Relationships of CDXs and apical sodium-dependent bile acid transporter in Barrett's esophagus.

Abstract:

:Barrett's esophagus (BE) is characterized by intestinal metaplasia with the differentiated epithelium replaced by another type of epithelium morphologically similar to normal intestinal epithelium. The metaplasia is preceded by bile and acid reflux into the esophagus. BE is a premalignant condition associated with increased risk of esophageal cancer, especially esophageal adenocarcinoma. The Caudal-related homeodomain transcription factors Caudal-related homeodomain transcription factor CDX1 and CDX2 are expressed exclusively in the small and large intestine, playing important roles in proliferation and differentiation of intestinal epithelial cells. Ectopic expression of CDX1 and CDX2 occurs in BE. The apical sodium-dependent bile acid transporter (ASBT) is expressed primarily in terminal ileum where it is a key factor for intestinal reabsorption of bile salts. In addition to upregulation of CDX1 and CDX2, ASBT expression is up-regulated in BE. Furthermore, both CDX1/CDX2 and ASBT expressions are down-regulated in high-grade esophageal dysplasia. The alteration of the above-mentioned factors calls for attention: what is the relationship between CDXs and ASBT aberrant expression in BE? In this commentary, we discuss this issue on basis of the recent study done by Ma et al.

journal_name

World J Gastroenterol

authors

Zhao J,Gregersen H

doi

10.3748/wjg.v19.i18.2736

subject

Has Abstract

pub_date

2013-05-14 00:00:00

pages

2736-9

issue

18

eissn

1007-9327

issn

2219-2840

journal_volume

19

pub_type

评论,杂志文章
  • Impact of postoperative glycemic control and nutritional status on clinical outcomes after total pancreatectomy.

    abstract:AIM:To evaluate the impact of glycemic control and nutritional status after total pancreatectomy (TP) on complications, tumor recurrence and overall survival. METHODS:Retrospective records of 52 patients with pancreatic tumors who underwent TP were collected from 2007 to 2015. A series of clinical parameters collected...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v23.i2.265

    authors: Shi HJ,Jin C,Fu DL

    更新日期:2017-01-14 00:00:00

  • Inhibitory effect of schisandrin B on gastric cancer cells in vitro.

    abstract:AIM:To investigate the inhibitory effect and possible mechanism of action of schisandrin B in SC-B on gastric cancer cells in vitro. METHODS:SC-B consisted of schisandrin B, aloe-emodin, and Astragalus polysaccharides. Exponentially growing human gastric cancer SGC-7901 cells were divided into six treatment groups: (1...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v13.i48.6506

    authors: Liu XN,Zhang CY,Jin XD,Li YZ,Zheng XZ,Li L

    更新日期:2007-12-28 00:00:00

  • Solid lipid nanoparticles delivering anti-inflammatory drugs to treat inflammatory bowel disease: Effects in an in vivo model.

    abstract:AIM:To improve anti-inflammatory activity while reducing drug doses, we developed a nanoformulation carrying dexamethasone and butyrate. METHODS:Dexamethasone cholesteryl butyrate-solid lipid nanoparticles (DxCb-SLN) were obtained with the warm microemulsion method. The anti-inflammatory activity of this novel nanofor...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v23.i23.4200

    authors: Dianzani C,Foglietta F,Ferrara B,Rosa AC,Muntoni E,Gasco P,Della Pepa C,Canaparo R,Serpe L

    更新日期:2017-06-21 00:00:00

  • The effect pathway of retinoic acid through regulation of retinoic acid receptor alpha in gastric cancer cells.

    abstract:AIM:To evaluate the role of RARalpha gene in mediating the growth inhibitory effect of all-trans retinoic acid (ATRA) on gastric cancer cells. METHODS:The expression levels of retinoic acid receptors (RARs) in gastric cancer cells were detected by Northern blot. Transient transfection and chlorophenicol acetyl transfe...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v7.i5.662

    authors: Liu S,Wu Q,Chen ZM,Su WJ

    更新日期:2001-10-01 00:00:00

  • Clinical characteristics and prognostic factors of splenic abscess: a review of 67 cases in a single medical center of Taiwan.

    abstract:AIM:To analyze 67 cases of splenic abscess in a medical center of Taiwan during a period of 19 years. METHODS:From January 1986 to December 2004, a total of 67 patients with splenic abscess were enrolled for the retrospective study. The clinical characteristics, underlying diseases, organism spectra, therapeutic metho...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v12.i3.460

    authors: Chang KC,Chuah SK,Changchien CS,Tsai TL,Lu SN,Chiu YC,Chen YS,Wang CC,Lin JW,Lee CM,Hu TH

    更新日期:2006-01-21 00:00:00

  • Transarterial radioembolization for hepatocellular carcinoma: An update and perspectives.

    abstract::In the last decade trans-arterial radioembolization has given promising results in the treatment of patients with intermediate or advanced stage hepatocellular carcinoma (HCC), both in terms of disease control and tolerability profile. This technique consists of the selective intra-arterial administration of microsphe...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v21.i21.6518

    authors: Sacco R,Mismas V,Marceglia S,Romano A,Giacomelli L,Bertini M,Federici G,Metrangolo S,Parisi G,Tumino E,Bresci G,Corti A,Tredici M,Piccinno M,Giorgi L,Bartolozzi C,Bargellini I

    更新日期:2015-06-07 00:00:00

  • Stents for colorectal obstruction: Past, present, and future.

    abstract::Since the development of uncovered self-expanding metal stents (SEMS) in the 1990s, endoscopic stents have evolved dramatically. Application of new materials and new designs has expanded the indications for enteral SEMS. At present, enteral stents are considered the first-line modality for palliative care, and numerou...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v22.i2.842

    authors: Kim EJ,Kim YJ

    更新日期:2016-01-14 00:00:00

  • Study on liver targeting and hepatocytes permeable valaciclovir polybutylcyanoacrylate nanoparticles.

    abstract::AIM:To prepare valaciclovir polybutylcyan_oacrylate nanoparticles (VACV-PBCA-NP) with liver targeting and hepatocyte permeable charateristics.METHODS: Emulsion polymerization method was employed to prepare VACV-PBCA-NP.The formula and preparation conditions were optimized by using the uniform design. The organ distrib...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v5.i4.330

    authors: Zhang ZR,He Q

    更新日期:1999-08-01 00:00:00

  • Subtotal colonic bypass plus colostomy with antiperistaltic cecoproctostomy for the treatment of slow transit constipation in an aged population: A retrospective control study.

    abstract:AIM:To compare the efficacy, improved quality of life, and prognosis in patients undergoing either subtotal colonic bypass with antiperistaltic cecoproctostomy (SCBAC) or subtotal colonic bypass plus colostomy with antiperistaltic cecoproctostomy (SCBCAC) for the treatment of slow transit constipation. METHODS:Between...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v24.i23.2491

    authors: Yang Y,Cao YL,Wang WH,Zhang YY,Zhao N,Wei D

    更新日期:2018-06-21 00:00:00

  • Evolution and future of laparoscopic colorectal surgery.

    abstract::The advances of laparoscopic surgery since the early 1990s have caused one of the largest technical revolutions in medicine since the detection of antibiotics (1922, Flemming), the discovery of DNA structure (1953, Watson and Crick), and solid organ transplantation (1954, Murray). Perseverance through a rocky start an...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v20.i41.15119

    authors: Kaiser AM

    更新日期:2014-11-07 00:00:00

  • Do the expressions of gap junction gene connexin messenger RNA in noncancerous liver remnants of patients with hepatocellular carcinoma correlate with postoperative recurrences?

    abstract:AIM:To investigate whether the changes of gap junction gene connexin messenger RNA in the noncancerous liver tissue of patients with hepatocellular carcinoma (HCC) could play a significant role in its postresection recurrence. METHODS:Seventy-nine consecutive patients having undergone curative resection for HCC entere...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i2.171

    authors: Sheen IS,Jeng KS,Shih SC,Kao CR,Wang PC,Chen CZ,Chang WH,Wang HY,Shyung LR

    更新日期:2005-01-14 00:00:00

  • Relationship between antral distension and postprandial symptoms in functional dyspepsia.

    abstract:AIM:To investigate in patients with functional dyspepsia (FD) after an every-day meal whether (1) gastrointestinal (GI) and extra-GI symptoms had any relation with the degree of antral volume, (2) the onset of postprandial symptoms was associated with, and may predict, delayed gastric emptying. METHODS:In 94 symptomat...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v12.i43.6982

    authors: Pallotta N,Pezzotti P,Corazziari E

    更新日期:2006-11-21 00:00:00

  • Regulatory effect of a Chinese herbal medicine formula on non-alcoholic fatty liver disease.

    abstract:BACKGROUND:Non-alcoholic fatty liver disease (NAFLD) has become a major cause of chronic liver disease. The Chinese herbal medicine (CHM) Dachaihu decoction (DCHD) has been proved to treat NAFLD with good efficacy in previous studies. Based on the TCM principle of formula formation, we divided DCHD into soothing liver ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v25.i34.5105

    authors: Yang JM,Sun Y,Wang M,Zhang XL,Zhang SJ,Gao YS,Chen L,Wu MY,Zhou L,Zhou YM,Wang Y,Zheng FJ,Li YH

    更新日期:2019-09-14 00:00:00

  • Acute abdomen: rare and unusual presentation of right colic xanthogranulomatosis.

    abstract::Xanthogranulomatous inflammation (XGI) is a disease of unknown origin, most frequently described in the kidney and gallbladder; its localization in the colorectal tract is extremely rare. The extension of the typical inflammatory process to the surrounding tissues may lead to misdiagnosis as cancer. We report the case...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v20.i26.8717

    authors: Addario Chieco P,Antolino L,Giaccaglia V,Centanini F,Cunsolo GV,Sparagna A,Uccini S,Ziparo V

    更新日期:2014-07-14 00:00:00

  • Liver cell adenoma showing sequential alteration of radiological findings suggestive of well-differentiated hepatocellular carcinoma.

    abstract::A liver tumor 35 mm in diameter was found incidentally in a 40-year-old woman who had no history of liver diseases or the use of oral contraceptives. Radiological diagnostics showed the typical findings of liver cell adenoma (LCA). Dynamic computed tomography revealed that the tumor showed a homogenous enhancement in ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.15.1267

    authors: Kogure T,Ueno Y,Sekiguchi S,Ishida K,Igarashi T,Wakui Y,Iwasaki T,Shimosegawa T

    更新日期:2009-03-14 00:00:00

  • Cloning and expression of core gene cDNA of Chinese hepatitis C virus in cosmid pTM3.

    abstract::AIM:To clone core gene cDNA of Chinese hepatitis C virus (HCV) into eukaryotic expression vector cosmid pTM3 and to express HCV core antigen in HepG2 cells.METHODS:Core gene cDNA of HCV was introduced into eukaryotic expression vector cosmid pTM3.Using vaccinia virus/bacteriophage T7 hybrid expression system, HepG2 ce...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v6.i2.220

    authors: Jiang RL,Lu QS,Luo KX

    更新日期:2000-04-01 00:00:00

  • Evaluation of esophageal function in patients with esophageal motor abnormalities using multichannel intraluminal impedance esophageal manometry.

    abstract:AIM:To evaluate the functional aspect of esophageal motility in healthy subjects and in patients who were referred for esophageal function testing using multichannel intraluminal impedance-esophageal manometry (MII-EM), and to assess the clinical utility of MII-EM. METHODS:From September 2003 to January 2004, we perfo...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v12.i39.6349

    authors: Cho YK,Choi MG,Park JM,Oh JH,Paik CN,Lee JW,Lee IS,Kim SW,Chung IS

    更新日期:2006-10-21 00:00:00

  • Effect of ginger on gastric motility and symptoms of functional dyspepsia.

    abstract:AIM:To evaluate the effects of ginger on gastric motility and emptying, abdominal symptoms, and hormones that influence motility in dyspepsia. METHODS:Eleven patients with functional dyspepsia were studied twice in a randomized double-blind manner. After an 8-h fast, the patients ingested three capsules that contained...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,随机对照试验

    doi:10.3748/wjg.v17.i1.105

    authors: Hu ML,Rayner CK,Wu KL,Chuah SK,Tai WC,Chou YP,Chiu YC,Chiu KW,Hu TH

    更新日期:2011-01-07 00:00:00

  • Effect of ligand of peroxisome proliferator-activated receptor gamma on the biological characters of hepatic stellate cells.

    abstract:AIM:To study the effect of rosiglitazone, which is a ligand of peroxisome proliferator-activated receptor gamma (PPARgamma), on the expression of PPARgamma in hepatic stellate cells (HSCs) and on the biological characteristics of HSCs. METHODS:The activated HSCs were divided into three groups: control group, 3 micromo...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i30.4735

    authors: Guo YT,Leng XS,Li T,Peng JR,Song SH,Xiong LF,Qin ZZ

    更新日期:2005-08-14 00:00:00

  • Oxaliplatin-induced severe anaphylactic reactions in metastatic colorectal cancer: case series analysis.

    abstract:AIM:To investigate oxaliplatin-induced severe anaphylactic reactions (SAR) in metastatic colorectal cancer in a retrospective case series analysis and to conduct a systemic literature review. METHODS:During a 6-year period from 2006 to 2011 at Kaohsiung Veterans General Hospital, a total of 412 patients exposed to oxa...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v18.i38.5427

    authors: Wang JH,King TM,Chang MC,Hsu CW

    更新日期:2012-10-14 00:00:00

  • Mucosa repair mechanisms of Tong-Xie-Yao-Fang mediated by CRH-R2 in murine, dextran sulfate sodium-induced colitis.

    abstract:AIM:To explore the significance of corticotropin-releasing hormone (CRH)-receptor (R)2 in mucosal healing of dextran sulfate sodium (DSS)-induced colitis and the effect of Tong-Xie-Yao-Fang (TXYF) on CRH-R2 expression and regulation. METHODS:Ulcerative colitis was induced in mice by administration of 3% (w/v) DSS for ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v24.i16.1766

    authors: Gong SS,Fan YH,Wang SY,Han QQ,Lv B,Xu Y,Chen X,He YE

    更新日期:2018-04-28 00:00:00

  • Polymorphisms of uridine-diphosphoglucuronosyltransferase 1A7 gene in Taiwan Chinese.

    abstract:AIM:Single nucleotide polymorphisms (SNPs) of uridine-diphosphoglucuro-nosyltransferase 1A7 (UGT1A7) gene are associated with the development of orolaryngeal cancer, hepatocellular carcinoma, and colorectal cancer. We performed this research to establish the techniques for determining UGT1A7 gene and basic data of this...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i6.797

    authors: Huang MJ,Yang SS,Lin MS,Huang CS

    更新日期:2005-02-14 00:00:00

  • Clinicopathological and biological significance of cripto overexpression in human colon cancer.

    abstract:AIM:To assess the clinicopathological and biological significance of cripto in human colorectal cancer. METHODS:Real-time reverse-transcription polymerase chain reaction (PCR) was used to examine cripto mRNA levels in primary colon cancer and normal colon tissues as well as normal and metastatic lymph nodes from colon...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v19.i46.8630

    authors: Jiang PC,Zhu L,Fan Y,Zhao HL

    更新日期:2013-12-14 00:00:00

  • Rate of adverse events of gastroduodenal snare polypectomy for non-flat polyp is low: A prospective and multicenter study.

    abstract:AIM:To evaluate the rate of adverse events (AEs) during consecutive gastric and duodenal polypectomies in several Spanish centers. METHODS:Polypectomies of protruded gastric or duodenal polyps ≥ 5 mm using hot snare were prospectively included. Prophylactic measures of hemorrhage were allowed in predefined cases. AEs ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,多中心研究

    doi:10.3748/wjg.v23.i47.8405

    authors: Córdova H,Argüello L,Loras C,Naranjo Rodríguez A,Riu Pons F,Gornals JB,Nicolás-Pérez D,Andújar Murcia X,Hernández L,Santolaria S,Leal C,Pons C,Pérez-Cuadrado-Robles E,García-Bosch O,Papo Berger M,Ulla Rocha JL,Sánchez-Mon

    更新日期:2017-12-21 00:00:00

  • Repression of allo-cell transplant rejection through CIITA ribonuclease P+ hepatocyte.

    abstract:AIM:Allo-cell transplant rejection and autoimmune responses were associated with the presence of class II major histocompatibility complex (MHC II) molecules on cells. This paper studied the effect of Ribonuclease P (RNase P) against CIITA, which was a major regulator of MHCII molecules, on repressing the expression of...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v9.i5.1077

    authors: Guo R,Zou P,Fan HH,Gao F,Shang QX,Cao YL,Lu HZ

    更新日期:2003-05-01 00:00:00

  • Expression of survivin in primary and metastatic gastric cancer cells obtained by laser capture microdissection.

    abstract:AIM:Survivin, a recently identified member of the inhibitor of apoptosis protein family, is expressed during development and in various human cancers. However, its expression in normal tissues and clinical relevance in cancers are still debated. In the present study, we analyzed the expression of the survivin gene in h...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v10.i21.3094

    authors: Wang ZN,Xu HM,Jiang L,Zhou X,Lu C,Zhang X

    更新日期:2004-11-01 00:00:00

  • Syndecan-1 and E-cadherin expression in differentiated type of early gastric cancer.

    abstract:AIM:To elucidate the role and alterations of syndecan-1 and E-cadherin expression in different cellular phenotypes of differentiated-type gastric cancers (DGCs). METHODS:A total of 120 DGCs at an early stage, and their adjacent mucosa, were studied both by immunohistochemistry. Syndecan-1 and E-cadherin were assessed ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i19.2975

    authors: Huang MF,Zhu YQ,Chen ZF,Xiao J,Huang X,Xiong YY,Yang GF

    更新日期:2005-05-21 00:00:00

  • Sealing of the hepatic resection area using fibrin glue reduces significant amount of postoperative drain fluid.

    abstract:AIM:To investigate whether the routine use of fibrin glue applied onto the hepatic resection area can diminish postoperative volume of bloody or biliary fluids drained via intraoperatively placed perihepatic tubes and can thus lower the complication rate. METHODS:Two groups of consecutive patients with a comparable sp...

    journal_title:World journal of gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.3748/wjg.v11.i38.5984

    authors: Eder F,Meyer F,Nestler G,Halloul Z,Lippert H

    更新日期:2005-10-14 00:00:00

  • Glutathione-S-transferase (GSTM1, GSTT1) and the risk of gastrointestinal cancer in a Korean population.

    abstract:AIM:To evaluate the association of glutathione S-transferase mu (GSTM1) and glutathione S-transferase theta (GSTT1) null genotypes with the risk of gastric cancer (GC) and colorectal cancer (CRC) in a South Korean population. METHODS:We conducted a population-based, large-scale case-control study including 2213 GCs, 1...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.15.5716

    authors: Piao JM,Shin MH,Kweon SS,Kim HN,Choi JS,Bae WK,Shim HJ,Kim HR,Park YK,Choi YD,Kim SH

    更新日期:2009-12-07 00:00:00

  • Adult intussusception caused by cystic lymphangioma of the colon: a rare case report.

    abstract::We experienced a case of intussusception caused by cys- tic lymphangioma of the colon in a 32 years old female who was admitted to our hospital for the chief complaint of bloody stool. In the colonoscopic examination, cystic mass with stalk which had smooth mucosal surface was noted at the descending colon. Abdominal ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v12.i13.2130

    authors: Kim TO,Lee JH,Kim GH,Heo J,Kang DH,Song GA,Cho M

    更新日期:2006-04-07 00:00:00