Differential diagnosis of benign and malignant branch duct intraductal papillary mucinous neoplasm using contrast-enhanced endoscopic ultrasonography.

Abstract:

AIM:To elucidate the role of contrast-enhanced endoscopic ultrasonography (CE-EUS) in the diagnosis of branch duct intraductal papillary mucinous neoplasm (BD-IPMN). METHODS:A total of 50 patients diagnosed with BD-IPMN by computed tomography (CT) and endoscopic ultrasonography (EUS) at our institute were included in this study. CE-EUS was performed when mural lesions were detected by EUS. The diagnostic accuracy for identifying mural nodules (MNs) was evaluated by CT, EUS, and EUS combined with CE-EUS. In the patients who underwent resection, the accuracy of measuring MN height with each imaging modality was compared. The cut-off values to diagnose malignant BD-IPMNs based on MN height for each imaging modality were determined using receiver operating characteristic curve analysis. RESULTS:Fifteen patients were diagnosed with BD-IPMN with MNs and underwent resection. The remaining 35 patients were diagnosed with BD-IPMN without MNs and underwent follow-up monitoring. The pathological findings revealed 14 cases with MNs and one case without. The accuracy for diagnosing MNs was 92% using CT and 72% using EUS; the diagnostic accuracy increased to 98% when EUS and CE-EUS were combined. The accuracy for measuring MN height significantly improved when using CE-EUS compared with using CT or EUS (median measurement error value, CT: 3.3 mm vs CE-EUS: 0.6 mm, P < 0.05; EUS: 2.1 mm vs CE-EUS: 0.6 mm, P < 0.01). A cut-off value of 8.8 mm for MN height as measured by CE-EUS improved the accuracy of diagnosing malignant BD-IPMN to 93%. CONCLUSION:Using CE-EUS to measure MN height provides a highly accurate method for differentiating benign from malignant BD-IPMN.

journal_name

World J Gastroenterol

authors

Harima H,Kaino S,Shinoda S,Kawano M,Suenaga S,Sakaida I

doi

10.3748/wjg.v21.i20.6252

subject

Has Abstract

pub_date

2015-05-28 00:00:00

pages

6252-60

issue

20

eissn

1007-9327

issn

2219-2840

journal_volume

21

pub_type

杂志文章
  • Epithelial-to-mesenchymal and mesenchymal-to-epithelial transitions in the colon.

    abstract::Epithelial-to-mesenchymal and mesenchymal-to-epithelial transitions are well established biological events which have an important role in not just normal tissue and organ development, but in the pathogenesis of diseases. Increasing evidence has established their presence in the human colon during colorectal carcinoge...

    journal_title:World journal of gastroenterology

    pub_type: 社论,评审

    doi:10.3748/wjg.v18.i7.601

    authors: Sipos F,Galamb O

    更新日期:2012-02-21 00:00:00

  • Management of recurrent rectal cancer: a population based study in greater Amsterdam.

    abstract:AIM:To analyze, retrospectively in a population-based study, the management and survival of patients with recurrent rectal cancer initially treated with a macroscopically radical resection obtained with total mesorectal excision (TME). METHODS:All rectal carcinomas diagnosed during 1998 to 2000 and initially treated w...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.14.6018

    authors: Bakx R,Visser O,Josso J,Meijer S,Slors JF,van Lanschot JJ

    更新日期:2008-10-21 00:00:00

  • Endoscopic stenting for recurrence-related colorectal anastomotic site obstruction: preliminary experience.

    abstract:AIM:To evaluate the efficacy of stents in treating patients with anastomotic site obstructions due to cancer recurrence following colorectal surgery. METHODS:The medical records of patients who underwent endoscopic self-expanding metal stents (SEMS) insertion for colorectal obstructions between February 2004 and Janua...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v20.i38.13936

    authors: Kim JH,Lee JJ,Cho JH,Kim KO,Chung JW,Kim YJ,Kwon KA,Park DK,Kim JH

    更新日期:2014-10-14 00:00:00

  • Relationship between antral distension and postprandial symptoms in functional dyspepsia.

    abstract:AIM:To investigate in patients with functional dyspepsia (FD) after an every-day meal whether (1) gastrointestinal (GI) and extra-GI symptoms had any relation with the degree of antral volume, (2) the onset of postprandial symptoms was associated with, and may predict, delayed gastric emptying. METHODS:In 94 symptomat...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v12.i43.6982

    authors: Pallotta N,Pezzotti P,Corazziari E

    更新日期:2006-11-21 00:00:00

  • Diabetes mellitus, insulin resistance and hepatitis C virus infection: A contemporary review.

    abstract:AIM:To summarise the literature data on hepatitis C virus (HCV)-infected patients concerning the prevalence of glucose abnormalities and associated risk. METHODS:We conducted a PubMed search and selected all studies found with the key words "HCV" or "hepatitis C virus" and "diabetes" or "insulin resistance". We includ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v23.i9.1697

    authors: Desbois AC,Cacoub P

    更新日期:2017-03-07 00:00:00

  • Rationale for the potential use of mesenchymal stromal cells in liver transplantation.

    abstract::Mesenchymal stromal cells (MSCs) are multipotent and self-renewing cells that reside essentially in the bone marrow as a non-hematopoietic cell population, but may also be isolated from the connective tissues of most organs. MSCs represent a heterogeneous population of adult, fibroblast-like cells characterized by the...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v20.i44.16418

    authors: Vandermeulen M,Grégoire C,Briquet A,Lechanteur C,Beguin Y,Detry O

    更新日期:2014-11-28 00:00:00

  • Escalating complexity of endoscopic retrograde cholangiopancreatography over the last decade with increasing reliance on advanced cannulation techniques.

    abstract:BACKGROUND:At our academic tertiary care medical center, we have noted patients referred for endoscopic retrograde cholangiopancreatography (ERCP) who increasingly require advanced cannulation techniques. This trend is noted despite increased endoscopist experience and annual ERCP volume over the same period. AIM:To e...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v26.i41.6391

    authors: Barakat MT,Girotra M,Thosani N,Kothari S,Banerjee S

    更新日期:2020-11-07 00:00:00

  • Eicosanoid pathway in colorectal cancer: Recent updates.

    abstract::Enzymatic metabolism of the 20C polyunsaturated fatty acid (PUFA) arachidonic acid (AA) occurs via the cyclooxygenase (COX) and lipoxygenase (LOX) pathways, and leads to the production of various bioactive lipids termed eicosanoids. These eicosanoids have a variety of functions, including stimulation of homeostatic re...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v21.i41.11748

    authors: Tuncer S,Banerjee S

    更新日期:2015-11-07 00:00:00

  • A critical role of gastric mucosal ascorbic acid in the progression of acute gastric mucosal lesions induced by compound 48/80 in rats.

    abstract:AIM:To study the role of gastric mucosal ascorbic acid (AA) in the progression of acute gastric mucosal lesions induced by compound 48/80 (C48/80), a mast cell degranulator, in rats. METHODS:C48/80 (0.75 mg/kg) was intraperitoneally injected to fasted Wistar rats. Oral administration of AA (10, 50 or 100 mg/kg) was pe...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i9.1324

    authors: Kamiya Y,Ohta Y,Imai Y,Arisawa T,Nakano H

    更新日期:2005-03-07 00:00:00

  • Chemotherapy beyond second-line in advanced gastric cancer.

    abstract::Patients with advanced gastric cancer (AGC) can be treated with multiple lines of chemotherapy. Although several randomized trials have demonstrated the benefit of second-line chemotherapy compared with best supportive care, there is no evidence that further lines of chemotherapy will result in substantial prolongatio...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v21.i29.8811

    authors: Kim SM,Park SH

    更新日期:2015-08-07 00:00:00

  • Biodegradable stents in gastrointestinal endoscopy.

    abstract::Biodegradable stents (BDSs) are an attractive option to avoid ongoing dilation or surgery in patients with benign stenoses of the small and large intestines. The experience with the currently the only BDS for endoscopic placement, made of Poly-dioxanone, have shown promising results. However some aspects should be imp...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v20.i9.2212

    authors: Lorenzo-Zúñiga V,Moreno-de-Vega V,Marín I,Boix J

    更新日期:2014-03-07 00:00:00

  • Protein kinase C/zeta (PRKCZ) gene is associated with type 2 diabetes in Han population of North China and analysis of its haplotypes.

    abstract:AIM:To identify the susceptible gene (s) for type 2 diabetes in the previously mapped region, 1p36.33-p36.23, in Han population of North China using single nucleotide polymorphisms (SNPs) and to analyze the haplotypes of the gene (s) related to type 2 diabetes. METHODS:Twenty three SNPs located in 10 candidate genes i...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v9.i9.2078

    authors: Li YF,Sun HX,Wu GD,Du WN,Zuo J,Shen Y,Qiang BQ,Yao ZJ,Wang H,Huang W,Chen Z,Xiong MM,Meng Y,Fang FD

    更新日期:2003-09-01 00:00:00

  • Novel method for extracting exosomes of hepatocellular carcinoma cells.

    abstract:AIM:To develop a novel method for the rapid and efficient extraction of exosomes secreted by tumor cells. METHODS:Unlike the traditional extraction method, the supernatants of cell cultures were concentrated, and the exosomes were isolated promptly and effectively using a novel nanomaterial called ExoQuick. Coomassie ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v20.i21.6651

    authors: Zhu L,Qu XH,Sun YL,Qian YM,Zhao XH

    更新日期:2014-06-07 00:00:00

  • Molecular targeted therapy for hepatocellular carcinoma: current and future.

    abstract::Hepatocellular carcinoma (HCC) is one of the most frequent tumors worldwide. The majority of HCC cases occur in patients with chronic liver disease. Despite regular surveillance to detect small HCC in these patients, HCC is often diagnosed at an advanced stage. Because HCC is highly resistant to conventional systemic ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v19.i37.6144

    authors: Shin JW,Chung YH

    更新日期:2013-10-07 00:00:00

  • Mutations of pre-core and basal core promoter before and after hepatitis B e antigen seroconversion.

    abstract:AIM:To investigate the role of pre-core and basal core promoter (BCP) mutations before and after hepatitis B e antigen (HBeAg) seroconversion. METHODS:The proportion of pre-core (G1896A) and basal core promoter (A1762T and G1764A) mutant viruses and serum levels of hepatitis B virus (HBV) DNA, hepatitis B surface anti...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v21.i2.541

    authors: Kamijo N,Matsumoto A,Umemura T,Shibata S,Ichikawa Y,Kimura T,Komatsu M,Tanaka E

    更新日期:2015-01-14 00:00:00

  • Fields of applications, diagnostic yields and findings of OMOM capsule endoscopy in 2400 Chinese patients.

    abstract:AIM:To retrospectively analyze the fields of application, diagnostic yields and findings of OMOM capsule endoscopy in Chinese patients. METHODS:A database including 2400 Chinese patients who received OMOM capsule endoscopy in 27 endoscopy centers in China was retrieved from the Jianshan Science and Technology Ltd. OMO...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v16.i21.2669

    authors: Liao Z,Gao R,Li F,Xu C,Zhou Y,Wang JS,Li ZS

    更新日期:2010-06-07 00:00:00

  • Basaloid squamous carcinoma of esophagus:a clinicopathological, immunohistochemical and electron microscopic study of sixteen cases.

    abstract::AIM:To further clarify the clinicopathological, immunohistochemical and electron microscopic features, and prognostic aspect of basaloid squamous carcinoma (BSC), a rare esophageal carcinoma.METHODS:We reviewed 763 documented cases of esophageal malignancies from year (1977-1996) from our hospital, and discovered 16 (...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v4.i5.397

    authors: Zhang XH,Sun GQ,Zhou XJ,Guo HF,Zhang TH

    更新日期:1998-10-01 00:00:00

  • Effects of urotensin-II on cytokines in early acute liver failure in mice.

    abstract:AIM:To investigate urotensin-II (UII) and its effects on tumor necrosis factor (TNF)-α and interleukin (IL)-1β in early acute liver failure (ALF). METHODS:We investigated the time-dependent alteration in UII levels and its effects on TNF-α and IL-1β in liver and blood in the early stage of lipopolysaccharide/D-galacto...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v21.i11.3239

    authors: Liu LM,Zhao L,Liang DY,Yu FP,Ye CG,Tu WJ,Zhu T

    更新日期:2015-03-21 00:00:00

  • Nonalcoholic fatty liver disease as a multi-systemic disease.

    abstract::Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease. NAFLD includes a wide spectrum of liver conditions ranging from simple steatosis to nonalcoholic steatohepatitis and advanced hepatic fibrosis. NAFLD has been recognized as a hepatic manifestation of metabolic syndrome linked w...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v22.i16.4079

    authors: Fotbolcu H,Zorlu E

    更新日期:2016-04-28 00:00:00

  • Selection of a peptide mimicking neutralization epitope of hepatitis E virus with phage peptide display technology.

    abstract:AIM:To select the peptide mimicking the neutralization epitope of hepatitis E virus which bound to non-type-specific and conformational monoclonal antibodies (mAbs) 8C11 and 8H3 fromed 7-peptide phage display library, and expressed the peptide recombinant with HBcAg in E.coli, and to observe whether the recombinant HBc...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v10.i11.1583

    authors: Gu Y,Zhang J,Wang YB,Li SW,Yang HJ,Luo WX,Xia NS

    更新日期:2004-06-01 00:00:00

  • Oxaliplatin-induced severe anaphylactic reactions in metastatic colorectal cancer: case series analysis.

    abstract:AIM:To investigate oxaliplatin-induced severe anaphylactic reactions (SAR) in metastatic colorectal cancer in a retrospective case series analysis and to conduct a systemic literature review. METHODS:During a 6-year period from 2006 to 2011 at Kaohsiung Veterans General Hospital, a total of 412 patients exposed to oxa...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v18.i38.5427

    authors: Wang JH,King TM,Chang MC,Hsu CW

    更新日期:2012-10-14 00:00:00

  • Therapeutic procedures for submucosal tumors in the gastrointestinal tract.

    abstract::This review is part three of three and will present an update on the therapeutic options and procedures concerning gastrointestinal (GI) submucosal tumors (SMTs). The aim of this paper is to investigate the treatments of GI SMTs and to present a case of a gastrointestinal stromal tumor (GIST). Literature searches were...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v13.i24.3316

    authors: Ponsaing LG,Hansen MB

    更新日期:2007-06-28 00:00:00

  • Virulence and potential pathogenicity of coccoid Helicobacter pylori induced by antibiotics.

    abstract:AIM:To explore the virulence and the potential pathogenicity of coccoid Helicobacter pylori (H. pylori) transformed from spiral form by exposure to antibiotic. METHODS:Three strains of H. pylori, isolated from gastric biopsy specimens of confirmed peptic ulcer, were converted from spiral into coccoid from by exposure ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v7.i2.254

    authors: She FF,Su DH,Lin JY,Zhou LY

    更新日期:2001-04-01 00:00:00

  • Constant serum levels of secreted asialoglycoprotein receptor sH2a and decrease with cirrhosis.

    abstract:AIM:To investigate the existence and levels of sH2a, a soluble secreted form of the asialoglycoprotein receptor in human serum. METHODS:Production of recombinant sH2a and development of a monoclonal antibody and an enzyme-linked immunosorbent assay (ELISA). This assay was used to determine the presence and concentrati...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v17.i48.5305

    authors: Benyair R,Kondratyev M,Veselkin E,Tolchinsky S,Shenkman M,Lurie Y,Lederkremer GZ

    更新日期:2011-12-28 00:00:00

  • Possible ameliorative effect of breastfeeding and the uptake of human colostrum against coeliac disease in autistic rats.

    abstract:AIM:To examine the possible ameliorative effect of breastfeeding and the uptake of human colostrum against coeliac disease in autistic rats. METHODS:Female rats were fed a standard diet and received a single intraperitoneal injection of 600 mg/kg sodium valproate on day 12.5 after conception. In study 1, neonatal rats...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v19.i21.3281

    authors: Selim ME,Al-Ayadhi LY

    更新日期:2013-06-07 00:00:00

  • Relationship between methylation and colonic inflammation in inflammatory bowel disease.

    abstract:AIM:To investigate the relationship between the methylation status in the SLIT2 and TGFB2 promoters and colonic inflammation in inflammatory bowel disease patients. METHODS:We evaluated the methylation status of 2 genes (SLIT2 and TGFB2) in 226 biopsies taken from 62 colonoscopies of 38 patients (29 ulcerative colitis...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v20.i30.10591

    authors: Lobatón T,Azuara D,Rodríguez-Moranta F,Loayza C,Sanjuan X,de Oca J,Fernández-Robles A,Guardiola J,Capellá G

    更新日期:2014-08-14 00:00:00

  • Human antigen R mediated post-transcriptional regulation of inhibitors of apoptosis proteins in pancreatic cancer.

    abstract:AIM:To determine the association of human antigen R (HuR) and inhibitors of apoptosis proteins (IAP1, IAP2) and prognosis in pancreatic cancer. METHODS:Protein and mRNA expression levels of IAP1, IAP2 and HuR in pancreatic ductal adenocarcinoma (PDAC) were compared with normal pancreatic tissue. The correlations among...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v25.i2.205

    authors: Lukosiute-Urboniene A,Jasukaitiene A,Silkuniene G,Barauskas V,Gulbinas A,Dambrauskas Z

    更新日期:2019-01-14 00:00:00

  • Pseudolymphoma of the liver associated with primary biliary cirrhosis: a case report and review of literature.

    abstract::We report a case of two pseudolymphomas of the liver in a 63-year-old Japanese woman with primary biliary cirrhosis. One of the lesions was found incidentally during a medical examination, presenting as a 10 mm hypodense nodule that revealed hyperdensity in the early phase and hypodensity in the late phase in computed...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.15.4587

    authors: Okada T,Mibayashi H,Hasatani K,Hayashi Y,Tsuji S,Kaneko Y,Yoshimitsu M,Tani T,Zen Y,Yamagishi M

    更新日期:2009-09-28 00:00:00

  • Relationship between microvessel count and post-hepatectomy survival in patients with hepatocellular carcinoma.

    abstract:AIM:To elucidate the relationship between the microvessel count (MVC) by CD34 analyzed by immunohistochemical method and prognosis in hepatocellular carcinoma (HCC) patients who underwent hepatectomy based on our preliminary study. METHODS:We examined relationships between MVC and clinicopathological factors in 128 HC...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.14.4915

    authors: Nanashima A,Nakayama T,Sumida Y,Abo T,Takeshita H,Shibata K,Hidaka S,Sawai T,Yasutake T,Nagayasu T

    更新日期:2008-08-21 00:00:00

  • Safety of interferon beta treatment for chronic HCV hepatitis.

    abstract::Hepatitis C is a major cause of liver-related morbidity and mortality worldwide. In fact, chronic hepatitis C is considered as one of the primary causes of chronic liver disease, cirrhosis and hepatocellular carcinoma, and is the most common reason for liver transplantation. The primary objectives for the treatment of...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v10.i1.12

    authors: Festi D,Sandri L,Mazzella G,Roda E,Sacco T,Staniscia T,Capodicasa S,Vestito A,Colecchia A

    更新日期:2004-01-01 00:00:00