当前位置： SCI文献检索 > WORLD JOURNAL OF GASTROENTEROLOGY期刊下所有文献 > Assessment of the hepatic microvascular changes in liver cirrhosis by perfusion computed tomography.

Assessment of the hepatic microvascular changes in liver cirrhosis by perfusion computed tomography.

Abstract：

AIM:To assess the hepatic microvascular parameters in patients with liver cirrhosis by perfusion computed tomography (CT). METHODS:Perfusion CT was performed in 29 patients without liver disease (control subjects) and 39 patients with liver cirrhosis, including 22 patients with compensated cirrhosis and 17 patients with decompensated cirrhosis, proved by clinical and laboratory parameters. CT cine-scans were obtained over 50 s beginning with the injection of 50 mL of contrast agent. Hepatic microvascular parameters, mean transit time (MTT) and permeability surface area product (PS) were obtained with the Perfusion 3 software (General Electric, ADW 4.2). RESULTS:The overall differences of MTT and PS between control subjects, patients with compensated cirrhosis and those with decompensated cirrhosis were statistically significant (P = 0.010 and P = 0.002, respectively). MTT values were 15.613 +/- 4.1746 s, 12.592 +/- 4.7518 s, and 11.721 +/- 4.5681 s for the three groups, respectively, while PS were 18.945 +/- 7.2347 mL/min per 100 mL, 22.767 +/- 8.3936 mL/min per 100 mL, and 28.735 +/- 13.0654 mL/min per 100 mL. MTT in decompensated cirrhotic patients were significantly decreased compared to controls (P = 0.017), whereas PS values were remarkably increased (P = 0.001). CONCLUSION:The hepatic microvascular changes in patients with liver cirrhosis can be quantitatively assessed by perfusion CT. Hepatic microvascular parameters (MTT and PS), as measured by perfusion CT, were significantly altered in decompensated cirrhosis.

journal_name

World J Gastroenterol

journal_title

World journal of gastroenterology

authors

Chen ML,Zeng QY,Huo JW,Yin XM,Li BP,Liu JX

doi

10.3748/wjg.15.3532

subject

Has Abstract

pub_date

2009-07-28 00:00:00

pages

3532-7

issue

28

eissn

1007-9327

issn

2219-2840

journal_volume

15

pub_type

杂志文章

相关文献

WORLD JOURNAL OF GASTROENTEROLOGY文献大全
  • Cooperative inhibitory effects of antisense oligonucleotide of cell adhesion molecules and cimetidine on cancer cell adhesion.

    abstract：AIM:To explore the cooperative effects of antisense oligonucleotide (ASON) of cell adhesion molecules and cimetidine on the expression of E-selectin and ICAM-1 in endothelial cells and their adhesion to tumor cells. METHODS:After treatment of endothelial cells with ASON and/or cimetidine and induction with TNF-alpha, ...

    journal_title：World journal of gastroenterology

    pub_type： 杂志文章

    doi：10.3748/wjg.v10.i1.62

    authors： Tang NH,Chen YL,Wang XQ,Li XJ,Yin FZ,Wang XZ

    更新日期：2004-01-01 00:00:00

  • Surveillance of colonic polyps: Are we getting it right?

    abstract：:Colorectal cancer (CRC) is the third most commonly diagnosed cancer worldwide. The identification of colonic polyps can reduce CRC mortality through earlier diagnosis of cancers and the removal of polyps: the precursor lesion of CRC. Following the finding and removal of colonic polyps at an initial colonoscopy, some p...

    journal_title：World journal of gastroenterology

    pub_type： 社论,评审

    doi：10.3748/wjg.v22.i6.1925

    authors： Bonnington SN,Rutter MD

    更新日期：2016-02-14 00:00:00

  • Clinical approaches to non-alcoholic fatty liver disease.

    abstract：:Non-alcoholic fatty liver disease (NAFLD) ranges from simple steatosis to nonalcoholic steatohepatitis (NASH), leading to fibrosis and potentially cirrhosis, and it is one of the most common causes of liver disease worldwide. NAFLD is associated with other medical conditions such as metabolic syndrome, obesity, cardio...

    journal_title：World journal of gastroenterology

    pub_type： 杂志文章,评审

    doi：10.3748/wjg.v20.i7.1712

    authors： Schwenger KJ,Allard JP

    更新日期：2014-02-21 00:00:00

  • Immunostaining of PD-1/PD-Ls in liver tissues of patients with hepatitis and hepatocellular carcinoma.

    abstract：AIM:To investigate the expression of programmed death (PD)-1, PD ligand 1 (PD-L1) and PD-L2 in liver tissues in the context of chronic hepatitis and hepatocellular carcinoma (HCC). METHODS:Liver biopsies and HCC specimens from patients were collected and histologically examined. The expression of PD-1, PD-L1, and PD-L...

    journal_title：World journal of gastroenterology

    pub_type： 杂志文章

    doi：10.3748/wjg.v17.i28.3322

    authors： Wang BJ,Bao JJ,Wang JZ,Wang Y,Jiang M,Xing MY,Zhang WG,Qi JY,Roggendorf M,Lu MJ,Yang DL

    更新日期：2011-07-28 00:00:00

  • Coexistence of small cell neuroendocrine carcinoma and villous adenoma in the ampulla of Vater.

    abstract：:Small cell neuroendocrine carcinoma of the ampulla of Vater is extremely rare and different from the common ampullary adenocarcinoma. The ampullary adenoma is also a rare neoplasm and has the potential to develop an adenocarcinoma. Their coexistence has been rarely reported in the literature. We herein describe an unu...

    journal_title：World journal of gastroenterology

    pub_type： 杂志文章

    doi：10.3748/wjg.14.4709

    authors： Sun JH,Chao M,Zhang SZ,Zhang GQ,Li B,Wu JJ

    更新日期：2008-08-07 00:00:00

  • Comparison of protocatechuic aldchyde in Radix Salvia miltiorrhiza and corresponding pharmacological sera from normal and fibrotic rats by high performance liquid chromatography.

    abstract：AIM:To observe the effect of protocatechuic aldchyde on the proliferation of hepatic stellate cells (HSCs). METHODS:Liver fibrosis was induced in rats by carbon tetrachloride (CCl4). Then normal and fibrotic drug sera were extracted from rats. The effects of protocatechuic aldchyde, raw Radix Salvia miltiorrhiza and d...

    journal_title：World journal of gastroenterology

    pub_type： 杂志文章

    doi：10.3748/wjg.v12.i14.2195

    authors： Lv T,Yao XX

    更新日期：2006-04-14 00:00:00

  • Genetic polymorphisms predict response to anti-tumor necrosis factor treatment in Crohn's disease.

    abstract：AIM:To investigate genetic factors that might help define which Crohn's disease (CD) patients are likely to benefit from anti-tumor necrosis factor (TNF) therapy. METHODS:This was a prospective cohort study. Patients were recruited from a university digestive disease practice database. We included CD patients who rece...

    journal_title：World journal of gastroenterology

    pub_type： 杂志文章

    doi：10.3748/wjg.v23.i27.4958

    authors： Netz U,Carter JV,Eichenberger MR,Dryden GW,Pan J,Rai SN,Galandiuk S

    更新日期：2017-07-21 00:00:00

  • Surgical resection for hepatoportal bile duct cancer.

    abstract：:AIM:To discuss the effect of surgical procedures on the prognosis of patients of bile duct cancer and their indications.METHODS:A retrospective analysis was made for 52 cases of hepatoportal bile duct cancer treated from January 1991 to December 1996. All the cases were classified according to the modified Bismuth-Cor...

    journal_title：World journal of gastroenterology

    pub_type： 杂志文章

    doi：10.3748/wjg.v5.i2.128

    authors： He XS,Huang JF,Liang LJ,Lu MD,Cao XH

    更新日期：1999-04-01 00:00:00

  • Sitagliptin in patients with non-alcoholic steatohepatitis: A randomized, placebo-controlled trial.

    abstract：AIM:To evaluate the effect of sitagliptin vs placebo on histologic and non-histologic parameters of non-alcoholic steatohepatitis (NASH). METHODS:Twelve patients with biopsy-proven NASH were randomized to sitagliptin (100 mg daily) (n = 6) or placebo (n = 6) for 24 wk. The primary outcome was improvement in liver fibr...

    journal_title：World journal of gastroenterology

    pub_type： 杂志文章,随机对照试验

    doi：10.3748/wjg.v23.i1.141

    authors： Joy TR,McKenzie CA,Tirona RG,Summers K,Seney S,Chakrabarti S,Malhotra N,Beaton MD

    更新日期：2017-01-07 00:00:00

  • Two synchronous somatostatinomas of the duodenum and pancreatic head in one patient.

    abstract：:Somatostatinomas are extremely rare neuroendocrine tumors of the gastrointestinal tract, first described in the pancreas in 1977 and in the duodenum in 1979. They may be functional and cause somatostatinoma or inhibitory syndrome, but more frequently are non-functioning pancreatic endocrine tumors that produce somatos...

    journal_title：World journal of gastroenterology

    pub_type： 杂志文章

    doi：10.3748/wjg.15.5859

    authors： Colović RB,Matić SV,Micev MT,Grubor NM,Atkinson HD,Latincić SM

    更新日期：2009-12-14 00:00:00

  • Simultaneous transcatheter arterial chemoembolization and portal vein embolization for patients with large hepatocellular carcinoma before major hepatectomy.

    abstract：BACKGROUND:Sequential transarterial chemoembolization (TACE) and portal vein embolization (PVE) are associated with long time interval that can allow tumor growth and nullify treatments' benefits. AIM:To evaluate the effect of simultaneous TACE and PVE for patients with large hepatocellular carcinoma (HCC) prior to el...

    journal_title：World journal of gastroenterology

    pub_type： 杂志文章

    doi：10.3748/wjg.v26.i30.4489

    authors： Zhang CW,Dou CW,Zhang XL,Liu XQ,Huang DS,Hu ZM,Liu J

    更新日期：2020-08-14 00:00:00

  • Hepatocellular carcinoma occurring in a Crohn's disease patient.

    abstract：:We report a case of hepatocellular carcinoma (HCC) occurring in a patient with Crohn's disease (CD) without chronic hepatitis or liver cirrhosis, and review the clinicopathological features of HCC in CD patients. A 37-year-old Japanese man with an 8-year history of CD and a medication history of azathioprine underwent...

    journal_title：World journal of gastroenterology

    pub_type： 杂志文章

    doi：10.3748/wjg.v16.i25.3215

    authors： Ishida M,Naka S,Shiomi H,Tsujikawa T,Andoh A,Nakahara T,Saito Y,Kurumi Y,Takikita-Suzuki M,Kojima F,Hotta M,Tani T,Fujiyama Y,Okabe H

    更新日期：2010-07-07 00:00:00

  • Laparoscopic VS open hepatectomy for hepatolithiasis: An updated systematic review and meta-analysis.

    abstract：AIM:To perform a meta-analysis on laparoscopic hepatectomy VS conventional liver resection for treating hepatolithiasis. METHODS:We conducted a systematic literature search on PubMed, Embase, Web of Science and Cochrane Library, and undertook a meta-analysis to compare the efficacy and safety of laparoscopic hepatecto...

    journal_title：World journal of gastroenterology

    pub_type： 杂志文章,meta分析,评审

    doi：10.3748/wjg.v23.i43.7791

    authors： Li H,Zheng J,Cai JY,Li SH,Zhang JB,Wang XM,Chen GH,Yang Y,Wang GS

    更新日期：2017-11-21 00:00:00

  • 1,2,3,4,6-penta-O-galloyl-beta-D-glucose up-regulates heme oxygenase-1 expression by stimulating Nrf2 nuclear translocation in an extracellular signal-regulated kinase-dependent manner in HepG2 cells.

    abstract：AIM:To examine the potency of 1,2,3,4,6-penta-O-galloyl-beta-D-glucose (PGG) as a hepatic heme oxygenase-1 (HO-1) inducer and its regulation in HepG2 cells. METHODS:Expression of HO-1 and NF-E2-related factor 2 (Nrf2) and activation of mitogen-activated protein (MAP) kinases were analyzed by Western blot, immunofluore...

    journal_title：World journal of gastroenterology

    pub_type： 杂志文章

    doi：10.3748/wjg.v12.i2.214

    authors： Pae HO,Oh GS,Jeong SO,Jeong GS,Lee BS,Choi BM,Lee HS,Chung HT

    更新日期：2006-01-14 00:00:00

  • Intrahepatic and peripheral T-cell responses in genotype 1b hepatitis C virus-infected patients with persistently normal and elevated aminotransferase levels.

    abstract：AIM:To evaluate whether the cytokine responses in liver and serum differ in chronic hepatitis C patients with normal and high alanine aminotransferase (ALT) levels. METHODS:Thirty-three (16 with normal ALT level as group 1 and 17 with elevated ALT level as group 2) patients infected with genotype 1b hepatitis C virus ...

    journal_title：World journal of gastroenterology

    pub_type： 杂志文章

    doi：10.3748/wjg.v11.i45.7188

    authors： Akyüz F,Polat N,Kaymakoglu S,Aksoy N,Demir K,Beşişik F,Badur S,Cakaloglu Y,Okten A

    更新日期：2005-12-07 00:00:00

  • Endoscopic sphincterotomy in patients with stenosis of ampulla of Vater: three-year follow-up of exocrine pancreatic function and clinical symptoms.

    abstract：AIM:To investigate retrospectively the long-term effect of endoscopic sphincterotomy (ES) including exocrine pancreatic function in patients with stenosis of ampulla of Vater. METHODS:After diagnostic endoscopic retrograde cholangiopancreatography (ERCP) and ES because of stenosis of the ampulla of Vater (SOD Type I),...

    journal_title：World journal of gastroenterology

    pub_type： 杂志文章

    doi：10.3748/wjg.v13.i6.901

    authors： Ewald N,Marzeion AM,Bretzel RG,Kloer HU,Hardt PD

    更新日期：2007-02-14 00:00:00

  • Endoscopic findings and clinicopathologic characteristics of colonic schistosomiasis: a report of 46 cases.

    abstract：AIM:To make a retrospective analysis of endoscopy findings and clinicopathologic characteristics of colonic schistosomiasis in order to further improve our understanding of the disease and decrease its misdiagnosis. METHODS:Endoscopy findings and clinicopathologic characteristics of 46 intestinal schistosomiasis patie...

    journal_title：World journal of gastroenterology

    pub_type： 杂志文章

    doi：10.3748/wjg.v16.i6.723

    authors： Cao J,Liu WJ,Xu XY,Zou XP

    更新日期：2010-02-14 00:00:00

  • A pilot study of single-use endoscopy in screening acute gastrointestinal bleeding.

    abstract：AIM:To investigate the feasibility of a single-use endoscopy as an alternative procedure to nasogastric lavage in patients with acute gastrointestinal (GI) bleeding. METHODS:Patients who presented with hematemesis, melena or hematochezia were enrolled in this study. EG scan™ and conventional esophagogastroduodenoscopy...

    journal_title：World journal of gastroenterology

    pub_type： 杂志文章

    doi：10.3748/wjg.v19.i1.103

    authors： Cho JH,Kim HM,Lee S,Kim YJ,Han KJ,Cho HG,Song SY

    更新日期：2013-01-07 00:00:00

  • Prevalence of IgA-antiendomysial antibody in a patient cohort with idiopathic low bone mineral density.

    abstract：AIM:To investigate the frequency of serum IgA-antiendomysial antibody positivity in patients with low bone mineral density and to assess the risk group for screening of celiac disease. METHODS:One hundred and thirty-five patients (14 male, 121 female) with idiopathic low bone mineral density were evaluated. The median...

    journal_title：World journal of gastroenterology

    pub_type： 杂志文章

    doi：10.3748/wjg.v13.i21.2978

    authors： Karakan T,Ozyemisci-Taskiran O,Gunendi Z,Atalay F,Tuncer C

    更新日期：2007-06-07 00:00:00

  • Are gap junction gene connexins 26, 32 and 43 of prognostic values in hepatocellular carcinoma? A prospective study.

    abstract：AIM:To investigate the prognostic value of the expression of connexin (Cx) 26, 32 and 43 messenger RNA (mRNA) in hepatocellular carcinoma (HCC) tissues. METHODS:Using a reverse-transcriptase polymerase chain reaction (RT-PCR), Cx 26, Cx 32 and Cx 43 mRNAs were determined in the liver tissues of 15 controls and in HCC ...

    journal_title：World journal of gastroenterology

    pub_type： 杂志文章

    doi：10.3748/wjg.v10.i19.2785

    authors： Sheen IS,Jeng KS,Wang PC,Shih SC,Chang WH,Wang HY,Chen CC,Shyung LR

    更新日期：2004-10-01 00:00:00

  • Strangulated small bowel hernia through the port site: a case report.

    abstract：:Port site hernia develops through a fascial or peritoneal layer that was inadequate or not repaired. It is a rare complication of laparoscopic surgery which may lead to serious problems. Here, we present a 77-year-old female, diagnosed with a small bowel hernia through a 10-mm port site. We had performed ten cases of ...

    journal_title：World journal of gastroenterology

    pub_type： 杂志文章

    doi：10.3748/wjg.14.6881

    authors： Lee JH,Kim W

    更新日期：2008-11-28 00:00:00

  • Region-dependent effects of diabetes and insulin-replacement on neuronal nitric oxide synthase- and heme oxygenase-immunoreactive submucous neurons.

    abstract：AIM:To investigate the intestinal segment-specific effects of diabetes and insulin replacement on the density of different subpopulations of submucous neurons. METHODS:Ten weeks after the onset of type 1 diabetes samples were taken from the duodenum, ileum and colon of streptozotocin-induce diabetic, insulin-treated d...

    journal_title：World journal of gastroenterology

    pub_type： 杂志文章

    doi：10.3748/wjg.v23.i41.7359

    authors： Bódi N,Szalai Z,Chandrakumar L,Bagyánszki M

    更新日期：2017-11-07 00:00:00

  • Pseudo-Meigs' syndrome secondary to metachronous ovarian metastases from transverse colon cancer.

    abstract：:Pseudo-Meigs' syndrome associated with colorectal cancer is extremely rare. We report here a case of pseudo-Meigs' syndrome secondary to metachronous ovarian metastases from colon cancer. A 65-year-old female with a history of surgery for transverse colon cancer and peritoneal dissemination suffered from metachronous ...

    journal_title：World journal of gastroenterology

    pub_type： 杂志文章

    doi：10.3748/wjg.v22.i18.4604

    authors： Kyo K,Maema A,Shirakawa M,Nakamura T,Koda K,Yokoyama H

    更新日期：2016-05-14 00:00:00

  • New trends in colorectal surgery: single port and natural orifice techniques.

    abstract：:Single-incision laparoscopic surgery (SILS) and natural orifice transluminal endoscopic surgery (NOTES) have rapidly gained pace worldwide, potentially replacing conventional laparoscopic surgery (CLS) as the preferred colorectal surgery technique. Currently available data mainly consist of retrospective series analyz...

    journal_title：World journal of gastroenterology

    pub_type： 历史文章,杂志文章,评审

    doi：10.3748/wjg.v20.i48.18104

    authors： Daher R,Chouillard E,Panis Y

    更新日期：2014-12-28 00:00:00

  • Transient elastography improves detection of liver cirrhosis compared to routine screening tests.

    abstract：AIM:To investigate the diagnostic significance of transient elastography (TE) in a daily routine clinical setting in comparison to clinical signs, laboratory parameters and ultrasound. METHODS:TE, ultrasound, laboratory parameters and cutaneous liver signs were assessed in 291 consecutive patients with chronic liver d...

    journal_title：World journal of gastroenterology

    pub_type： 杂志文章

    doi：10.3748/wjg.v21.i3.953

    authors： Göbel T,Schadewaldt-Tümmers J,Greiner L,Poremba C,Häussinger D,Erhardt A

    更新日期：2015-01-21 00:00:00

  • Hepatic preconditioning of doxorubicin in stop-flow chemotherapy: NF-kappaB/IkappaB-alpha pathway and expression of HSP72.

    abstract：AIM:To provide hepatic protection through administration of doxorubicin before stop-flow chemotherapy (SFC) and to investigate the expression of heat shock protein 72 (HSP72) and role of nuclear factor kappa B (NF-kappaB) in this effect. METHODS:The hepatic preconditioning of doxorubicin was established in a porcine m...

    journal_title：World journal of gastroenterology

    pub_type： 杂志文章

    doi：10.3748/wjg.v11.i14.2136

    authors： Lu H,Zhu ZG,Yao XX,Zhao R,Yan C,Zhang Y,Liu BY,Yin HR,Lin YZ

    更新日期：2005-04-14 00:00:00

  • Overexpression of insulin-like growth factor-I receptor as a pertinent biomarker for hepatocytes malignant transformation.

    abstract：AIM:To investigate the dynamic features of insulin-like growth factor-I receptor (IGF-IR) expression in rat hepatocarcinogenesis, and the relationship between IGF-IR and hepatocytes malignant transformation at mRNA or protein level. METHODS:Hepatoma models were made by inducing with 2-fluorenylacetamide (2-FAA) on mal...

    journal_title：World journal of gastroenterology

    pub_type： 杂志文章

    doi：10.3748/wjg.v19.i36.6084

    authors： Yan XD,Yao M,Wang L,Zhang HJ,Yan MJ,Gu X,Shi Y,Chen J,Dong ZZ,Yao DF

    更新日期：2013-09-28 00:00:00

  • Characteristics of upper digestive tract diseases in Bohai Bay fishermen.

    abstract：AIM:To study the characteristics of upper digestive tract diseases (UDTDs) in fishermen who live in Bohai Bay. METHODS:An investigation was carried out in 1488 fishermen with symptoms of UDTDs (aside from liver, biliary and pancreatic diseases) during the time period between December 1991 and February 1995. This inves...

    journal_title：World journal of gastroenterology

    pub_type： 杂志文章

    doi：10.3748/wjg.v3.i3.171

    authors： Wang YB,Wang YP,Zou J,Bai BJ,Ren GC,Cai BQ

    更新日期：1997-09-15 00:00:00

  • Transforming growth factor-beta and fibrosis.

    abstract：:Transforming growth factor-beta (TGF-beta), a prototype of multifunctional cytokine, is a key regulator of extracellular matrix (ECM) assembly and remodeling. Specifically, TGF-beta isoforms have the ability to induce the expression of ECM proteins in mesenchymal cells, and to stimulate the production of protease inhi...

    journal_title：World journal of gastroenterology

    pub_type： 杂志文章,评审

    doi：10.3748/wjg.v13.i22.3056

    authors： Verrecchia F,Mauviel A

    更新日期：2007-06-14 00:00:00

  • Resistance of Helicobacter pylori to antibiotics from 2000 to 2009 in Shanghai.

    abstract：AIM:To investigate the resistance of Helicobacter pylori (H. pylori) to 6 commonly used antibiotics from 2000 to 2009 in Shanghai. METHODS:A total of 293 H. pylori strains were collected from 2000 to 2009 in Shanghai and tested for their susceptibility to metronidazole, clarithromycin, amoxicillin, furazolidone, levof...

    journal_title：World journal of gastroenterology

    pub_type： 杂志文章

    doi：10.3748/wjg.v16.i40.5118

    authors： Sun QJ,Liang X,Zheng Q,Gu WQ,Liu WZ,Xiao SD,Lu H

    更新日期：2010-10-28 00:00:00