Mitochondrial microsatellite instability in gastric cancer and its precancerous lesions.

Abstract:

AIM:To evaluate the role of mitochondrial microsatellite instability (mtMSI) in gastric carcinogenesis. METHODS:MtMSI was measured with PCR-single strand conformation polymorphism (PCR-SSCP) in 68 cases of advanced gastric cancer, 40 cases of chronic gastritis, 30 cases of intestinal metaplasia and 20 cases of dysplasia. RESULTS:MtMSI was observed in 12.5% (5 of 40) of chronic gastritis, 20.0% (6 of 30) of intestinal metaplasia, 25.0% (5 of 20) of dysplasia and 38.2% (26 of 68) of gastric cancer. These findings showed a sequential accumulation of mtMSI in the histological progression from chronic gastritis to gastric cancer. An association of mtMSI with intestinal histological type and distal location was found (P=0.001 and P=0.002), whereas no significant correlation was found between mtMSI and age at diagnosis, sex, tumor size, depth of invasion, lymph node spread and clinical stages (P>0.05). CONCLUSION:MtMSI may play an early and important role in the gastric carcinogenesis pathway, especially in the intestinal type and distal gastric cancer.

journal_name

World J Gastroenterol

authors

Ling XL,Fang DC,Wang RQ,Yang SM,Fang L

doi

10.3748/wjg.v10.i6.800

keywords:

subject

Has Abstract

pub_date

2004-03-15 00:00:00

pages

800-3

issue

6

eissn

1007-9327

issn

2219-2840

journal_volume

10

pub_type

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