Hepatocellular carcinoma after direct-acting antiviral hepatitis C virus therapy: A debate near the end.

Abstract:

:Direct acting antivirals (DAAs) have revolutionized the treatment of hepatitis C virus (HCV) infection, achieving high rates (≥ 95%) of sustained virological response, with a good safety profile and high compliance rates. Consequently, it had been expected that viral clearance will reduce morbidity and mortality rates, as well as the risk of hepatocellular carcinoma (HCC). However, since 2016, concerns have been raised over an unexpected high rate of HCC occurrence and recurrence after DAA therapy, which led to an avalanche of studies with contradictory results. We aimed to review the most recent and relevant articles regarding the risk of HCC after DAA treatment and identify the associated risk factors.

journal_name

World J Gastroenterol

authors

Muzica CM,Stanciu C,Huiban L,Singeap AM,Sfarti C,Zenovia S,Cojocariu C,Trifan A

doi

10.3748/wjg.v26.i43.6770

subject

Has Abstract

pub_date

2020-11-21 00:00:00

pages

6770-6781

issue

43

eissn

1007-9327

issn

2219-2840

journal_volume

26

pub_type

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