Abstract：
:The risk factors for hepatocellular carcinoma (HCC) development have been established, and include chronic hepatitis B and C, heavy alcohol consumption, and aflatoxins. In fact, 5%-30% of patients with HCC still lack a readily identifiable risk factor. It has been reported that the majority of ''cryptogenic'' HCC may be attributed to nonalcoholic fatty liver disease, the hepatic presentation of the metabolic syndrome (MS). Obesity is associated with the development of the MS. Recently, adipose tissue has been considered as an endocrine organ because of its capacity to secrete a variety of cytokines, which are collectively known as the adipokines. Leptin, the product of the obese gene, is mainly produced by adipose tissue. Since leptin was first characterized in 1994, accumulated literature has demonstrated the involvement of this adipokine in several areas of human physiology. After binding to its receptor, leptin initiates a cascade of signaling events and subsequent cellular effects. In addition to being the regulatory mediator of energy homeostasis, several in vitro studies have demonstrated the fibrogenic role of leptin in the liver. Furthermore, the deregulated expression of leptin and its receptor have been demonstrated to be associated with a variety of metabolic disorders as well as human cancers. Most importantly, direct evidence supporting the inhibitory and/or activating role of leptin in the process of carcinogenesis and progression of human HCC has been accumulating rapidly. This review aims to provide important insights into the potential mechanisms of leptin in the development of HCC. Hopefully, further investigations will shed light on a new therapeutic target in HCC.
journal_name
World J Gastroenteroljournal_title
World journal of gastroenterologyauthors
Wang SN,Lee KT,Ker CGdoi
10.3748/wjg.v16.i46.5801subject
Has Abstractpub_date
2010-12-14 00:00:00pages
5801-9issue
46eissn
1007-9327issn
2219-2840journal_volume
16pub_type
杂志文章,评审abstract：:Pancreatic cancer is a leading cause of cancer mortality and the incidence of this disease is expected to continue increasing. While patients with pancreatic cancer have traditionally faced a dismal prognosis, over the past several years various advances in diagnosis and treatment have begun to positively impact this ...
journal_title：World journal of gastroenterology
pub_type： 杂志文章,评审
doi：10.3748/wjg.v20.i28.9354
更新日期：2014-07-28 00:00:00
abstract：BACKGROUND:Polygonum multiflorum is one of the leading causes of herb-induced liver injury in China. HLA-B*35:01 is reported to be a potential biomarker of Polygonum multiflorum-induced liver injury (PM-DILI). However, little is known about the relationship between single-nucleotide polymorphisms (SNPs) and PM-DILI. A...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v26.i12.1329
更新日期：2020-03-28 00:00:00
abstract：AIM:To investigate the feasibility of a single-use endoscopy as an alternative procedure to nasogastric lavage in patients with acute gastrointestinal (GI) bleeding. METHODS:Patients who presented with hematemesis, melena or hematochezia were enrolled in this study. EG scan™ and conventional esophagogastroduodenoscopy...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v19.i1.103
更新日期：2013-01-07 00:00:00
abstract：AIM:To evaluate the long-term outcome of standard 5-FU based adjuvant or neoadjuvant radiochemotherapy and to identify the predictive factors, especially anemia before and after radiotherapy as well as hemoglobin increase or decrease during radiotherapy. METHODS:Two hundred and eighty-six patients with Union Internati...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v12.i12.1849
更新日期：2006-03-28 00:00:00
abstract：:We experienced a case of intussusception caused by cys- tic lymphangioma of the colon in a 32 years old female who was admitted to our hospital for the chief complaint of bloody stool. In the colonoscopic examination, cystic mass with stalk which had smooth mucosal surface was noted at the descending colon. Abdominal ...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v12.i13.2130
更新日期：2006-04-07 00:00:00
abstract：AIM:To evaluate the efficacy of furazolidone-based triple and quadruple therapy in eradicating Helicobacter pylori (H. pylori) in a multi-center randomized controlled trial. METHODS:A total of 720 H. pylori positive patients with duodenal ulcer disease were enrolled at 10 different hospitals in Jiangxi province in Chi...
journal_title：World journal of gastroenterology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.3748/wjg.v20.i32.11415
更新日期：2014-08-28 00:00:00
abstract：AIM:To evaluate the accuracy of two non-invasive tests in a population of Alaska Native persons. High rates of Helicobacter pylori (H. pylori) infection, H. pylori treatment failure, and gastric cancer in this population necessitate documentation of infection status at multiple time points over a patient's life. METHO...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v17.i42.4682
更新日期：2011-11-14 00:00:00
abstract：BACKGROUND:The role of the Notch pathway in carcinogenesis and tumor progression has been demonstrated in many organs, including the colon. Accordingly, studies aimed at developing therapies targeting this pathway in various cancers require the identification of several factors that may play a role in regulating Notch-...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v26.i26.3814
更新日期：2020-07-14 00:00:00
abstract：AIM:To improve anti-inflammatory activity while reducing drug doses, we developed a nanoformulation carrying dexamethasone and butyrate. METHODS:Dexamethasone cholesteryl butyrate-solid lipid nanoparticles (DxCb-SLN) were obtained with the warm microemulsion method. The anti-inflammatory activity of this novel nanofor...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v23.i23.4200
更新日期：2017-06-21 00:00:00
abstract：AIM:To test whether ethanol feeding could induce Toll-like receptor 4 (TLR4) responses, assess the hepatoprotective effect of betaine and its inhibitive effect on TLR4 in animal models of alcoholic liver injury. METHODS:Forty-eight female Sprague-Dawley rats were randomly divided into four groups as control, model, lo...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v16.i7.897
更新日期：2010-02-21 00:00:00
abstract：BACKGROUND:Esophagomediastinal fistula is a very rare complication of tuberculosis in otherwise healthy adults, and mediastinal bronchial artery aneurysm is even rarer. In this case report, we describe a rare case of tuberculosis complication that presented with acute upper gastrointestinal (GI) bleeding. It also highl...
journal_title：World journal of gastroenterology
pub_type：
doi：10.3748/wjg.v25.i17.2144
更新日期：2019-05-07 00:00:00
abstract：AIM:To investigate the inhibitory effect and possible mechanism of action of schisandrin B in SC-B on gastric cancer cells in vitro. METHODS:SC-B consisted of schisandrin B, aloe-emodin, and Astragalus polysaccharides. Exponentially growing human gastric cancer SGC-7901 cells were divided into six treatment groups: (1...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v13.i48.6506
更新日期：2007-12-28 00:00:00
abstract：AIM:To evaluate the prognosis of type II diabetes mellitus (T2DM) after gastrectomy and related factors in gastric cancer patients. METHODS:403 gastric cancer patients with T2DM were studied, who underwent gastrectomy between May 2003 and September 2009. A review of medical records and telephone interviews was perform...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v18.i1.49
更新日期：2012-01-07 00:00:00
abstract：AIM:Hepatitis B virus (HBV) re-activation often occurs spontaneously or after withdrawal of immunosuppressive therapy in patients with chronic hepatitis B. Severe exacerbation, sometimes developing into fulminant hepatic failure, is at high risk of mortality. The efficacy of corticosteroid therapy in "clinically severe...
journal_title：World journal of gastroenterology
pub_type： 临床试验,杂志文章
doi：10.3748/wjg.v11.i8.1109
更新日期：2005-02-28 00:00:00
abstract：:Several drugs are used in the treatment of irritable bowel syndrome (IBS) but all have side effects and variable efficacy. Considering the role of the gut-brain axis, immune, neural, and endocrine pathways in the pathogenesis of IBS and possible beneficial effects of benzodiazepines (BZD) in this axis, the present sys...
journal_title：World journal of gastroenterology
pub_type： 社论,评审
doi：10.3748/wjg.v17.i38.4251
更新日期：2011-10-14 00:00:00
abstract：:Wireless capsule endoscopy (CE) is a technology developed for the endoscopic exploration of the small bowel. The first capsule model was approved by the Food and Drug Administration in 2001, and its first and essential indication was occult gastrointestinal (GI) bleeding. Over subsequent years, this technology has bee...
journal_title：World journal of gastroenterology
pub_type： 杂志文章,评审
doi：10.3748/wjg.v20.i42.15664
更新日期：2014-11-14 00:00:00
abstract：:A 53-year-old male patient with a large hydatid cyst of the left hemidiaphragm and smaller secondary cysts located in the left thoracic cavity and upper left abdominal quadrant presented with two progressively enlarging lipoma-like masses in the left hypochondrium and under the left scapulae respectively. Total excisi...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v12.i44.7210
更新日期：2006-11-28 00:00:00
abstract：AIM:To analyze the relationship between perisinusoidal stellate cell (PSC) activation and the dietary fat quantity and composition in the treatment of hepatic steatosis. METHODS:Using an experimental rat model of steatosis based on the intake of a hyperlipidic diet (14% fat as olive oil or sunflower oil, HL-O and HL-S...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v11.i47.7480
更新日期：2005-12-21 00:00:00
abstract：AIM:To investigate the gastrin secreting cells (G cells) and the somatostatin secreting cells (D cells) of antral mucosa in rats at the ultrastructural level. METHODS:Revised immunoelectron microscopic technique was used to detect the G cells and D cells in rat antral mucosa through gastrin and somatostatin antibodies...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v9.i12.2768
更新日期：2003-12-01 00:00:00
abstract：AIM:To investigate the association between interleukin-28B (IL28B) genotype and response to treatment and hepatic fibrosis in patients with hepatitis C virus (HCV) genotype 4. METHODS:Two hundred and one HCV-genotype 4 patients were included. All patients were treated with Peginterferon alph2a/Ribavirin for 48 wk. End...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v18.i47.7003
更新日期：2012-12-21 00:00:00
abstract：AIM:To investigate the procedure, feasibility and effects of laparoscope-assisted continuous circulatory hyperthermic intraperitoneal perfusion chemotherapy (CHIPC) in treatment of malignant ascites induced by peritoneal carcinomatosis from gastric cancers. METHODS:From August 2006 to March 2008, the laparoscopic appr...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v16.i15.1901
更新日期：2010-04-21 00:00:00
abstract：AIM:To examine whether a dose-up to 900 mg of ursodeoxycholic acid (UDCA) decreases transaminases in hepatitis C patients. METHODS:From January to December 2007, patients with chronic hepatitis C or compensated liver cirrhosis with hepatitis C virus (HCV) (43-80 years old) showing positive serum HCV-RNA who had alread...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.15.2782
更新日期：2009-06-14 00:00:00
abstract：:Chronic hepatitis B virus (HBV) infection is the most common cause of hepatic fibrosis and hepatocellular carcinoma (HCC), mainly as a result of chronic necroinflammatory liver disease. A characteristic feature of chronic hepatitis B infection, alcoholic liver disease and nonalcoholic fatty liver disease (NAFLD) is he...
journal_title：World journal of gastroenterology
pub_type： 杂志文章,评审
doi：10.3748/wjg.v13.i32.4295
更新日期：2007-08-28 00:00:00
abstract：AIM:To determine the effect of chemotherapy on wound healing by giving early preoperative 5-fluorouracil (5-FU) to rats with colonic anastomoses. METHODS:Sixty Albino-Wistar male rats (median weight, 235 g) were used in this study. The rats were fed with standard laboratory food and given tap water ad libitum. The ani...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.15.4156
更新日期：2009-09-07 00:00:00
abstract：AIM:To assess the risk factors and the efficacy of medications of patients with gastric and duodenal ulcers among Chinese patients in Taiwan. METHODS:Patients with peptic ulcers, diagnosed by upper endoscopy, were retrospectively collected between January 2008 and December 2008. The differences were compared. RESULTS...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v16.i16.2017
更新日期：2010-04-28 00:00:00
abstract：AIM:To investigate the role of mitochondria in cell apoptosis during hepatic ischemia-reperfusion injury and protective effect of ischemic postconditioning (IPC). METHODS:A rat model of acute hepatic ischemia-reperfusion was established, 24 healthy male Wistar rats were randomly divided into sham-operated group, ische...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v10.i13.1934
更新日期：2004-07-01 00:00:00
abstract：:Achalasia cardia is one of the common causes of motor dysphagia. Though the disease was first described more than 300 years ago, exact pathogenesis of this condition still remains enigmatic. Pathophysiologically, achalasia cardia is caused by loss of inhibitory ganglion in the myenteric plexus of the esophagus. In the...
journal_title：World journal of gastroenterology
pub_type： 杂志文章,评审
doi：10.3748/wjg.v18.i24.3050
更新日期：2012-06-28 00:00:00
abstract：AIM:To investigate the correlation between ezrin expression and invasive phenotype formation in malignantly transformed esophageal epithelial cells. METHODS:The experimental cell line employed in the present study was originated form the progressive induction of a human embryonic esophageal epithelial cell line (SHEE)...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.v9.i6.1182
更新日期：2003-06-01 00:00:00
abstract：AIM:To investigate and evaluate the technical feasibility and clinical effectiveness of fluoroscopically guided peroral uncovered expandable metal stent placement to treat gastric outlet and duodenal obstructions. METHODS:Fifteen consecutive patients underwent peroral placement of Wallstent(TM) Enteral Endoprosthesis ...
journal_title：World journal of gastroenterology
pub_type： 临床试验,杂志文章
doi：10.3748/wjg.v13.i40.5376
更新日期：2007-10-28 00:00:00
abstract：AIM:To investigate the relationship of changes in expression of marker genes in functional categories or molecular networks comprising one functional category or multiple categories in progression of hepatic fibrosis in hepatitis C (HCV) patients. METHODS:Marker genes were initially identified using DNA microarray dat...
journal_title：World journal of gastroenterology
pub_type： 杂志文章
doi：10.3748/wjg.14.2010
更新日期：2008-04-07 00:00:00
