Levels of matrix metalloproteinase-1 and tissue inhibitors of metalloproteinase-1 in gastric cancer.

Abstract:

AIM:To evaluate the levels of preoperative serum matrix metalloproteinase-1 (MMP-1) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in gastric cancer. METHODS:One hundred gastric cancer patients who underwent gastrectomy were enrolled in this study. The serum concentrations of MMP-1 and TIMP-1 in these patients and in fifty healthy controls were determined using an enzyme-linked immunosorbent assay. RESULTS:Higher serum MMP-1 and TIMP-1 levels were observed in patients than in controls (P < 0.001). Serum MMP-1 and TIMP-1 levels were positively associated with morphological appearance, tumor size, depth of wall invasion, lymph node metastasis, liver metastasis, perineural invasion, and pathological stage. They were not significantly associated with age, gender, tumor location, or histological type. CONCLUSION:Increased MMP-1 and TIMP-1 were associated with gastric cancer. Although these markers are not good markers for diagnosis, these markers show in advanced gastric cancer.

journal_name

World J Gastroenterol

authors

Kemik O,Kemik AS,Sümer A,Dulger AC,Adas M,Begenik H,Hasirci I,Yilmaz O,Purisa S,Kisli E,Tuzun S,Kotan C

doi

10.3748/wjg.v17.i16.2109

subject

Has Abstract

pub_date

2011-04-28 00:00:00

pages

2109-12

issue

16

eissn

1007-9327

issn

2219-2840

journal_volume

17

pub_type

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