Abstract:
AIM:To explore the efficacy and safety of herbal medicines (HM) in the treatment of irritable bowel syndrome (IBS). METHODS:A computer-based as well as manual literature search was performed. We reviewed randomized controlled trials on the treatment of IBS with and without HM. RESULTS:A total of 22 studies with 25 HMs met the inclusion criteria. Four of these studies were of good quality, while the remaining 18 studies involving 17 Chinese herbal medicine (CHM) formulas were of poor quality. Eight of these reports using 9 HMs showed global improvement of IBS symptoms, 4 studies with 3 HMs were efficacious in diarrhea-predominant IBS, and 2 studies with 2 HMs showed improvement in constipation-predominant IBS. Out of a total of 1279 patients, 15 adverse events in 47 subjects were reported with HM. No serious adverse events or abnormal laboratory tests were observed. The incidence of the adverse events was low (2.97%; 95% CI: 2.04%-3.90%). CONCLUSION:Herbal medicines have therapeutic benefit in IBS, and adverse events are seldom reported in literature. Nevertheless, herbal medicines should be used with caution. It is necessary to conduct rigorous, well-designed clinical trials to evaluate their effectiveness and safety in the treatment of IBS.
journal_name
World J Gastroenteroljournal_title
World journal of gastroenterologyauthors
Shi J,Tong Y,Shen JG,Li HXdoi
10.3748/wjg.14.454subject
Has Abstractpub_date
2008-01-21 00:00:00pages
454-62issue
3eissn
1007-9327issn
2219-2840journal_volume
14pub_type
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pub_type: 杂志文章,评审
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更新日期:2015-09-14 00:00:00
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pub_type: 杂志文章,随机对照试验
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pub_type: 评论,信件
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更新日期:2009-10-28 00:00:00
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