MicroRNAs potential utility in colon cancer: Early detection, prognosis, and chemosensitivity.

Abstract:

:Over the past decade, research has shown that aberrant expression of microRNA (miRNA) is involved in colorectal cancer development and progression. MicroRNAs are small sequences of non-coding RNA that regulate expression of genes involved in important cellular functions, such as cell differentiation, multiplication, and apoptosis. A specific miRNA may display the effects of a tumor suppressor or oncogene. Altered miRNA expression is found in colorectal cancer (CRC) and patterns of miRNA expression correlate with CRC detection and outcome. Studies also have examined the use of circulating serum miRNA and fecal miRNA expression as non-invasive markers for early detection. Here, we review recent evidence demonstrating the potential role of miRNA in CRC and the implications of its use in the diagnosis, prognosis, and management of CRC.

journal_name

World J Gastroenterol

authors

Hollis M,Nair K,Vyas A,Chaturvedi LS,Gambhir S,Vyas D

doi

10.3748/wjg.v21.i27.8284

subject

Has Abstract

pub_date

2015-07-21 00:00:00

pages

8284-92

issue

27

eissn

1007-9327

issn

2219-2840

journal_volume

21

pub_type

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