Abstract:
AIM:To discuss the expression of human leukocyte antigen (HLA) class I antigens in gastric cancer and correlate these with pathologic type and TNM stage. METHODS:The expression of HLA class I antigen was detected by immunohistochemistry in 185 specimens of gastric cancer, 20 gastric cancer specimens with lymphatic metastasis and 22 controls of normal gastric mucosa using four monoclonal antibodies. RESULTS:The expression of HLA class I antigen (B/C locus) was significantly downregulated in gastric cancer and in lymphatic metastasis than that in normal gastric mucosa (chi2=7.712, P<0.05). The expression of other HLA class I antigens was also downregulated, but the change was slight. There was no relationship between the downregulation of HLA class I antigen and that of beta2m and LMP2. The expression of HLA class I (B/C locus) was statistically correlated with pathologic stage in gastric adenocarcinoma (chi2=4.164, P<0.05). CONCLUSION:The expression of HLA class I antigen (B/C locus) was obviously downregulated in gastric cancer and in lymphatic metastasis. This abnormal expression would provide the tumor cells with a way to avoid immunological recognition.
journal_name
World J Gastroenteroljournal_title
World journal of gastroenterologyauthors
Shen YQ,Zhang JQ,Miao FQ,Zhang JM,Jiang Q,Chen H,Shan XN,Xie Wdoi
10.3748/wjg.v11.i23.3628keywords:
subject
Has Abstractpub_date
2005-06-21 00:00:00pages
3628-31issue
23eissn
1007-9327issn
2219-2840journal_volume
11pub_type
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