Molecular targeted therapy for hepatocellular carcinoma: current and future.

abstract：AIM:To detect distribution and relative frequency of endocrine cells in gastrointestinal tract of flower fish (Pseudophoxinus antalyae). METHODS:The intestinal tract of flower fish was divided into four portions from proximal to distal; the enlarged area after oesophagus and anterior, middle and posterior intestine. I...

journal_title：World journal of gastroenterology

authors： Cinar K,Senol N,Ozen MR

更新日期：2006-11-14 00:00:00

abstract：:Mesenchymal stem cells (MSC) are cells of stromal origin which exhibit unlimited self-renewal capacity and pluripotency in vitro. It has recently been observed that MSC may also exert a profound immunosuppressive and anti-inflammatory effect both in vitro and in vivo with consequent potential use in autoimmune disorde...

journal_title：World journal of gastroenterology

authors： Taddio A,Tommasini A,Valencic E,Biagi E,Decorti G,De Iudicibus S,Cuzzoni E,Gaipa G,Badolato R,Prandini A,Biondi A,Ventura A

更新日期：2015-04-14 00:00:00

abstract：:Significant disparities exist between genders for the development and progression of several gastro-intestinal (GI) diseases including cancer. Differences in incidence between men vs women for colon, gastric and hepatocellular cancers suggest a role for steroid sex hormones in regulation of GI carcinogenesis. Involvem...

journal_title：World journal of gastroenterology

authors： Sukocheva OA,Li B,Due SL,Hussey DJ,Watson DI

更新日期：2015-05-28 00:00:00

abstract：AIM:To evaluate the role of mitochondrial microsatellite instability (mtMSI) in gastric carcinogenesis. METHODS:MtMSI was measured with PCR-single strand conformation polymorphism (PCR-SSCP) in 68 cases of advanced gastric cancer, 40 cases of chronic gastritis, 30 cases of intestinal metaplasia and 20 cases of dysplas...

journal_title：World journal of gastroenterology

authors： Ling XL,Fang DC,Wang RQ,Yang SM,Fang L

更新日期：2004-03-15 00:00:00

abstract：:Management of acute diarrhea remains a global challenge, particularly in resource-limiting countries. Oral rehydration solution (ORS), a passive rehydrating therapy developed approximately 40 years ago, remains the mainstay treatment. Although ORS is effective for hydration, since it does not inhibit enterotoxin-media...

journal_title：World journal of gastroenterology

authors： Cheng SX

更新日期：2016-03-07 00:00:00

abstract：AIM:As the conventional combined liver-small bowel transplantation is complicated with many postoperative complications, the aim of this study was to describe a modified technique for the combined liver-small bowel transplantation with preservation of the duodenum, partial head of pancreas and hepatic biliary system in...

journal_title：World journal of gastroenterology

authors： Yin ZY,Ni XD,Jiang F,Li N,Li YS,Li JS

更新日期：2003-07-01 00:00:00

abstract：AIM:To evaluate the effects of ginger on gastric motility and emptying, abdominal symptoms, and hormones that influence motility in dyspepsia. METHODS:Eleven patients with functional dyspepsia were studied twice in a randomized double-blind manner. After an 8-h fast, the patients ingested three capsules that contained...

journal_title：World journal of gastroenterology

authors： Hu ML,Rayner CK,Wu KL,Chuah SK,Tai WC,Chou YP,Chiu YC,Chiu KW,Hu TH

更新日期：2011-01-07 00:00:00

abstract：AIM:To study the relationship between the patterns of postprandial peristalsis and transduodenal bolus transport in healthy subjects. METHODS:Synchronous recording of chyme transport and peristaltic activity was performed during the fasting state and after administration of a test meal using a special catheter device ...

journal_title：World journal of gastroenterology

authors： Nguyen HN,Winograd R,Domingues GR,Lammert F

更新日期：2006-10-07 00:00:00

abstract：:Novel molecular targets are being discovered as we learn more about the aberrant processes underlying various cancers. Efforts to translate this knowledge are starting to impact on the care of patients with gastrointestinal cancers. The epidermal growth factor receptor (EGFR) pathway and angiogenesis have been targete...

journal_title：World journal of gastroenterology

authors： Ma WW,Hidalgo M

更新日期：2007-11-28 00:00:00

abstract：AIM:To investigate the expression of three types of mucin (MUC1, MUC2, MUC5AC) and E-cadherin in human gastric carcinomas and their clinical significance. METHODS:Ninety-four gastric cancer specimens were classified according to WHO criteria and detected by immunohistochemical assay of expression of mucins and E-cadhe...

journal_title：World journal of gastroenterology

authors： Zhang HK,Zhang QM,Zhao TH,Li YY,Yi YF

更新日期：2004-10-15 00:00:00

abstract：AIM:To establish an animal model with human hepatocyte-repopulated liver for the study of liver cancer metastasis. METHODS:Cell transplantation into mouse livers was conducted using alpha-fetoprotein (AFP)-producing human gastric cancer cells (h-GCCs) and h-hepatocytes as donor cells in a transgenic mouse line express...

journal_title：World journal of gastroenterology

authors： Fujiwara S,Fujioka H,Tateno C,Taniguchi K,Ito M,Ohishi H,Utoh R,Ishibashi H,Kanematsu T,Yoshizato K

更新日期：2012-08-07 00:00:00

abstract：AIM:To investigate control of two different types of massive presacral bleeding according to the anatomy of the presacral venous system. METHODS:A retrospective review was performed in 1628 patients with middle or low rectal carcinoma who were treated surgically in the Department of Colorectal Surgery, Changhai Hospit...

journal_title：World journal of gastroenterology

authors： Lou Z,Zhang W,Meng RG,Fu CG

更新日期：2013-07-07 00:00:00

abstract：:Proteus syndrome is an extremely rare congenital disorder that produces multifocal overgrowth of tissue. This report presents a surgical case of a large lipoma in the abdominal wall of a patient with Proteus syndrome. She was diagnosed with Proteus syndrome based on certain diagnostic criteria. The neoplasm increased ...

journal_title：World journal of gastroenterology

authors： Nakayama Y,Kusuda S,Nagata N,Yamaguchi K

更新日期：2009-07-14 00:00:00

abstract：AIM:To evaluate the role of RARalpha gene in mediating the growth inhibitory effect of all-trans retinoic acid (ATRA) on gastric cancer cells. METHODS:The expression levels of retinoic acid receptors (RARs) in gastric cancer cells were detected by Northern blot. Transient transfection and chlorophenicol acetyl transfe...

journal_title：World journal of gastroenterology

authors： Liu S,Wu Q,Chen ZM,Su WJ

更新日期：2001-10-01 00:00:00

abstract：AIM:To determine whether a specific adenosine A(2A) receptor agonist (ATL-146e) can ameliorate aspirin-induced gastric mucosal lesions in rats, and reduce neutrophil accumulation and production of pro-inflammatory cytokines. METHODS:Gastric lesions were produced by oral gavage of aspirin (200 mg/kg) and HCl (0.15 mol/...

journal_title：World journal of gastroenterology

authors： Odashima M,Otaka M,Jin M,Komatsu K,Wada I,Horikawa Y,Matsuhashi T,Hatakeyama N,Oyake J,Ohba R,Watanabe S,Linden J

更新日期：2006-01-28 00:00:00

abstract：AIM:The significance of hepatitis C virus (HCV) serum titers has been examined in several clinical situations. There is much evidence that patients with a lower viral load have better response rates to anti-viral therapy compared to those with higher levels. Moreover, a direct association has been observed between seru...

journal_title：World journal of gastroenterology

authors： Anand BS,Velez M

更新日期：2004-08-15 00:00:00

abstract：:The thrombophilia in adult life has major implications in the hepatic vessels. The resulting portal vein thrombosis has various outcomes and complications. Esophageal varices, portal gastropathy, ascites, severe hypersplenism and liver failure needing liver transplantation are known well. The newly formed collateral v...

journal_title：World journal of gastroenterology

authors： Harmanci O,Bayraktar Y

更新日期：2007-05-14 00:00:00

abstract：:Liver cancer is one of the world's most common cancers and the second leading cause of cancer deaths. Hepatocellular carcinoma (HCC), a primary hepatic cancer, accounts for 90%-95% of liver cancer cases. The pathogenesis of HCC consists of a stepwise process of liver damage that extends over decades, due to hepatitis,...

journal_title：World journal of gastroenterology

authors： Lu JW,Ho YJ,Yang YJ,Liao HA,Ciou SC,Lin LI,Ou DL

更新日期：2015-11-14 00:00:00

abstract：AIM:To evaluate the impact of therapeutic education on adherence to antiviral treatment and sustained virological response (SVR) in a real-life setting in genotype 2/3 hepatitis C, as there are few adherence data in genotype 2/3 infection, even from randomized trials. METHODS:This prospective survey included genotype ...

journal_title：World journal of gastroenterology

authors： Cacoub P,Ouzan D,Melin P,Lang JP,Rotily M,Fontanges T,Varastet M,Chousterman M,Marcellin P

更新日期：2008-10-28 00:00:00

abstract：:Based on reviews of the literature and experts' consensus, the Chinese Society of Hepatology developed guidelines for the diagnosis and treatment of liver cirrhosis, in order to improve clinical practice. In addition to what has been covered in previously published guidelines on the management of cirrhosis complicatio...

journal_title：World journal of gastroenterology

authors： Xu XY,Ding HG,Li WG,Xu JH,Han Y,Jia JD,Wei L,Duan ZP,Ling-Hu EQ,Zhuang H

更新日期：2020-12-07 00:00:00

abstract：BACKGROUND:At our academic tertiary care medical center, we have noted patients referred for endoscopic retrograde cholangiopancreatography (ERCP) who increasingly require advanced cannulation techniques. This trend is noted despite increased endoscopist experience and annual ERCP volume over the same period. AIM:To e...

journal_title：World journal of gastroenterology

authors： Barakat MT,Girotra M,Thosani N,Kothari S,Banerjee S

更新日期：2020-11-07 00:00:00

abstract：AIM:To study the influence of redox environment of Escherichia coli (E. coli) cytoplasm on disulfide bond formation of recombinant proteins. METHODS:Bovine fibroblast growth factor (BbFGF) was selected as a model of simple proteins with a single disulfide bond and free cysteines. Anti-HBsAg single-chain Fv (HBscFv), a...

journal_title：World journal of gastroenterology

authors： Xiong S,Wang YF,Ren XR,Li B,Zhang MY,Luo Y,Zhang L,Xie QL,Su KY

更新日期：2005-02-21 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the major causes of morbidity and mortality in patients with chronic liver disease. Transarterial chemoembolization (TACE) can significantly improve the survival rate of patients with HCC and is the first treatment choice for patients who are not suitable for surgical resection...

journal_title：World journal of gastroenterology

authors： Yang K,Zhang XM,Yang L,Xu H,Peng J

更新日期：2016-05-28 00:00:00

abstract：AIM:To study the effect of selenium on peripheral blood mononuclear cell (PBMC) membrane fluidity and immune function in patients with chronic hepatitis. METHODS:PBMCs were pretreated with selenium (1.156x10(-7) mol/L) for 6 h in vitro or extracted directly from patients after administration of selenium-yeast continuo...

journal_title：World journal of gastroenterology

authors： He SX,Wu B,Chang XM,Li HX,Qiao W

更新日期：2004-12-01 00:00:00

abstract：:Desmoid tumor is a locally invasive, myofibroblastic, nonmetastatic tumor. Its pathogenesis remains unclear and it may involve genetic abnormalities, sex hormones and traumatic injury, including surgery. Postoperative intra-abdominal desmoid tumor is rare, especially in the retroperitoneum. We report a case of postope...

journal_title：World journal of gastroenterology

authors： Shih LY,Wei CK,Lin CW,Tseng CE

更新日期：2012-11-14 00:00:00

abstract：:To review the implication of CXCR4 for gastrointestinal cancer, a "Pubmed" analysis was performed in order to evaluate the relevance of CXCR4 and its ligands for gastrointestinal cancers. Search terms applied were "cancer, malignoma, esophageal, gastric, colon, colorectal, hepatic, pancreatic, CXCR4, SDF-1alpha, and S...

journal_title：World journal of gastroenterology

authors： Schimanski CC,Galle PR,Moehler M

更新日期：2008-08-14 00:00:00

abstract：AIM:To study the effect of nicotine on the migration and invasion of human esophageal squamous carcinoma cells and to investigate whether nimesulide can inhibit the effect of nicotine. METHODS:The esophageal squamous carcinoma cell line (TE-13) was treated with different concentrations of nicotine (100 microg/mL and 2...

journal_title：World journal of gastroenterology

authors： Zong Y,Zhang ST,Zhu ST

更新日期：2009-05-28 00:00:00

abstract：AIM:To investigate the expression of gastrokine 1 (GKN1) in normal gastric mucosa, precancerous lesions and gastric cancer tissues, and to analyse its correlations with tumour site and pathological pattern. METHODS:Thirty gastric cancer patients (12 cases of diffuse type and 18 cases of intestinal type), 13 atrophic g...

journal_title：World journal of gastroenterology

authors： Guo XY,Dong L,Qin B,Jiang J,Shi AM

更新日期：2014-11-28 00:00:00

abstract：AIM:To investigate the role of single nucleotide polymorphisms (SNPs) in CD24 gene in susceptibility and overall survival of gastric cancer (GC). METHODS:We genotyped 3 tagging SNPs of CD24-P-534 in the promoter region, P170 in the coding region of exon 2 and P1527 in the 3' untranslated region - using polymerase chai...

journal_title：World journal of gastroenterology

authors： Jia ZF,Wang LZ,Cao XY,Wang C,Cao DH,Wu X,You LL,Jin MS,Wang YP,Zhou BS,Jiang J

更新日期：2016-02-21 00:00:00

abstract：BACKGROUND:Lifestyle factors such as body mass index (BMI), alcohol drinking, and cigarette smoking, are likely to impact the prognosis of gastric cancer, but the evidence has been inconsistent. AIM:To investigate the association of lifestyle factors and long-term prognosis of gastric cancer patients in the China Nati...

journal_title：World journal of gastroenterology

authors： Zhao LL,Huang H,Wang Y,Wang TB,Zhou H,Ma FH,Ren H,Niu PH,Zhao DB,Chen YT

更新日期：2020-04-14 00:00:00