Loss of interstitial cells of Cajal network in severe idiopathic gastroparesis.

Abstract:

AIM:To report a case of severe idiopathic gastroparesis in complete absence of Kit-positive gastric interstitial cells of Cajal (ICC). METHODS:Gastric tissue from a patient with severe idiopathic gastroparesis unresponsive to medical treatment and requiring surgery was analyzed by conventional histology and immunohistochemistry. RESULTS:Gastric pacemaker cells expressing Kit receptor had completely disappeared while the local level of stem cell factor, the essential ligand for its development and maintenance, was increased. No signs of cell death were observed in the pacemaker region. CONCLUSION:These results are consistent with the hypothesis that a lack of Kit expression may lead to impaired functioning of ICC. Total gastrectomy proves to be curative.

journal_name

World J Gastroenterol

authors

Battaglia E,Bassotti G,Bellone G,Dughera L,Serra AM,Chiusa L,Repici A,Mioli P,Emanuelli G

doi

10.3748/wjg.v12.i38.6172

subject

Has Abstract

pub_date

2006-10-14 00:00:00

pages

6172-7

issue

38

eissn

1007-9327

issn

2219-2840

journal_volume

12

pub_type

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