Ten years of sorafenib in hepatocellular carcinoma: Are there any predictive and/or prognostic markers?


:Sorafenib has been considered the standard of care for patients with advanced unresectable hepatocellular carcinoma (HCC) since 2007 and numerous studies have investigated the role of markers involved in the angiogenesis process at both the expression and genetic level and clinical aspect. What results have ten years of research produced? Several clinical and biological markers are associated with prognosis. The most interesting clinical parameters are adverse events, Barcelona Clinic Liver Cancer stage, and macroscopic vascular invasion, while several single nucleotide polymorphisms and plasma angiopoietin-2 levels represent the most promising biological biomarkers. A recent pooled analysis of two phase III randomized trials showed that the neutrophil-to-lymphocyte ratio, etiology and extra-hepatic spread are predictive factors of response to sorafenib, but did not identify any predictive biological markers. After 10 years of research into sorafenib there are still no validated prognostic or predictive factors of response to the drug in HCC. The aim of the present review was to summarize 10 years of research into sorafenib, looking in particular at the potential of associated clinical and biological markers to predict its efficacy in patients with advanced HCC.


World J Gastroenterol


Marisi G,Cucchetti A,Ulivi P,Canale M,Cabibbo G,Solaini L,Foschi FG,De Matteis S,Ercolani G,Valgiusti M,Frassineti GL,Scartozzi M,Casadei Gardini A




Has Abstract


2018-09-28 00:00:00












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    abstract:AIM:To investigate protective effects and molecular mechanisms of green tea polyphenols (GTP) on non-alcoholic fatty liver disease (NAFLD) in Zucker fatty (ZF) rats. METHODS:Male ZF rats were fed a high-fat diet (HFD) for 2 wk then treated with GTP (200 mg/kg) or saline (5 mL/kg) for 8 wk, with Zucker lean rat as thei...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Tan Y,Kim J,Cheng J,Ong M,Lao WG,Jin XL,Lin YG,Xiao L,Zhu XQ,Qu XQ

    更新日期:2017-06-07 00:00:00

  • Dynamic changes of HBV DNA in serum and peripheral blood mononuclear cells of chronic hepatitis patients after lamivudine treatment.

    abstract:AIM:To study the dynamic changes of hepatitis B virus (HBV) DNA in serum and peripheral blood mononuclear cells (PBMCs) of patients after lamivudine therapy. METHODS:A total of 72 patients with chronic HBV infection were included in this study. All patients were confirmed to have the following conditions: above 16 yea...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,随机对照试验


    authors: Ke CZ,Chen Y,Gong ZJ,Meng ZJ,Liu L,Ren ZJ,Zhou ZH

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    abstract::Ischemic colitis is a rare complication of interferon administration. Only 9 cases in 6 reports have been described to-date. This report describes a case of ischemic colitis during pegylated interferon and ribavirin treatment for chronic hepatitis C, and includes a review of the relevant literature. A 48-year-old woma...

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    pub_type: 杂志文章,评审


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    abstract::Corticosteroids and immunomodulators have been the mainstay therapies for Crohn's disease. Corticosteroids are highly effective to control symptoms in the short-term, but they are not effective in maintaining remission, they heal the mucosa in a reduced proportion of cases, and long-time exposure is associated with an...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Ricart E,García-Bosch O,Ordás I,Panés J

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    pub_type: 杂志文章


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    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


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    pub_type: 杂志文章


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    pub_type: 杂志文章,评审


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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


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    更新日期:2013-05-14 00:00:00

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    pub_type: 杂志文章


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    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Liu ZQ,Zheng PY,Yang PC

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    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审


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    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审


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    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Babickova J,Gardlik R

    更新日期:2015-10-28 00:00:00

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    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Ueda T,Hokari R,Higashiyama M,Yasutake Y,Maruta K,Kurihara C,Tomita K,Komoto S,Okada Y,Watanabe C,Usui S,Nagao S,Miura S

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    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Jiang M,Liu F,Xiong WJ,Zhong L,Chen XM

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