Abstract:
AIM:To investigate the influence of remote ischemic preconditioning (RIPC) on anastomotic integrity. METHODS:Sixty male Wistar rats were randomized to six groups. The control group (n = 10) had an end-to-end ileal anastomosis without RIPC. The preconditioned groups (n = 34) varied in time of ischemia and time of reperfusion. One group received the amino acid L-arginine before constructing the anastomosis (n = 9). On postoperative day 4, the rats were re-laparotomized, and bursting pressure, hydroxyproline concentration, intra-abdominal adhesions, and a histological score concerning the mucosal ischemic injury were collected. The data are given as median (range). RESULTS:On postoperative day 4, median bursting pressure was 124 mmHg (60-146 mmHg) in the control group. The experimental groups did not show a statistically significant difference (P > 0.05). Regarding the hydroxyproline concentration, we did not find any significant variation in the experimental groups. We detected significantly less mucosal injury in the RIPC groups. Furthermore, we assessed more extensive intra-abdominal adhesions in the preconditioned groups than in the control group. CONCLUSION:RIPC directly before performing small bowel anastomosis does not affect anastomotic stability in the early period, as seen in ischemic preconditioning.
journal_name
World J Gastroenteroljournal_title
World journal of gastroenterologyauthors
Holzner PA,Kulemann B,Kuesters S,Timme S,Hoeppner J,Hopt UT,Marjanovic Gdoi
10.3748/wjg.v17.i10.1308subject
Has Abstractpub_date
2011-03-14 00:00:00pages
1308-16issue
10eissn
1007-9327issn
2219-2840journal_volume
17pub_type
杂志文章abstract:AIM:To explore the inducing effect of human mutant p27 gene on the apoptosis of the human gastric cancer cell line MKN-45 and its associated mechanisms. METHODS:The recombinant adenovirus Ad-p27mt was constructed to infect the human gastric cancer cell line MKN-45. Using flow cytometry, TUNEL assay and DNA fragment an...
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journal_title:World journal of gastroenterology
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更新日期:2014-07-14 00:00:00
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pub_type: 杂志文章,评审
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journal_title:World journal of gastroenterology
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
doi:10.3748/wjg.v19.i10.1632
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pub_type: 社论,评审
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更新日期:2009-04-14 00:00:00
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更新日期:2006-05-28 00:00:00
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更新日期:2014-04-14 00:00:00
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更新日期:2016-05-28 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 社论
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更新日期:2016-07-28 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
doi:10.3748/wjg.v8.i6.1134
更新日期:2002-12-01 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 社论,评审
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更新日期:2008-12-14 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章,多中心研究
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更新日期:2014-09-14 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章,评审
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更新日期:2014-06-07 00:00:00
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pub_type: 杂志文章
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更新日期:2012-12-28 00:00:00