Abstract:
AIM:To investigate the association of seven single nucleotide polymorphisms (SNPs) of the IL23R gene with the clinical picture of ulcerative colitis (UC). METHODS:Genomic DNA samples of 131 patients (66 males, 65 females, mean age 55.4 ± 15.8 years) with Caucasian origin, diagnosed with UC were investigated. The diagnosis of UC was based on the established clinical, endoscopic, radiological, and histopathological guidelines. DNA was extracted from peripheral blood leukocytes by routine salting out method. Polymerase chain reaction and restriction fragment length polymorphism were used to identify the alleles of seven SNPs of IL23R gene (rs11209026, rs10889677, rs1004819, rs2201841, rs7517847, rs10489629, rs7530511). RESULTS:Four out of seven analyzed SNPs had statistically significant influence on the clinical picture of UC. Two SNPs were associated with greater colonic extension (rs2201841 P = 0.0084; rs10489629 P = 0.0405). For two of the SNPs, there was more frequently need for operations (rs2201841 P = 0.0348, OR = 8.0; rs10889677 P = 0.0347, OR = 8.0). The rs2201841 showed to be a risk factor for the development of iron deficiency (P = 0.0388, OR = 6.1837). For patients with the rs10889677, a therapy with azathioprine was more frequently necessary (P = 0.0116, OR = 6.1707). Patients with rs10489629 SNP had a lower risk for weight loss (P = 0.0169, OR = 0.3394). Carriers of the heterozygous variant had a higher risk for an extended disease (P = 0.0284). The rs7517847 showed a protective character leading to mild bowel movements. Three SNPs demonstrated no statistically significant influence on any examined clinical features of UC. CONCLUSION:We demonstrated susceptible or protective character of the investigated IL23R SNPs on the phenotype of UC, confirming the genetic association.
journal_name
World J Gastroenteroljournal_title
World journal of gastroenterologyauthors
Fischer S,Kövesdi E,Magyari L,Csöngei V,Hadzsiev K,Melegh B,Hegyi P,Sarlós Pdoi
10.3748/wjg.v23.i3.447subject
Has Abstractpub_date
2017-01-21 00:00:00pages
447-454issue
3eissn
1007-9327issn
2219-2840journal_volume
23pub_type
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pub_type: 杂志文章,meta分析,评审
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doi:10.3748/wjg.v11.i28.4332
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
doi:10.3748/wjg.15.2708
更新日期:2009-06-14 00:00:00
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更新日期:2013-12-14 00:00:00
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更新日期:2014-12-07 00:00:00
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pub_type: 杂志文章
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更新日期:2018-10-14 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
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更新日期:2017-05-28 00:00:00
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更新日期:2006-07-28 00:00:00
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