Abstract:
:Recently, there have been reports from liver biopsies that showed the progression of liver fibrosis in liver transplant patients after the cessation of immunosuppression. Herein, we focused on activated hepatic stellate cells expressing alpha smooth muscle actin (α-SMA) to understand the correlation between immunosuppressant medication and liver fibrosis. The study enrolled two pediatric patients who underwent living donor liver transplantation and ceased immunosuppressant therapy. The number of α-SMA-positive cells in the specimens obtained by liver biopsy from these two patients showed a three-fold increase compared with the number from four transplanted pediatric patients who were continuing immunosuppressant therapy. In addition, the α-SMA-positive area evaluated using the WinRooF image processing software program continued to increase over time in three adult transplanted patients with liver fibrosis, and the α-SMA-positive area was increasing even during the pre-fibrotic stage in these adult cases, according to a retrospective review. Therefore, α-SMA could be a useful marker for the detection of early stage fibrosis.
journal_name
World J Gastroenteroljournal_title
World journal of gastroenterologyauthors
Hirabaru M,Mochizuki K,Takatsuki M,Soyama A,Kosaka T,Kuroki T,Shimokawa I,Eguchi Sdoi
10.3748/wjg.v20.i22.7067subject
Has Abstractpub_date
2014-06-14 00:00:00pages
7067-74issue
22eissn
1007-9327issn
2219-2840journal_volume
20pub_type
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