Management of antiviral drug resistance in chronic hepatitis B.

Abstract:

:Rescue antiviral treatment for patients with resistance to preexisting nucleos(t)ide analogues remains a clinical challenge. The correct choice of a first-line treatment of high potency and with a high genetic barrier to achieve sustained long-term suppression of viral replication provides the best chance of preventing treatment failure and the emergence of drug resistance. The management of treatment failure and drug resistance requires a precise and accurate clinical and virologic monitoring. Combination treatment with antiviral drugs that belong to different groups is associated with a lower chance of developing resistance to rescue drugs. To guarantee better control of viral replication in patients with drug resistance, the addition of another drug without a cross resistance profile should be given as early as possible, preferably at the time when genotypic resistance emerges. Long-term surveillance for treatment efficacy and possible emergence of drug resistance should be continued to prevent the emergence of multidrug-resistant strains.

journal_name

World J Gastroenterol

authors

Bang KB,Kim HJ

doi

10.3748/wjg.v20.i33.11641

subject

Has Abstract

pub_date

2014-09-07 00:00:00

pages

11641-9

issue

33

eissn

1007-9327

issn

2219-2840

journal_volume

20

pub_type

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