Protein kinase C/zeta (PRKCZ) gene is associated with type 2 diabetes in Han population of North China and analysis of its haplotypes.

Abstract:

AIM:To identify the susceptible gene (s) for type 2 diabetes in the previously mapped region, 1p36.33-p36.23, in Han population of North China using single nucleotide polymorphisms (SNPs) and to analyze the haplotypes of the gene (s) related to type 2 diabetes. METHODS:Twenty three SNPs located in 10 candidate genes in the mapped region were chosen from public SNP domains with bioinformatic methods, and the single base extension (SBE) method was used to genotype the loci for 192 sporadic type 2 diabetes patients and 172 normal individuals, all with Han ethical origin, to perform this case-control study. The haplotypes with significant difference in the gene (s) were further analyzed. RESULTS:Among the 23 SNPs, 8 were found to be common in Chinese Han population. Allele frequency of one SNP, rs436045 in the protein kinase C/zetagene (PRKCZ) was statistically different between the case and control groups(P<0.05). Furthermore, haplotypes at five SNP sites of PRKCZ gene were identified. CONCLUSION:PRKCZ gene may be associated with type 2 diabetes in Han population in North China. The haplotypes at five SNP sites in this gene may be responsible for this association.

journal_name

World J Gastroenterol

authors

Li YF,Sun HX,Wu GD,Du WN,Zuo J,Shen Y,Qiang BQ,Yao ZJ,Wang H,Huang W,Chen Z,Xiong MM,Meng Y,Fang FD

doi

10.3748/wjg.v9.i9.2078

keywords:

subject

Has Abstract

pub_date

2003-09-01 00:00:00

pages

2078-82

issue

9

eissn

1007-9327

issn

2219-2840

journal_volume

9

pub_type

杂志文章
  • Intensive or not surveillance of patients with colorectal cancer after curative resection.

    abstract::It is common practice to follow patients with colorectal cancer for some years after resection and/or adjuvant treatment. Data are lacking about how often patients should be seen, what tests should be performed, and what surveillance strategy has a significant impact on patient outcome. Seven randomized trials have ad...

    journal_title:World journal of gastroenterology

    pub_type: 社论

    doi:10.3748/wjg.v16.i12.1427

    authors: Rosati G

    更新日期:2010-03-28 00:00:00

  • Analysis of the urinary peptidome associated with Helicobacter pylori infection.

    abstract:AIM:To investigate the relationship between urinary peptide changes and Helicobacter pylori (H. pylori) infection using urinary peptidome profiling. METHODS:The study was performed in volunteers (n=137) who gave informed consent. Urinary peptides were enriched by magnetic beads based weak cation exchange chromatograph...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v17.i5.618

    authors: Xiao D,Meng FL,He LH,Gu YX,Zhang JZ

    更新日期:2011-02-07 00:00:00

  • Viral kinetics of enterovirus 71 in human abdomyosarcoma cells.

    abstract:AIM:To characterise the viral kinetics of enterovirus 71 (EV71). METHODS:In this study, human rhabdomyosarcoma (RD) cells were infected with EV71 at different multiplicity of infection (MOI). After infection, the cytopathic effect (CPE) was monitored and recorded using a phase contrast microscope associated with a CCD...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v17.i36.4135

    authors: Lu J,He YQ,Yi LN,Zan H,Kung HF,He ML

    更新日期:2011-09-28 00:00:00

  • Post-partum reactivation of chronic hepatitis B virus infection among hepatitis B e-antigen-negative women.

    abstract:AIM:To investigate the frequency and timing of post-partum chronic hepatitis B virus (HBV) reactivation and identify its pre-partum predictors. METHODS:Forty-one hepatitis B e antigen (HBeAg)-negative chronic HBV infected pregnant women were prospectively evaluated between the 28th and the 32nd week of gestation. Subj...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v21.i4.1261

    authors: Elefsiniotis I,Vezali E,Vrachatis D,Hatzianastasiou S,Pappas S,Farmakidis G,Vrioni G,Tsakris A

    更新日期:2015-01-28 00:00:00

  • Unusual presentations of eosinophilic gastroenteritis: case series and review of literature.

    abstract::Eosinophilic gastroenteritis (EG) is an uncommon disease characterized by focal or diffuse eosinophilic infiltration of the gastrointestinal tract, and is usually associated with dyspepsia, diarrhea and peripheral eosinophilia. Diffuse gastrointestinal tract and colonic involvement are uncommon. The endoscopic appeara...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.15.2156

    authors: Sheikh RA,Prindiville TP,Pecha RE,Ruebner BH

    更新日期:2009-05-07 00:00:00

  • Successful endoscopic treatment of biliary stricture following mesenteric tear caused by blunt abdominal trauma.

    abstract::Biliary duct injuries are frequently iatrogenic, being associated with surgery for gallbladder stones. However, blunt abdominal trauma such as a motor vehicle crash is a rare cause of extrahepatic biliary stricture. A few reports have been published on biliary strictures treated with endoscopic therapy. In the present...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.14.2277

    authors: Kang DO,Kim TH,You SS,Min HJ,Kim HJ,Jung WT,Lee OJ

    更新日期:2008-04-14 00:00:00

  • Nasogastric tube syndrome induced by an indwelling long intestinal tube.

    abstract::The nasogastric tube (NGT) has become a frequently used device to alleviate gastrointestinal symptoms. Nasogastric tube syndrome (NTS) is an uncommon but potentially life-threatening complication of an indwelling NGT. NTS is characterized by acute upper airway obstruction due to bilateral vocal cord paralysis. We repo...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v22.i15.4057

    authors: Sano N,Yamamoto M,Nagai K,Yamada K,Ohkohchi N

    更新日期:2016-04-21 00:00:00

  • Characteristics of nonvariceal upper gastrointestinal hemorrhage in patients with chronic kidney disease.

    abstract:AIM:To evaluate the clinical characteristics of nonvariceal upper gastrointestinal hemorrhage (NGIH) in patients with chronic kidney disease (CKD). METHODS:From 2003 to 2010, a total of 72 CKD patients (male n = 52, 72.2%; female n = 20, 27.8%) who had undergone endoscopic treatments for NGIH were retrospectively iden...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v19.i43.7719

    authors: Bang CS,Lee YS,Lee YH,Sung H,Park HJ,Kim HS,Kim JB,Baik GH,Kim YS,Yoon JH,Kim DJ,Suk KT

    更新日期:2013-11-21 00:00:00

  • Prognostic value of perioperative leukocyte count in resectable gastric cancer.

    abstract:AIM:To investigate the prognostic significance of perioperative leukopenia in patients with resected gastric cancer. METHODS:A total of 614 eligible gastric cancer patients who underwent curative D2 gastrectomy and adjuvant chemotherapy were enrolled in this study. The relationship between pre- and postoperative hemat...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v22.i9.2818

    authors: Chen XF,Qian J,Pei D,Zhou C,Røe OD,Zhu F,He SH,Qian YY,Zhou Y,Xu J,Xu J,Li X,Ping GQ,Liu YQ,Wang P,Guo RH,Shu YQ

    更新日期:2016-03-07 00:00:00

  • Optimizing clarithromycin-containing therapy for Helicobacter pylori in the era of antibiotic resistance.

    abstract::The efficacy of triple therapy for Helicobacter pylori infection has dramatically declined over the last decade, largely related to increasing clarithromycin resistance rates. From a microbiological standpoint, bismuth quadruple therapy is the ideal replacement since it combines drugs for which resistance does not imp...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v20.i30.10338

    authors: Molina-Infante J,Gisbert JP

    更新日期:2014-08-14 00:00:00

  • Probiotics in hepatology.

    abstract::The paper provides a basic review of intestinal microflora and its importance in liver diseases. The intestinal microflora has many important functions, above all to maintain the microbial barrier against established as well as potential pathogens. Furthermore, it influences the motility and perfusion of the intestina...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v17.i24.2890

    authors: Lata J,Jurankova J,Kopacova M,Vitek P

    更新日期:2011-06-28 00:00:00

  • Proinflammatory effects and molecular mechanisms of interleukin-17 in intestinal epithelial cell line HT-29.

    abstract:AIM:To evaluate the proinflammatory effects and molecular mechanisms of interleukin (IL)-17 in intestinal epithelial cell line HT-29. METHODS:HT-29 cells were cultured with IL-17, tumor necrosis factor (TNF)-α, or the combination of both IL-17 and TNF-α. Real-time PCR and Western blot were used to measure the gene exp...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v20.i47.17924

    authors: Wang YL,Fang M,Wang XM,Liu WY,Zheng YJ,Wu XB,Tao R

    更新日期:2014-12-21 00:00:00

  • Influence of BOL on hyaluronic acid, laminin and hyperplasia in hepatofibrotic rats.

    abstract:AIM:To study the anti-hepatofibrosis mechanism of Bie Jia Jian oral liquid (BOL). METHODS:The model was induced by subcutaneous injection of CCl(4). BOL was administered and the change of serum hyaluronic acid (HA) and laminin (LN) was observed and the degeneration of liver cells and the degree of fibre hyperplasia an...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v7.i6.872

    authors: Yao L,Yao ZM,Yu T

    更新日期:2001-12-01 00:00:00

  • Human papillomavirus does not have a causal role in colorectal carcinogenesis.

    abstract:AIM:To investigate the presence of human papillomavirus (HPV) DNA along with the integration, the quantification and the expression of the HPV16 in colorectal cancers. METHODS:A prospective series of colorectal tumors were genotyped for HPV DNA. The clinical and pathological variables of the HPV-positive tumors were c...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v21.i1.342

    authors: Lorenzon L,Mazzetta F,Pilozzi E,Uggeri G,Torrisi MR,Ferri M,Ziparo V,French D

    更新日期:2015-01-07 00:00:00

  • Significance of expression of heat shock protein90alpha in human gastric cancer.

    abstract:AIM:To evaluate the significance of hsp90alpha expression in human gastric cancer tissues. METHODS:Immunohistochemical staining was used in clinical specimens from 33 cases of gastric cancer and 33 cases of gastritis with rabbit anti-human hsp90alpha multi-clonal antibody in order to explore the relationship between t...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v9.i11.2616

    authors: Zuo DS,Dai J,Bo AH,Fan J,Xiao XY

    更新日期:2003-11-01 00:00:00

  • Expression and immunoreactivity of an epitope of HCV in a foreign epitope presenting system.

    abstract:AIM:To construct and highly express an epitope of hepatitis C virus (HCV) in a foreign epitope presenting vector based on an insect virus, and to study the antigenicity of the epitope. METHODS:The HCV epitope sequence (amino acid residues 315 to 328: EGHRMAWDMMMNWS) of the E1 region was constructed at different positi...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i22.3363

    authors: Peng M,Dai CB,Chen YD

    更新日期:2005-06-14 00:00:00

  • Diagnosing coeliac disease: Out with the old and in with the new?

    abstract::Coeliac disease (CD) is a complex condition resulting from an interplay between genetic and environmental factors. When diagnosing the condition, serological testing and genotyping are useful in excluding CD, although the gold standard of testing is currently histopathological examination of the small intestine. There...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v26.i1.1

    authors: Charlesworth RP

    更新日期:2020-01-07 00:00:00

  • Anti-Helicobacter pylori therapy significantly reduces Helicobacter pylori -induced gastric mucosal damage in Mongolian gerbils.

    abstract:AIM:To investigate the effectiveness of 4 d' anti-Helicobacter pylori therapy on the H pylori-infected Mongolian gerbils based on physiological and pathological changes. METHODS:We used 6-wk-old male gerbils orally inoculated with H pylori (ATCC43504, 2X10(8) CFU/mL). Seven weeks after H pylori inoculation, the animal...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i7.982

    authors: Chang CC,Chen SH,Lien GS,Lee YJ,Lou HY,Hsieh CR,Fang CL,Pan S

    更新日期:2005-02-21 00:00:00

  • Laparoscopic hemicolectomy in a patient with situs inversus totalis.

    abstract::As among persons with normal anatomy, occasional patients with situs inversus develop malignant tumors. Recently, several laparoscopic operations have been reported in patients with situs inversus. We describe laparoscopic hemicolectomy with radical lymphadenectomy in such a patient. Careful consideration of the mirro...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v13.i37.5035

    authors: Fujiwara Y,Fukunaga Y,Higashino M,Tanimura S,Takemura M,Tanaka Y,Osugi H

    更新日期:2007-10-07 00:00:00

  • American ginseng supplementation attenuates creatine kinase level induced by submaximal exercise in human beings.

    abstract:AIM:To investigate whether American ginseng (AG, Panax quinquefolium) supplementation was able to improve endurance exercise performance. METHODS:Thirteen physically active male college students were divided into two groups (AG or placebo) and received supplementation for 4 wk, before the exhaustive running exercise. ...

    journal_title:World journal of gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.3748/wjg.v11.i34.5327

    authors: Hsu CC,Ho MC,Lin LC,Su B,Hsu MC

    更新日期:2005-09-14 00:00:00

  • Role of inflammation and infection in the pathogenesis of human acute liver failure: Clinical implications for monitoring and therapy.

    abstract::Acute liver failure is a rare and devastating clinical condition. At present, emergency liver transplantation is the only life-saving therapy in advanced cases, yet the feasibility of transplantation is affected by the presence of systemic inflammation, infection and resultant multi-organ failure. The importance of im...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v22.i26.5958

    authors: Donnelly MC,Hayes PC,Simpson KJ

    更新日期:2016-07-14 00:00:00

  • Comparison of two different laparotomy methods for modeling rabbit VX2 hepatocarcinoma.

    abstract:AIM:To compare two different laparotomy methods for modeling rabbit VX2 hepatocarcinoma. METHODS:Thirty New Zealand rabbits were randomly divided into two groups: A and B. Group A was assigned a traditional laparotomy method (embedding tumor fragments directly into the liver with tweezers). Group B was subjected to an...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v21.i16.4875

    authors: Chen Z,Kang Z,Xiao EH,Tong M,Xiao YD,Li HB

    更新日期:2015-04-28 00:00:00

  • Alanine aminotransferase is an inadequate surrogate marker for detecting lamivudine resistance.

    abstract:AIM:To investigate the accuracy of serum alanine aminotransferase (ALT) in diagnosing lamivudine resistance and factors that contributed to abnormal serum ALT. METHODS:This was a retrospective study of chronic hepatitis B patients on lamivudine therapy who were followed for 3-mo with liver function tests and hepatitis...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v16.i37.4691

    authors: Lim LG,Aung MO,Seet BL,Tan C,Dan YY,Lee YM,Sutedja DS,Fernandes M,Lee GH,Koay E,Lim SG

    更新日期:2010-10-07 00:00:00

  • Hepatitis C in non-hepatic solid organ transplant candidates and recipients: A new horizon.

    abstract::Hepatitis C virus (HCV) infection is estimated to affect 130-150 million people globally which corresponds to 2%-3% of the total world population. It remains the leading indication for liver transplant worldwide and has been demonstrated to negatively impact both patient and graft survival following non-hepatic organ ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v22.i4.1650

    authors: Belga S,Doucette KE

    更新日期:2016-01-28 00:00:00

  • Hemolymphangioma of the spleen: A report of a rare case.

    abstract::Hemolymphangioma is a malformation of both lymphatic vessels and blood vessels. Splenic hemolymphangioma is extremely rare. Herein, we present a case of 62-year-old woman with ambiguous upper quadrant abdominal pain for two months who was found to have an occupying lesion in the spleen on computed tomography. She was ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v21.i17.5442

    authors: Mei Y,Peng CJ,Chen L,Li XX,Li WN,Shu DJ,Xie WT

    更新日期:2015-05-07 00:00:00

  • Gallbladder motor function, plasma cholecystokinin and cholecystokinin receptor of gallbladder in cholesterol stone patients.

    abstract:AIM:To study the interactive relationship of gallbladder motor function, plasma cholecystokinin (CCK) and cholecystokinin A receptor (CCK-R) of gallbladder in patients with cholesterol stone disease. METHODS:Gallbladder motility was studied by ultrasonography in 33 patients with gallbladder stone and 10 health subject...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i11.1685

    authors: Zhu J,Han TQ,Chen S,Jiang Y,Zhang SD

    更新日期:2005-03-21 00:00:00

  • Pathogenic effects of Opolysaccharide from Shigella flexneri strain.

    abstract::AIM:To investigate the specific pathogenesis of O-polysaccharide (O-PS) which is on the outer membrane of lipopolysaccharides (LPS) from Shigella flexneri.METHODS:The O-PS was isolated and purified from Shigella flexneri 5 M90T by enzymatic hydrolysis and gel chromatography. Effects of O-PS were observed by in vitro e...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v5.i3.245

    authors: Zhong QP

    更新日期:1999-06-01 00:00:00

  • Sex- and gender-specific disparities in colorectal cancer risk.

    abstract::Colorectal cancer is one of the most common causes of cancer morbidity both in men and in women. However, females over 65 years old show higher mortality and lower 5-year survival rate of colorectal cancer compared to their age-matched male counterparts. The objective of this review is to suggest gender-based innovati...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v21.i17.5167

    authors: Kim SE,Paik HY,Yoon H,Lee JE,Kim N,Sung MK

    更新日期:2015-05-07 00:00:00

  • Effects of palmatine on potassium and calcium currents in isolated rat hepatocytes.

    abstract:AIM:To study the effects of palmatine, a known inhibitor on delayed rectifier potassium current and L-type calcium current (I(Ca,L)) in guinea pig ventricular myocytes, on the potassium and calcium currents in isolated rat hepatocytes. METHODS:Tight-seal whole-cell patch-clamp techniques were performed to investigate ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v9.i2.329

    authors: Wang F,Zhou HY,Cheng L,Zhao G,Zhou J,Fu LY,Yao WX

    更新日期:2003-02-01 00:00:00

  • Efficiency of bowel preparation for capsule endoscopy examination: a meta-analysis.

    abstract::Good preparation before endoscopic procedures is essential for successful visualization. The small bowel is difficult to evaluate because of its length and complex configuration. A meta-analysis was conducted of studies comparing small bowel visualization by capsule endoscopy with and without preparation. Medical data...

    journal_title:World journal of gastroenterology

    pub_type: 社论,meta分析

    doi:10.3748/wjg.14.1313

    authors: Niv Y

    更新日期:2008-03-07 00:00:00