Signaling pathway/molecular targets and new targeted agents under development in hepatocellular carcinoma.

abstract：AIM:To study the influence of redox environment of Escherichia coli (E. coli) cytoplasm on disulfide bond formation of recombinant proteins. METHODS:Bovine fibroblast growth factor (BbFGF) was selected as a model of simple proteins with a single disulfide bond and free cysteines. Anti-HBsAg single-chain Fv (HBscFv), a...

journal_title：World journal of gastroenterology

authors： Xiong S,Wang YF,Ren XR,Li B,Zhang MY,Luo Y,Zhang L,Xie QL,Su KY

更新日期：2005-02-21 00:00:00

abstract：:Hepatitis C virus (HCV) infection disrupts the normal metabolism processes, but is also influenced by several of the host's metabolic factors. An obvious and significantly detrimental pathophysiological feature of HCV infection is insulin resistance in hepatic and peripheral tissues. Substantial research efforts have ...

journal_title：World journal of gastroenterology

authors： Kawaguchi Y,Mizuta T

更新日期：2014-03-21 00:00:00

abstract：AIM:To study the outcome of patients undergoing surgical resection of the bowel for sustained radiation-induced damage intractable to conservative management. METHODS:During a 7-year period we operated on 17 cases (5 male, 12 female) admitted to our surgical department with intestinal radiation injury (IRI). They were...

journal_title：World journal of gastroenterology

authors： Perrakis N,Athanassiou E,Vamvakopoulou D,Kyriazi M,Kappos H,Vamvakopoulos NC,Nomikos I

更新日期：2011-09-21 00:00:00

abstract：:In recent years, a number of studies detected a significantly higher prevalence of Campylobacter species such as Campylobacter concisus (C. concisus) in intestinal biopsies and fecal samples collected from patients with inflammatory bowel disease (IBD) compared to controls. Most of these Campylobacter species are not ...

journal_title：World journal of gastroenterology

authors： Zhang L

更新日期：2015-08-21 00:00:00

abstract：AIM:To investigate whether the patatin-like phospholipase domain containing-3 gene (PNPLA3) I148M polymorphism is associated with steatosis, fibrosis stage, and cirrhosis in hereditary hemochromatosis (HH). METHODS:We studied 174 consecutive unrelated homozygous for the C282Y HFE mutation of HH (C282Y+/+ HH) patients ...

journal_title：World journal of gastroenterology

authors： Valenti L,Maggioni P,Piperno A,Rametta R,Pelucchi S,Mariani R,Dongiovanni P,Fracanzani AL,Fargion S

更新日期：2012-06-14 00:00:00

abstract：:A 76-year-old man with known situs inversus totalis presented with left-sided discomfort. Abdominal ultrasonography and CT scan confirmed the diagnosis of a gallstone, as well as, situs inversus; the liver and gallbladder on the left side and the spleen on the right. The biliary system was thought to be left-right rev...

journal_title：World journal of gastroenterology

authors： Kamitani S,Tsutamoto Y,Hanasawa K,Tani T

更新日期：2005-09-07 00:00:00

abstract：:In colon cancer, classic disease staging remains the key prognosis and treatment determinant. Although adjuvant chemotherapy has an established role in stage III colon cancer patients, in stage II it is still a subject of controversy due to its restriction to a small subgroup of patients with high-risk histopathologic...

journal_title：World journal of gastroenterology

authors： Saridaki Z,Souglakos J,Georgoulias V

更新日期：2014-06-14 00:00:00

abstract：AIM:To investigate the outcome of repeating endoscopic retrograde cholangiopancreaticography (ERCP) after initially failed precut sphincterotomy to achieve biliary cannulation. METHODS:In this retrospective study, consecutive ERCPs performed between January 2009 and September 2012 were included. Data from our endoscop...

journal_title：World journal of gastroenterology

authors： Pavlides M,Barnabas A,Fernandopulle N,Bailey AA,Collier J,Phillips-Hughes J,Ellis A,Chapman R,Braden B

更新日期：2014-09-28 00:00:00

abstract：AIM:This study is aimed at investigating the expression and possible significances of very low-density lipoprotein receptor (VLDLR) subtypes in gastroenteric adenocarcinoma tissues and cells with various differentiations. METHODS:Thirty-one cases of gastroenteric carcinoma/adjacent normal tissues were enrolled in the ...

journal_title：World journal of gastroenterology

authors： Chen T,Wu F,Chen FM,Tian J,Qu S

更新日期：2005-05-14 00:00:00

abstract：AIM:To assess the value of multidetector-row computed tomography (MDCT) in choosing retreatment methods of hepatocellular carcinoma (HCC) through evaluating the blood supply of low-density area of HCC after transcatheter arterial chemoembolization (TACE). METHODS:Thirty-two patients with HCC after TACE treatment were ...

journal_title：World journal of gastroenterology

authors： Guan YS,Zheng XH,Zhou XP,Huang J,Sun L,Chen X,Li X,He Q

更新日期：2004-07-15 00:00:00

abstract：AIM:To assess the efficacy and safety of TECA type hybrid artificial liver support system (TECA-HALSS) in providing liver function of detoxification, metabolism and physiology by treating the patients with acute liver failure (ALF). METHODS:The porcine liver cells (1-2) x 10(10) were separated from the Chinese small s...

journal_title：World journal of gastroenterology

authors： Xue YL,Zhao SF,Luo Y,Li XJ,Duan ZP,Chen XP,Li WG,Huang XQ,Li YL,Cui X,Zhong DG,Zhang ZY,Huang ZQ

更新日期：2001-12-01 00:00:00

abstract：:The occurrence of pancreatic pleural effusion, secondary to an internal pancreatic fistula, is a rare clinical syndrome and diagnosis is often missed. The key to the diagnosis is a dramatically elevated pleural fluid amylase. This pancreatic pleural effusion is also called a pancreatic pleural fistula. It is character...

journal_title：World journal of gastroenterology

authors： Jin SG,Chen ZY,Yan LN,Zeng Y

更新日期：2010-09-21 00:00:00

abstract：AIM:To investigate the relationship between the expression of p16 gene and the gastric carcinogenesis, depth of invasion and lymph node metastases, and to evaluate the deletion and mutation of exon 2 in p16 gene in gastric carcinoma. METHODS:The expression of p16 protein was examined by streptavidin-peroxidase conjuga...

journal_title：World journal of gastroenterology

authors： He XS,Su Q,Chen ZC,He XT,Long ZF,Ling H,Zhang LR

更新日期：2001-08-01 00:00:00

abstract：:Treatment of chronic pancreatitis has been exclusively surgical for a long time. Recently, endoscopic therapy has become widely used as a primary therapeutic option. Initially performed for drainage of pancreatic cysts and pseudocysts, endoscopic treatments were adapted to biliary and pancreatic ducts stenosis. Pancre...

journal_title：World journal of gastroenterology

authors： Heyries L,Sahel J

更新日期：2007-12-14 00:00:00

abstract：AIM:To examine the possible effects of honey supplementation on hepatic damage due to obstruction of the common bile duct in an experimental rat model. METHODS:The study was performed with 30 male rats divided into three groups: a sham group, an obstructive jaundice group, and an obstructive jaundice plus honey group....

journal_title：World journal of gastroenterology

authors： Erguder BI,Kilicoglu SS,Namuslu M,Kilicoglu B,Devrim E,Kismet K,Durak I

更新日期：2008-06-21 00:00:00

abstract：:Hemolymphangioma is a malformation of both lymphatic vessels and blood vessels. Splenic hemolymphangioma is extremely rare. Herein, we present a case of 62-year-old woman with ambiguous upper quadrant abdominal pain for two months who was found to have an occupying lesion in the spleen on computed tomography. She was ...

journal_title：World journal of gastroenterology

authors： Mei Y,Peng CJ,Chen L,Li XX,Li WN,Shu DJ,Xie WT

更新日期：2015-05-07 00:00:00

abstract：AIM:To investigate the global gene expression of cancer related genes in hepatoma cell line HLE using Atlas Human Cancer Array membranes with 588 well-characterized human genes related with cancer and tumor biology. METHODS:Hybridization of cDNA blotting membrane was performed with (32)P-labeled cDNA probes synthesize...

journal_title：World journal of gastroenterology

authors： Liu LX,Liu ZH,Jiang HC,Zhang WH,Qi SY,Hu J,Wang XQ,Wu M

更新日期：2003-04-01 00:00:00

abstract：AIM:To investigate the distribution pathway of metastatic lymph nodes in gastric carcinoma as a foundation for rational lymphadenectomy. METHODS:We investigated 173 cases with solitary or single station metastatic lymph nodes (LN) from among 2476 gastric carcinoma patients. The location of metastatic LN, histological ...

journal_title：World journal of gastroenterology

authors： Liu CG,Lu P,Lu Y,Jin F,Xu HM,Wang SB,Chen JQ

更新日期：2007-09-21 00:00:00

abstract：AIM:To investigate the effect of tetrandrine (Tet) and verapamil (Ver) on liver fibrosis by evaluating their effects on the growth and proliferation of fibroblasts. METHODS:Flow cytometry and imaging analysis were used to study the effects of combined and individual treatment of Tet and Ver on fibroblastic proliferati...

journal_title：World journal of gastroenterology

authors： Liu XS,Li DG,Lu HM,Wu QF

更新日期：1997-06-15 00:00:00

abstract：AIM:To observe the kinetics of D (-)-lactate alteration in both portal and systemic circulation systems, and its relationship with intestinal injury in rats subjected to acute intestinal ischemia-reperfusion. METHODS:Anesthetized rats underwent a 75-min superior mesenteric artery occlusion followed by a 6-h reperfusio...

journal_title：World journal of gastroenterology

authors： Yao YM,Yu Y,Wu Y,Lu LR,Sheng ZY

更新日期：1997-12-15 00:00:00

abstract：AIM:To investigate the genetic relationship between Hirschsprung's disease (HD) and intestinal neuronal dysplasia (IND) in Chinese population. METHODS:Peripheral blood samples were obtained from 30 HD patients, 20 IND patients, 18 HD/IND combined patients and 20 normal individuals as control. Genomic DNA was extracted...

journal_title：World journal of gastroenterology

authors： Tou JF,Li MJ,Guan T,Li JC,Zhu XK,Feng ZG

更新日期：2006-02-21 00:00:00

abstract：AIM:To determine the immune-modulatory and the hepatoprotective effects of oral administration of two soy extracts in immune mediated liver injury and non-alcoholic steatohepatitis (NASH). METHODS:Two soy extracts, M1 and OS, were orally administered to mice with concanavalin A (ConA) immune-mediated hepatitis, to hig...

journal_title：World journal of gastroenterology

authors： Khoury T,Ben Ya'acov A,Shabat Y,Zolotarovya L,Snir R,Ilan Y

更新日期：2015-06-28 00:00:00

abstract：:The incidence of Barrett's metaplasia (BM) as well as Barrett's adenocarcinoma (BA) has been increasing in western populations. The prognosis of BA is worse because individuals present at a late stage. Attempts have been made to intervene at early stage using surveillance programmes, although proof of efficacy of endo...

journal_title：World journal of gastroenterology

authors： Ishaq S,Jankowski JA

更新日期：2001-08-01 00:00:00

abstract：:This paper reviews the progress made in understanding the mechanical behaviour of the biliary system. Gallstones and diseases of the biliary tract affect more than 10% of the adult population. The complications of gallstones, i.e. acute pancreatitis and obstructive jandice, can be lethal, and patients with acalculous ...

journal_title：World journal of gastroenterology

authors： Luo X,Li W,Bird N,Chin SB,Hill NA,Johnson AG

更新日期：2007-03-07 00:00:00

abstract：AIM:To evaluate the accuracy of spot urinary Na/K and Na/creatinine (Cr) ratios as an alternative to 24-h urinary sodium in monitoring dietary compliance in patients with liver cirrhosis and ascites treated with diuretics. METHODS:The study was carried on 40 patients with liver cirrhosis and ascites treated with diure...

journal_title：World journal of gastroenterology

authors： El-Bokl MA,Senousy BE,El-Karmouty KZ,Mohammed Iel K,Mohammed SM,Shabana SS,Shalaby H

更新日期：2009-08-07 00:00:00

abstract：AIM:To investigate the influence of remote ischemic preconditioning (RIPC) on anastomotic integrity. METHODS:Sixty male Wistar rats were randomized to six groups. The control group (n = 10) had an end-to-end ileal anastomosis without RIPC. The preconditioned groups (n = 34) varied in time of ischemia and time of reper...

journal_title：World journal of gastroenterology

authors： Holzner PA,Kulemann B,Kuesters S,Timme S,Hoeppner J,Hopt UT,Marjanovic G

更新日期：2011-03-14 00:00:00

abstract：:Arthrogryposis, renal dysfunction and cholestasis (ARC) syndrome is a rare genetic disorder and has not been described in China. We present a female infant with neonatal intrahepatic cholestasis from a Chinese family with ARC syndrome. All 23 coding exons and flanking introns of the VPS33B gene were amplified and sequ...

journal_title：World journal of gastroenterology

authors： Li LT,Zhao J,Chen R,Wang JS

更新日期：2014-01-07 00:00:00

abstract：AIM:To study the expression of ether à go-go (Eag1) potassium channel in colorectal cancer and the relation-ship between their expression and clinico-pathological features. METHODS:The expression levels of Eag1 protein were determined in 76 cancer tissues with paired non-cancerous matched tissues as well as 9 colorect...

journal_title：World journal of gastroenterology

authors： Ding XW,Yan JJ,An P,Lü P,Luo HS

更新日期：2007-02-28 00:00:00

abstract：AIM:To hypothesize that beta-7 integrin affects cellular migration of both, lymphocytes and enterocytes. METHODS:The nucleoside analog BrdU was ip injected in beta-7-deficient mice (C57BL/6-Itgb(tmlcgn)/J) of male gender and age-matched male C57BL/J J mice (wild type) 4, 20, or 40 h before analysis. The total small in...

journal_title：World journal of gastroenterology

authors： Kaemmerer E,Kuhn P,Schneider U,Clahsen T,Jeon MK,Klaus C,Andruszkow J,Härer M,Ernst S,Schippers A,Wagner N,Gassler N

更新日期：2015-02-14 00:00:00

abstract：AIM:To evaluate the myoelectric manifestations of peripheral fatigability in patients with primary biliary cirrhosis in comparison to healthy subjects. METHODS:Sixteen women with primary biliary cirrhosis without comorbidity and 13 healthy women matched for age and body mass index (BMI) completed the self-reported que...

journal_title：World journal of gastroenterology

authors： Biagini MR,Tozzi A,Grippo A,Galli A,Milani S,Amantini A

更新日期：2006-08-28 00:00:00