Abstract:
AIM:To investigate the expression of insulin-like growth factor binding protein-2 (IGFBP-2) in gastric carcinoma and its clinical significance and to explore its relationship with cell proliferation. METHODS:Expressions of IGFBP-2 and Ki-67 in 118 cases of gastric carcinoma and 40 cases of normal gastric mucosa were detected by EnVision immunohistochemical technique. RESULTS:Expression of IGFBP-2 in gastric carcinoma was higher than that in normal gastric mucosa (P < 0.01). There was no difference between high- and low-grade gastric carcinoma (P > 0.05). Expression of IGFBP-2 in advanced gastric carcinoma was higher than that in early gastric carcinoma (P < 0.05). Expression of IGFBP-2 in gastric carcinoma with lymph node metastasis was higher than that without lymph node metastasis (P < 0.01). IGFBP-2 expression was a positively related to the clinical stage of gastric carcinoma (P < 0.01). There was a positive correlation between IGFBP-2 and Ki-67 (P < 0.05). CONCLUSION:IGFBP-2 may be involved in carcino-genesis and progression of gastric carcinoma by promoting cell proliferation.
journal_name
World J Gastroenteroljournal_title
World journal of gastroenterologyauthors
Shi LH,Zhu XQ,Zhao GH,Xia YB,Zhang YSdoi
10.3748/wjg.v12.i39.6285subject
Has Abstractpub_date
2006-10-21 00:00:00pages
6285-9issue
39eissn
1007-9327issn
2219-2840journal_volume
12pub_type
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journal_title:World journal of gastroenterology
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