Chemokine receptor CXCR4-prognostic factor for gastrointestinal tumors.

Abstract:

:To review the implication of CXCR4 for gastrointestinal cancer, a "Pubmed" analysis was performed in order to evaluate the relevance of CXCR4 and its ligands for gastrointestinal cancers. Search terms applied were "cancer, malignoma, esophageal, gastric, colon, colorectal, hepatic, pancreatic, CXCR4, SDF-1alpha, and SDF-1beta". CXCR4 expression correlated with dissemination of diverse gastrointestinal malignomas. The CXCR4 ligand SDF-1alpha might act as "chemorepellent" while SDF-1beta might act as "chemorepellent" for CTLs, inducing tumor rejection. The paracrine expression of SDF-1alpha was furthermore closely associated with neoangiogenesis. CXCR4 and its ligands influence the dissemination, immune rejection, and neoangiogenesis of human gastrointestinal cancers. Inhibition of CXCR4 might be an interesting therapeutic option.

journal_name

World J Gastroenterol

authors

Schimanski CC,Galle PR,Moehler M

doi

10.3748/wjg.14.4721

subject

Has Abstract

pub_date

2008-08-14 00:00:00

pages

4721-4

issue

30

eissn

1007-9327

issn

2219-2840

journal_volume

14

pub_type

社论,评审
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    pub_type: 杂志文章

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    更新日期:2019-02-28 00:00:00

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    pub_type: 杂志文章,评审

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    更新日期:2008-08-28 00:00:00

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    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v13.i22.3056

    authors: Verrecchia F,Mauviel A

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    更新日期:2005-12-28 00:00:00

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    abstract:AIM:To determine whether circular RNAs (circRNAs) are involved in pathological processes of gastric cancer (GC). METHODS:Three circRNAs with differential expression in GC and colorectal cancer were randomly selected for validation by quantitative reverse transcription-polymerase chain reaction (qRT-PCR), using 20 pair...

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    pub_type: 杂志文章,随机对照试验

    doi:10.3748/wjg.v23.i34.6330

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    更新日期:2017-09-14 00:00:00

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    abstract::Hepatitis B virus (HBV) is a very common infection worldwide. Its reactivation in patients receiving immunosuppression has been widely described as being associated with significant morbidity and mortality unless anti-viral prophylaxis is administered. Treatment in inflammatory bowel disease (IBD) patients has changed...

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    pub_type: 杂志文章,评审

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    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v16.i16.1939

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    pub_type: 临床试验,杂志文章

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    authors: Guan YS,Zheng XH,Zhou XP,Huang J,Sun L,Chen X,Li X,He Q

    更新日期:2004-07-15 00:00:00

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    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v20.i32.11262

    authors: Zhang XD,Zhang LJ,Wu SY,Lu GM

    更新日期:2014-08-28 00:00:00

  • Integrin-linked kinase overexpression promotes epithelial-mesenchymal transition via nuclear factor-κB signaling in colorectal cancer cells.

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    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v22.i15.3969

    authors: Shen H,Ma JL,Zhang Y,Deng GL,Qu YL,Wu XL,He JX,Zhang S,Zeng S

    更新日期:2016-04-21 00:00:00

  • Do the expressions of gap junction gene connexin messenger RNA in noncancerous liver remnants of patients with hepatocellular carcinoma correlate with postoperative recurrences?

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    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i2.171

    authors: Sheen IS,Jeng KS,Shih SC,Kao CR,Wang PC,Chen CZ,Chang WH,Wang HY,Shyung LR

    更新日期:2005-01-14 00:00:00

  • Pancreatic guidewire placement for achieving selective biliary cannulation during endoscopic retrograde cholangio-pancreatography.

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    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.14.5595

    authors: Ito K,Fujita N,Noda Y,Kobayashi G,Obana T,Horaguchi J,Takasawa O,Koshita S,Kanno Y

    更新日期:2008-09-28 00:00:00

  • Long-term result of endoscopic Histoacryl (N-butyl-2-cyanoacrylate) injection for treatment of gastric varices.

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    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v17.i11.1494

    authors: Kang EJ,Jeong SW,Jang JY,Cho JY,Lee SH,Kim HG,Kim SG,Kim YS,Cheon YK,Cho YD,Kim HS,Kim BS

    更新日期:2011-03-21 00:00:00

  • Utility of endoscopic ultrasound, cytology and fluid carcinoembryonic antigen and CA 19-9 levels in pancreatic cystic lesions.

    abstract:AIM:To assess the diagnostic accuracy of endoscopic ultrasound (EUS), fluid tumor markers and cytology in distinguishing benign from (pre)malignant pancreatic cystic lesions. METHODS:46 consecutive patients, referred to a gastroenterologist and surgeon for a symptomatic or incidental pancreatic cyst, were reviewed. EU...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v13.i29.3962

    authors: Aljebreen AM,Romagnuolo J,Perini R,Sutherland F

    更新日期:2007-08-07 00:00:00