Multimodality magnetic resonance imaging in hepatic encephalopathy: an update.

Abstract:

:Hepatic encephalopathy (HE) is a neuropsychiatric complication of cirrhosis or acute liver failure. Currently, HE is regarded as a continuous cognitive impairment ranging from the mildest stage, minimal HE to overt HE. Hyperammonaemia and neuroinflammation are two main underlying factors which contribute to the neurological alterations in HE. Both structural and functional impairments are found in the white mater and grey mater involved in HE. Although the investigations into HE pathophysiological mechanism are enormous, the exact pathophysiological causes underlying HE remain controversial. Multimodality magnetic resonance imaging (MRI) plays an important role in helping to understand the pathological process of HE. This paper reviews the up-to-date multimodality MRI methods and predominant findings in HE patients with a highlight of the increasingly important role of blood oxygen level dependent functional MRI.

journal_name

World J Gastroenterol

authors

Zhang XD,Zhang LJ,Wu SY,Lu GM

doi

10.3748/wjg.v20.i32.11262

subject

Has Abstract

pub_date

2014-08-28 00:00:00

pages

11262-72

issue

32

eissn

1007-9327

issn

2219-2840

journal_volume

20

pub_type

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