Expression of insulin-like growth factor binding protein-2 in gastric carcinoma and its relationship with cell proliferation.

Abstract:

AIM:To investigate the expression of insulin-like growth factor binding protein-2 (IGFBP-2) in gastric carcinoma and its clinical significance and to explore its relationship with cell proliferation. METHODS:Expressions of IGFBP-2 and Ki-67 in 118 cases of gastric carcinoma and 40 cases of normal gastric mucosa were detected by EnVision immunohistochemical technique. RESULTS:Expression of IGFBP-2 in gastric carcinoma was higher than that in normal gastric mucosa (P < 0.01). There was no difference between high- and low-grade gastric carcinoma (P > 0.05). Expression of IGFBP-2 in advanced gastric carcinoma was higher than that in early gastric carcinoma (P < 0.05). Expression of IGFBP-2 in gastric carcinoma with lymph node metastasis was higher than that without lymph node metastasis (P < 0.01). IGFBP-2 expression was a positively related to the clinical stage of gastric carcinoma (P < 0.01). There was a positive correlation between IGFBP-2 and Ki-67 (P < 0.05). CONCLUSION:IGFBP-2 may be involved in carcino-genesis and progression of gastric carcinoma by promoting cell proliferation.

journal_name

World J Gastroenterol

authors

Shi LH,Zhu XQ,Zhao GH,Xia YB,Zhang YS

doi

10.3748/wjg.v12.i39.6285

subject

Has Abstract

pub_date

2006-10-21 00:00:00

pages

6285-9

issue

39

eissn

1007-9327

issn

2219-2840

journal_volume

12

pub_type

杂志文章
  • Evaluation of esophageal function in patients with esophageal motor abnormalities using multichannel intraluminal impedance esophageal manometry.

    abstract:AIM:To evaluate the functional aspect of esophageal motility in healthy subjects and in patients who were referred for esophageal function testing using multichannel intraluminal impedance-esophageal manometry (MII-EM), and to assess the clinical utility of MII-EM. METHODS:From September 2003 to January 2004, we perfo...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v12.i39.6349

    authors: Cho YK,Choi MG,Park JM,Oh JH,Paik CN,Lee JW,Lee IS,Kim SW,Chung IS

    更新日期:2006-10-21 00:00:00

  • Effect of Danzhijiangtang capsule on monocyte chemoattractant protein-1 mRNA expression in newly diagnosed diabetes subclinical vascular lesions.

    abstract:AIM:To investigate the effect of Danzhijiangtang capsule (DJC) on monocyte chemoattractant protein-1 (MCP-1) mRNA expression in newly diagnosed type 2 diabetes mellitus (T2DM) subclinical vascular lesions. METHODS:Sixty-two patients with newly diagnosed T2DM subclinical vascular lesions were randomly divided into a co...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,随机对照试验

    doi:10.3748/wjg.v19.i19.2963

    authors: Fang ZH,Liu Y,Bao TT,Ni YQ,Liu J,Shi GB,Wu JP,Yang JP,Zhang H

    更新日期:2013-05-21 00:00:00

  • Stretta: a valuable endoscopic treatment modality for gastroesophageal reflux disease.

    abstract::One potential option for the management of refractory gastro-esophageal reflux disease (GERD) is the delivery of radiofrequency energy to the gastro-esophageal junction (Stretta). This endoscopic therapy is safe, effective, durable, and repeatable if necessary and serves an unmet need for many GERD sufferers. Stretta ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v20.i24.7730

    authors: Triadafilopoulos G

    更新日期:2014-06-28 00:00:00

  • A dose-up of ursodeoxycholic acid decreases transaminases in hepatitis C patients.

    abstract:AIM:To examine whether a dose-up to 900 mg of ursodeoxycholic acid (UDCA) decreases transaminases in hepatitis C patients. METHODS:From January to December 2007, patients with chronic hepatitis C or compensated liver cirrhosis with hepatitis C virus (HCV) (43-80 years old) showing positive serum HCV-RNA who had alread...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.15.2782

    authors: Sato S,Miyake T,Tobita H,Oshima N,Ishine J,Hanaoka T,Amano Y,Kinoshita Y

    更新日期:2009-06-14 00:00:00

  • Evaluation of CMU-1 preservation solutions using an isolated perfused rat liver model.

    abstract:AIM:CMU-1 is a new preservation solution with a low potassium concentration as well as low viscosity that is highly effective in reducing preservation injury. The purpose of this experiment is to compare the protective effect of CMU-1 solution with that of UW during cold preservation and normothermic reperfusion. METH...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i16.2522

    authors: Cheng Y,Liu YF,Cheng DH,Li BF,Zhao N

    更新日期:2005-04-28 00:00:00

  • Posttransplant lymphoproliferative disorders following liver transplantation: Where are we now?

    abstract::Liver transplantation has emerged as a life-saving treatment for several patients with acute liver failure, end stage liver disease and primary hepatic malignancies. However, long term immunosuppressive therapy aiming to reduce the risk of transplant rejection increases the incidence of several complications including...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v21.i39.11034

    authors: Dierickx D,Cardinaels N

    更新日期:2015-10-21 00:00:00

  • Effect of composite yogurt enriched with acacia fiber and Bifidobacterium lactis.

    abstract:AIM:To investigate whether composite yogurt with acacia dietary fiber and Bifidobacterium lactis (B. lactis) has additive effects in irritable bowel syndrome (IBS). METHODS:A total of 130 patients were randomly allocated to consume, twice daily for 8 wk, either the composite yogurt or the control product. The composit...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,随机对照试验

    doi:10.3748/wjg.v18.i33.4563

    authors: Min YW,Park SU,Jang YS,Kim YH,Rhee PL,Ko SH,Joo N,Kim SI,Kim CH,Chang DK

    更新日期:2012-09-07 00:00:00

  • Effects of autoantibodies against beta(1)-adrenoceptor in hepatitis virus myocarditis on action potential and L-type Ca(2+) currents.

    abstract:AIM:To investigate the effects of autoantibodies against beta(1)-adrenoceptor in hepatitis virus myocarditis on action potential and L-type Ca(2+) currents. METHODS:Fifteen samples of autoantibodies against beta(1)-adrenoceptor positive sera of patients with hepatitis virus myocarditis were obtained and IgGs were puri...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v10.i8.1171

    authors: Liu K,Liao YH,Wang ZH,Li SL,Wang M,Zeng LL,Tang M

    更新日期:2004-04-15 00:00:00

  • Effects of time interval for hemofiltration on the prognosis of severe acute pancreatitis.

    abstract:AIM:To evaluate the impact of time interval for hemofiltration (HF) on the prognosis of severe acute pancreatitis (SAP). METHODS:Thirty-six consecutive patients with severe acute pancreatitis were included in the study. Atlanta classification system was applied for stratification. They were randomly divided into short...

    journal_title:World journal of gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.3748/wjg.v9.i2.373

    authors: Mao EQ,Tang YQ,Zhang SD

    更新日期:2003-02-01 00:00:00

  • Hexahydrocurcumin enhances inhibitory effect of 5-fluorouracil on HT-29 human colon cancer cells.

    abstract:AIM:To investigate the ability of hexahydrocurcumin (HHC) to enhance 5-fluorouracil (5-FU) in inhibiting the growth of HT-29 cells by focusing on cyclooxygenase (COX)-2 expression. METHODS:Antiproliferative effects of HHC and 5-FU, alone and in combination, on growth of HT-29 human colon cancer cells were assessed usi...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v18.i19.2383

    authors: Srimuangwong K,Tocharus C,Yoysungnoen Chintana P,Suksamrarn A,Tocharus J

    更新日期:2012-05-21 00:00:00

  • Are gap junction gene connexins 26, 32 and 43 of prognostic values in hepatocellular carcinoma? A prospective study.

    abstract:AIM:To investigate the prognostic value of the expression of connexin (Cx) 26, 32 and 43 messenger RNA (mRNA) in hepatocellular carcinoma (HCC) tissues. METHODS:Using a reverse-transcriptase polymerase chain reaction (RT-PCR), Cx 26, Cx 32 and Cx 43 mRNAs were determined in the liver tissues of 15 controls and in HCC ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v10.i19.2785

    authors: Sheen IS,Jeng KS,Wang PC,Shih SC,Chang WH,Wang HY,Chen CC,Shyung LR

    更新日期:2004-10-01 00:00:00

  • Characterisation of colonic dysplasia-like epithelial atypia in murine colitis.

    abstract:AIM:To determine if exacerbation of pre-existing chronic colitis in Winnie (Muc2 mutant) mice induces colonic dysplasia. METHODS:Winnie mice and C57BL6 as a genotype control, were administered 1% w/v dextran sulphate sodium (DSS) orally, followed by drinking water alone in week-long cycles for a total of three cycles....

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v22.i37.8334

    authors: Randall-Demllo S,Fernando R,Brain T,Sohal SS,Cook AL,Guven N,Kunde D,Spring K,Eri R

    更新日期:2016-10-07 00:00:00

  • E2F transcription factors and digestive system malignancies: how much do we know?

    abstract::E2F family of transcription factors regulates various cellular functions related to cell cycle and apoptosis. Its individual members have traditionally been classified into activators and repressors, based on in vitro studies. However their contribution in human cancer is more complicated and difficult to predict. We ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v19.i21.3189

    authors: Xanthoulis A,Tiniakos DG

    更新日期:2013-06-07 00:00:00

  • Changes of CD8+CD28- T regulatory cells in rat model of colitis induced by 2,4-dinitrofluorobenzene.

    abstract:AIM:To determine the changes of CD8+ T subsets especially CD8+CD28- T regulatory cells in rat model of experimental colitis induced by 2,4-dinitrofluorobenzene (DNFB). METHODS:The rat model of experimental colitis was induced by enema with DNFB. Ten days later, colonic intraepithelial and splenic lymphocytes were isol...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v9.i11.2528

    authors: Xiao WB,Liu YL

    更新日期:2003-11-01 00:00:00

  • Effects of ciglitazone and troglitazone on the proliferation of human stomach cancer cells.

    abstract:AIM:To determine the cytological and molecular effects of peroxisome proliferation-activated receptor (PPAR)-gamma and PPAR-gamma agonists on stomach cancer cells. METHODS:To determine the proliferation-suppressive effects of troglitazone and ciglitazone, SNU-216 and SNU-668 stomach cancer cells were plated in media c...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.15.310

    authors: Cheon CW,Kim DH,Kim DH,Cho YH,Kim JH

    更新日期:2009-01-21 00:00:00

  • Multifocal gastrointestinal epithelioid angiosarcomas diagnosed by endoscopic mucosal resection: A case report.

    abstract:BACKGROUND:Epithelioid angiosarcoma is a vascular neoplasm that is among the most aggressive subtypes of sarcomas. Its involvement in the gastrointestinal tract is rare. We here report a case of multifocal gastrointestinal epithelioid angiosarcomas presenting with gastrointestinal bleeding. CASE SUMMARY:A 77-year-old ...

    journal_title:World journal of gastroenterology

    pub_type:

    doi:10.3748/wjg.v26.i29.4372

    authors: Chen YW,Dong J,Chen WY,Dai YN

    更新日期:2020-08-07 00:00:00

  • Evaluation of the prognostic value of liver stiffness in patients with hepatitis C virus treated with triple or dual antiviral therapy: A prospective pilot study.

    abstract:AIM:To evaluate the association between liver stiffness (LS) prior to the initiation of dual/triple therapy and viral response. METHODS:LS was measured in all patients before treatment was administered. The therapeutic approach was based on hepatic, virological, and immunological evaluations and considered the fact th...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v21.i10.3013

    authors: Stasi C,Piluso A,Arena U,Salomoni E,Montalto P,Monti M,Boldrini B,Corti G,Marra F,Laffi G,Milani S,Zignego AL

    更新日期:2015-03-14 00:00:00

  • Duodenal variceal bleeding after balloon-occluded retrograde transverse obliteration: treatment with transjugular intrahepatic portosystemic shunt.

    abstract::We report a case of duodenal varix bleeding as a long term complication of balloon occluded retrograde transvenous obliteration (BRTO), which was successfully treated with a transjugular intrahepatic portosystemic shunt (TIPS). A 57-year-old man was admitted to the emergency room suffering from melena. He had undergon...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v18.i22.2877

    authors: Kim MJ,Jang BK,Chung WJ,Hwang JS,Kim YH

    更新日期:2012-06-14 00:00:00

  • Associations between NOD2/CARD15 genotype and phenotype in Crohn's disease--Are we there yet?

    abstract::There have been multiple NOD2/CARD15 genotype-phenotype analyses undertaken in patients with Crohn's disease since the gene's discovery in 2001. This review focuses on the major published series based upon their size and on the presence of specific clinical and genetic information provided in the published material fr...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,meta分析,评审

    doi:10.3748/wjg.v12.i44.7097

    authors: Radford-Smith G,Pandeya N

    更新日期:2006-11-28 00:00:00

  • Transient elastography improves detection of liver cirrhosis compared to routine screening tests.

    abstract:AIM:To investigate the diagnostic significance of transient elastography (TE) in a daily routine clinical setting in comparison to clinical signs, laboratory parameters and ultrasound. METHODS:TE, ultrasound, laboratory parameters and cutaneous liver signs were assessed in 291 consecutive patients with chronic liver d...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v21.i3.953

    authors: Göbel T,Schadewaldt-Tümmers J,Greiner L,Poremba C,Häussinger D,Erhardt A

    更新日期:2015-01-21 00:00:00

  • Two-week bismuth-containing quadruple therapy and concomitant therapy are effective first-line treatments for Helicobacter pylori eradication: A prospective open-label randomized trial.

    abstract:BACKGROUND:Increasing levels of antibiotic resistance have reduced the Helicobacter pylori (H. pylori) eradication rates afforded by the standard triple therapy. Thus, 2-wk first-line four-drug regimens must be considered. AIM:To analyze the eradication rates of modified bismuth-containing quadruple therapy (mBCQT) an...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,随机对照试验

    doi:10.3748/wjg.v25.i46.6790

    authors: Kim SJ,Chung JW,Woo HS,Kim SY,Kim JH,Kim YJ,Kim KO,Kwon KA,Park DK

    更新日期:2019-12-14 00:00:00

  • Multivariate analysis of the risk for pulmonary complication after gastrointestinal surgery.

    abstract:AIM:To identify the risk factors for postoperative pulmonary complications (PPC) after gastrointestinal surgery. METHODS:A total of 1 002 patients undergoing gastrointestinal surgery in the Second Affiliated Hospital, Sun Yat-Sen University, during December 1999 and December 2003, were retrospectively studied. RESULT...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i24.3735

    authors: Jiang SP,Li ZY,Huang LW,Zhang W,Lu ZQ,Zheng ZY

    更新日期:2005-06-28 00:00:00

  • Surveillance for hepatocellular carcinoma in chronic liver disease: evidence and controversies.

    abstract::Primary liver cancer is the sixth most common cancer in the world and the third cause of cancer-related death. Hepatocellular carcinoma (HCC) represents more than 90% of primary liver cancers and generally occurs in patients with underlying chronic liver disease such as viral hepatitis, hemochromatosis, primary biliar...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v19.i40.6744

    authors: van Meer S,de Man RA,Siersema PD,van Erpecum KJ

    更新日期:2013-10-28 00:00:00

  • Serum vitamin D and colonic vitamin D receptor in inflammatory bowel disease.

    abstract:AIM:To determine serum vitamin D levels and colonic vitamin D receptor (VDR) expression in inflammatory bowel disease (IBD) and non-IBD patients and correlate these with histopathology. METHODS:Puerto Rican IBD (n = 10) and non-IBD (n = 10) patients ≥ 21 years old scheduled for colonoscopy were recruited. Each patient...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v22.i13.3581

    authors: Abreu-Delgado Y,Isidro RA,Torres EA,González A,Cruz ML,Isidro AA,González-Keelan CI,Medero P,Appleyard CB

    更新日期:2016-04-07 00:00:00

  • Specific serum immunoglobulin G to H pylori and CagA in healthy children and adults (south-east of Iran).

    abstract:AIM:To evaluate the serologic IgG response to H pylori and CagA across age groups and in healthy children and adults. METHODS:Totally, 386 children aged 1-15 years and 200 adults aged 20-60 years, were enrolled to study. The serum samples of participant were tested for presence of anti-H pylori and anti-CagA IgG by us...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v13.i22.3117

    authors: Jafarzadeh A,Rezayati MT,Nemati M

    更新日期:2007-06-14 00:00:00

  • Incidence and clinical features of endoscopic ulcers developing after gastrectomy.

    abstract:AIM:To determine the precise incidence and clinical features of endoscopic ulcers following gastrectomy. METHODS:A consecutive series of patients who underwent endoscopic examination following gastrectomy between 2005 and 2010 was retrospectively analyzed. A total of 78 patients with endoscopic ulcers and 759 without ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v18.i25.3260

    authors: Chung WC,Jeon EJ,Lee KM,Paik CN,Jung SH,Oh JH,Kim JH,Jun KH,Chin HM

    更新日期:2012-07-07 00:00:00

  • Role of gastrin-peptides in Barrett's and colorectal carcinogenesis.

    abstract::Gastrin is the main hormone responsible for the stimulation of gastric acid secretion; in addition, gastrin and its derivatives exert proliferative and antiapoptotic effects on several cell types. Gastrin synthesis and secretion are increased in certain situations, for example, when proton pump inhibitors are used. Th...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v18.i45.6560

    authors: Chueca E,Lanas A,Piazuelo E

    更新日期:2012-12-07 00:00:00

  • Investigation of immune escape-associated mutations of hepatitis B virus in patients harboring hepatitis B virus drug-resistance mutations.

    abstract:BACKGROUND:It is unclear whether immune escape-associated mutations in the major hydrophilic region of hepatitis B virus surface antigen (HBsAg) are associated with nucleoside/nucleotide analog resistance. AIM:To evaluate the association between immune escape-associated mutations and nucleoside/nucleotide analog resis...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v26.i35.5314

    authors: Huang BX,Liu Y,Fan ZP,Si LL,Chen RJ,Wang J,Luo D,Wang FS,Xu DP,Liu XG

    更新日期:2020-09-21 00:00:00

  • Anterior vs conventional approach hepatectomy for large liver cancer: a meta-analysis.

    abstract:AIM:To evaluate the clinical outcomes and safety of anterior- and conventional-approach hepatectomy for patients with large liver tumors. METHODS:PubMed, EMBASE, Google Scholar and the Cochrane Library databases were searched for randomized controlled trials (RCTs) and controlled clinical trials comparing anterior-app...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,meta分析,评审

    doi:10.3748/wjg.v20.i45.17235

    authors: Li L,Wang HQ,Wang Q,Yang J,Yang JY

    更新日期:2014-12-07 00:00:00

  • Fields of applications, diagnostic yields and findings of OMOM capsule endoscopy in 2400 Chinese patients.

    abstract:AIM:To retrospectively analyze the fields of application, diagnostic yields and findings of OMOM capsule endoscopy in Chinese patients. METHODS:A database including 2400 Chinese patients who received OMOM capsule endoscopy in 27 endoscopy centers in China was retrieved from the Jianshan Science and Technology Ltd. OMO...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v16.i21.2669

    authors: Liao Z,Gao R,Li F,Xu C,Zhou Y,Wang JS,Li ZS

    更新日期:2010-06-07 00:00:00