Hepatocellular carcinoma in nonalcoholic fatty liver: role of environmental and genetic factors.

abstract：AIM:To analyze the role of rs12979860 and rs8099917 polymorphisms in hepatitis C virus (HCV) genotype 1 infection of Brazilians. METHODS:A total of 145 adult patients diagnosed with genotype 1 chronic hepatitis C (CHC) who had completed a 48-wk regimen of pegylated-interferon α-2a or -2b plus ribavirin combination the...

journal_title：World journal of gastroenterology

authors： Garcia RF,Moreira S,de Araújo Ramos AL,Ferreira LE,de Mattos AA,Tovo CV,Nader LA,Ramos JA,Rondinelli E,de Jesus Dominici A,Garcia CE,de Souza Leite Pinho M,Brandão-Mello CE,Villela-Nogueira CA,de França PH

更新日期：2013-11-14 00:00:00

abstract：AIM:To establish cell line and patient-derived xenograft (PDX) models for neuroendocrine carcinomas (NEC) which is highly desirable for gaining insight into tumor development as well as preclinical research including biomarker testing and drug response prediction. METHODS:Cell line establishment was conducted from dir...

journal_title：World journal of gastroenterology

authors： Gock M,Mullins CS,Harnack C,Prall F,Ramer R,Göder A,Krämer OH,Klar E,Linnebacher M

更新日期：2018-09-07 00:00:00

abstract：AIM:To establish the transgenic mouse line harbouring complete hepatitis B virus (HBV) genome with mutant s gene (adr subtype). METHODS:Transgenic mice were generated by microinjecting HBV genome into fertilized eggs. Integration, expression, replication of HBV gene and histological changes in transgenic mice were est...

journal_title：World journal of gastroenterology

authors： Ge JH,Zhang LZ,Li JX,Liu H,Liu HM,He J,Yao YC,Yang YJ,Yu HY,Hu YP

更新日期：2004-11-01 00:00:00

abstract：AIM:To assess the efficacy and safety of TECA type hybrid artificial liver support system (TECA-HALSS) in providing liver function of detoxification, metabolism and physiology by treating the patients with acute liver failure (ALF). METHODS:The porcine liver cells (1-2) x 10(10) were separated from the Chinese small s...

journal_title：World journal of gastroenterology

authors： Xue YL,Zhao SF,Luo Y,Li XJ,Duan ZP,Chen XP,Li WG,Huang XQ,Li YL,Cui X,Zhong DG,Zhang ZY,Huang ZQ

更新日期：2001-12-01 00:00:00

abstract：:In 2008, the European Association for the study of the liver (EASL) defined occult hepatitis B virus infection (OBI) as the "presence of hepatitis B virus (HBV) DNA in the liver (with detectable or undetectable HBV DNA in the serum) of individuals testing hepatitis B surface antigen (HBsAg) negative by currently avail...

journal_title：World journal of gastroenterology

authors： Ocana S,Casas ML,Buhigas I,Lledo JL

更新日期：2011-03-28 00:00:00

abstract：AIM:To assess the use of topical negative pressure (TNP) in the management of severe peritonitis. METHODS:This is a four-year prospective analysis from January 2005 to December 2008 of 20 patients requiring TNP following laparotomy for severe peritonitis. RESULTS:There were 11 males with an average age of (59.3 +/- 3...

journal_title：World journal of gastroenterology

authors： Amin AI,Shaikh IA

更新日期：2009-07-21 00:00:00

abstract：:AIM:To explore the status of extrahepatic hepatitis C virus (HCV) infection and replication in hepatitis C patients,and its potential implication in HCV infection and pathogenicity.METHODS:By reverse-transcriptase poly-merase chain reaction (RT-PCR),in situ hybridization (ISH) and immunohis-tochemistry, HCV RNA, HCV r...

journal_title：World journal of gastroenterology

authors： Yan FM,Chen AS,Hao F,Zhao XP,Gu CH,Zhao LB,Yang DL,Hao LJ

更新日期：2000-12-01 00:00:00

abstract：AIM:To determine the role of NOB1, a regulator of cell survival in yeast, in human colorectal cancer cells. METHODS:Lentivirus-mediated small interfering RNA (siRNA) was used to inhibit NOB1 expression in RKO human colorectal cancer cells in vitro and in vivo in a mouse xenograft model. The in vitro and in vivo knockd...

journal_title：World journal of gastroenterology

authors： He XW,Feng T,Yin QL,Jian YW,Liu T

更新日期：2015-01-21 00:00:00

abstract：:Patients with ulcerative colitis (UC) and Crohn's disease (CD) are at increased risk for developing colorectal cancer (CRC), and this is believed to be a result of chronic inflammation. Although conclusive evidence is still missing, both epidemiological and experimental observations suggest that certain drugs used to ...

journal_title：World journal of gastroenterology

authors： Stolfi C,Pellegrini R,Franze E,Pallone F,Monteleone G

更新日期：2008-07-28 00:00:00

abstract：:Gallstone ileus is a rare disease and accounts for 1%-4% of all cases of mechanical intestinal obstruction. It usually occurs in the elderly with a female predominance and may result in a high mortality rate. Its diagnosis is difficult and early diagnosis could reduce the mortality. Surgery remains the mainstay of tre...

journal_title：World journal of gastroenterology

authors： Chou JW,Hsu CH,Liao KF,Lai HC,Cheng KS,Peng CY,Yang MD,Chen YF

更新日期：2007-02-28 00:00:00

abstract：AIM:To confirm if p53 mutation could be a routine predictive marker for the prognosis of hepatocellular carcinoma (HCC) patients. METHODS:Two hundreds and forty-four formalin-fixed paraffin-embedded tumor samples of the patients with HCC receiving liver resection were detected for nuclear accumulation of p53. The perc...

journal_title：World journal of gastroenterology

authors： Qin LX,Tang ZY,Ma ZC,Wu ZQ,Zhou XD,Ye QH,Ji Y,Huang LW,Jia HL,Sun HC,Wang L

更新日期：2002-06-01 00:00:00

abstract：:In the last decade trans-arterial radioembolization has given promising results in the treatment of patients with intermediate or advanced stage hepatocellular carcinoma (HCC), both in terms of disease control and tolerability profile. This technique consists of the selective intra-arterial administration of microsphe...

journal_title：World journal of gastroenterology

authors： Sacco R,Mismas V,Marceglia S,Romano A,Giacomelli L,Bertini M,Federici G,Metrangolo S,Parisi G,Tumino E,Bresci G,Corti A,Tredici M,Piccinno M,Giorgi L,Bartolozzi C,Bargellini I

更新日期：2015-06-07 00:00:00

abstract：AIM:To estimate the effect of a therapeutic vaccine against pancreatic carcinoma based on dendritic cell (DC) vaccine modified with tumor lysate and Interleukin-18 gene. METHODS:The BALB/C mice model of pancreatic carcinoma was induced with DMBA. DC vaccine was constructed through pulsed with tumor lysate and transfec...

journal_title：World journal of gastroenterology

authors： Tang ZH,Qiu WH,Wu GS,Yang XP,Zou SQ,Qiu FZ

更新日期：2002-10-01 00:00:00

abstract：AIM:To evaluate the safety of lamivudine (LAM) treatment for chronic hepatitis B in early pregnancy. METHODS:A total of 92 pregnant women who received LAM treatment either before pregnancy or in early pregnancy were enrolled in this study. All of the pregnant women volunteered to take lamivudine during pregnancy and w...

journal_title：World journal of gastroenterology

authors： Yi W,Liu M,Cai HD

更新日期：2012-12-07 00:00:00

abstract：AIM:To assess the incidence and risk factors associated with colonic perforation due to colonoscopy. METHODS:This was a retrospective cross-sectional study. Patients were retrospectively eligible for inclusion if they were 18 years and older and had an inpatient or outpatient colonoscopy procedure code in any facility...

journal_title：World journal of gastroenterology

authors： Hamdani U,Naeem R,Haider F,Bansal P,Komar M,Diehl DL,Kirchner HL

更新日期：2013-06-21 00:00:00

abstract：AIM:To investigate the efficacy and safety of gemcitabine (Gem)-based combination chemotherapies for the treatment of advanced biliary tract cancer. METHODS:Clinical trials were identified by searching scientific literature databases (PubMed, EMBASE and the Cochrane Library) for studies published between 1975 and 2013...

journal_title：World journal of gastroenterology

authors： Liu H,Zhang QD,Li ZH,Zhang QQ,Lu LG

更新日期：2014-12-21 00:00:00

abstract：AIM:To optimize the efficacy of noninvasive evaluations in monitoring the endoscopic activity of inflammatory bowel disease (IBD). METHODS:Fecal calprotectin (FC), clinical activity index (CDAI or CAI), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and procalcitonin (PCT) were measured for 136 IBD pa...

journal_title：World journal of gastroenterology

authors： Chen JM,Liu T,Gao S,Tong XD,Deng FH,Nie B

更新日期：2017-12-14 00:00:00

abstract：AIM:To study the relationship between the patterns of postprandial peristalsis and transduodenal bolus transport in healthy subjects. METHODS:Synchronous recording of chyme transport and peristaltic activity was performed during the fasting state and after administration of a test meal using a special catheter device ...

journal_title：World journal of gastroenterology

authors： Nguyen HN,Winograd R,Domingues GR,Lammert F

更新日期：2006-10-07 00:00:00

abstract：AIM:To evaluate the impact of time interval for hemofiltration (HF) on the prognosis of severe acute pancreatitis (SAP). METHODS:Thirty-six consecutive patients with severe acute pancreatitis were included in the study. Atlanta classification system was applied for stratification. They were randomly divided into short...

journal_title：World journal of gastroenterology

authors： Mao EQ,Tang YQ,Zhang SD

更新日期：2003-02-01 00:00:00

abstract：AIM:To investigate the hotspots, direction, and the time course of evolution of hepatitis A virus in the process of consecutive cell culture passage in human KMB17 diploid cells. METHODS:Wild type hepatitis A virus H2w was serially propagated in KMB17 cells until passage 30, and the full-length genomes of H2w and its ...

journal_title：World journal of gastroenterology

authors： Tang CH,Mao JS,Chai SA,Chen Y,Zhuang FC

更新日期：2007-09-14 00:00:00

abstract：:Barrett's esophagus (BE) is characterized by intestinal metaplasia with the differentiated epithelium replaced by another type of epithelium morphologically similar to normal intestinal epithelium. The metaplasia is preceded by bile and acid reflux into the esophagus. BE is a premalignant condition associated with inc...

journal_title：World journal of gastroenterology

authors： Zhao J,Gregersen H

更新日期：2013-05-14 00:00:00

abstract：AIM:To check the efficacy of the PERFACT procedure in highly complex fistula-in-ano. METHODS:The PERFACT procedure (proximal superficial cauterization, emptying regularly fistula tracts and curettage of tracts) entails two steps: superficial cauterization of mucosa at and around the internal opening and keeping all th...

journal_title：World journal of gastroenterology

authors： Garg P,Garg M

更新日期：2015-04-07 00:00:00

abstract：AIM:To translate into Serbian and to investigate the validity of the cross-culturally adapted the chronic liver disease questionnaire (CLDQ). METHODS:The questionnaire was validated in 103 consecutive CLD patients treated between October 2009 and October 2010 at the Clinic for Gastroenterology, Clinical Centre of Serb...

journal_title：World journal of gastroenterology

authors： Popovic DDj,Kovacevic NV,Kisic Tepavcevic DB,Trajkovic GZ,Alempijevic TM,Spuran MM,Krstic MN,Jesic RS,Younossi ZM,Pekmezovic TD

更新日期：2013-08-14 00:00:00

abstract：:Advances in molecular cell biology over the last decade have clarified the mechanisms involved in cancer growth, invasion, and metastasis, and enabled the development of molecular-targeted agents. To date, sorafenib is the only molecular-targeted agent whose survival benefit has been demonstrated in two global phase I...

journal_title：World journal of gastroenterology

authors： Kudo M

更新日期：2012-11-14 00:00:00

abstract：AIM:To elucidate the sequential gene expression profile in AGS cells co-cultured with wild-type Helicobacter pylori (H pylori) as a model of H pylori-infected gastric epithelium, and to further examine the contribution of cag-pathogenicity islands (cagPAI)-coding type IV secretion system and the two pathways, nuclear f...

journal_title：World journal of gastroenterology

authors： Shibata W,Hirata Y,Yoshida H,Otsuka M,Hoshida Y,Ogura K,Maeda S,Ohmae T,Yanai A,Mitsuno Y,Seki N,Kawabe T,Omata M

更新日期：2005-10-21 00:00:00

abstract：AIM:To assess the efficacy and safety of fourth-generation quinolones for Helicobacter pylori (H. pylori) eradication, we conducted this systematic review and meta-analysis of randomized clinical trials. METHODS:Major literature databases (PubMed, EMBASE and the Cochrane Central Register of Controlled Trials) were sea...

journal_title：World journal of gastroenterology

authors： An Y,Wang Y,Wu S,Wang YH,Qian X,Li Z,Fu YJ,Xie Y

更新日期：2018-08-07 00:00:00

abstract：AIM:To determine the incidence of brain metastasis in a contemporary group of patients with carcinoma of the esophagus. METHODS:Retrospective analysis of 53 patients with esophageal carcinoma who received radiotherapy as a component of treatment between 1998 and 2007, including patient and tumor characteristics, and s...

journal_title：World journal of gastroenterology

authors： Smith RS,Miller RC

更新日期：2011-05-21 00:00:00

abstract：:Undifferentiated carcinoma with osteoclast-like giant cells of the pancreas (UCOGCP) is an unusual pancreatic neoplasm that represents < 1% of all pancreatic malignancies. Moreover, the giant cells of UCOGCP morphologically resemble the benign giant cells of bone tumors. Due to the rarity of this tumor type, the histo...

journal_title：World journal of gastroenterology

authors： Gao HQ,Yang YM,Zhuang Y,Liu P

更新日期：2015-01-14 00:00:00

abstract：:We report a case of two pseudolymphomas of the liver in a 63-year-old Japanese woman with primary biliary cirrhosis. One of the lesions was found incidentally during a medical examination, presenting as a 10 mm hypodense nodule that revealed hyperdensity in the early phase and hypodensity in the late phase in computed...

journal_title：World journal of gastroenterology

authors： Okada T,Mibayashi H,Hasatani K,Hayashi Y,Tsuji S,Kaneko Y,Yoshimitsu M,Tani T,Zen Y,Yamagishi M

更新日期：2009-09-28 00:00:00

abstract：:There was remarkable progress in the understanding of the role genetic risk factors in chronic pancreatitis. These factors seem to be much more important than thought in the past. The rare autosomal-dominant mutations N29I and R122H of PRSS1 (cationic trypsinogen) as well as the variant N34S of SPINK1 (pancreatic secr...

journal_title：World journal of gastroenterology

authors： Keim V

更新日期：2008-02-21 00:00:00