Expression of alpha smooth muscle actin in living donor liver transplant recipients.

Abstract:

:Recently, there have been reports from liver biopsies that showed the progression of liver fibrosis in liver transplant patients after the cessation of immunosuppression. Herein, we focused on activated hepatic stellate cells expressing alpha smooth muscle actin (α-SMA) to understand the correlation between immunosuppressant medication and liver fibrosis. The study enrolled two pediatric patients who underwent living donor liver transplantation and ceased immunosuppressant therapy. The number of α-SMA-positive cells in the specimens obtained by liver biopsy from these two patients showed a three-fold increase compared with the number from four transplanted pediatric patients who were continuing immunosuppressant therapy. In addition, the α-SMA-positive area evaluated using the WinRooF image processing software program continued to increase over time in three adult transplanted patients with liver fibrosis, and the α-SMA-positive area was increasing even during the pre-fibrotic stage in these adult cases, according to a retrospective review. Therefore, α-SMA could be a useful marker for the detection of early stage fibrosis.

journal_name

World J Gastroenterol

authors

Hirabaru M,Mochizuki K,Takatsuki M,Soyama A,Kosaka T,Kuroki T,Shimokawa I,Eguchi S

doi

10.3748/wjg.v20.i22.7067

subject

Has Abstract

pub_date

2014-06-14 00:00:00

pages

7067-74

issue

22

eissn

1007-9327

issn

2219-2840

journal_volume

20

pub_type

杂志文章
  • NF-kappaB and ERK-signaling pathways contribute to the gene expression induced by cag PAI-positive-Helicobacter pylori infection.

    abstract:AIM:To elucidate the sequential gene expression profile in AGS cells co-cultured with wild-type Helicobacter pylori (H pylori) as a model of H pylori-infected gastric epithelium, and to further examine the contribution of cag-pathogenicity islands (cagPAI)-coding type IV secretion system and the two pathways, nuclear f...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i39.6134

    authors: Shibata W,Hirata Y,Yoshida H,Otsuka M,Hoshida Y,Ogura K,Maeda S,Ohmae T,Yanai A,Mitsuno Y,Seki N,Kawabe T,Omata M

    更新日期:2005-10-21 00:00:00

  • Chitinase 3-like 1 secreted by peritumoral macrophages in esophageal squamous cell carcinoma is a favorable prognostic factor for survival.

    abstract:AIM:To identify whether chitinase 3-like 1 (CHI3L1) serves as a suitable biomarker for the prognosis of esophageal squamous cell carcinoma (ESCC) and to analyze this protein's cellular source. METHODS:An ELISA was conducted to detect the concentration of CHI3L1 in the serum of 150 ESCC patients diagnosed between Janua...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v23.i43.7693

    authors: Xing S,Zheng X,Zeng T,Zeng MS,Zhong Q,Cao YS,Pan KL,Wei C,Hou F,Liu WL

    更新日期:2017-11-21 00:00:00

  • Update on the management of pancreatic cancer: surgery is not enough.

    abstract::Pancreatic ductal adenocarcinoma (PDAC) represents the fourth cause of death in cancer and has a 5-year survival of < 5%. Only about 15% of the patients present with a resectable PDAC with potential to undergo "curative" surgery. After surgery, local and systemic recurrence, is though very common. The median survival ...

    journal_title:World journal of gastroenterology

    pub_type: 社论,评审

    doi:10.3748/wjg.v21.i11.3157

    authors: Ansari D,Gustafsson A,Andersson R

    更新日期:2015-03-21 00:00:00

  • Reduced microRNA 375 in colorectal cancer upregulates metadherin-mediated signaling.

    abstract:BACKGROUND:The human microRNA 375 (MIR375) is significantly downregulated in human colorectal cancer (CRC) and we have previously shown that MIR375 is a CRC-associated miRNA. The metadherin (MTDH) is a candidate target gene of MIR375. AIM:To investigate the interaction and function between MIR375 and MTDH in human CRC...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v25.i44.6495

    authors: Han SH,Mo JS,Park WC,Chae SC

    更新日期:2019-11-28 00:00:00

  • Rationales for expression and altered expression of apoptotic protease activating factor-1 gene in gastric cancer.

    abstract:AIM:To elucidate the relationship between apoptotic protease activating factor-1 (Apaf-1) gene and gastric cancer. METHODS:Thirty-five postoperative cancer and adjacent normal tissue samples were collected in the present study. Expression of the Apaf-1 gene in these samples was analyzed by semi-quantitative RT-PCR. Lo...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v13.i38.5060

    authors: Wang HL,Bai H,Li Y,Sun J,Wang XQ

    更新日期:2007-10-14 00:00:00

  • Inflammatory pathways in the early steps of colorectal cancer development.

    abstract::Colorectal cancer is a major cause of cancer-related death in many countries. Colorectal carcinogenesis is a stepwise process which, from normal mucosa leads to malignancy. Many factors have been shown to influence this process, however, at present, several points remain obscure. In recent years some hypotheses have b...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v20.i29.9716

    authors: Mariani F,Sena P,Roncucci L

    更新日期:2014-08-07 00:00:00

  • Incidence of hepatocellular carcinoma in patients with chronic liver disease due to hepatitis B or C and coinfected with the human immunodeficiency virus: A retrospective cohort study.

    abstract:AIM:To assess the incidence of hepatocellular carcinoma (HCC) in chronic liver disease due to hepatitis B virus (HBV) or hepatitis C virus (HCV) coinfected with human immunodeficiency virus (HIV). METHODS:A retrospective cohort study was performed, including patients with chronic liver disease due to HBV or HCV, with ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v24.i5.613

    authors: Marcon PDS,Tovo CV,Kliemann DA,Fisch P,de Mattos AA

    更新日期:2018-02-07 00:00:00

  • Predictive factors for lymph node metastasis in poorly differentiated early gastric cancer and their impact on the surgical strategy.

    abstract:AIM:To identify the predictive clinicopathological factors for lymph node metastasis (LNM) in poorly differentiated early gastric cancer (EGC) and to further expand the possibility of using endoscopic mucosal resection (EMR) for the treatment of poorly differentiated EGC. METHODS:Data were collected from 85 poorly-dif...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.14.4222

    authors: Li H,Lu P,Lu Y,Liu CG,Xu HM,Wang SB,Chen JQ

    更新日期:2008-07-14 00:00:00

  • Cellular DNA repair cofactors affecting hepatitis B virus infection and replication.

    abstract:AIM:To investigate whether hepatitis B virus (HBV) infection activates DNA damage response and DNA repair cofactors inhibit HBV infection and replication. METHODS:Human hepatocyte cell line HL7702 was studied. Immunoblotting was performed to test the expression of ataxia telangiectasia-mutated (ATM)-Rad3-related prote...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.14.5059

    authors: Zhao F,Hou NB,Song T,He X,Zheng ZR,Ma QJ,Li L,Zhang YH,Zhong H

    更新日期:2008-08-28 00:00:00

  • A tribute to Dr. Frank I Tovey on his 90th birthday.

    abstract::This paper pays a tribute to Dr. Frank I Tovey on his 90th birthday which happens on September 1, 2011, and briefly describes the major findings in his research career and contributions as follows. The geographical prevalence of duodenal ulceration is related to staple diets. Unrefined wheat and maize, soya, certain p...

    journal_title:World journal of gastroenterology

    pub_type: 社论

    doi:10.3748/wjg.v17.i31.3565

    authors: Ma LS

    更新日期:2011-08-21 00:00:00

  • Nuclear and mitochondrial DNA microsatellite instability in hepatocellular carcinoma in Chinese.

    abstract:AIM:To study the nuclear microsatellite instability (nMSI) at BAT26 and mitochondrial microsatellite instability (mtMSI) in the occurrence and development of hepatocellular carcinoma and the relationship between nMSI and mtMSI. METHODS:nMSI was observed with PCR and mtMSI with PCR-SSCP in 52 cases of hepatocellular ca...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v10.i3.371

    authors: Fang DC,Fang L,Wang RQ,Yang SM

    更新日期:2004-02-01 00:00:00

  • Topical negative pressure in managing severe peritonitis: a positive contribution?

    abstract:AIM:To assess the use of topical negative pressure (TNP) in the management of severe peritonitis. METHODS:This is a four-year prospective analysis from January 2005 to December 2008 of 20 patients requiring TNP following laparotomy for severe peritonitis. RESULTS:There were 11 males with an average age of (59.3 +/- 3...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.15.3394

    authors: Amin AI,Shaikh IA

    更新日期:2009-07-21 00:00:00

  • Expression of insulin-like growth factor binding protein-2 in gastric carcinoma and its relationship with cell proliferation.

    abstract:AIM:To investigate the expression of insulin-like growth factor binding protein-2 (IGFBP-2) in gastric carcinoma and its clinical significance and to explore its relationship with cell proliferation. METHODS:Expressions of IGFBP-2 and Ki-67 in 118 cases of gastric carcinoma and 40 cases of normal gastric mucosa were d...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v12.i39.6285

    authors: Shi LH,Zhu XQ,Zhao GH,Xia YB,Zhang YS

    更新日期:2006-10-21 00:00:00

  • Role of MGST1 in reactive intermediate-induced injury.

    abstract::Microsomal glutathione transferase (MGST1, EC 2.5.1.18) is a membrane bound glutathione transferase extensively studied for its ability to detoxify reactive intermediates, including metabolic electrophile intermediates and lipophilic hydroperoxides through its glutathione dependent transferase and peroxidase activitie...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v17.i20.2552

    authors: Schaffert CS

    更新日期:2011-05-28 00:00:00

  • Protein kinase C/zeta (PRKCZ) gene is associated with type 2 diabetes in Han population of North China and analysis of its haplotypes.

    abstract:AIM:To identify the susceptible gene (s) for type 2 diabetes in the previously mapped region, 1p36.33-p36.23, in Han population of North China using single nucleotide polymorphisms (SNPs) and to analyze the haplotypes of the gene (s) related to type 2 diabetes. METHODS:Twenty three SNPs located in 10 candidate genes i...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v9.i9.2078

    authors: Li YF,Sun HX,Wu GD,Du WN,Zuo J,Shen Y,Qiang BQ,Yao ZJ,Wang H,Huang W,Chen Z,Xiong MM,Meng Y,Fang FD

    更新日期:2003-09-01 00:00:00

  • Association of NOD1 (CARD4) insertion/deletion polymorphism with susceptibility to IBD: a meta-analysis.

    abstract:AIM:To find evidences about whether NOD1/CARD4 insertion/deletion polymorphism is associated with inflammatory bowel disease by meta-analysis. METHODS:We surveyed the studies on the association of NOD1/CARD4 insertion/deletion polymorphism with inflammatory bowel disease in PubMed. Meta-analysis was performed for geno...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,meta分析

    doi:10.3748/wjg.v16.i34.4348

    authors: Lu WG,Zou YF,Feng XL,Yuan FL,Gu YL,Li X,Li CW,Jin C,Li JP

    更新日期:2010-09-14 00:00:00

  • Expression of CD14 protein and its gene in liver sinusoidal endothelial cells during endotoxemia.

    abstract:AIM:To observe expression of CD14 protein and CD14 gene in rat liver sinusoidal endothelial cells (LSECs) during endotoxemia, and the role of CD14 protein in the activation of lipopolysaccharide (LPS)-induced LSECs. METHODS:Wistar rat endotoxemia model was established first by injection of a dose of LPS (5mg/kg, Esche...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v8.i3.551

    authors: Gong JP,Dai LL,Liu CA,Wu CX,Shi YJ,Li SW,Li XH

    更新日期:2002-06-01 00:00:00

  • Efficacy of surgical resection in management of isolated extrahepatic metastases of hepatocellular carcinoma.

    abstract:AIM:To clarify the benefit of surgical excision for patients with extrahepatic metastases of hepatocellular carcinoma (HCC). METHODS:We retrospectively reviewed the medical records of 140 patients with pathologically proven extrahepatic metastases of HCC and evaluated the outcomes of those who had undergone surgical r...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.15.5481

    authors: Chan KM,Yu MC,Wu TJ,Lee CF,Chen TC,Lee WC,Chen MF

    更新日期:2009-11-21 00:00:00

  • Comparison of multichannel intraluminal impedance-pH monitoring and reflux scintigraphy in pediatric patients with suspected gastroesophageal reflux.

    abstract:AIM:To evaluate the agreement of multichannel intraluminal impedance-pH monitoring (MII-pHM) and gastroesophageal reflux scintigraphy (GES) for the diagnosis of gastroesophageal reflux disease. METHODS:Seventy-five consecutive patients with suspected gastroesophageal reflux disease (GERD) underwent 24-h combined MII-p...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v22.i43.9595

    authors: Uslu Kızılkan N,Bozkurt MF,Saltık Temizel IN,Demir H,Yüce A,Caner B,Özen H

    更新日期:2016-11-21 00:00:00

  • Benign retroperitoneal schwannoma presenting as colitis: a case report.

    abstract::We report a case of a patient presenting with clinical, radiological and endoscopic features of colitis due to a compressive left para-aortic mass. Total open surgical excision was performed, which resulted in complete resolution of colitis. Histopathology and immunohistochemistry revealed benign retroperitoneal schwa...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v13.i41.5521

    authors: Fass G,Hossey D,Nyst M,Smets D,Saligheh EN,Duttmann R,Claes K,da Costa PM

    更新日期:2007-11-07 00:00:00

  • Mechanical properties of hepatocellular carcinoma cells.

    abstract:AIM:To study the viscoelastic properties of human hepatocytes and hepatocellular carcinoma (HCC) cells under cytoskeletal perturbation, and to further to study the viscoelastic properties and the adhesive properties of mouse hepatoma cells (HTC) in different cell cycle. METHODS:Micropipette aspiration technique was ad...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v8.i2.243

    authors: Zhang G,Long M,Wu ZZ,Yu WQ

    更新日期:2002-04-01 00:00:00

  • Oropharyngeal acid reflux and motility abnormalities of the proximal esophagus.

    abstract:AIM:To investigate the relationship between pathological oropharyngeal (OP) acid exposure and esophageal motility in patients with extra-esophageal syndromes. METHODS:In this prospective study we enrolled consecutive outpatients with extra-esophageal symptoms suspected to be related to gastroesophageal reflux disease ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v22.i40.8991

    authors: Passaretti S,Mazzoleni G,Vailati C,Testoni PA

    更新日期:2016-10-28 00:00:00

  • Characterisation of colonic dysplasia-like epithelial atypia in murine colitis.

    abstract:AIM:To determine if exacerbation of pre-existing chronic colitis in Winnie (Muc2 mutant) mice induces colonic dysplasia. METHODS:Winnie mice and C57BL6 as a genotype control, were administered 1% w/v dextran sulphate sodium (DSS) orally, followed by drinking water alone in week-long cycles for a total of three cycles....

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v22.i37.8334

    authors: Randall-Demllo S,Fernando R,Brain T,Sohal SS,Cook AL,Guven N,Kunde D,Spring K,Eri R

    更新日期:2016-10-07 00:00:00

  • Interleukin 28B-related polymorphisms: a pathway for understanding hepatitis C virus infection?

    abstract:AIM:To analyze the role of rs12979860 and rs8099917 polymorphisms in hepatitis C virus (HCV) genotype 1 infection of Brazilians. METHODS:A total of 145 adult patients diagnosed with genotype 1 chronic hepatitis C (CHC) who had completed a 48-wk regimen of pegylated-interferon α-2a or -2b plus ribavirin combination the...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,多中心研究

    doi:10.3748/wjg.v19.i42.7399

    authors: Garcia RF,Moreira S,de Araújo Ramos AL,Ferreira LE,de Mattos AA,Tovo CV,Nader LA,Ramos JA,Rondinelli E,de Jesus Dominici A,Garcia CE,de Souza Leite Pinho M,Brandão-Mello CE,Villela-Nogueira CA,de França PH

    更新日期:2013-11-14 00:00:00

  • Endoscopic ultrasound-guided biliary drainage: Bilateral systems drainage via left duct approach.

    abstract::Endoscopic ultrasound (EUS)-guided biliary drainage is accepted as a less invasive, alternative treatment for patients in whom endoscopic retrograde cholangiopancreatography has failed. Most patients with malignant hilar obstruction undergo EUS-guided hepaticogastrostomy. The authors present the case of a 77-year-old ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v21.i34.10045

    authors: Prachayakul V,Aswakul P

    更新日期:2015-09-14 00:00:00

  • Feasibility of confocal endomicroscopy in the diagnosis of pediatric gastrointestinal disorders.

    abstract:AIM:To evaluate the feasibility and utility of confocal laser endomicroscopy (CLE) in the description of normal gastrointestinal (GI) mucosa and in the diagnosis of GI disorders in children, in comparison to histology. METHODS:Forty-four patients (19 female) median age 10.9 years (range 0.7-16.6 years) with suspected ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.15.2214

    authors: Venkatesh K,Cohen M,Evans C,Delaney P,Thomas S,Taylor C,Abou-Taleb A,Kiesslich R,Thomson M

    更新日期:2009-05-14 00:00:00

  • Experimental obstructive jaundice alters claudin-4 expression in intestinal mucosa: effect of bombesin and neurotensin.

    abstract:AIM:To investigate the influence of experimental obstructive jaundice and exogenous bombesin (BBS) and neurotensin (NT) administration on the expression of the tight junction (TJ)-protein claudin-4 in intestinal epithelium of rats. METHODS:Forty male Wistar rats were randomly divided into five groups: I = controls, II...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v12.i21.3410

    authors: Assimakopoulos SF,Vagianos CE,Charonis AS,Alexandris IH,Spiliopoulou I,Thomopoulos KC,Nikolopoulou VN,Scopa CD

    更新日期:2006-06-07 00:00:00

  • Prognostic significance of preoperative circulating vascular endothelial growth factor messenger RNA expression in resectable hepatocellular carcinoma: a prospective study.

    abstract:AIM:To investigate the prognostic value of vascular endothelial growth factor messenger RNA (VEGF mRNA) in the peripheral blood (PB) of patients with hepatocellular carcinoma (HCC) undergoing curative resection. METHODS:Using a reverse-transcription polymerase chain reaction (RT-PCR)-based assay, VEGF mRNA in the PB w...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v10.i5.643

    authors: Jeng KS,Sheen IS,Wang YC,Gu SL,Chu CM,Shih SC,Wang PC,Chang WH,Wang HY

    更新日期:2004-03-01 00:00:00

  • Characteristics of symptomatic reflux episodes in Japanese proton pump inhibitor-refractory non-erosive reflux disease patients.

    abstract:AIM:To clarify the pathogenesis of gastroesophageal reflux disease symptoms in non-erosive reflux disease (NERD) patients. METHODS:Thirty-five NERD patients with persistent symptoms, despite taking rabeprazole 10 mg twice daily for at least 8 wk, were included in this study. All patients underwent 24 h combined impeda...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v21.i47.13352

    authors: Nakagawa K,Koike T,Iijima K,Saito M,Kikuchi H,Hatta W,Ara N,Uno K,Asano N,Shimosegawa T

    更新日期:2015-12-21 00:00:00

  • Malignant extra-gastrointestinal stromal tumor of the pancreas: report of two cases and review of the literature.

    abstract::Gastrointestinal stromal tumors (GISTs) are mesenchymal tumors that arise from the gastrointestinal tract. In rare cases, these tumors are found in intra-abdominal sites unrelated to the gastrointestinal tract, such as the mesentery, omentum and retroperitoneum. However, pancreatic extra-gastrointestinal stromal tumor...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v20.i3.863

    authors: Tian YT,Liu H,Shi SS,Xie YB,Xu Q,Zhang JW,Zhao DB,Wang CF,Chen YT

    更新日期:2014-01-21 00:00:00