Anterior vs conventional approach hepatectomy for large liver cancer: a meta-analysis.


AIM:To evaluate the clinical outcomes and safety of anterior- and conventional-approach hepatectomy for patients with large liver tumors. METHODS:PubMed, EMBASE, Google Scholar and the Cochrane Library databases were searched for randomized controlled trials (RCTs) and controlled clinical trials comparing anterior-approach hepatectomy (AAH) and conventional-approach hepatectomy (CAH). Two observers independently extracted the data using a spreadsheet and assessed the studies for inclusion. Studies that fulfilled the inclusion criteria and addressed the clinical questions of this analysis were further assessed using either fixed effects or random effects models. RESULTS:Two RCTs and six controlled clinical trials involving 807 patients met the predefined inclusion criteria. A total of 363 patients underwent AAH and 444 underwent CAH. Meta-analysis indicated that the AAH group had fewer requirements for transfusion (OR = 0.37, 95%CI: 0.21-0.63), less recurrence (OR = 0.57, 95%CI: 0.37-0.87), and lower mortality (OR = 0.29, 95%CI: 0.13-0.63). There were no significant differences between AAH and CAH with regard to perioperative complications (OR = 0.94, 95%CI: 0.58-1.51), intraoperative tumor rupture (OR = 0.98, 95%CI: 0.40-2.40), or length of hospital stay (weighted mean difference = -0.17, 95%CI: -2.36-2.02). CONCLUSION:AAH has advantages of decreased transfusion, mortality and recurrence compared to CAH. It is a safe and effective method for large cancers requiring right hepatectomy.


World J Gastroenterol


Li L,Wang HQ,Wang Q,Yang J,Yang JY




Has Abstract


2014-12-07 00:00:00












  • Prolongation of liver allograft survival by dendritic cells modified with NF-kappaB decoy oligodeoxynucleotides.

    abstract:AIM:To induce the tolerance of rat liver allograft by dendritic cells (DCs) modified with NF-kappaB decoy oligodeoxynucleotides (ODNs). METHODS:Bone marrow (BM)-derived DCs from SD rats were propagated in the presence of GM-CSF or GM-CSF+IL-4 to obtain immature DCs or mature DCs. GM-CSF+IL-4-propagated DCs were treate...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Xu MQ,Suo YP,Gong JP,Zhang MM,Yan LN

    更新日期:2004-08-15 00:00:00

  • Expression of matrix metalloproteinases and tissue inhibitor metalloproteinases increases in X-irradiated rat ileum despite the disappearance of CD8a T cells.

    abstract:AIM:To investigate their expression and activity in the rat ileum after exposure to ionizing radiation along with that of the cellular effectors and molecular mediators involved in the regulation of MMPs. METHODS:Rats were exposed to a single 10-Gy dose of X-rays delivered to the abdomen. A combination of methods, suc...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Strup-Perrot C,Vozenin-Brotons MC,Vandamme M,Linard C,Mathé D

    更新日期:2005-10-28 00:00:00

  • Human intestinal capillariasis in Thailand.

    abstract::Intestinal capillariasis caused by Capillaria philippinensis appeared first in the Philippines and subsequently in Thailand, Japan, Iran, Egypt and Taiwan; major outbreaks have occurred in the Philippines and Thailand. This article reviews the epidemiology, history and sources of C. philippinensis infection in Thailan...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Saichua P,Nithikathkul C,Kaewpitoon N

    更新日期:2008-01-28 00:00:00

  • Targeted and immune therapies for hepatocellular carcinoma: Predictions for 2019 and beyond.

    abstract::Systemic therapy for hepatocellular carcinoma (HCC) has markedly advanced since the survival benefit of a molecular targeted agent, sorafenib, were demonstrated in the SHARP and Asia Pacific trials in 2007. Treatment options for patients with advanced HCC increased by sorafenib, and long-term survival for patients wit...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Kudo M

    更新日期:2019-02-21 00:00:00

  • Protons pump inhibitor treatment and lower gastrointestinal bleeding: Balancing risks and benefits.

    abstract::Proton pump inhibitors (PPIs) represent a milestone in the treatment of acid-related diseases, and are the mainstay in preventing upper gastrointestinal bleeding in high-risk patients treated with nonsteroidal anti-inflammatory drugs (NSAIDs) or low-dose aspirin. However, this beneficial effect does not extend to the ...

    journal_title:World journal of gastroenterology

    pub_type: 社论


    authors: Lué A,Lanas A

    更新日期:2016-12-28 00:00:00

  • Reduction of ischemia reperfusion injury after liver resection and hepatic inflow occlusion by alpha-lipoic acid in humans.

    abstract:AIM:To evaluate the protective effects of preconditioning by alpha-lipoic acid (LA) in patients undergoing hepatic resection under inflow occlusion of the liver. METHODS:Twenty-four patients undergoing liver resection for various reasons either received 600 mg LA or NaCl 15 min before transection performed under inflo...

    journal_title:World journal of gastroenterology

    pub_type: 临床试验,杂志文章


    authors: Dünschede F,Erbes K,Kircher A,Westermann S,Seifert J,Schad A,Oliver K,Kiemer AK,Theodor J

    更新日期:2006-11-14 00:00:00

  • Overexpression of c-fos in Helicobacter pylori-induced gastric precancerosis of Mongolian gerbil.

    abstract:AIM:To explore dysregulation of c-fos in several human malignancies, and to further investigate the role of c-fos in Helicobacter pylori (H. pylori)-induced gastric precancerosis. METHODS:Four-week-old male Mongolian gerbils were employed in the study. 0.5 mL 1X10(8) cfu/L suspension of H. pylori NCTC 11 637 in Brucel...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Yang YL,Xu B,Song YG,Zhang WD

    更新日期:2003-03-01 00:00:00

  • Endoscopic treatment for pancreatic diseases: Needle-knife-guided cannulation via the minor papilla.

    abstract:AIM:To determine the efficacy and safety of meticulous cannulation by needle-knife. METHODS:Three needle-knife procedures were used to facilitate cannulation in cases when standard cannulation techniques failed. A total of 104 cannulations via the minor papilla attempted in 74 patients at our center between January 20...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Wang W,Gong B,Jiang WS,Liu L,Bielike K,Xv B,Wu YL

    更新日期:2015-05-21 00:00:00

  • Endoscopic diverticulotomy with an isolated-tip needle-knife papillotome (Iso-Tome) and a fitted overtube for the treatment of a Killian-Jamieson diverticulum.

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    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Lee CK,Chung IK,Park JY,Lee TH,Lee SH,Park SH,Kim HS,Kim SJ

    更新日期:2008-11-14 00:00:00

  • Honey prevents hepatic damage induced by obstruction of the common bile duct.

    abstract:AIM:To examine the possible effects of honey supplementation on hepatic damage due to obstruction of the common bile duct in an experimental rat model. METHODS:The study was performed with 30 male rats divided into three groups: a sham group, an obstructive jaundice group, and an obstructive jaundice plus honey group....

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Erguder BI,Kilicoglu SS,Namuslu M,Kilicoglu B,Devrim E,Kismet K,Durak I

    更新日期:2008-06-21 00:00:00

  • Effect of oral erythromycin on gastric and small bowel transit time of capsule endoscopy.

    abstract:AIM:To determine the effect of oral erythromycin on gastric and small bowel transit time of capsule endoscopy. METHODS:Consecutive patients who underwent capsule endoscopy during the 16-mo study period were either given 250 mg oral erythromycin, 1 h prior to swallowing the capsule endoscope or nothing. The gastric and...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Leung WK,Chan FK,Fung SS,Wong MY,Sung JJ

    更新日期:2005-08-21 00:00:00

  • Angioedema associated with Crohn's disease: response to biologics.

    abstract::A 46-year-old female patient with terminal ileum Crohn's disease and ankylosing spondylitis presented with recurrent angioedema and urticaria. Investigations ruled out hereditary angioedema, and environmental or food allergen triggers. She was diagnosed with chronic idiopathic urticaria with angioedema, and was treate...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Habal F,Huang V

    更新日期:2012-09-14 00:00:00

  • Tumor rupture during surgery for gastrointestinal stromal tumors: pay attention!

    abstract::In a recently published letter to the editor, we debated the proposal by Coccolini et al to treat gastrointestinal stromal tumors (GISTs) of the esophagogastric junction with enucleation and, if indicated, adjuvant therapy. We highlighted that, because the prognostic impact of a T1 high-mitotic rate esophageal GIST is...

    journal_title:World journal of gastroenterology

    pub_type: 评论,信件


    authors: Peparini N,Chirletti P

    更新日期:2013-03-28 00:00:00

  • Role of serotonin in development of esophageal and gastric fundal varices.

    abstract:AIM:to determine the effect of free serotonin concentrations in plasma on development of esophageal and gastric fundal varices. METHODS:this prospective study included 33 patients with liver cirrhosis and 24 healthy controls. Ultrasonography and measurement of serotonin concentration in plasma were carried out in both...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Rudić JS,Culafić DM,Mirković DS,Ješić RS,Krstić MN

    更新日期:2010-12-28 00:00:00

  • Atrial fibrillation and gastroesophageal reflux disease: From the cardiologist perspective.

    abstract::We have read with interest the paper by Roman C. and colleagues discussing the relationship between gastroesophageal reflux disease and atrial fibrillation. The review is presenting the available evidence for the common pathogenic mechanisms. However, from a cardiologist perspective, some available data were not highl...

    journal_title:World journal of gastroenterology

    pub_type: 评论,杂志文章


    authors: Floria M,Drug VL

    更新日期:2015-03-14 00:00:00

  • Intensive or not surveillance of patients with colorectal cancer after curative resection.

    abstract::It is common practice to follow patients with colorectal cancer for some years after resection and/or adjuvant treatment. Data are lacking about how often patients should be seen, what tests should be performed, and what surveillance strategy has a significant impact on patient outcome. Seven randomized trials have ad...

    journal_title:World journal of gastroenterology

    pub_type: 社论


    authors: Rosati G

    更新日期:2010-03-28 00:00:00

  • TIP30 regulates apoptosis-related genes in its apoptotic signal transduction pathway.

    abstract:AIM:To investigate the role of TIP30 in apoptotic signal pathway in hepatoblastoma cells and to provide a basis for TIP30 as a gene therapy candidate in the regression of hepatoblastoma cells. METHODS:Apoptosis of human hepatoblastoma cell lines HepG2 (p53 wild), Hep3B (p53 null) and PLC/RPF/5 (p53 mutant) infected wi...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Shi M,Zhang X,Wang P,Zhang HW,Zhang BH,Wu MC

    更新日期:2005-01-14 00:00:00

  • Diagnostic strategy for occult hepatitis B virus infection.

    abstract::In 2008, the European Association for the study of the liver (EASL) defined occult hepatitis B virus infection (OBI) as the "presence of hepatitis B virus (HBV) DNA in the liver (with detectable or undetectable HBV DNA in the serum) of individuals testing hepatitis B surface antigen (HBsAg) negative by currently avail...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Ocana S,Casas ML,Buhigas I,Lledo JL

    更新日期:2011-03-28 00:00:00

  • Cryptogenic multifocal ulcerous stenosing enteritis: Radiologic features and clinical behavior.

    abstract:AIM:To investigate the characteristic radiologic findings of cryptogenic multifocal ulcerous stenosing enteritis (CMUSE) which can be differentiated from other similar bowel disease and to assess their clinical behavior. METHODS:Twenty pathologically and clinically confirmed CMUSE patients (males:females = 8:12; mean ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Hwang J,Kim JS,Kim AY,Lim JS,Kim SH,Kim MJ,Kim MS,Song KD,Woo JY

    更新日期:2017-07-07 00:00:00

  • Liuweiwuling tablets protect against acetaminophen hepatotoxicity: What is the protective mechanism?

    abstract::Study of the effects of natural products, including traditional Chinese Medicines, on acetaminophen hepatotoxicity has gained considerable popularity in recent years, and some of them showed positive results and even promising therapeutic potentials. A recent report suggested that Liuweiwuling tablets protect against ...

    journal_title:World journal of gastroenterology

    pub_type: 评论,信件


    authors: Du K,Jaeschke H

    更新日期:2016-03-21 00:00:00

  • Necrosis of a large hepatic tumor after hemorrhage and subsequent selective arterial embolization.

    abstract::This case report describes a young female patient presenting with acute intra-abdominal hemorrhage originating from a large tumor in the liver, most likely a hepatocellular adenoma. The bleeding was stopped by selective embolization of right hepatic artery branches. Subsequently, partial hepatectomy was performed afte...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Huurman VA,Stoot JH,van der Linden E,Terpstra OT,Schaapherder AF

    更新日期:2006-10-07 00:00:00

  • Occupational exposure to vinyl chloride and liver diseases.

    abstract::Portal hypertension, liver fibrosis, and angiosarcoma of the liver (ASL) have been reported among workers exposed to vinyl chloride monomer (VCM) since the 1970s. In 2007, the International Agency for Research on Cancer established the association of VCM with hepatocellular carcinoma (HCC), though only on the basis of...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Fedeli U,Girardi P,Mastrangelo G

    更新日期:2019-09-07 00:00:00

  • Inhibitory effect of schisandrin B on gastric cancer cells in vitro.

    abstract:AIM:To investigate the inhibitory effect and possible mechanism of action of schisandrin B in SC-B on gastric cancer cells in vitro. METHODS:SC-B consisted of schisandrin B, aloe-emodin, and Astragalus polysaccharides. Exponentially growing human gastric cancer SGC-7901 cells were divided into six treatment groups: (1...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Liu XN,Zhang CY,Jin XD,Li YZ,Zheng XZ,Li L

    更新日期:2007-12-28 00:00:00

  • Zebrafish as a disease model for studying human hepatocellular carcinoma.

    abstract::Liver cancer is one of the world's most common cancers and the second leading cause of cancer deaths. Hepatocellular carcinoma (HCC), a primary hepatic cancer, accounts for 90%-95% of liver cancer cases. The pathogenesis of HCC consists of a stepwise process of liver damage that extends over decades, due to hepatitis,...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Lu JW,Ho YJ,Yang YJ,Liao HA,Ciou SC,Lin LI,Ou DL

    更新日期:2015-11-14 00:00:00

  • Establishment of model of visceral pain due to colorectal distension and its behavioral assessment in rats.

    abstract:AIM:To establish a visceral pain model via colorectal distension (CRD) and to evaluate the efficiency of behavioral responses of CRD by measuring the score of abdominal withdrawal reflex (AWR) in rats. METHODS:Thirty-eight male SD rats weighing 180-240 g were used to establish the visceral pain model. The rat was inse...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Yang JP,Yao M,Jiang XH,Wang LN

    更新日期:2006-05-07 00:00:00

  • Hemodynamics and vasoactive substance levels during renal congestion that occurs in the anhepatic phase of liver transplantation.

    abstract:AIM:To explore hemodynamics and vasoactive substance levels during renal vein congestion that occurs in the anhepatic phase of liver transplantation. METHODS:New Zealand rabbits received ligation of the hepatic pedicle, supra-hepatic vena cava and infra-hepatic vena cava [anhepatic phase group (APH); n = 8], the renal...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Li ZX,Wang MC,Zhang YC,Mao J,Chen M,Ni R,Wei FX,Wang GN,Zhang LY

    更新日期:2015-05-14 00:00:00

  • Liver cell adenoma showing sequential alteration of radiological findings suggestive of well-differentiated hepatocellular carcinoma.

    abstract::A liver tumor 35 mm in diameter was found incidentally in a 40-year-old woman who had no history of liver diseases or the use of oral contraceptives. Radiological diagnostics showed the typical findings of liver cell adenoma (LCA). Dynamic computed tomography revealed that the tumor showed a homogenous enhancement in ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Kogure T,Ueno Y,Sekiguchi S,Ishida K,Igarashi T,Wakui Y,Iwasaki T,Shimosegawa T

    更新日期:2009-03-14 00:00:00

  • Single endoscopist-performed percutaneous endoscopic gastrostomy tube placement.

    abstract:AIM:To investigate whether single endoscopist-performed percutaneous endoscopic gastrostomy (PEG) is safe and to compare the complications of PEG with those reported in the literature. METHODS:Patients who underwent PEG placement between June 2001 and August 2011 at the Baskent University Alanya Teaching and Research ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Erdogan A

    更新日期:2013-07-14 00:00:00

  • Ruptured angiosarcoma of the liver treated by emergency catheter-directed embolization.

    abstract::Angiosarcoma is a rare primary malignant neoplasm of the liver with a poor prognosis. Here, we report a case of a patient with a ruptured hepatic angiosarcoma which was treated by emergency catheter-directed embolization, followed by left-sided hemihepatectomy. ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Leowardi C,Hormann Y,Hinz U,Wente MN,Hallscheidt P,Flechtenmacher C,Buchler MW,Friess H,Schwarzbach MH

    更新日期:2006-02-07 00:00:00

  • Influence of continuous veno-venous hemofiltration on the course of acute pancreatitis.

    abstract:AIM:To investigate whether continuous veno-venous hemofiltration (CVVH) in different filtration rate to eliminate cytokines would result in different efficiency in acute pancreatitis, whether the saturation time of filter membrane was related to different filtration rate, and whether the onset time of CVVH could influe...

    journal_title:World journal of gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Jiang HL,Xue WJ,Li DQ,Yin AP,Xin X,Li CM,Gao JL

    更新日期:2005-08-21 00:00:00