Epigenetic regulation in alcoholic liver disease.

abstract：AIM:To determine the evolution of transient elastography (TE) in patients with alcoholic liver disease according to alcohol cessation or continuation. METHODS:We retrospectively selected in our local database all patients who had two TE between June 2005 and November 2010 with chronic alcohol excessive consumption and...

journal_title：World journal of gastroenterology

authors： Bardou-Jacquet E,Legros L,Soro D,Latournerie M,Guillygomarc'h A,Le Lan C,Brissot P,Guyader D,Moirand R

更新日期：2013-01-28 00:00:00

abstract：AIM:To investigate the efficacy of adding prokinetics to proton pump inhibitors (PPIs) for the treatment of gastroesophageal reflux disease (GERD). METHODS:PubMed, Cochrane Library, and Web of Knowledge databases (prior to October 2013) were systematically searched for randomized controlled trials (RCTs) that compared...

journal_title：World journal of gastroenterology

authors： Ren LH,Chen WX,Qian LJ,Li S,Gu M,Shi RH

更新日期：2014-03-07 00:00:00

abstract：:Novel molecular targets are being discovered as we learn more about the aberrant processes underlying various cancers. Efforts to translate this knowledge are starting to impact on the care of patients with gastrointestinal cancers. The epidermal growth factor receptor (EGFR) pathway and angiogenesis have been targete...

journal_title：World journal of gastroenterology

authors： Ma WW,Hidalgo M

更新日期：2007-11-28 00:00:00

abstract：AIM:To investigate the association between adiponectin levels and risk of colorectal adenoma and cancer (early and advanced). METHODS:A cross-sectional study in a cohort of hospital-based patients was conducted between January 2004 and March 2006 at Yamagata University Hospital. Male subjects, who had colorectal tumor...

journal_title：World journal of gastroenterology

authors： Otake S,Takeda H,Fujishima S,Fukui T,Orii T,Sato T,Sasaki Y,Nishise S,Kawata S

更新日期：2010-03-14 00:00:00

abstract：AIM:To evaluate the clinical outcomes of patients undergoing hepatectomy with hemihepatic vascular occlusion (HHO) compared with total hepatic inflow occlusion (THO). METHODS:Randomized controlled trials (RCTs) comparing hemihepatic vascular occlusion and total hepatic inflow occlusion were included by a systematic li...

journal_title：World journal of gastroenterology

authors： Wang HQ,Yang JY,Yan LN

更新日期：2011-07-14 00:00:00

abstract：AIM:To determine the gene expression profile data for the whole liver during development of dimethylni-trosamine (DMN)-induced hepatic fibrosis. METHODS:Marker genes were identified for different types of hepatic cells, including hepatic stellate cells (HSCs), Kupffer cells (including other inflammatory cells), and he...

journal_title：World journal of gastroenterology

authors： Takahara Y,Takahashi M,Wagatsuma H,Yokoya F,Zhang QW,Yamaguchi M,Aburatani H,Kawada N

更新日期：2006-10-28 00:00:00

abstract：AIM:To assess the outcome of patients, who underwent transarterial chemoembolization (TACE) for hepatocellular carcinoma (HCC) and subsequently liver transplantation (OLT) irrespective of tumor size when no tumor progression was observed. METHODS:Records, imaging studies and pathology of 84 patients with HCC were revi...

journal_title：World journal of gastroenterology

authors： Obed A,Beham A,Püllmann K,Becker H,Schlitt HJ,Lorf T

更新日期：2007-02-07 00:00:00

abstract：AIM:To assess the usefulness of contrast-enhanced harmonic endoscopic ultrasonography (CH-EUS) for lymph node metastasis in pancreatobiliary carcinoma. METHODS:All patients suspected of pancreatobiliary carcinoma with visible lymph nodes after standard EUS between June, 2009 and January, 2012 were enrolled. In the pri...

journal_title：World journal of gastroenterology

authors： Miyata T,Kitano M,Omoto S,Kadosaka K,Kamata K,Imai H,Sakamoto H,Nisida N,Harwani Y,Murakami T,Takeyama Y,Chiba Y,Kudo M

更新日期：2016-03-28 00:00:00

abstract：AIM:To investigate whether common variants in the oxidative pathway genes influence inflammatory bowel disease (IBD) risk among Moroccan patients. METHODS:The distribution of (TAAA)n_rs12720460 and (CCTTT)n _rs3833912 NOS2A microsatellite repeats, HIF-1A_rs11549467 and NFKB1-94ins/delATTG_rs28362491 was analyzed in 50...

journal_title：World journal of gastroenterology

authors： Senhaji N,Nadifi S,Zaid Y,Serrano A,Rodriguez DAL,Serbati N,Karkouri M,Badre W,Martín J

更新日期：2017-12-21 00:00:00

abstract：AIM:To investigate the effects of extended lymphadenectomy and postoperative chemotherapy on gastric cancer without lymph node metastasis. METHODS:Clinical data of 311 node-negative gastric cancer patients who underwent potentially curative gastrectomy with more than 15 lymph nodes resected, from January 2002 to Decem...

journal_title：World journal of gastroenterology

authors： Xue Q,Wang XN,Deng JY,Zhang RP,Liang H

更新日期：2013-09-07 00:00:00

abstract：:The occurrence of pancreatic pleural effusion, secondary to an internal pancreatic fistula, is a rare clinical syndrome and diagnosis is often missed. The key to the diagnosis is a dramatically elevated pleural fluid amylase. This pancreatic pleural effusion is also called a pancreatic pleural fistula. It is character...

journal_title：World journal of gastroenterology

authors： Jin SG,Chen ZY,Yan LN,Zeng Y

更新日期：2010-09-21 00:00:00

abstract：AIM:To study the relationship between the patterns of postprandial peristalsis and transduodenal bolus transport in healthy subjects. METHODS:Synchronous recording of chyme transport and peristaltic activity was performed during the fasting state and after administration of a test meal using a special catheter device ...

journal_title：World journal of gastroenterology

authors： Nguyen HN,Winograd R,Domingues GR,Lammert F

更新日期：2006-10-07 00:00:00

abstract：AIM:To determine the prognostic significance of isolated tumor cells (ITCs) and lymph node micrometastases in gastric cancer. METHODS:Hematoxylin and eosin-stained slides of lymph node dissections of 632 consecutive gastric cancers were reviewed. Cytokeratin immunostaining was performed in 280 node-negative cases and ...

journal_title：World journal of gastroenterology

authors： Lee HS,Kim MA,Yang HK,Lee BL,Kim WH

更新日期：2005-10-14 00:00:00

abstract：AIM:To study the relationship between anti-beta2-glycoprotein I (abeta2GPI) antibodies and platelet activation state in patients with ulcerative colitis (UC) and its significance. METHODS:Peripheral blood samples were collected from 56 UC patients (34 males and 22 females, aged 43.5 years, range 21-66 years), includin...

journal_title：World journal of gastroenterology

authors： Gao YH,Gao PJ,Wang CG,Wang XC,Piao YF

更新日期：2008-02-07 00:00:00

abstract：AIM:To investigate the pattern of mucin expression and concentration in bile obtained during endoscopic retrograde cholangiography (ERC) in relation to gallstone disease. METHODS:Bile samples obtained at ERC from 29 consecutive patients, 17 with and 12 without gallstone disease were evaluated for mucin content by gel ...

journal_title：World journal of gastroenterology

authors： Vilkin A,Geller A,Levi Z,Niv Y

更新日期：2009-05-21 00:00:00

abstract：AIM:To study the effect of IGF-1/IGF-1R and gastrin/CCK-BR on carcinogenesis and development of human gastric carcinoma and to explore its mechanism and provide a credible theoretical foundation for early diagnosis and molecular therapy of gastric carcinoma. METHODS:mRNA expression levels of IGF-1/IGF-1R and gastrin/C...

journal_title：World journal of gastroenterology

authors： Zhao MD,Hu XM,Sun DJ,Zhang Q,Zhang YH,Meng W

更新日期：2005-06-07 00:00:00

abstract：AIM:To evaluate tumor necrosis factor-α converting enzyme (TACE) methylation status in patients with chronic hepatitis B (CHB). METHODS:Eighty patients with hepatitis B e antigen (HBeAg)-positive CHB, 80 with HBeAg-negative CHB, and 40 healthy controls (HCs) were randomly enrolled in this study. Genomic DNA was extrac...

journal_title：World journal of gastroenterology

authors： Wang ZL,Gao S,Li XY,Sun FK,Li F,Fan YC,Wang K

更新日期：2015-07-21 00:00:00

abstract：:Iatrogenic bile duct injuries (IBDI) remain an important problem in gastrointestinal surgery. They are most frequently caused by laparoscopic cholecystectomy which is one of the commonest surgical procedures in the world. The early and proper diagnosis of IBDI is very important for surgeons and gastroenterologists, be...

journal_title：World journal of gastroenterology

authors： Jabłońska B,Lampe P

更新日期：2009-09-07 00:00:00

abstract：AIM:To investigate the feasibility of detecting methylated fecal DNA as a screening tool for colorectal carcinoma (CRC) and precancerous lesions. METHODS:Methylated secreted frizzled-related protein gene 2 (SFRP2), hyperplastic polyposis protein gene (HPP1) and O6-methylguanine-DNA methyltransferase gene (MGMT) in sto...

journal_title：World journal of gastroenterology

authors： Huang ZH,Li LH,Yang F,Wang JF

更新日期：2007-02-14 00:00:00

abstract：:Epidemiological and clinical data point to a close association between chronic hepatitis B virus infection or chronic hepatitis C virus infection and development of hepatocellular carcinoma (HCC). HCC develops over several decades and is associated with fibrosis. This sequence suggests that persistent viral infection ...

journal_title：World journal of gastroenterology

authors： Murata M,Yoshida K,Yamaguchi T,Matsuzaki K

更新日期：2014-11-07 00:00:00

abstract：AIM:To classify gallstone disease as a basis for assessment of post-cholecystectomy symptoms. METHODS:One hundred and fifty three patients with a clinical and ultrasonographic diagnosis of gallstones filled out a structured questionnaire on abdominal pain symptoms and functional gastrointestinal disorder (FGID) before...

journal_title：World journal of gastroenterology

authors： Schmidt M,Søndenaa K,Dumot JA,Rosenblatt S,Hausken T,Ramnefjell M,Njølstad G,Eide GE

更新日期：2012-03-28 00:00:00

abstract：AIM:To clarify the molecular mechanism involved in pathogenesis of colorectal cancer as well as clinical significance of genetic analysis of histological samples. METHODS:A total of 480 blood and tissue specimens were collected in our hospital from January 2011 to October 2012. In the observation group, there were 120...

journal_title：World journal of gastroenterology

authors： Yan ZH,Cui LH,Wang XH,Li C,He X

更新日期：2014-12-28 00:00:00

abstract：:Treatment of Helicobacter pylori (H. pylori) infection is paramount for the management of prevalent gastrointestinal disorders including peptic ulcer disease and gastric cancer. Due to the wide increase in prevalence of H. pylori resistance to antibiotics, clarithromycin-based triple therapies are not any more suitabl...

journal_title：World journal of gastroenterology

authors： Papastergiou V,Georgopoulos SD,Karatapanis S

更新日期：2014-08-07 00:00:00

abstract：:Sorafenib is the current standard treatment for advanced hepatocellular carcinoma (HCC), but its efficacy is modest with low response rates and short response duration. Predictive biomarkers for sorafenib efficacy are necessary. However, efforts to determine biomarkers for sorafenib have led only to potential candidat...

journal_title：World journal of gastroenterology

authors： Shao YY,Hsu CH,Cheng AL

更新日期：2015-09-28 00:00:00

abstract：:Despite advances in the management of patients with locally advanced, non-metastatic rectal adenocarcinoma (LARC), prognosis remains largely unsatisfactory due to a high rate of distant relapse. In fact, currently available neoadjuvant protocols, represented by fluoropyrimidine-based chemo-radiotherapy (CT-RT) or shor...

journal_title：World journal of gastroenterology

authors： Fornaro L,Caparello C,Vivaldi C,Rotella V,Musettini G,Falcone A,Baldini E,Masi G

更新日期：2014-05-28 00:00:00

abstract：AIM:To explore the cooperative effects of antisense oligonucleotide (ASON) of cell adhesion molecules and cimetidine on the expression of E-selectin and ICAM-1 in endothelial cells and their adhesion to tumor cells. METHODS:After treatment of endothelial cells with ASON and/or cimetidine and induction with TNF-alpha, ...

journal_title：World journal of gastroenterology

authors： Tang NH,Chen YL,Wang XQ,Li XJ,Yin FZ,Wang XZ

更新日期：2004-01-01 00:00:00

abstract：:The progressive loss of efficacy of standard eradication therapies has made the treatment of Helicobacter pylori (H. pylori) more challenging than ever. Endoscopic-guided antibiotic susceptibility testing had previously been suggested to guide treatment after failure of second-line therapies. However, its role has exp...

journal_title：World journal of gastroenterology

authors： Cammarota G,Ianiro G,Bibbò S,Di Rienzo TA,Masucci L,Sanguinetti M,Gasbarrini A

更新日期：2014-05-14 00:00:00

abstract：:Management of hepatocellular carcinoma (HCC) with portal vein thrombosis (PVT) is complex and requires an understanding of multiple therapeutic options. PVT is present in 10%-40% of HCC at the time of diagnosis, and is an adverse prognostic factor. Management options are limited, as transplantation is generally contra...

journal_title：World journal of gastroenterology

authors： Quirk M,Kim YH,Saab S,Lee EW

更新日期：2015-03-28 00:00:00

abstract：AIM:To explore the effects of peptide S-8300 from shark liver (S-8300) on liver function as well as in regulating immune functions in experimental injury models. METHODS:Mice were administered with different doses of S-8300 for four consecutive days, followed by mice injected with tetrachloromethane (CCl(4)) on d 3. T...

journal_title：World journal of gastroenterology

authors： Huang FJ,Lv ZB,Li Q,Wei LJ,Zhang L,Wu WT

更新日期：2005-03-28 00:00:00

abstract：:Alcohol-related cirrhosis is a consequence of heavy and prolonged drinking. Similarly to patients with cirrhosis of other etiologies, patients with alcoholic cirrhosis develop portal hypertension and the hepatic, splanchnic and systemic hemodynamic alterations that follow. However, in alcoholic cirrhosis, some specifi...

journal_title：World journal of gastroenterology

authors： Bolognesi M,Verardo A,Di Pascoli M

更新日期：2014-07-07 00:00:00