Superiority of split dose midazolam as conscious sedation for outpatient colonoscopy.

Abstract:

AIM:To elucidate the efficacy and safety of a split dose of midazolam in combination with meperidine for colonoscopy. METHODS:Eighty subjects undergoing outpatient colonoscopy were randomly assigned to group A or B. Group A (n = 40) received a split dose of midazolam in combination with meperidine. Group B (n = 40) received a single dose of midazolam in combination with meperidine. Outcome measurements were level of sedation, duration of sedation and recovery, degree of pain and satisfaction, procedure-related memory, controllability, and adverse events. RESULTS:Group A had a lower frequency of significant hypoxemia (P = 0.043) and a higher sedation score on withdrawal of the endoscope from the descending colon than group B (P = 0.043). Group B recovered from sedation slightly sooner than group A (P < 0.002). Scores for pain and memory, except insertion-related memory, were lower in group A one week after colonoscopic examination (P = 0.018 and P < 0.030, respectively). Poor patient controllability was noted by the endoscopist and nurse in group B (P = 0.038 and P = 0.032, respectively). CONCLUSION:Split dose midazolam in combination with meperidine resulted in a safer, more equable sedation status during colonoscopic examination and a reduction in procedure-related pain and memory, but resulted in longer recovery time.

journal_name

World J Gastroenterol

authors

Lee H,Kim JH

doi

10.3748/wjg.15.3783

subject

Has Abstract

pub_date

2009-08-14 00:00:00

pages

3783-7

issue

30

eissn

1007-9327

issn

2219-2840

journal_volume

15

pub_type

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