Abstract:
AIM:To analyze the relationship between perisinusoidal stellate cell (PSC) activation and the dietary fat quantity and composition in the treatment of hepatic steatosis. METHODS:Using an experimental rat model of steatosis based on the intake of a hyperlipidic diet (14% fat as olive oil or sunflower oil, HL-O and HL-S, respectively), we analyzed the liver's capability of recovery after the treatment with a normal-lipidic diet (5% fat as olive oil or sunflower oil, NL-O and NL-S, respectively) by immunocytochemical and Western blot analysis of glial fibrillary acidic protein (GFAP) expression in PSCs, collagen quantification and serum aminotransferase determination. RESULTS:The fatty infiltration in the steatotic livers decreased after the treatment with both NL diets, indicating liver recovery. This decrease was accompanied with a lower collagen deposition and aminotransferase level as well as changes in the PSC population that increased the GFAP expression. The above-mentioned effects were more pronounced in animals fed on NL-O based diet. CONCLUSION:Treatment with a balanced diet enriched in olive oil contributes to the liver recovery from a steatotic process. The PSC phenotype is a marker of this hepatic-recovery model.
journal_name
World J Gastroenteroljournal_title
World journal of gastroenterologyauthors
Hernández R,Martínez-Lara E,Cañuelo A,del Moral ML,Blanco S,Siles E,Jiménez A,Pedrosa JA,Peinado MAdoi
10.3748/wjg.v11.i47.7480keywords:
subject
Has Abstractpub_date
2005-12-21 00:00:00pages
7480-5issue
47eissn
1007-9327issn
2219-2840journal_volume
11pub_type
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