Do probiotics have a therapeutic role in gastroenterology?

Abstract:

:Several hundred species of bacteria inhabit the gut, and affect its cell biology, morphology and homeostasis. Many bacteria are however potential pathogens, especially if the integrity of the epithelial barrier is physically or functionally breached. Conversely, the interaction between host and commensal microbes can confer important health benefits. This has led to commercial and public interest in "probiotics", live microbes principally taken as food supplements. Might probiotics also be used in disease therapy? Experimental evidence that probiotics modulate gut physiology, particularly barrier integrity and immunological function, underpins exciting new gastroenterological research. We discuss below the scientific basis for probiotic effects and present a critical perspective for their use in relation to gastrointestinal disease.

journal_name

World J Gastroenterol

authors

Limdi JK,O'Neill C,McLaughlin J

doi

10.3748/wjg.v12.i34.5447

subject

Has Abstract

pub_date

2006-09-14 00:00:00

pages

5447-57

issue

34

eissn

1007-9327

issn

2219-2840

journal_volume

12

pub_type

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