Abstract:
AIM:To investigate the prevalence of celiac disease (CD) in adult patients referred to an open access gastroenterology clinic in the south of Italy and submitted to esophago-gastro-duodenoscopy (EGD) for evaluation of refractory functional dyspepsia. METHODS:Seven hundred and twenty six consecutive dyspeptic patients (282 male, 444 female; mean age 39.6 years, range 18-75 years) with unexplained prolonged dyspepsia were prospectively enrolled. Duodenal biopsies were taken and processed by standard staining. Histological evaluation was carried out according to the Marsh-Oberhuber criteria. RESULTS:The endoscopic findings were: normal in 61.2%, peptic lesions in 20.5%, malignancies in 0.5%, miscellaneous in 16.7%. CD was endoscopically diagnosed in 8 patients (1.1%), histologically in 15 patients (2%). The endoscopic features alone showed a sensitivity of 34.8% and specificity of 100%, with a positive predictive value (PPV) of 100% and a negative predictive value (NPP) of 97.9%. CONCLUSION:This prospective study showed that CD has a high prevalence (1:48) in adult dyspeptic patients and suggests the routine use of duodenal biopsy in this type of patient undergoing EGD.
journal_name
World J Gastroenteroljournal_title
World journal of gastroenterologyauthors
Giangreco E,D'agate C,Barbera C,Puzzo L,Aprile G,Naso P,Bonanno G,Russo FP,Nicoletti A,Incarbone S,Trama G,Russo Adoi
10.3748/wjg.14.6948subject
Has Abstractpub_date
2008-12-07 00:00:00pages
6948-53issue
45eissn
1007-9327issn
2219-2840journal_volume
14pub_type
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