Abstract:
AIM:To evaluate the levels of preoperative serum matrix metalloproteinase-1 (MMP-1) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in gastric cancer. METHODS:One hundred gastric cancer patients who underwent gastrectomy were enrolled in this study. The serum concentrations of MMP-1 and TIMP-1 in these patients and in fifty healthy controls were determined using an enzyme-linked immunosorbent assay. RESULTS:Higher serum MMP-1 and TIMP-1 levels were observed in patients than in controls (P < 0.001). Serum MMP-1 and TIMP-1 levels were positively associated with morphological appearance, tumor size, depth of wall invasion, lymph node metastasis, liver metastasis, perineural invasion, and pathological stage. They were not significantly associated with age, gender, tumor location, or histological type. CONCLUSION:Increased MMP-1 and TIMP-1 were associated with gastric cancer. Although these markers are not good markers for diagnosis, these markers show in advanced gastric cancer.
journal_name
World J Gastroenteroljournal_title
World journal of gastroenterologyauthors
Kemik O,Kemik AS,Sümer A,Dulger AC,Adas M,Begenik H,Hasirci I,Yilmaz O,Purisa S,Kisli E,Tuzun S,Kotan Cdoi
10.3748/wjg.v17.i16.2109subject
Has Abstractpub_date
2011-04-28 00:00:00pages
2109-12issue
16eissn
1007-9327issn
2219-2840journal_volume
17pub_type
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journal_title:World journal of gastroenterology
pub_type: 杂志文章,评审
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pub_type: 临床试验,杂志文章
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journal_title:World journal of gastroenterology
pub_type: 杂志文章,多中心研究
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更新日期:2013-10-28 00:00:00
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pub_type: 杂志文章
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更新日期:2013-08-28 00:00:00