Screening compounds against HCV based on MAVS/IFN-β pathway in a replicon model.

abstract：AIM:To study the inhibitory effects of a Shuangling Fuzheng anticancer preparation (SFAP) on the human gastric cancer cell line SGC-7901 in vitro as well as its immune-modulated effects in a cyclophosphamide-treated murine model. METHODS:MTT experiments and immunocytochemistry ABC experiments were performed for detect...

journal_title：World journal of gastroenterology

authors： Chen HS,Chen J,Cui DL,Zheng YY,Xu AH,Chen G,Jia LC

更新日期：2007-12-28 00:00:00

abstract：AIM:To hypothesize that beta-7 integrin affects cellular migration of both, lymphocytes and enterocytes. METHODS:The nucleoside analog BrdU was ip injected in beta-7-deficient mice (C57BL/6-Itgb(tmlcgn)/J) of male gender and age-matched male C57BL/J J mice (wild type) 4, 20, or 40 h before analysis. The total small in...

journal_title：World journal of gastroenterology

authors： Kaemmerer E,Kuhn P,Schneider U,Clahsen T,Jeon MK,Klaus C,Andruszkow J,Härer M,Ernst S,Schippers A,Wagner N,Gassler N

更新日期：2015-02-14 00:00:00

abstract：AIM:To investigate the molecular mechanism for regulation of cholesterol metabolism by hepatitis C virus (HCV) core protein in HepG2 cells. METHODS:HCV genotype 1b core protein was cloned and expressed in HepG2 cells. The cholesterol content was determined after transfection. The expression of sterol regulatory elemen...

journal_title：World journal of gastroenterology

authors： Li M,Wang Q,Liu SA,Zhang JQ,Ju W,Quan M,Feng SH,Dong JL,Gao P,Cheng J

更新日期：2015-04-21 00:00:00

abstract：AIM:To investigated the effects of urotensin II (UII) on hepatic insulin resistance in HepG2 cells and the potential mechanisms involved. METHODS:Human hepatoma HepG2 cells were cultured with or without exogenous UII for 24 h, in the presence or absence of 100 nmol/L insulin for the last 30 min. Glucose levels were de...

journal_title：World journal of gastroenterology

authors： Li YY,Shi ZM,Yu XY,Feng P,Wang XJ

更新日期：2016-07-07 00:00:00

abstract：AIM:To examine fibrinogen-like protein 2 (fgl2) expression during taurocholate-induced acute pancreatitis progression in rats and its correlation with pancreatic injury severity. METHODS:Forty-eight male Sprague-Dawley rats were randomly divided into the severe acute pancreatitis (SAP) group (n = 24) and the sham oper...

journal_title：World journal of gastroenterology

authors： Ye XH,Chen TZ,Huai JP,Lu GR,Zhuge XJ,Chen RP,Chen WJ,Wang C,Huang ZM

更新日期：2013-04-28 00:00:00

abstract：AIM:To study the role of gastric mucosal ascorbic acid (AA) in the progression of acute gastric mucosal lesions induced by compound 48/80 (C48/80), a mast cell degranulator, in rats. METHODS:C48/80 (0.75 mg/kg) was intraperitoneally injected to fasted Wistar rats. Oral administration of AA (10, 50 or 100 mg/kg) was pe...

journal_title：World journal of gastroenterology

authors： Kamiya Y,Ohta Y,Imai Y,Arisawa T,Nakano H

更新日期：2005-03-07 00:00:00

abstract：AIM:To evaluate whether contrast enhanced ultrasound (CEUS) might also be used for response prediction and early response evaluation in patients receiving bevacizumab based chemotherapy for metastasized colorectal cancer. METHODS:Thirty consecutive patients with non primary resectable liver metastases from colorectal ...

journal_title：World journal of gastroenterology

authors： Schirin-Sokhan R,Winograd R,Roderburg C,Bubenzer J,do Ó NC,Guggenberger D,Hecker H,Trautwein C,Tischendorf JJ

更新日期：2012-02-14 00:00:00

abstract：AIM:To evaluate the role of three-dimensional contrast-enhanced magnetic resonance angiography (3D CE MRA) in the diagnosis of Budd-Chiari syndrome (BCS). METHODS:Twenty-three patients with BCS underwent 3D CE MRA examination, in which 13 cases were secondary to either hepatocellular carcinoma (11 cases), right adrena...

journal_title：World journal of gastroenterology

authors： Lin J,Chen XH,Zhou KR,Chen ZW,Wang JH,Yan ZP,Wang P

更新日期：2003-10-01 00:00:00

abstract：:Advances in molecular diagnostic tools have allowed the identification of lymph node micrometastasis (LNM), including isolated tumor cells, in cancer patients. While immunohistochemistry and reverse transcription-polymerase chain reaction have been used to identify LNM in patients with gastric cancer, the clinical sig...

journal_title：World journal of gastroenterology

authors： Sonoda H,Tani T

更新日期：2014-10-14 00:00:00

abstract：AIM:To analyze the clinical characteristics of small bowel tumors detected by double-balloon enteroscopy (DBE) and to evaluate the diagnostic value of DBE in tumors. METHODS:Four hundred and forty consecutive DBE examinations were performed in 400 patients (250 males and 150 females, mean age 46.9 ± 16.3 years, range ...

journal_title：World journal of gastroenterology

authors： Chen WG,Shan GD,Zhang H,Li L,Yue M,Xiang Z,Cheng Y,Wu CJ,Fang Y,Chen LH

更新日期：2013-06-21 00:00:00

abstract：AIM:To study the condition and potentiality of human umbilical cord blood stem cells (HUCBSC) to differentiate into hepatocytes in vivo or in vitro. METHODS:In a cell culture study of human umbilical cord blood stem cell (HUCBSC) differentiation, human umbilical cord blood mononuclear cells (HUCBMNC) were separated by...

journal_title：World journal of gastroenterology

authors： Tang XP,Zhang M,Yang X,Chen LM,Zeng Y

更新日期：2006-07-07 00:00:00

abstract：:We report a patient with HBV-related hepatocellular carcinoma (HCC) and refractory ascites who had received a peritoneal-venous shunt (PVS) 1 year before liver transplantation. Urgent surgical intervention following bowel obstruction and failure of immunosuppression therapy. No intestinal obstruction was found during ...

journal_title：World journal of gastroenterology

authors： Lin CH,Yu JC,Chen TW,Chan DC,Chen CJ,Hsieh CB

更新日期：2005-09-14 00:00:00

abstract：AIM:To evaluate the value of ABC (D) stratification [combination of serum pepsinogen and Helicobacter pylori (H. pylori) antibody] of patients with gastric cancer. METHODS:Ninety-five consecutive patients with gastric cancer were enrolled into the study. The serum pepsinogen I (PG I)/pepsinogen II (PG II) and H. pylor...

journal_title：World journal of gastroenterology

authors： Kudo T,Kakizaki S,Sohara N,Onozato Y,Okamura S,Inui Y,Mori M

更新日期：2011-11-21 00:00:00

abstract：AIM:To longitudinally investigate cytokine gene expression and protein levels in Th17 and Treg cells, to observe T-cell phenotypes during hepatitis B virus (HBV)-related acute-on-chronic liver failure (ACHBLF) and to analyze changes in Th17 and Treg phenotypes during disease progression. METHODS:We measured the expres...

journal_title：World journal of gastroenterology

authors： Liang XS,Li CZ,Zhou Y,Yin W,Liu YY,Fan WH

更新日期：2014-07-14 00:00:00

abstract：:Casais et al have reported an inverse correlation between serum phosphate and body weight after administration of sodium phosphate at a dose of 60 g. Our group has already described the relationship between body weight and hyperphosphatemia with these preparations, although our study was not quoted by Casais. We perfo...

journal_title：World journal of gastroenterology

authors： Deepak P,Ehrenpreis ED

更新日期：2011-06-07 00:00:00

abstract：AIM:To assess the usefulness of contrast-enhanced harmonic endoscopic ultrasonography (CH-EUS) for lymph node metastasis in pancreatobiliary carcinoma. METHODS:All patients suspected of pancreatobiliary carcinoma with visible lymph nodes after standard EUS between June, 2009 and January, 2012 were enrolled. In the pri...

journal_title：World journal of gastroenterology

authors： Miyata T,Kitano M,Omoto S,Kadosaka K,Kamata K,Imai H,Sakamoto H,Nisida N,Harwani Y,Murakami T,Takeyama Y,Chiba Y,Kudo M

更新日期：2016-03-28 00:00:00

abstract：AIM:To evaluate the efficacy of amantadine plus interferon-alpha and ribavirin in non-responder patients with chronic hepatitis C. METHODS:Twenty-six non-responder patients received the regimen of IFN-alpha-2a at a dose of 6 million units three times a week, 1 000-1 200 mg of ribavirin daily, and 200 mg of amantadine ...

journal_title：World journal of gastroenterology

authors： Oguz D,Cicek B,Filik L,Odemis B,Kilic M,Altintas E,Zengin N,Altiparmak E

更新日期：2005-01-28 00:00:00

abstract：AIM:To explore the possibility of the replacement of the gag gene between human immunodeficiency virus and bovine immunodeficiency virus, to achieve chimeric virions, and thereby gain a new kind of AIDS vaccine based on BHIV chimeric viruses. METHODS:A series of chimeric BHIV proviral DNAs differing in the replacement...

journal_title：World journal of gastroenterology

authors： Zhu YX,Liu C,Liu XL,Qiao WT,Chen QM,Zeng Y,Geng YQ

更新日期：2005-05-07 00:00:00

abstract：AIM:To investigate the effects of osteopontin (OPN) gene expression knockdown on colon cancer Lovo cells in vitro. METHODS:Four candidate small interfering RNA (siRNA) constructs targeting the OPN gene and a scrambled control sequence (NC-siRNA) were synthesized and inserted into a pGPU6/GFP/Neo expression vector. Aft...

journal_title：World journal of gastroenterology

authors： Wu XL,Lin KJ,Bai AP,Wang WX,Meng XK,Su XL,Hou MX,Dong PD,Zhang JJ,Wang ZY,Shi L

更新日期：2014-08-14 00:00:00

abstract：AIM:To compare ghrelin levels in plasma and gastric mucosa before and after Helicobacter pylori (H. pylori) treatment in children with H. pylori-associated functional dyspepsia. METHODS:Children with H. pylori-associated functional dyspepsia were enrolled in this study. H. pylori infection was confirmed by positive ba...

journal_title：World journal of gastroenterology

authors： Deng ZH,Chu B,Xu YZ,Zhang B,Jiang LR

更新日期：2012-09-28 00:00:00

abstract：AIM:To assess the viability of orthotopic and heterotopic patient-derived pancreatic cancer xenografts implanted into nude mice. METHODS:This study presents a prospective experimental analytical follow-up of the development of tumours in mice upon implantation of human pancreatic adenocarcinoma samples. Specimens were...

journal_title：World journal of gastroenterology

authors： Rubio-Manzanares Dorado M,Marín Gómez LM,Aparicio Sánchez D,Pereira Arenas S,Praena-Fernández JM,Borrero Martín JJ,Farfán López F,Gómez Bravo MÁ,Muntané Relat J,Padillo Ruiz J

更新日期：2018-02-21 00:00:00

abstract：AIM:To transfer hepatitis E virus (HEV) ORF2 partial gene to tomato plants, to investigate its expression in transformants and the immunoactivity of expression products, and to explore the feasibility of developing a new type of plant-derived HEV oral vaccine. METHODS:Plant binary expression vector p1301E2, carrying a...

journal_title：World journal of gastroenterology

authors： Ma Y,Lin SQ,Gao Y,Li M,Luo WX,Zhang J,Xia NS

更新日期：2003-10-01 00:00:00

abstract：AIM:To determine the utility of endoscopic ultrasound-guided biliary drainage (EUS-BD) with a fully covered self-expandable metal stent for managing malignant biliary stricture. METHODS:We collected data from 13 patients who presented with malignant biliary obstruction and underwent EUS-BD with a nitinol fully covered...

journal_title：World journal of gastroenterology

authors： Kim TH,Kim SH,Oh HJ,Sohn YW,Lee SO

更新日期：2012-05-28 00:00:00

abstract：:Recently, there have been reports from liver biopsies that showed the progression of liver fibrosis in liver transplant patients after the cessation of immunosuppression. Herein, we focused on activated hepatic stellate cells expressing alpha smooth muscle actin (α-SMA) to understand the correlation between immunosupp...

journal_title：World journal of gastroenterology

authors： Hirabaru M,Mochizuki K,Takatsuki M,Soyama A,Kosaka T,Kuroki T,Shimokawa I,Eguchi S

更新日期：2014-06-14 00:00:00

abstract：:Gastroduodenal disease (GDD) was initially thought to be uncommon in Africa. Amongst others, lack of access to optimal health infrastructure and suspicion of conventional medicine resulted in the reported prevalence of GDD being significantly lower than that in other areas of the world. Following the increasing availa...

journal_title：World journal of gastroenterology

authors： Archampong TN,Asmah RH,Richards CJ,Martin VJ,Bayliss CD,Botão E,David L,Beleza S,Carrilho C

更新日期：2019-07-14 00:00:00

abstract：AIM:To determine the changes of CD8+ T subsets especially CD8+CD28- T regulatory cells in rat model of experimental colitis induced by 2,4-dinitrofluorobenzene (DNFB). METHODS:The rat model of experimental colitis was induced by enema with DNFB. Ten days later, colonic intraepithelial and splenic lymphocytes were isol...

journal_title：World journal of gastroenterology

authors： Xiao WB,Liu YL

更新日期：2003-11-01 00:00:00

abstract：AIM:To unravel the differences between systematic inflammatory response syndrome (SIRS) of acute pancreatitis compared to the same syndrome in sepsis. METHODS:Twenty-five patients were enrolled, 12 with sepsis and 13 acute pancreatitis. After diagnosis 20 mL blood was sampled. Half were assayed for isolation of monocy...

journal_title：World journal of gastroenterology

authors： Koussoulas V,Tzivras M,Karagianni V,Spyridaki E,Plachouras D,Giamarellou H,Giamarellos-Bourboulis EJ

更新日期：2006-11-07 00:00:00

abstract：AIM:To validate the clinical Rockall score in predicting outcomes (rebleeding, surgery and mortality) in elderly patients with acute upper gastrointestinal bleeding (AUGIB). METHODS:A retrospective analysis was undertaken in 341 patients admitted to the emergency room and Intensive Care Unit of Xuanwu Hospital of Capi...

journal_title：World journal of gastroenterology

authors： Wang CY,Qin J,Wang J,Sun CY,Cao T,Zhu DD

更新日期：2013-06-14 00:00:00

abstract：AIM:To examine the effects of aspirin and enoxaparin on liver function, coagulation index and histopathology in a rat model of liver fibrosis. METHODS Forty-five male Sprague-Dawley rats were randomly divided into the control group (n = 5) and model group (n = 40). Thioacetamide (TAA) was used to induce liver fibrosis ...

journal_title：World journal of gastroenterology

authors： Li CJ,Yang ZH,Shi XL,Liu DL

更新日期：2017-09-21 00:00:00

abstract：AIM:To analyze the clinicopathologic characteristics and prognostic factors of rectal neuroendocrine tumors. METHODS:The records of 48 patients with rectal neuroendocrine tumors who were treated at the Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing, from March 2004 to September 2009 were r...

journal_title：World journal of gastroenterology

authors： Chi Y,Du F,Zhao H,Wang JW,Cai JQ

更新日期：2014-11-21 00:00:00