Effect of the timing of gluten introduction on the development of celiac disease.

Abstract:

:Celiac disease (CD) is a permanent auto-immune enteropathy, triggered in genetically predisposed individuals by the ingestion of dietary gluten. Gluten is the alcohol-soluble protein component of the cereals wheat, rye and barley. CD is a multifactorial condition, originating from the interplay of genetic and environmental factors. The necessary environmental trigger is gluten, while the genetic predisposition has been identified in the major histocompatibility complex region on chromosome 6p21, with over 90% of CD patients expressing HLA DQ2 and the remaining celiac patients express DQ8. The fact that only about 4% of DQ2/8-positive individuals exposed to gluten develop CD, has led to the recognition that other genetic and environmental factors are also necessary. In the last few years, several epidemiological studies have suggested that the timing of the introduction of gluten, as well as the pattern of breastfeeding, may play an important role in the subsequent development of CD. Here, we present and review the most recent evidences regarding the effect of timing of gluten introduction during weaning, the amount of gluten introduced and simultaneous breastfeeding, on the development of CD.

journal_name

World J Gastroenterol

authors

Silano M,Agostoni C,Guandalini S

doi

10.3748/wjg.v16.i16.1939

subject

Has Abstract

pub_date

2010-04-28 00:00:00

pages

1939-42

issue

16

eissn

1007-9327

issn

2219-2840

journal_volume

16

pub_type

杂志文章,评审
  • Multicenter, randomized study to optimize bowel preparation for colon capsule endoscopy.

    abstract:AIM:To assess the cleansing efficacy and safety of a new Colon capsule endoscopy (CCE) bowel preparation regimen. METHODS:This was a multicenter, prospective, randomized, controlled study comparing two CCE regimens. Subjects were asymptomatic and average risk for colorectal cancer. The second generation CCE system (Pi...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.3748/wjg.v23.i48.8615

    authors: Kastenberg D,Burch WC Jr,Romeo DP,Kashyap PK,Pound DC,Papageorgiou N,Sainz IF,Sokach CE,Rex DK

    更新日期:2017-12-28 00:00:00

  • Circulating miR-125a but not miR-125b is decreased in active disease status and negatively correlates with disease severity as well as inflammatory cytokines in patients with Crohn's disease.

    abstract:AIM:To determine the association of circulating miR-125a/b expression with the risk and disease severity of Crohn's disease (CD), and with inflammatory cytokines. METHODS:Plasma samples were collected from patients with active CD (A-CD), or CD in remission (R-CD) and from healthy controls (HCs). The levels of the infl...

    journal_title:World journal of gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.3748/wjg.v23.i44.7888

    authors: Sun CM,Wu J,Zhang H,Shi G,Chen ZT

    更新日期:2017-11-28 00:00:00

  • Endoscopic ultrasound-guided biliary drainage: Bilateral systems drainage via left duct approach.

    abstract::Endoscopic ultrasound (EUS)-guided biliary drainage is accepted as a less invasive, alternative treatment for patients in whom endoscopic retrograde cholangiopancreatography has failed. Most patients with malignant hilar obstruction undergo EUS-guided hepaticogastrostomy. The authors present the case of a 77-year-old ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v21.i34.10045

    authors: Prachayakul V,Aswakul P

    更新日期:2015-09-14 00:00:00

  • Hepatitis C in non-hepatic solid organ transplant candidates and recipients: A new horizon.

    abstract::Hepatitis C virus (HCV) infection is estimated to affect 130-150 million people globally which corresponds to 2%-3% of the total world population. It remains the leading indication for liver transplant worldwide and has been demonstrated to negatively impact both patient and graft survival following non-hepatic organ ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v22.i4.1650

    authors: Belga S,Doucette KE

    更新日期:2016-01-28 00:00:00

  • Ethanol and liver: recent insights into the mechanisms of ethanol-induced fatty liver.

    abstract::Alcoholic fatty liver disease (AFLD), a potentially pathologic condition, can progress to steatohepatitis, fibrosis, and cirrhosis, leading to an increased probability of hepatic failure and death. Alcohol induces fatty liver by increasing the ratio of reduced form of nicotinamide adenine dinucleotide to oxidized form...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v20.i40.14672

    authors: Liu J

    更新日期:2014-10-28 00:00:00

  • Acceptance on colorectal cancer screening upper age limit in South Korea.

    abstract:BACKGROUND:The Korea National Cancer Screening Program currently provides screening for colorectal cancer (CRC) for adults older than 50 years with no upper age limit. In general, people are likely to only pay attention to the benefits of cancer screening and to neglect its risks. Most consider the benefits of cancer s...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v26.i27.3963

    authors: Luu XQ,Lee K,Lee YY,Suh M,Kim Y,Choi KS

    更新日期:2020-07-21 00:00:00

  • Gastroesophageal reflux disease management according to contemporary international guidelines: a translational study.

    abstract:AIM:To test the Genval recommendations and the usefulness of a short trial of proton pump inhibitor (PPI) in the initial management and maintenance treatment of gastroesophageal reflux disease (GERD) patients. METHODS:Five hundred and seventy seven patients with heartburn were recruited. After completing a psychometri...

    journal_title:World journal of gastroenterology

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.3748/wjg.v17.i9.1160

    authors: Pace F,Riegler G,de Leone A,Dominici P,Grossi E,EMERGE Study Group.

    更新日期:2011-03-07 00:00:00

  • CMA down-regulates p53 expression through degradation of HMGB1 protein to inhibit irradiation-triggered apoptosis in hepatocellular carcinoma.

    abstract:AIM:To investigate the mechanism of chaperone-mediated autophagy (CMA)-induced resistance to irradiation-triggered apoptosis through regulation of the p53 protein in hepatocellular carcinoma (HCC). METHODS:Firstly, we detected expression of lysosome-associated membrane protein 2a (Lamp-2a), which is the key protein of...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v23.i13.2308

    authors: Wu JH,Guo JP,Shi J,Wang H,Li LL,Guo B,Liu DX,Cao Q,Yuan ZY

    更新日期:2017-04-07 00:00:00

  • Generation of human/rat xenograft animal model for the study of human donor stem cell behaviors in vivo.

    abstract:AIM:To accurately and realistically elucidate human stem cell behaviors in vivo and the fundamental mechanisms controlling human stem cell fates in vivo, which is urgently required in regenerative medicine and treatments for some human diseases, a surrogate human-rat chimera model was developed. METHODS:Human-rat chim...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v13.i19.2707

    authors: Sun Y,Xiao D,Pan XH,Zhang RS,Cui GH,Chen XG

    更新日期:2007-05-21 00:00:00

  • Effect of gastrectomy with bursectomy on prognosis of gastric cancer: a meta-analysis.

    abstract:AIM:To evaluate the effect of bursectomy on overall survival, recurrence-free survival and safety of patients with gastric cancer by performing a meta-analysis. METHODS:A literature search was performed in PubMed, EMBASE, and the Cochrane Library databases for clinical research that compared bursectomy with non-bursec...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,meta分析,评审

    doi:10.3748/wjg.v20.i40.14986

    authors: Shen WS,Xi HQ,Wei B,Chen L

    更新日期:2014-10-28 00:00:00

  • Acoustic radiation force imaging sonoelastography for noninvasive staging of liver fibrosis.

    abstract:AIM:To investigate the diagnostic accuracy of acoustic radiation force impulse (ARFI) imaging as a noninvasive method for the assessment of liver fibrosis in chronic hepatitis C (CHC) patients. METHODS:We performed a prospective blind comparison of ARFI elastography, APRI index and FibroMax in a consecutive series of ...

    journal_title:World journal of gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.3748/wjg.15.5525

    authors: Fierbinteanu-Braticevici C,Andronescu D,Usvat R,Cretoiu D,Baicus C,Marinoschi G

    更新日期:2009-11-28 00:00:00

  • Characterization of hepatic progenitors from human fetal liver using CD34 as a hepatic progenitor marker.

    abstract:AIM:To enrich putative hepatic progenitors from the developing human fetal liver using CD34 as a marker. METHODS:Aborted fetuses of 13-20 wk were used for the isolation of liver cells. The cells were labeled with anti CD34; a marker used for isolating progenitor population and the cells were sorted using magnetic cell...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v13.i16.2319

    authors: Nyamath P,Alvi A,Habeeb A,Khosla S,Khan AA,Habibullah CM

    更新日期:2007-04-28 00:00:00

  • Strongyloides hyper-infection causing life-threatening gastrointestinal bleeding.

    abstract::A 55-year old male patient was diagnosed with strongy-loides hyper-infection with stool analysis and intestinal biopsy shortly after his chemotherapy for myeloma. He was commenced on albendazole anthelmintic therapy. After initiation of the treatment he suffered life-threatening gastrointestinal (GI) bleeding. Repeate...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v12.i39.6401

    authors: Csermely L,Jaafar H,Kristensen J,Castella A,Gorka W,Chebli AA,Trab F,Alizadeh H,Hunyady B

    更新日期:2006-10-21 00:00:00

  • Multidetector CT in evaluating blood supply of hepatocellular carcinoma after transcatheter arterial chemoembolization.

    abstract:AIM:To assess the value of multidetector-row computed tomography (MDCT) in choosing retreatment methods of hepatocellular carcinoma (HCC) through evaluating the blood supply of low-density area of HCC after transcatheter arterial chemoembolization (TACE). METHODS:Thirty-two patients with HCC after TACE treatment were ...

    journal_title:World journal of gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.3748/wjg.v10.i14.2127

    authors: Guan YS,Zheng XH,Zhou XP,Huang J,Sun L,Chen X,Li X,He Q

    更新日期:2004-07-15 00:00:00

  • Effect of naked eukaryotic expression plasmid encoding rat augmenter of liver regeneration on acute hepatic injury and hepatic failure in rats.

    abstract:AIM:To study the protective effect of eukaryotic expression plasmid encoding augmenter of liver regeneration (ALR) on acute hepatic injury and hepatic failure in rats. METHODS:The PCR-amplified ALR gene was recombined with pcDNA3 plasmid, and used to treat rats with acute hepatic injury. The rats with acute hepatic in...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i24.3680

    authors: Zhang LM,Liu DW,Liu JB,Zhang XL,Wang XB,Tang LM,Wang LQ

    更新日期:2005-06-28 00:00:00

  • Drug induced acute pancreatitis: does it exist?

    abstract::As the incidence of acute pancreatitis continues to rise, establishing the etiology in order to prevent recurrence is important. Although the etiology of acute pancreatitis is not difficult in the majority of patients, almost a quarter of patients are initially labeled as having idiopathic acute pancreatitis. When con...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v20.i44.16529

    authors: Tenner S

    更新日期:2014-11-28 00:00:00

  • Immune response to vaccines in children with celiac disease.

    abstract::Celiac disease (CD) is an immune-mediated systemic condition evoked by ingestion of gluten and related prolamines in genetically susceptible subjects. The disease is featured by a variable combination of clinical signs, specific antibodies, HLA-DQ2 and HLA-DQ8 haplotypes, and enteropathy. Vaccination is the most poten...

    journal_title:World journal of gastroenterology

    pub_type: 社论,评审

    doi:10.3748/wjg.v23.i18.3205

    authors: Anania C,Olivero F,Spagnolo A,Chiesa C,Pacifico L

    更新日期:2017-05-14 00:00:00

  • Prognostic impact of the red cell distribution width in esophageal cancer patients: A systematic review and meta-analysis.

    abstract:AIM:To clarify the previous discrepant conclusions, we performed a meta-analysis to evaluate the prognostic value of red cell distribution width (RDW) in esophageal cancer (EC). METHODS:We searched the PubMed, EMBASE, Web of Science and Cochrane Library databases to identify clinical studies, followed by using STATA v...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,meta分析,评审

    doi:10.3748/wjg.v24.i19.2120

    authors: Xu WY,Yang XB,Wang WQ,Bai Y,Long JY,Lin JZ,Xiong JP,Zheng YC,He XD,Zhao HT,Sang XT

    更新日期:2018-05-21 00:00:00

  • Effects of Changtai granules, a traditional compound Chinese medicine, on chronic trinitrobenzene sulfonic acid-induced colitis in rats.

    abstract:AIM:To study the effects of Changtai granules (CTG), a traditional compound Chinese medicine, on chronic trinitrobenzene sulfonic acid-induced colitis in rats. METHODS:Healthy adult Sprague-Dawley (SD) rats of both sexes, weighing 250-300 g, were employed in the present study. The rat colitis models were induced by 2,...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i23.3539

    authors: Cao YB,Zhang JD,Diao YY,Yan L,Wang DJ,Jia XM,Gao PH,Cheng MH,Xu Z,Wang Y,Jiang YY

    更新日期:2005-06-21 00:00:00

  • Age distribution, polyps and rectal cancer in the Egyptian population-based cancer registry.

    abstract:AIM:To describe the clinical and epidemiologic profiles of the disease and to compare the findings with those generated from the previous hospital-based studies. METHODS:The Gharbiah cancer registry is the only population-based cancer registry in Egypt since 1998. We analyzed the data of all colorectal cancer patients...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v18.i30.3997

    authors: Veruttipong D,Soliman AS,Gilbert SF,Blachley TS,Hablas A,Ramadan M,Rozek LS,Seifeldin IA

    更新日期:2012-08-14 00:00:00

  • Role of stress-activated MAP kinase P38 in cisplatin- and DTT-induced apoptosis of the esophageal carcinoma cell line Eca109.

    abstract:AIM:To study the role of P38 kinase in esophageal cancer cell apoptosis induced by genotoxin, cisplatin and the unfolded protein response (UPR) inducer, dithiothreitol (DTT). METHODS:Esophageal carcinoma cell line Eca109 was cultured in RPMI 1640 medium to 70% confluency and treated with either cisplatin, DTT, or cisp...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i29.4451

    authors: Zhang QX,Feng R,Zhang W,Ding Y,Yang JY,Liu GH

    更新日期:2005-08-07 00:00:00

  • Liposome transfected to plasmid-encoding endostatin gene combined with radiotherapy inhibits liver cancer growth in nude mice.

    abstract:AIM:To evaluate whether intratumoral injection of liposome-endostatin complexes could enhance the antitumor efficacy of radiation therapy in human liver carcinoma (BEL7402) model. METHODS:Recombinant plasmid pcDNA3.End was transfected into human liver carcinoma cell line (BEL7402) with lipofectamine to produce conditi...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i28.4439

    authors: Zheng AQ,Song XR,Yu JM,Wei L,Wang XW

    更新日期:2005-07-28 00:00:00

  • Effects of tetrandrine and verapamil on fibroblastic growth and proliferation.

    abstract:AIM:To investigate the effect of tetrandrine (Tet) and verapamil (Ver) on liver fibrosis by evaluating their effects on the growth and proliferation of fibroblasts. METHODS:Flow cytometry and imaging analysis were used to study the effects of combined and individual treatment of Tet and Ver on fibroblastic proliferati...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v3.i2.68

    authors: Liu XS,Li DG,Lu HM,Wu QF

    更新日期:1997-06-15 00:00:00

  • Effect of rifaximin on gut microbiota composition in advanced liver disease and its complications.

    abstract::Liver cirrhosis is a paradigm of intestinal dysbiosis. The qualitative and quantitative derangement of intestinal microbial community reported in cirrhotic patients seems to be strictly related with the impairment of liver function. A kind of gut microbial "fingerprint", characterized by the reduced ratio of "good" to...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v21.i43.12322

    authors: Ponziani FR,Gerardi V,Pecere S,D'Aversa F,Lopetuso L,Zocco MA,Pompili M,Gasbarrini A

    更新日期:2015-11-21 00:00:00

  • Anti-HBV effect of liposome-encapsulated matrine in vitro and in vivo.

    abstract:AIM:To study the anti-HBV effect of liposome-encapsulated matrine (Lip-M) in vitro and in vivo. METHODS:2.2.15 cell line was cultured in vitro to observe the effect of Lip-M and matrine on the secretion of HBsAg and HBeAg. The toxicity of Lip-M and matrine to 2.2.15 cell line was also studied by MTT method. In in vivo...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i3.426

    authors: Li CQ,Zhu YT,Zhang FX,Fu LC,Li XH,Cheng Y,Li XY

    更新日期:2005-01-21 00:00:00

  • Primary sclerosing cholangitis--what is the difference between east and west?

    abstract::Primary sclerosing cholangitis (PSC) is a chronic, progressive, cholestatic liver disease characterized by inflammation and fibrotic obliteration of the hepatic biliary tree. It is commonly associated with inflammatory bowel disease (IBD). A number of complications can occur which require special consideration, the mo...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.14.3974

    authors: Shorbagi A,Bayraktar Y

    更新日期:2008-07-07 00:00:00

  • Polymorphisms of uridine-diphosphoglucuronosyltransferase 1A7 gene in Taiwan Chinese.

    abstract:AIM:Single nucleotide polymorphisms (SNPs) of uridine-diphosphoglucuro-nosyltransferase 1A7 (UGT1A7) gene are associated with the development of orolaryngeal cancer, hepatocellular carcinoma, and colorectal cancer. We performed this research to establish the techniques for determining UGT1A7 gene and basic data of this...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i6.797

    authors: Huang MJ,Yang SS,Lin MS,Huang CS

    更新日期:2005-02-14 00:00:00

  • Superiority of split dose midazolam as conscious sedation for outpatient colonoscopy.

    abstract:AIM:To elucidate the efficacy and safety of a split dose of midazolam in combination with meperidine for colonoscopy. METHODS:Eighty subjects undergoing outpatient colonoscopy were randomly assigned to group A or B. Group A (n = 40) received a split dose of midazolam in combination with meperidine. Group B (n = 40) re...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,随机对照试验

    doi:10.3748/wjg.15.3783

    authors: Lee H,Kim JH

    更新日期:2009-08-14 00:00:00

  • Study on hepatoprotective effect of peptide S-8300 from shark liver.

    abstract:AIM:To explore the effects of peptide S-8300 from shark liver (S-8300) on liver function as well as in regulating immune functions in experimental injury models. METHODS:Mice were administered with different doses of S-8300 for four consecutive days, followed by mice injected with tetrachloromethane (CCl(4)) on d 3. T...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i12.1809

    authors: Huang FJ,Lv ZB,Li Q,Wei LJ,Zhang L,Wu WT

    更新日期:2005-03-28 00:00:00

  • Effects of short-term application of low-dose growth hormone on trace element metabolism and blood glucose in surgical patients.

    abstract:AIM:To investigate the effects of short-term application of low-dose growth hormone on trace element metabolism and blood glucose in surgical patients. METHODS:A total of 48 consecutive patients undergoing abdominal operations were randomized to receive either subcutaneous rhGH (0.15 IU/kg) or placebo (menstruum) inje...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,随机对照试验

    doi:10.3748/wjg.v13.i46.6259

    authors: Qian K,Wan Z,Hao LS,Zhang MM,Zhou Y,Wu XT

    更新日期:2007-12-14 00:00:00