 19 healthy controls (NC) were collected to measure their serum levels of IFN-...

journal_title：World journal of gastroenterology

authors： Tang JT,Fang JY,Gu WQ,Li EL

更新日期：2006-05-21 00:00:00

abstract：:Of the diverse biological agents used for patients with ulcerative colitis, the anti-tumor necrosis factor-α agents infliximab and adalimumab have been used in large-scale clinical trials and are currently widely used in the treatment of inflammatory bowel disease patients. Recent studies have indicated that golimumab...

journal_title：World journal of gastroenterology

authors： Seo GS,Chae SC

更新日期：2014-10-07 00:00:00

abstract：AIM:To evaluate the association of pre-treatment (13)C-urea breath test (UBT) results with H pylori density and efficacy of eradication therapy in patients with active duodenal ulcers. METHODS:One hundred and seventeen consecutive outpatients with active duodenal ulcer and H pylori infection were recruited. H pylori d...

journal_title：World journal of gastroenterology

authors： Lai YC,Yang JC,Huang SH

更新日期：2004-04-01 00:00:00

abstract：:Alcoholism and cirrhosis, which are two of the most serious health problems worldwide, have a broad spectrum of clinical outcomes. Both diseases are influenced by genetic susceptibility and cultural traits that differ globally but are specific for each population. In contrast to other regions around the world, Mexican...

journal_title：World journal of gastroenterology

authors： Roman S,Zepeda-Carrillo EA,Moreno-Luna LE,Panduro A

更新日期：2013-11-28 00:00:00

abstract：AIM:To investigate the dynamic features of insulin-like growth factor-I receptor (IGF-IR) expression in rat hepatocarcinogenesis, and the relationship between IGF-IR and hepatocytes malignant transformation at mRNA or protein level. METHODS:Hepatoma models were made by inducing with 2-fluorenylacetamide (2-FAA) on mal...

journal_title：World journal of gastroenterology

authors： Yan XD,Yao M,Wang L,Zhang HJ,Yan MJ,Gu X,Shi Y,Chen J,Dong ZZ,Yao DF

更新日期：2013-09-28 00:00:00

abstract：AIM:To evaluate the effect of the shunting branch of the portal vein (PV) (left or right) and the initial stent position (optimal or suboptimal) of a transjugular intrahepatic portosystemic shunt (TIPS). METHODS:We retrospectively reviewed 307 consecutive cirrhotic patients who underwent TIPS placement for variceal bl...

journal_title：World journal of gastroenterology

authors： Bai M,He CY,Qi XS,Yin ZX,Wang JH,Guo WG,Niu J,Xia JL,Zhang ZL,Larson AC,Wu KC,Fan DM,Han GH

更新日期：2014-01-21 00:00:00