Decreased expression of gastrokine 1 in gastric mucosa of gastric cancer patients.

Abstract:

AIM:To investigate the expression of gastrokine 1 (GKN1) in normal gastric mucosa, precancerous lesions and gastric cancer tissues, and to analyse its correlations with tumour site and pathological pattern. METHODS:Thirty gastric cancer patients (12 cases of diffuse type and 18 cases of intestinal type), 13 atrophic gastritis patients and 15 healthy volunteers with almost normal gastric mucosa (superficial gastritis) were enrolled in this study. Helicobacter pylori (H. pylori) infection was examined in all subjects. All gastric mucosa biopsy specimens were obtained. Cancer-adjacent specimens were taken from corresponding gastric cancer patients. Immunohistochemistry and real-time PCR were performed to determine the expressions of the GKN1 protein and mRNA, respectively. RESULTS:H. pylori infection had no significant association with age, gender, tumour site or pathological pattern in all subjects. Compared with the superficial gastritis and atrophic gastritis groups, the expression of GKN1 protein (P = 0.011) and mRNA (P < 0.001) in gastric cancer was significantly decreased. The GKN1 mRNA level in diffuse type gastric cancer was significantly lower than in intestinal type gastric cancer (0.296 ± 0.076 vs 0.525 ± 0.164, P < 0.001). CONCLUSION:Compared with almost normal gastric mucosa, GKN1 expression in the gastric mucosa of gastric cancer patients is decreased; this is associated with progression and prognosis of gastric cancer.

journal_name

World J Gastroenterol

authors

Guo XY,Dong L,Qin B,Jiang J,Shi AM

doi

10.3748/wjg.v20.i44.16702

subject

Has Abstract

pub_date

2014-11-28 00:00:00

pages

16702-6

issue

44

eissn

1007-9327

issn

2219-2840

journal_volume

20

pub_type

杂志文章
  • Decreased accumulation of ultrasound contrast in the liver of nonalcoholic steatohepatitis rat model.

    abstract:AIM:To investigate the diagnosis of nonalcoholic steatohepatitis (NASH) using contrast ultrasonography in the NASH rat model. METHODS:The liver in methionine choline-deficient diet (MCDD) rats, a NASH model constructed by feeding an MCDD, was examined by contrast ultrasonography at weeks 2, 4, 8, 12 and 16, with late ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v17.i37.4191

    authors: Miyata Y,Miyahara T,Moriyasu F

    更新日期:2011-10-07 00:00:00

  • Protective effects of oral glutathione on fasting-induced intestinal atrophy through oxidative stress.

    abstract:AIM:To determine whether oral glutathione (GSH) administration can alleviate the effects of fasting-induced intestinal atrophy in the small intestinal mucosa. METHODS:Rats were divided into eight groups. One group was fed ad libitum, another was fed ad libitum and received oral GSH, and six groups were administrated s...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v23.i36.6650

    authors: Uchida H,Nakajima Y,Ohtake K,Ito J,Morita M,Kamimura A,Kobayashi J

    更新日期:2017-09-28 00:00:00

  • Predictors of colorectal cancer testing using the California Health Inventory Survey.

    abstract:AIM:To identify key variables associated with colon cancer testing using the 2009 California Health Inventory Survey (CHIS). METHODS:The CHIS has been conducted biennially since 2001 using a two-stage, geographically stratified random-digit-dial sample design to produce a representative sample of the entire State. For...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v19.i8.1247

    authors: Modiri A,Makipour K,Gomez J,Friedenberg F

    更新日期:2013-02-28 00:00:00

  • Factors related to lymph node metastasis and surgical strategy used to treat early gastric carcinoma.

    abstract:AIM:The prognosis of early gastric carcinoma (EGC) is generally excellent after surgery. The presence or absence of lymph node metastasis in EGC is an important prognostic factor. The survival and recurrence rates of node-negative EGC are much better than those of node-positive EGC. This study examined the factors rela...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v10.i5.737

    authors: Kim DY,Joo JK,Ryu SY,Kim YJ,Kim SK

    更新日期:2004-03-01 00:00:00

  • High concentration of antimitochondrial antibodies predicts progressive primary biliary cirrhosis.

    abstract:AIM:To evaluate the serum concentration of antimitochondrial antibodies (AMAs) as a prognostic indicator of progressive primary biliary cirrhosis (pPBC). METHODS:Serum concentrations of AMA subtypes (anti-M2, anti-M4, and anti-M9), biochemical indices of liver function and Mayo risk factor (MRF) were determined in 30 ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i36.5706

    authors: Flisiak R,Pelszynska M,Prokopowicz D,Rogalska M,Grygoruk U

    更新日期:2005-09-28 00:00:00

  • Clinical correlation of B7-H3 and B3GALT4 with the prognosis of colorectal cancer.

    abstract:AIM:To investigate the expression and clinical significance of B7 homolog 3 (B7-H3) and β-1,3-galactosyltransferase-4 (B3GALT4) in colorectal cancer (CRC) patients. METHODS:Using tissue microarray, we identified the expression of B7-H3 and B3GALT4 in 223 CRC patient samples by immunohistochemistry and evaluated the po...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v24.i31.3538

    authors: Zhang T,Wang F,Wu JY,Qiu ZC,Wang Y,Liu F,Ge XS,Qi XW,Mao Y,Hua D

    更新日期:2018-08-21 00:00:00

  • Effectiveness and safety of herbal medicines in the treatment of irritable bowel syndrome: a systematic review.

    abstract:AIM:To explore the efficacy and safety of herbal medicines (HM) in the treatment of irritable bowel syndrome (IBS). METHODS:A computer-based as well as manual literature search was performed. We reviewed randomized controlled trials on the treatment of IBS with and without HM. RESULTS:A total of 22 studies with 25 HM...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.14.454

    authors: Shi J,Tong Y,Shen JG,Li HX

    更新日期:2008-01-21 00:00:00

  • NOB1 is essential for the survival of RKO colorectal cancer cells.

    abstract:AIM:To determine the role of NOB1, a regulator of cell survival in yeast, in human colorectal cancer cells. METHODS:Lentivirus-mediated small interfering RNA (siRNA) was used to inhibit NOB1 expression in RKO human colorectal cancer cells in vitro and in vivo in a mouse xenograft model. The in vitro and in vivo knockd...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v21.i3.868

    authors: He XW,Feng T,Yin QL,Jian YW,Liu T

    更新日期:2015-01-21 00:00:00

  • Jaundice associated pruritis: a review of pathophysiology and treatment.

    abstract::To review the underlying pathophysiology and currently available treatments for pruritis associated with jaundice. English language literature was reviewed using MEDLINE, PubMed, EMBASE and clinicaltrials.gov for papers and trails addressing the pathophysiology and potential treatments for pruritis associated with jau...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v21.i5.1404

    authors: Bassari R,Koea JB

    更新日期:2015-02-07 00:00:00

  • Effects of frying oil and Houttuynia cordata thunb on xenobiotic-metabolizing enzyme system of rodents.

    abstract:AIM:To evaluate the effects of frying oil and Houttuynia cordata Thunb (H. cordata), a vegetable traditionally consumed in Taiwan, on the xenobiotic-metabolizing enzyme system of rodents. METHODS:Forty-eight Sprague-Dawley rats were fed with a diet containing 0%, 2% or 5% H. cordata powder and 15% fresh soybean oil or...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i3.389

    authors: Chen YY,Chen CM,Chao PY,Chang TJ,Liu JF

    更新日期:2005-01-21 00:00:00

  • Nested case-control study on the risk factors of colorectal cancer.

    abstract:AIM:To investigate the risk factors of colon cancer and rectal cancer. METHODS:A nested case-control study was conducted in a cohort of 64 693 subjects who participated in a colorectal cancer screening program from 1989 to 1998 in Jiashan county, Zhejiang, China. 196 cases of colorectal cancer were detected from 1990 ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v9.i1.99

    authors: Chen K,Cai J,Liu XY,Ma XY,Yao KY,Zheng S

    更新日期:2003-01-01 00:00:00

  • Successful endoscopic repair of an unusual colonic perforation following polypectomy using an endoclip device.

    abstract::Colonic perforation during endoscopic diagnostic or therapeutic procedures, represents an uncommon occurrence even if, together with haemorrhage, it is still the most common complication of colonoscopy, with an incidence ranging between 0.1% and 2% of all colonoscopic procedures. The ideal treatment in these cases rem...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v13.i20.2889

    authors: Barbagallo F,Castello G,Latteri S,Grasso E,Gagliardo S,La Greca G,Di Blasi M

    更新日期:2007-05-28 00:00:00

  • Medical treatment for a fish bone-induced ileal micro-perforation: a case report.

    abstract::Ingested fish bone induced intestinal perforations are seldom diagnosed preoperatively due to incomplete patient history taking and difficulties in image evidence identification. Most literature suggests early surgical intervention to prevent sepsis and complications resulting from fish bone migrations. We report the ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v18.i41.5994

    authors: Kuo CC,Jen TK,Wen CH,Liu CP,Hsiao HS,Liu YC,Chen KH

    更新日期:2012-11-07 00:00:00

  • "Rescue" regimens after Helicobacter pylori treatment failure.

    abstract::Helicobacter pylori (H pylori) infection is the main cause of gastritis, gastroduodenal ulcer disease, and gastric cancer. After more than 20 years of experience in H pylori treatment, in my opinion, the ideal regimen to treat this infection is still to be found. Currently, apart from having to know first-line eradica...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.14.5385

    authors: Gisbert JP

    更新日期:2008-09-21 00:00:00

  • Living-related liver transplantation for multiple liver metastases from rectal carcinoid tumor: a case report.

    abstract::A 42-year-old woman was admitted to our hospital because of multiple liver tumors detected by ultrasonography. Colonoscopy revealed submucosal tumor in the rectum, which was considered the primary lesion. Endoscopic mucosal resection followed by histopathological examination revealed that the tumor was carcinoid. The ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v12.i11.1805

    authors: Nakajima Y,Takagi H,Sohara N,Sato K,Kakizaki S,Nomoto K,Suzuki H,Suehiro T,Shimura T,Asao T,Kuwano H,Mori M,Nishikura K

    更新日期:2006-03-21 00:00:00

  • Two synchronous somatostatinomas of the duodenum and pancreatic head in one patient.

    abstract::Somatostatinomas are extremely rare neuroendocrine tumors of the gastrointestinal tract, first described in the pancreas in 1977 and in the duodenum in 1979. They may be functional and cause somatostatinoma or inhibitory syndrome, but more frequently are non-functioning pancreatic endocrine tumors that produce somatos...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.15.5859

    authors: Colović RB,Matić SV,Micev MT,Grubor NM,Atkinson HD,Latincić SM

    更新日期:2009-12-14 00:00:00

  • Endoscopic submucosal tunnel dissection of upper gastrointestinal submucosal tumors: A comparative study of hook knife vs hybrid knife.

    abstract:AIM:To compare the efficacy and safety of a hook knife (HO) with a hybrid knife (HK) during endoscopic submucosal tunnel dissection (ESTD) procedure. METHODS:Between August 2012 and December 2015, the ESTD procedure was performed for 83 upper GI submucosal lesions, which originated from the muscularis propria layer id...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v23.i10.1843

    authors: Zhou JQ,Tang XW,Ren YT,Wei ZJ,Huang SL,Gao QP,Zhang XF,Yang JF,Gong W,Jiang B

    更新日期:2017-03-14 00:00:00

  • Helicobacter pylori and gastric mucin expression: A systematic review and meta-analysis.

    abstract:AIM:To investigate the relationship between Helicobacter pylori (H. pylori) and mucin expression in gastric mucosa. METHODS:English Medical literature searches were conducted for gastric mucin expression in H. pylori infected people vs uninfected people. Searches were performed up to December 31(th) 2014, using MEDLIN...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,meta分析,评审

    doi:10.3748/wjg.v21.i31.9430

    authors: Niv Y

    更新日期:2015-08-21 00:00:00

  • Prominent role of gamma-glutamyl-transpeptidase on the growth of Helicobacter pylori.

    abstract:AIM:gamma-glutamyl transpeptidase (GGT) has been reported as a virulence and colonizing factor of Helicobacter pylori (H pylori). This study examined the effect of GGT on the growth of H pylori. METHODS:Standard H pylori strain NCTC 11637 and 4 clinical isolates with different levels of GGT activity as measured by an ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v10.i20.2994

    authors: Gong M,Ho B

    更新日期:2004-10-15 00:00:00

  • Complicated small-bowel diverticulosis: a case report and review of the literature.

    abstract::While jejunoileal diverticula are rare and often asymptomatic, they may lead to chronic non-specific or acute symptoms. The large majority of complications present with an acute abdomen similar to appendicitis, cholecystitis or colonic diverticulitis but they also may appear with atypical symptoms. As a result, diagno...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v13.i15.2240

    authors: Kassahun WT,Fangmann J,Harms J,Bartels M,Hauss J

    更新日期:2007-04-21 00:00:00

  • Increased expression of mitogen-activated protein kinase and its upstream regulating signal in human gastric cancer.

    abstract:AIM:To investigate the expression of mitogen-activated protein kinases (MAPKs) and its upstream protein kinase in human gastric cancer and to evaluate the relationship between protein levels and clinicopathological parameters. METHODS:Western blot was used to measure the expression of extracellular signal-regulated ki...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i5.623

    authors: Liang B,Wang S,Zhu XG,Yu YX,Cui ZR,Yu YZ

    更新日期:2005-02-07 00:00:00

  • Value of transient elastography for the prediction of variceal bleeding.

    abstract:AIM:To determine if liver stiffness (LS) measurements by means of transient elastography (TE) correlate with the presence of significant esophageal varices (EV) and if they can predict the occurrence of variceal bleeding. METHODS:We studied 1000 cases of liver cirrhosis divided into 2 groups: patients without EV or wi...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v17.i17.2206

    authors: Sporea I,Raţiu I,Sirli R,Popescu A,Bota S

    更新日期:2011-05-07 00:00:00

  • Repression of allo-cell transplant rejection through CIITA ribonuclease P+ hepatocyte.

    abstract:AIM:Allo-cell transplant rejection and autoimmune responses were associated with the presence of class II major histocompatibility complex (MHC II) molecules on cells. This paper studied the effect of Ribonuclease P (RNase P) against CIITA, which was a major regulator of MHCII molecules, on repressing the expression of...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v9.i5.1077

    authors: Guo R,Zou P,Fan HH,Gao F,Shang QX,Cao YL,Lu HZ

    更新日期:2003-05-01 00:00:00

  • Steatosis recovery after treatment with a balanced sunflower or olive oil-based diet: involvement of perisinusoidal stellate cells.

    abstract:AIM:To analyze the relationship between perisinusoidal stellate cell (PSC) activation and the dietary fat quantity and composition in the treatment of hepatic steatosis. METHODS:Using an experimental rat model of steatosis based on the intake of a hyperlipidic diet (14% fat as olive oil or sunflower oil, HL-O and HL-S...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i47.7480

    authors: Hernández R,Martínez-Lara E,Cañuelo A,del Moral ML,Blanco S,Siles E,Jiménez A,Pedrosa JA,Peinado MA

    更新日期:2005-12-21 00:00:00

  • Sealing of the hepatic resection area using fibrin glue reduces significant amount of postoperative drain fluid.

    abstract:AIM:To investigate whether the routine use of fibrin glue applied onto the hepatic resection area can diminish postoperative volume of bloody or biliary fluids drained via intraoperatively placed perihepatic tubes and can thus lower the complication rate. METHODS:Two groups of consecutive patients with a comparable sp...

    journal_title:World journal of gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.3748/wjg.v11.i38.5984

    authors: Eder F,Meyer F,Nestler G,Halloul Z,Lippert H

    更新日期:2005-10-14 00:00:00

  • Effects of short-term application of low-dose growth hormone on trace element metabolism and blood glucose in surgical patients.

    abstract:AIM:To investigate the effects of short-term application of low-dose growth hormone on trace element metabolism and blood glucose in surgical patients. METHODS:A total of 48 consecutive patients undergoing abdominal operations were randomized to receive either subcutaneous rhGH (0.15 IU/kg) or placebo (menstruum) inje...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,随机对照试验

    doi:10.3748/wjg.v13.i46.6259

    authors: Qian K,Wan Z,Hao LS,Zhang MM,Zhou Y,Wu XT

    更新日期:2007-12-14 00:00:00

  • Protective effect and mechanism of stronger neo-minophagen C against fulminant hepatic failure.

    abstract:AIM:To investigate the protective effect of stronger neo-minophafen C (SNMC) on fulminant hepatic failure (FHF) and its underlying mechanism. METHODS:A mouse model of FHF was established by intraperitoneal injection of galactosamine (D-Gal N) and lipopolysaccharide (LPS). The survival rate, liver function, inflammator...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v13.i3.462

    authors: Yang BS,Ma YJ,Wang Y,Chen LY,Bi MR,Yan BZ,Bai L,Zhou H,Wang FX

    更新日期:2007-01-21 00:00:00

  • Functional brain imaging of gastrointestinal sensation in health and disease.

    abstract::It has since long been known, from everyday experience as well as from animal and human studies, that psychological processes-both affective and cognitive-exert an influence on gastrointestinal sensorimotor function. More specifically, a link between psychological factors and visceral hypersensitivity has been suggest...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v13.i25.3438

    authors: Van Oudenhove L,Coen SJ,Aziz Q

    更新日期:2007-07-07 00:00:00

  • Late course accelerated hyperfractionated radiotherapy for clinical T1-2 esophageal carcinoma.

    abstract:AIM:This retrospective study was designed to analyze the results and the failure patterns of late course accelerated hyperfractionated radiotherapy for clinical T(1-2)N(0)M(0) esophageal carcinoma. METHODS:From Aug. 1994 to Feb. 2001, 56 patients with clinical T(1-2) esophageal carcinoma received late course accelerat...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v9.i6.1374

    authors: Zhao KL,Wang Y,Shi XH

    更新日期:2003-06-01 00:00:00

  • Expression of protein S100A4 is a predictor of recurrence in colorectal cancer.

    abstract:AIM:To investigate the prognostic significance of S100A4 expression in colorectal cancer and its correlation with expression of E-cadherin and p53. METHODS:A cohort of archival formalin-fixed paraffin-embedded specimens was selected from 127 patients with colorectal cancer who underwent surgical resection between Apri...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v16.i31.3897

    authors: Kwak JM,Lee HJ,Kim SH,Kim HK,Mok YJ,Park YT,Choi JS,Moon HY

    更新日期:2010-08-21 00:00:00