Abstract：
:In the last decade trans-arterial radioembolization has given promising results in the treatment of patients with intermediate or advanced stage hepatocellular carcinoma (HCC), both in terms of disease control and tolerability profile. This technique consists of the selective intra-arterial administration of microspheres loaded with a radioactive compound (usually Yttrium(90)), and exerts its therapeutic effect through the radiation carried by these microspheres. A careful and meticulous selection of patients is crucial before performing the radioembolization to correctly perform the procedure and reduce the incidence of complications. Radioembolization is a technically complex and expensive technique, which has only recently entered clinical practice and is supported by scant results from phase III clinical trials. Nevertheless, it may represent a valid alternative to transarterial chemoembolization (TACE) in the treatment of intermediate-stage HCC patients, as shown by a comparative retrospective assessment that reported a longer time to progression, but not of overall survival, and a more favorable safety profile for radioembolization. In addition, this treatment has reported a higher percentage of tumor shrinkage, if compared to TACE, for pre-transplant downsizing and it represents a promising therapeutic option in patients with large extent of disease and insufficient residual liver volume who are not immediately eligible for surgery. Radioembolization might also be a suitable companion to sorafenib in advanced HCC or it can be used as a potential alternative to this treatment in patients who are not responding or do not tolerate sorafenib.
journal_name
World J Gastroenteroljournal_title
World journal of gastroenterologyauthors
Sacco R,Mismas V,Marceglia S,Romano A,Giacomelli L,Bertini M,Federici G,Metrangolo S,Parisi G,Tumino E,Bresci G,Corti A,Tredici M,Piccinno M,Giorgi L,Bartolozzi C,Bargellini Idoi
10.3748/wjg.v21.i21.6518subject
Has Abstractpub_date
2015-06-07 00:00:00pages
6518-25issue
21eissn
1007-9327issn
2219-2840journal_volume
21pub_type
杂志文章,评审abstract：:Metastases of esophageal carcinoma to the skeletal muscle are rare, but the incidence may be increasing because of better diagnosis resulting from widespread use of positron emission tomography/computed tomography (PET/CT). A cohort of 205 patients with esophageal carcinoma treated at our center who had PET/CT between...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v18.i35.4962
更新日期：2012-09-21 00:00:00
abstract：AIM:To evaluate the safety and effectiveness of intravenous ketamine-midazolam sedation during pediatric endoscopy in the Arab world. METHODS:A retrospective cohort study of all pediatric endoscopic procedures performed between 2002-2008 at the shared endoscopy suite of King Abdullah University Hospital, Jordan Univer...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v17.i31.3630
更新日期：2011-08-21 00:00:00
abstract：:AIM:To construct Hsp90 antisense RNA eukaryotic expression vector, transfect it into SGC7901 and SGC7901/VCR of MDR-type human gastric cancer cell lines, HCC7402 of human hepatic cancer and Ec109 of human esophageal cancer cell lines, and to study the cell cycle distribution of the gene transected cells and their resp...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v5.i3.199
更新日期：1999-06-01 00:00:00
abstract：AIM:To examine the association between obesity-related adipokines (adiponectin, leptin, resistin, interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) and colorectal cancer (CRC) risk. METHODS:Serum levels of adipokines were measured in 100 CRC patients and age- and sex-matched controls for the data analysis. Unc...
journal_title：World journal of gastroenterology
pub_type： 杂志文章,meta分析,评审
doi：10.3748/wjg.v20.i24.7941
更新日期：2014-06-28 00:00:00
abstract：AIM:To investigate the relationship between exercise-provoked esophageal motility disorders and the prognosis for patients with chest pain. METHODS:The study involved 63 subjects with recurrent angina-like chest pain non-responsive to empirical therapy with proton pump inhibitor (PPI). In all, a coronary artery angiog...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v16.i35.4428
更新日期：2010-09-21 00:00:00
abstract：AIM:To clarify the strategy for early diagnosis of pancreaticobiliary maljunction (PBM) without biliary dilatation and to pathologically examine gallbladder before cancer develops. METHODS:The anatomy of the union of the pancreatic and bile ducts was assessed by using endoscopic retrograde cholangiopancreatography (ER...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v18.i26.3409
更新日期：2012-07-14 00:00:00
abstract：AIM:To investigate the prevalence of celiac disease (CD) in adult patients referred to an open access gastroenterology clinic in the south of Italy and submitted to esophago-gastro-duodenoscopy (EGD) for evaluation of refractory functional dyspepsia. METHODS:Seven hundred and twenty six consecutive dyspeptic patients ...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.14.6948
更新日期：2008-12-07 00:00:00
abstract：AIM:To analyze the associations of pancreatic fat with other fat depots and β-cell function in pediatric nonalcoholic fatty liver disease (NAFLD). METHODS:We examined 158 overweight/obese children and adolescents, 80 with NAFLD [hepatic fat fraction (HFF) ≥ 5%] and 78 without fatty liver. Visceral adipose tissue (VAT)...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v21.i15.4688
更新日期：2015-04-21 00:00:00
abstract：AIM:To detect linc00675 expression in pancreatic ductal adenocarcinoma (PDAC), to analyze the relationship between the expression level of linc00675 and the clinical pathological characteristics, to explore the biological functions of linc00675, and to determine whether linc00675 has independent prognostic value in PDA...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v21.i31.9348
更新日期：2015-08-21 00:00:00
abstract：AIM:To evaluate the best diagnostic technique and risk factors of the human Cytomegalovirus (HCMV) and Epstein-Barr virus (EBV) infection in inflammatory bowel disease (IBD). METHODS:A cohort of 40 IBD patients (17 refractory) and 40 controls underwent peripheral blood and endoscopic colonic mucosal sample harvest. Vi...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v21.i6.1915
更新日期：2015-02-14 00:00:00
abstract：AIM:To analyze the effects of NF- kappa B inhibition by antioxidant pyrrolidine dithiocarbamate (PDTC) or TNF inhibitor pentoxifylline (PTX) on liver regeneration after partial hepatectomy (PH). METHODS:Saline, PDTC or PTX were injected 1 h before PH and rats were killed at 0.5 and 24 h after PH. Several control group...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v11.i46.7345
更新日期：2005-12-14 00:00:00
abstract：:Alcoholic liver disease (ALD) is characterized by steatosis or fat deposition in the liver and inflammation, which leads to cirrhosis and hepatocellular carcinoma. Induction of target genes without involving changes in DNA sequence seems to contribute greatly to liver injury. Chromatin modifications including alterati...
journal_title：World journal of gastroenterology
pub_type： 杂志文章,评审
doi：10.3748/wjg.v17.i20.2456
更新日期：2011-05-28 00:00:00
abstract：:Colorectal adenocarcinoma (CRC) is the third most common type of cancer and the fourth most frequent cause of death due to cancer worldwide. Given the natural history of CRC, early diagnosis appears to be the most appropriate tool to reduce disease-related mortality. A field of recent interest is clinical proteomics, ...
journal_title：World journal of gastroenterology
pub_type： 杂志文章,评审
doi：10.3748/wjg.v12.i41.6594
更新日期：2006-11-07 00:00:00
abstract：AIM:To investigate the prognostic significance of perioperative leukopenia in patients with resected gastric cancer. METHODS:A total of 614 eligible gastric cancer patients who underwent curative D2 gastrectomy and adjuvant chemotherapy were enrolled in this study. The relationship between pre- and postoperative hemat...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v22.i9.2818
更新日期：2016-03-07 00:00:00
abstract：AIM:To investigate the tumor-suppressive effect of the phosphatase and tensin homologue deleted from chromosome (PTEN) in human gastric cancer cells that were wild type for PTEN. METHODS:Adenoviruses expressing PTEN or luciferase as a control were introduced into gastric cancer cells. The effect of exogenous PTEN gene...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v11.i15.2224
更新日期：2005-04-21 00:00:00
abstract：:Celiac disease (CD) is an immune-mediated systemic condition evoked by ingestion of gluten and related prolamines in genetically susceptible subjects. The disease is featured by a variable combination of clinical signs, specific antibodies, HLA-DQ2 and HLA-DQ8 haplotypes, and enteropathy. Vaccination is the most poten...
journal_title：World journal of gastroenterology
pub_type： 社论,评审
doi：10.3748/wjg.v23.i18.3205
更新日期：2017-05-14 00:00:00
abstract：AIM:To investigate the effect of regulatory peptides bombesin (BBS) and neurotensin (NT) on intestinal barrier function in partially hepatectomized rats. METHODS:Ninety male Wistar rats were randomly divided into five groups: I (n=0): controls, II (n= 20): sham operated, III (n=20): partial hepatectomy 70% (PHx), IV (...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v11.i43.6757
更新日期：2005-11-21 00:00:00
abstract：:The chronic inflammatory process underlying inflammatory bowel disease (IBD), comprising Crohn's disease and ulcerative colitis, derives from the interplay of several components in a genetically susceptible host. These components include environmental elements and gut microbiota a dysbiosis. For decades, immune abnorm...
journal_title：World journal of gastroenterology
pub_type： 杂志文章,评审
doi：10.3748/wjg.v24.i41.4622
更新日期：2018-11-07 00:00:00
abstract：:The risk factors for hepatocellular carcinoma (HCC) development have been established, and include chronic hepatitis B and C, heavy alcohol consumption, and aflatoxins. In fact, 5%-30% of patients with HCC still lack a readily identifiable risk factor. It has been reported that the majority of ''cryptogenic'' HCC may ...
journal_title：World journal of gastroenterology
pub_type： 杂志文章,评审
doi：10.3748/wjg.v16.i46.5801
更新日期：2010-12-14 00:00:00
abstract：AIM:To investigate H2O2-induced promotion proliferation and malignant transformation in WB-F344 cells and anti-tumor effects of ursolic acid (UA) and oleanolic acid (OA). METHODS:WB-F344 cells were continuously exposed to 7 x 10(-7) mol/L H2O2 for 21 d. Observations of cell morphology, colony formation rates, flow cyt...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v20.i5.1348
更新日期：2014-02-07 00:00:00
abstract：AIM:To elucidate longitudinal changes of an endoscopic Barrett esophagus (BE), especially of short segment endoscopic BE (SSBE). METHODS:This study comprised 779 patients who underwent two or more endoscopies between January 2009 and December 2015. The intervals between the first and the last endoscopy were at least 6...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v22.i35.8060
更新日期：2016-09-21 00:00:00
abstract：:Despite advances in the management of patients with locally advanced, non-metastatic rectal adenocarcinoma (LARC), prognosis remains largely unsatisfactory due to a high rate of distant relapse. In fact, currently available neoadjuvant protocols, represented by fluoropyrimidine-based chemo-radiotherapy (CT-RT) or shor...
journal_title：World journal of gastroenterology
pub_type： 杂志文章,评审
doi：10.3748/wjg.v20.i20.6081
更新日期：2014-05-28 00:00:00
abstract：AIM:To investigate a suitable long-term culture system and optimal cryopreservation of intestinal organoid to improve organoid-based therapy by acquiring large numbers of cells. METHODS:Crypts were isolated from jejunum of C57BL/6 mouse. Two hundred crypts were cultured in organoid medium with either epidermal growth ...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v23.i6.964
更新日期：2017-02-14 00:00:00
abstract：:We report the case of a 21-year-old man who was noted to have pneumomediastinum during an admission for an acute flare of ulcerative colitis. At that time, he was on maintenance treatment with azathioprine at a dose of 1.25 mg/kg per day, and had not received supplementary steroids for 9 mo. He had never received anti...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.15.1897
更新日期：2009-04-21 00:00:00
abstract：:We report a case of pancreatic hemolymphangioma. Hemolymphangioma is a malformation of both lymphatic vessels and blood vessels. The incidence of this disease in the pancreas is extremely rare. To the best of our knowledge, only seven cases have been reported worldwide (PubMed). A 39-year-old woman with a one-day hist...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v19.i22.3520
更新日期：2013-06-14 00:00:00
abstract：AIM:To prospectively evaluate the effectiveness and safety of continuous wound infiltration (CWI) for pain management after open gastrectomy. METHODS:Seventy-five adult patients with American Society of Anesthesiologists (ASA) Physical Status Classification System (ASA) grade 1-3 undergoing open gastrectomy were rando...
journal_title：World journal of gastroenterology
pub_type： 杂志文章,随机对照试验
doi：10.3748/wjg.v22.i5.1902
更新日期：2016-02-07 00:00:00
abstract：AIM:To study the expression levels of E- selectin, integrin beta1 and immunoglobulin superfamily member-intercellular adhesion molecule-1 (ICAM-1) in human gastric carcinoma cells, and to explore the relationship between these three kinds of cell adhesion molecules and gastric carcinoma. METHODS:The serum contents of ...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v12.i22.3609
更新日期：2006-06-14 00:00:00
abstract：:Weight loss supplements often contain powerful pharmacoactive ingredients with the potential to cause harm. Trials used to determine product safety and effectiveness, meanwhile, tend to be small, of short duration, and frequently lack financial conflict of interest disclosures. These factors could conspire to place co...
journal_title：World journal of gastroenterology
pub_type： 评论,信件
doi：10.3748/wjg.v16.i38.4880
更新日期：2010-10-14 00:00:00
abstract：AIM:To examine whether high-flow nasal oxygen (HFNO) availability influences the use of general anesthesia (GA) in patients undergoing endoscopic retrograde cholangiopancreatography (ERCP) and endoscopic ultrasound (EUS) and associated outcomes. METHODS:In this retrospective study, patients were stratified into 3 eras...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v22.i47.10398
更新日期：2016-12-21 00:00:00
abstract：:The role of whole-body FDG [((18)F) 2-fluoro-2-deoxyglucose] positron emission tomography (PET) scanning as an imaging modality in the management of patients with malignancy has evolved enormously over the past two decades. FDG-PET has demonstrated significant efficacy in the staging, prognostication and detection of ...
journal_title：World journal of gastroenterology
pub_type： 杂志文章,评审
doi：10.3748/wjg.v17.i46.5059
更新日期：2011-12-14 00:00:00
