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Furazolidone-based triple and quadruple eradication therapy for Helicobacter pylori infection.

Abstract：

AIM:To evaluate the efficacy of furazolidone-based triple and quadruple therapy in eradicating Helicobacter pylori (H. pylori) in a multi-center randomized controlled trial. METHODS:A total of 720 H. pylori positive patients with duodenal ulcer disease were enrolled at 10 different hospitals in Jiangxi province in China. The patients were randomly assigned to four treatment groups as follows: patients in Groups 1 and 3 received rabeprazole (10 mg), amoxicillin (1000 mg) and furazolidone (100 mg) twice daily for 7 and 10 d, respectively; patients in Groups 2 and 4 received rabeprazole (10 mg), bismuth (220 mg), amoxicillin (1000 mg) and furazolidone (100 mg) twice daily for 7 and 10 d, respectively. The primary outcome measure was H. pylori eradication rate 4 wk after treatment by intention-to-treat and per protocol analysis, while the secondary outcome measures were symptom and sign changes at the end of treatment and 4 wk after the end of treatment, as well as the proportion of patients who developed adverse events. RESULTS:The demographic data of the four groups were not significantly different. Overall, 666 patients completed the scheme and were re-assessed with the (13)C-urea breath test. The intention-to-treat analysis of the H. pylori eradication rates in Groups 1, 2, 3 and 4 were 74.44%, 82.78%, 78.89% and 86.11%, respectively. The H. pylori eradication rate in Group 4 was significantly higher than that in Group 1. According to the per protocol analysis, the H. pylori eradication rates in Groups 1, 2, 3 and 4 were 81.21%, 89.22%, 85.54% and 92.26%, respectively. The H. pylori eradication rate in Group 4 was significantly higher than that in Group 1. The number of adverse events was 15 (8.3%), 16 (8.9%), 15 (8.3%) and 17 (9.4%) in Groups 1, 2, 3 and 4, respectively, including dizziness, vomiting, diarrhea, nausea, skin rash, itchy skin, and malaise. The symptoms were relieved without special treatment in all of the patients. CONCLUSION:Both 7- and 10-d quadruple furazolidone-based therapies achieve satisfactory H. pylori eradication rates.

journal_name

World J Gastroenterol

journal_title

World journal of gastroenterology

authors

Xie Y,Zhu Y,Zhou H,Lu ZF,Yang Z,Shu X,Guo XB,Fan HZ,Tang JH,Zeng XP,Wen JB,Li XQ,He XX,Ma JH,Liu DS,Huang CB,Xu NJ,Wang NR,Lu NH

doi

10.3748/wjg.v20.i32.11415

subject

Has Abstract

pub_date

2014-08-28 00:00:00

pages

11415-21

issue

eissn

1007-9327

issn

2219-2840

journal_volume

pub_type

杂志文章,多中心研究,随机对照试验

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Furazolidone-based triple and quadruple eradication therapy for Helicobacter pylori infection.