Restrictive vs liberal transfusion for upper gastrointestinal bleeding: a meta-analysis of randomized controlled trials.

Abstract:

AIM:To compare the outcome of upper gastrointestinal bleeding (UGIB) between patients receiving restrictive and liberal transfusion. METHODS:PubMed, EMBASE, and Cochrane Library databases were employed to identify all relevant randomized controlled trials regarding the outcome of UGIB after restrictive or liberal transfusion. Primary outcomes were death and rebleeding. Secondary outcomes were length of hospitalization, amount of blood transfused, and hematocrit and hemoglobin at discharge or after expansion. RESULTS:Overall, 4 papers were included in this meta-analysis. The incidence of death was significantly lower in patients receiving restrictive transfusion than those receiving liberal transfusion (OR: 0.52, 95%CI: 0.31-0.87, P = 0.01). The incidence of rebleeding was lower in patients receiving restrictive transfusion than those receiving liberal transfusion, but this difference did not reach any statistical significance (OR: 0.26, 95%CI: 0.03-2.10, P = 0.21). Compared with those receiving liberal transfusion, patients receiving restrictive transfusion had a significantly shorter length of hospitalization (standard mean difference: -0.17, 95%CI: -0.30--0.04, P = 0.009) and a significantly smaller amount of blood transfused (standard mean difference: -0.74, 95%CI: -1.15--0.32, P = 0.0005) with a lower hematocrit and hemoglobin level at discharge or after expansion. CONCLUSION:Restrictive transfusion should be employed in patients with UGIB.

journal_name

World J Gastroenterol

authors

Wang J,Bao YX,Bai M,Zhang YG,Xu WD,Qi XS

doi

10.3748/wjg.v19.i40.6919

subject

Has Abstract

pub_date

2013-10-28 00:00:00

pages

6919-27

issue

40

eissn

1007-9327

issn

2219-2840

journal_volume

19

pub_type

杂志文章,meta分析,评审
  • Hepatoid adenocarcinoma of the stomach: a report of three cases.

    abstract::Hepatoid adenocarcinoma of the stomach (HAS) is a rare form of gastric cancer that has unique clinicopathological features and an extremely poor prognosis. Here, we report on three patients with suspected gastric cancer who were referred to our hospital. Gastrointestinal fiberscopy on the three patients revealed two l...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v19.i27.4437

    authors: Ye MF,Tao F,Liu F,Sun AJ

    更新日期:2013-07-21 00:00:00

  • Decreased expression of gastrokine 1 in gastric mucosa of gastric cancer patients.

    abstract:AIM:To investigate the expression of gastrokine 1 (GKN1) in normal gastric mucosa, precancerous lesions and gastric cancer tissues, and to analyse its correlations with tumour site and pathological pattern. METHODS:Thirty gastric cancer patients (12 cases of diffuse type and 18 cases of intestinal type), 13 atrophic g...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v20.i44.16702

    authors: Guo XY,Dong L,Qin B,Jiang J,Shi AM

    更新日期:2014-11-28 00:00:00

  • Reprogramming of glucose metabolism in hepatocellular carcinoma: Progress and prospects.

    abstract::Hepatocellular carcinoma (HCC) is one of the most lethal cancers, and its rate of incidence is rising annually. Despite the progress in diagnosis and treatment, the overall prognoses of HCC patients remain dismal due to the difficulties in early diagnosis and the high level of tumor invasion, metastasis and recurrence...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v22.i45.9933

    authors: Shang RZ,Qu SB,Wang DS

    更新日期:2016-12-07 00:00:00

  • Hepatic adenylate energy charge levels in patients with hepatoma after hepatic artery embolization.

    abstract::AIM:To evaluate hepatic energy charge levels of the patients with hepatoma after hepatic artery embolization and its relation to postoperative complications.METHODS:Sixty-nine patients with hepatoma were continuously measured for their arterial blood ketone body ratio (AKBR) and compared with their postoperative clini...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v4.i2.109

    authors: Li L,Yan LN,Chen XL,Lu WS,Xie XD,Wu YT

    更新日期:1998-04-01 00:00:00

  • Serum manganese superoxide dismutase and thioredoxin are potential prognostic markers for hepatitis C virus-related hepatocellular carcinoma.

    abstract:AIM:To evaluate the clinical significance of oxidative stress markers in patients with hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC). METHODS:Sixty-four consecutive patients who were admitted to Kagoshima University Medical and Dental Hospital were enrolled in this retrospective study. All patients ha...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v17.i44.4890

    authors: Tamai T,Uto H,Takami Y,Oda K,Saishoji A,Hashiguchi M,Kumagai K,Kure T,Mawatari S,Moriuchi A,Oketani M,Ido A,Tsubouchi H

    更新日期:2011-11-28 00:00:00

  • Remote ischemic preconditioning as treatment for non-ischemic gastrointestinal disorders: beyond ischemia-reperfusion injury.

    abstract::Common gastrointestinal diseases such as radiation enteritis (RE), acute pancreatitis, inflammatory bowel diseases (IBD) and drug-induced hepatotoxicity share pathophysiological mechanisms at the molecular level, mostly involving the activation of many pathways of the immune response, ultimately leading to tissue inju...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v20.i13.3572

    authors: Camara-Lemarroy CR

    更新日期:2014-04-07 00:00:00

  • Group II p21-activated kinases as therapeutic targets in gastrointestinal cancer.

    abstract::P21-activated kinases (PAKs) are central players in various oncogenic signaling pathways. The six PAK family members are classified into group I (PAK1-3) and group II (PAK4-6). Focus is currently shifting from group I PAKs to group II PAKs. Group II PAKs play important roles in many fundamental cellular processes, som...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v22.i3.1224

    authors: Shao YG,Ning K,Li F

    更新日期:2016-01-21 00:00:00

  • Combined resection and radiofrequency ablation for multifocal hepatocellular carcinoma: prognosis and outcomes.

    abstract:AIM:To analyze the combined treatment of resection and intraoperative radiofrequency ablation (RFA) for multifocal hepatocellular carcinoma in terms of prognosis and surgical outcomes. METHODS:This study was a retrospective case comparison study using prospectively collected data. The study covered the period from Apr...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v16.i24.3056

    authors: Cheung TT,Ng KK,Chok KS,Chan SC,Poon RT,Lo CM,Fan ST

    更新日期:2010-06-28 00:00:00

  • Coexistence of hepatocellular carcinoma and gastrointestinal stromal tumor: a case report.

    abstract::Malignant gastrointestinal stromal tumors (GIST) are rare mesenchymal tumors originating from the wall of the gastrointestinal tract. Their coexistence with other tumors originating from other germ layers is unique. We have reported a case of a 63-year-old GIST patient presenting as an epigastric mass associated with ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v12.i4.665

    authors: Jaworski R,Jastrzebski T,Swierblewski M,Drucis K,Kobierska-Gulida G

    更新日期:2006-01-28 00:00:00

  • Surveillance for hepatocellular carcinoma in chronic liver disease: evidence and controversies.

    abstract::Primary liver cancer is the sixth most common cancer in the world and the third cause of cancer-related death. Hepatocellular carcinoma (HCC) represents more than 90% of primary liver cancers and generally occurs in patients with underlying chronic liver disease such as viral hepatitis, hemochromatosis, primary biliar...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v19.i40.6744

    authors: van Meer S,de Man RA,Siersema PD,van Erpecum KJ

    更新日期:2013-10-28 00:00:00

  • Disease monitoring in inflammatory bowel disease.

    abstract::The optimal method for monitoring quiescent disease in patients with Crohn's disease (CD) and ulcerative colitis is yet to be determined. Endoscopic evaluation with ileocolonoscopy is the gold standard but is invasive, costly, and time-consuming. There are many commercially available biomarkers that may be used in cli...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v21.i40.11246

    authors: Chang S,Malter L,Hudesman D

    更新日期:2015-10-28 00:00:00

  • Colorectal cancer with liver metastases: neoadjuvant chemotherapy, surgical resection first or palliation alone?

    abstract::Colorectal cancer (CRC) is one of the commonest cancers with 1.2 million new cases diagnosed each year in the world. It remains the fourth most common cause of cancer-related mortality in the world and accounts for > 600000 cancer-related deaths each year. There have been significant advances in treatment of metastati...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v20.i35.12391

    authors: Khan K,Wale A,Brown G,Chau I

    更新日期:2014-09-21 00:00:00

  • Carcinosarcoma of the liver with mesenchymal differentiation.

    abstract::We report an extremely rare case where a mesenchymal differentiation, especially embryonal sarcoma, was demonstrated in cholangiocarcinoma. At autopsy, a yellowish-white tumor (15 cm x 12 cm) was found in the right hepatic lobe, and there were several daughter nodules in both hepatic lobes. Histologically, most of the...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v13.i5.809

    authors: Sumiyoshi S,Kikuyama M,Matsubayashi Y,Kageyama F,Ide Y,Kobayashi Y,Nakamura H

    更新日期:2007-02-07 00:00:00

  • High-flow nasal oxygen availability for sedation decreases the use of general anesthesia during endoscopic retrograde cholangiopancreatography and endoscopic ultrasound.

    abstract:AIM:To examine whether high-flow nasal oxygen (HFNO) availability influences the use of general anesthesia (GA) in patients undergoing endoscopic retrograde cholangiopancreatography (ERCP) and endoscopic ultrasound (EUS) and associated outcomes. METHODS:In this retrospective study, patients were stratified into 3 eras...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v22.i47.10398

    authors: Schumann R,Natov NS,Rocuts-Martinez KA,Finkelman MD,Phan TV,Hegde SR,Knapp RM

    更新日期:2016-12-21 00:00:00

  • Coexistence of small cell neuroendocrine carcinoma and villous adenoma in the ampulla of Vater.

    abstract::Small cell neuroendocrine carcinoma of the ampulla of Vater is extremely rare and different from the common ampullary adenocarcinoma. The ampullary adenoma is also a rare neoplasm and has the potential to develop an adenocarcinoma. Their coexistence has been rarely reported in the literature. We herein describe an unu...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.14.4709

    authors: Sun JH,Chao M,Zhang SZ,Zhang GQ,Li B,Wu JJ

    更新日期:2008-08-07 00:00:00

  • Perforated appendiceal diverticulitis associated with appendiceal neurofibroma in neurofibromatosis type 1.

    abstract::An appendiceal neurofibroma (ANF) is a rare neoplasm associated with neurofibromatosis type 1(NF-1), an inheritable neurocutaneous disorder that involves multiple systems including the intraabdominal organs. Appendiceal diverticulitis occasionally ruptures in the absence of intense abdominal pain, which can lead to se...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v21.i33.9817

    authors: Ozaki A,Tsukada M,Watanabe K,Tsubokura M,Kato S,Tanimoto T,Kami M,Ohira H,Kanazawa Y

    更新日期:2015-09-07 00:00:00

  • Study of human B7 homolog 1 expression in patients with hepatitis B virus infection.

    abstract:AIM:To further investigate the role of human B7 homolog 1 (B7-H1) in the mechanism of persistent hepatitis B virus (HBV) infection. METHODS:Peripheral and intra-hepatic B7-H1 expression were compared by flow cytometry and immunochemical staining between two 2 distinct groups, one being chronic HBV tolerance patients (C...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v18.i28.3681

    authors: Zhang WJ,Xie HY,Duan X,Wan YL,Peng CH,Shi SH,Su R,Zheng ZH,Pan LL,Zhou L,Zheng SS

    更新日期:2012-07-28 00:00:00

  • Effect of p27(KIP1) on cell cycle and apoptosis in gastric cancer cells.

    abstract:AIM:To elucidate the effect of p27(KIP1) on cell cycle and apoptosis regulation in gastric carcinoma cells. METHODS:The whole length of p27(KIP1) cDNA was transfected into human gastric cancer cell line SCG7901 by lipofectamine. Expression of p27(KIP1) protein or mRNA was analyzed by Western blot and RNA dot blotting,...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i45.7072

    authors: Zheng JY,Wang WZ,Li KZ,Guan WX,Yan W

    更新日期:2005-12-07 00:00:00

  • Clinical outcomes and predictive factors in oral corticosteroid-refractory active ulcerative colitis.

    abstract:AIM:To evaluate the clinical outcomes and prognostic factors after intravenous corticosteroids following oral corticosteroid failure in active ulcerative colitis patients. METHODS:Consecutive patients with moderate to severe ulcerative colitis who had been treated with a course of intravenous corticosteroids after ora...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v19.i2.265

    authors: Jeon HH,Lee HJ,Jang HW,Yoon JY,Jung YS,Park SJ,Hong SP,Kim TI,Kim WH,Cheon JH

    更新日期:2013-01-14 00:00:00

  • Microbiota-based treatments in alcoholic liver disease.

    abstract::Gut microbiota plays a key role in the pathogenesis of alcoholic liver disease (ALD). Consumption of alcohol leads to increased gut permeability, small intestinal bacterial overgrowth, and enteric dysbiosis. These factors contribute to the increased translocation of microbial products to the liver via the portal tract...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v22.i29.6673

    authors: Sung H,Kim SW,Hong M,Suk KT

    更新日期:2016-08-07 00:00:00

  • Left-sided gallbladder: its clinical significance and imaging presentations.

    abstract:AIM:To assess the importance of preoperative diagnosis and presentation of left-sided gallbladder using ultrasound (US), CT and angiography. METHODS:Retrospective review of 1482 patients who underwent enhanced CT scanning was performed. Left-sided gallbladder was diagnosed if a right-sided ligamentum teres was present...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v13.i47.6404

    authors: Hsu SL,Chen TY,Huang TL,Sun CK,Concejero AM,Tsang LL,Cheng YF

    更新日期:2007-12-21 00:00:00

  • NF-kappaB and ERK-signaling pathways contribute to the gene expression induced by cag PAI-positive-Helicobacter pylori infection.

    abstract:AIM:To elucidate the sequential gene expression profile in AGS cells co-cultured with wild-type Helicobacter pylori (H pylori) as a model of H pylori-infected gastric epithelium, and to further examine the contribution of cag-pathogenicity islands (cagPAI)-coding type IV secretion system and the two pathways, nuclear f...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i39.6134

    authors: Shibata W,Hirata Y,Yoshida H,Otsuka M,Hoshida Y,Ogura K,Maeda S,Ohmae T,Yanai A,Mitsuno Y,Seki N,Kawabe T,Omata M

    更新日期:2005-10-21 00:00:00

  • Complicated small-bowel diverticulosis: a case report and review of the literature.

    abstract::While jejunoileal diverticula are rare and often asymptomatic, they may lead to chronic non-specific or acute symptoms. The large majority of complications present with an acute abdomen similar to appendicitis, cholecystitis or colonic diverticulitis but they also may appear with atypical symptoms. As a result, diagno...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v13.i15.2240

    authors: Kassahun WT,Fangmann J,Harms J,Bartels M,Hauss J

    更新日期:2007-04-21 00:00:00

  • Effect of liver regeneration on malignant hepatic tumors.

    abstract::Liver regeneration after major surgery may activate occult micrometastases and facilitate tumor growth, leading to liver tumor recurrence. Molecular changes during liver regeneration can provide a microenvironment that stimulates intrahepatic tumor propagation through alterations in cellular signaling pathways, where ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v20.i43.16167

    authors: Shi JH,Line PD

    更新日期:2014-11-21 00:00:00

  • Serial changes in expression of functionally clustered genes in progression of liver fibrosis in hepatitis C patients.

    abstract:AIM:To investigate the relationship of changes in expression of marker genes in functional categories or molecular networks comprising one functional category or multiple categories in progression of hepatic fibrosis in hepatitis C (HCV) patients. METHODS:Marker genes were initially identified using DNA microarray dat...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.14.2010

    authors: Takahara Y,Takahashi M,Zhang QW,Wagatsuma H,Mori M,Tamori A,Shiomi S,Nishiguchi S

    更新日期:2008-04-07 00:00:00

  • Prognostic value of KIT mutation in gastrointestinal stromal tumors.

    abstract:AIM:To examine the prevalence and prognostic significance of C-kit gene mutation and analysis the correlation of C-kit gene mutation and the clinicalpathologic parameters of GISTs. METHODS:Eighty-two GISTs were studied for the mutation of C-kit gene by PCR-SSCP, DNA sequence. Statistical comparison were used to analys...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i25.3948

    authors: Liu XH,Bai CG,Xie Q,Feng F,Xu ZY,Ma DL

    更新日期:2005-07-07 00:00:00

  • Syndecan-1 and E-cadherin expression in differentiated type of early gastric cancer.

    abstract:AIM:To elucidate the role and alterations of syndecan-1 and E-cadherin expression in different cellular phenotypes of differentiated-type gastric cancers (DGCs). METHODS:A total of 120 DGCs at an early stage, and their adjacent mucosa, were studied both by immunohistochemistry. Syndecan-1 and E-cadherin were assessed ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i19.2975

    authors: Huang MF,Zhu YQ,Chen ZF,Xiao J,Huang X,Xiong YY,Yang GF

    更新日期:2005-05-21 00:00:00

  • Clinical application of microRNA in gastric cancer in Eastern Asian area.

    abstract::Recent research has shown that microRNA (miRNA), which is involved in almost every step of gastric carcinogenesis, has broad prospective application in diagnosis and therapy of gastric carcinoma. Eastern Asia (South Korea, Japan and China) has the highest incidence of gastric cancer in the world. There were 988,000 ne...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v19.i13.2019

    authors: Gao M,Yin H,Fei ZW

    更新日期:2013-04-07 00:00:00

  • Primary biliary cirrhosis-associated hepatocellular carcinoma in Chinese patients: incidence and risk factors.

    abstract:AIM:To investigate the incidence, characteristics, and risk factors for hepatocellular carcinoma (HCC) in Chinese patients with primary biliary cirrhosis (PBC). METHODS:We reviewed the data of 52 PBC-associated HCC patients treated at Beijing 302 Hospital from January 2002 to December 2013 and analyzed its incidence a...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v21.i12.3554

    authors: Zhang XX,Wang LF,Jin L,Li YY,Hao SL,Shi YC,Zeng QL,Li ZW,Zhang Z,Lau GK,Wang FS

    更新日期:2015-03-28 00:00:00

  • Prognostic impact of metastatic lymph node ratio in advanced gastric cancer from cardia and fundus.

    abstract:AIM:To investigate the prognostic impact of the metastatic lymph node ratio (MLR) in advanced gastric cancer from the cardia and fundus. METHODS:Two hundred and thirty-six patients with gastric cancer from the cardia and fundus who underwent D2 curative resection were analyzed retrospectively. The correlations between...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.14.4383

    authors: Huang CM,Lin BJ,Lu HS,Zhang XF,Li P,Xie JW

    更新日期:2008-07-21 00:00:00