Ten years of sorafenib in hepatocellular carcinoma: Are there any predictive and/or prognostic markers?


:Sorafenib has been considered the standard of care for patients with advanced unresectable hepatocellular carcinoma (HCC) since 2007 and numerous studies have investigated the role of markers involved in the angiogenesis process at both the expression and genetic level and clinical aspect. What results have ten years of research produced? Several clinical and biological markers are associated with prognosis. The most interesting clinical parameters are adverse events, Barcelona Clinic Liver Cancer stage, and macroscopic vascular invasion, while several single nucleotide polymorphisms and plasma angiopoietin-2 levels represent the most promising biological biomarkers. A recent pooled analysis of two phase III randomized trials showed that the neutrophil-to-lymphocyte ratio, etiology and extra-hepatic spread are predictive factors of response to sorafenib, but did not identify any predictive biological markers. After 10 years of research into sorafenib there are still no validated prognostic or predictive factors of response to the drug in HCC. The aim of the present review was to summarize 10 years of research into sorafenib, looking in particular at the potential of associated clinical and biological markers to predict its efficacy in patients with advanced HCC.


World J Gastroenterol


Marisi G,Cucchetti A,Ulivi P,Canale M,Cabibbo G,Solaini L,Foschi FG,De Matteis S,Ercolani G,Valgiusti M,Frassineti GL,Scartozzi M,Casadei Gardini A




Has Abstract


2018-09-28 00:00:00












  • Colorectal cancer and 18FDG-PET/CT: what about adding the T to the N parameter in loco-regional staging?

    abstract:AIM:To evaluate whether FDG-positron emission tomography (PET)/computed tomography (CT) may be an accurate technique in the assessment of the T stage in patients with colorectal cancer. METHODS:Thirty four consecutive patients (20 men and 14 women; mean age: 63 years) with a histologically proven diagnosis of colorect...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Mainenti PP,Iodice D,Segreto S,Storto G,Magliulo M,De Palma GD,Salvatore M,Pace L

    更新日期:2011-03-21 00:00:00

  • Inhibition of hepatitis C virus replication by single-stranded RNA structural mimics.

    abstract:AIM:To examine the effect of hepatitis C virus (HCV) structural mimics of regulatory regions of the genome on HCV replication. METHODS:HCV RNA structural mimics were constructed and tested in a HCV genotype 1b aBB7 replicon, and a Japanese fulminant hepatitis-1 (JFH-1) HCV genotype 2a infection model. All sequences we...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Smolic R,Smolic M,Andorfer JH,Wu CH,Smith RM,Wu GY

    更新日期:2010-05-07 00:00:00

  • Laparoscopic liver resection: wedge resections to living donor hepatectomy, are we heading in the right direction?

    abstract::Despite inception over 15 years ago and over 3000 completed procedures, laparoscopic liver resection has remained mainly in the domain of selected centers and enthusiasts. Requirement of extensive open liver resection (OLR) experience, in-depth understanding of anatomy and considerable laparoscopic technical expertise...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Cherian PT,Mishra AK,Kumar P,Sachan VK,Bharathan A,Srikanth G,Senadhipan B,Rela MS

    更新日期:2014-10-07 00:00:00

  • Transjugular intrahepatic portosystemic shunt with accidental diagnosis of persistence of the left superior vena cava.

    abstract::Transjugular intrahepatic portosystemic shunt (TIPSS) is considered a valid therapeutic option for the treatment of portal hypertension and its complications. The guidelines for this procedure have already been established on the basis of the normal vascular anatomy and of various technical radiological aspects. In so...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Petridis I,Miraglia R,Marrone G,Gruttadauria S,Luca A,Vizzini GB,Gridelli B

    更新日期:2010-03-07 00:00:00

  • Stool DNA methylation assays in colorectal cancer screening.

    abstract::Colorectal cancer (CRC) is fourth most common cancer in men and third in women worldwide. Developing a diagnostic panel of sensitive and specific biomarkers for the early detection of CRC is recognised as to be crucial for early initial diagnosis, which in turn leads to better long term survival. Most of the research ...

    journal_title:World journal of gastroenterology

    pub_type: 社论,评审


    authors: Kadiyska T,Nossikoff A

    更新日期:2015-09-21 00:00:00

  • Frequency and prognostic role of mucosal healing in patients with Crohn's disease and ulcerative colitis after one-year of biological therapy.

    abstract:AIM:To assess the endoscopic activity before and after a one-year period of biological therapy and to evaluate the frequency of relapses and need for retreatment after stopping the biologicals in patients with Crohn's disease (CD) and ulcerative colitis (UC). METHODS:The data from 41 patients with CD and 22 patients w...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,多中心研究


    authors: Farkas K,Lakatos PL,Szűcs M,Pallagi-Kunstár É,Bálint A,Nagy F,Szepes Z,Vass N,Kiss LS,Wittmann T,Molnár T

    更新日期:2014-03-21 00:00:00

  • Tumor rupture during surgery for gastrointestinal stromal tumors: pay attention!

    abstract::In a recently published letter to the editor, we debated the proposal by Coccolini et al to treat gastrointestinal stromal tumors (GISTs) of the esophagogastric junction with enucleation and, if indicated, adjuvant therapy. We highlighted that, because the prognostic impact of a T1 high-mitotic rate esophageal GIST is...

    journal_title:World journal of gastroenterology

    pub_type: 评论,信件


    authors: Peparini N,Chirletti P

    更新日期:2013-03-28 00:00:00

  • Eicosanoid pathway in colorectal cancer: Recent updates.

    abstract::Enzymatic metabolism of the 20C polyunsaturated fatty acid (PUFA) arachidonic acid (AA) occurs via the cyclooxygenase (COX) and lipoxygenase (LOX) pathways, and leads to the production of various bioactive lipids termed eicosanoids. These eicosanoids have a variety of functions, including stimulation of homeostatic re...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Tuncer S,Banerjee S

    更新日期:2015-11-07 00:00:00

  • Update on pathogenesis and predictors of response of therapeutic strategies used in inflammatory bowel disease.

    abstract::The search for biomarkers that characterize specific aspects of inflammatory bowel disease (IBD), has received substantial interest in the past years and is moving forward rapidly with the help of modern technologies. Nevertheless, there is a direct demand to identify adequate biomarkers for predicting and evaluating ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Quetglas EG,Mujagic Z,Wigge S,Keszthelyi D,Wachten S,Masclee A,Reinisch W

    更新日期:2015-11-28 00:00:00

  • Ethanol and liver: recent insights into the mechanisms of ethanol-induced fatty liver.

    abstract::Alcoholic fatty liver disease (AFLD), a potentially pathologic condition, can progress to steatohepatitis, fibrosis, and cirrhosis, leading to an increased probability of hepatic failure and death. Alcohol induces fatty liver by increasing the ratio of reduced form of nicotinamide adenine dinucleotide to oxidized form...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Liu J

    更新日期:2014-10-28 00:00:00

  • Efficiency of bowel preparation for capsule endoscopy examination: a meta-analysis.

    abstract::Good preparation before endoscopic procedures is essential for successful visualization. The small bowel is difficult to evaluate because of its length and complex configuration. A meta-analysis was conducted of studies comparing small bowel visualization by capsule endoscopy with and without preparation. Medical data...

    journal_title:World journal of gastroenterology

    pub_type: 社论,meta分析


    authors: Niv Y

    更新日期:2008-03-07 00:00:00

  • MicroRNAs potential utility in colon cancer: Early detection, prognosis, and chemosensitivity.

    abstract::Over the past decade, research has shown that aberrant expression of microRNA (miRNA) is involved in colorectal cancer development and progression. MicroRNAs are small sequences of non-coding RNA that regulate expression of genes involved in important cellular functions, such as cell differentiation, multiplication, a...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Hollis M,Nair K,Vyas A,Chaturvedi LS,Gambhir S,Vyas D

    更新日期:2015-07-21 00:00:00

  • Cell proliferation of esophageal squamous epithelium in erosive and non-erosive reflux disease.

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    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Calabrese C,Montanaro L,Liguori G,Brighenti E,Vici M,Gionchetti P,Rizzello F,Campieri M,Derenzini M,Trerè D

    更新日期:2011-10-28 00:00:00

  • Role of succinate dehydrogenase deficiency and oncometabolites in gastrointestinal stromal tumors.

    abstract::Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. At the molecular level, GISTs can be categorized into two groups based on the causative oncogenic mutations. Approximately 85% of GISTs are caused by gain-of-function mutations in the tyrosine kinase receptor ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Zhao Y,Feng F,Guo QH,Wang YP,Zhao R

    更新日期:2020-09-14 00:00:00

  • Linc00675 is a novel marker of short survival and recurrence in patients with pancreatic ductal adenocarcinoma.

    abstract:AIM:To detect linc00675 expression in pancreatic ductal adenocarcinoma (PDAC), to analyze the relationship between the expression level of linc00675 and the clinical pathological characteristics, to explore the biological functions of linc00675, and to determine whether linc00675 has independent prognostic value in PDA...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Li DD,Fu ZQ,Lin Q,Zhou Y,Zhou QB,Li ZH,Tan LP,Chen RF,Liu YM

    更新日期:2015-08-21 00:00:00

  • Resistance of Helicobacter pylori to antibiotics from 2000 to 2009 in Shanghai.

    abstract:AIM:To investigate the resistance of Helicobacter pylori (H. pylori) to 6 commonly used antibiotics from 2000 to 2009 in Shanghai. METHODS:A total of 293 H. pylori strains were collected from 2000 to 2009 in Shanghai and tested for their susceptibility to metronidazole, clarithromycin, amoxicillin, furazolidone, levof...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Sun QJ,Liang X,Zheng Q,Gu WQ,Liu WZ,Xiao SD,Lu H

    更新日期:2010-10-28 00:00:00

  • Anti-inflammatory effects of bifidobacteria by inhibition of LPS-induced NF-kappaB activation.

    abstract:AIM:Different strains of bifidobacteria were analysed for their effects on HT-29 intestinal epithelial cells (IECs) in in vitro models both of the non-inflamed and inflamed intestinal epithelium. METHODS:A reporter gene system in HT-29 cells was used to measure levels of NF-kappaB activation after challenge with bifid...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Riedel CU,Foata F,Philippe D,Adolfsson O,Eikmanns BJ,Blum S

    更新日期:2006-06-21 00:00:00

  • Gastroenterology service in a teaching hospital in rural New Zealand, 1991-2003.

    abstract:AIM:To retrospectively collect inpatient and outpatient data and to assess the use of endoscopic procedures during the years 1991, 1997 and 2003 to analyse for trends. METHODS:This retrospective survey was conducted in a University-associated Gastroenterology Unit offering secondary and tertiary health care services f...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Schultz M,Davidson A,Donald S,Targonska B,Turnbull A,Weggery S,Livingstone V,Dockerty JD

    更新日期:2009-02-07 00:00:00

  • Response evaluation of chemotherapy in metastatic colorectal cancer by contrast enhanced ultrasound.

    abstract:AIM:To evaluate whether contrast enhanced ultrasound (CEUS) might also be used for response prediction and early response evaluation in patients receiving bevacizumab based chemotherapy for metastasized colorectal cancer. METHODS:Thirty consecutive patients with non primary resectable liver metastases from colorectal ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Schirin-Sokhan R,Winograd R,Roderburg C,Bubenzer J,do Ó NC,Guggenberger D,Hecker H,Trautwein C,Tischendorf JJ

    更新日期:2012-02-14 00:00:00

  • Omeprazole induces gastric transmucosal permeability to the peptide bradykinin.

    abstract:AIM:To investigate omeprazole-induced transepithelial gastric leak and its effects on the permeability of the peptides bradykinin and oxytocin. METHODS:Rat gastric corpus tissue was isolated and mounted in an Ussing chamber apparatus to evaluate the permeability of (3)H-bradykinin, (3)H-oxytocin, and (14)C-EDTA in the...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Gabello M,Valenzano MC,Zurbach EP,Mullin JM

    更新日期:2010-03-07 00:00:00

  • Preoperative gamma-glutamyltransferase to lymphocyte ratio predicts long-term outcomes in intrahepatic cholangiocarcinoma patients following hepatic resection.

    abstract:BACKGROUND:Intrahepatic cholangiocarcinoma (ICC) is a heterogeneous hepatobiliary cancer with limited treatment options. A number of studies have illuminated the relationship between inflammation-based prognostic scores and outcomes in patients with ICC. However, the use of reliable and personalized prognostic algorith...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Wang JJ,Li H,Li JX,Xu L,Wu H,Zeng Y

    更新日期:2020-04-07 00:00:00

  • Acute abdomen: rare and unusual presentation of right colic xanthogranulomatosis.

    abstract::Xanthogranulomatous inflammation (XGI) is a disease of unknown origin, most frequently described in the kidney and gallbladder; its localization in the colorectal tract is extremely rare. The extension of the typical inflammatory process to the surrounding tissues may lead to misdiagnosis as cancer. We report the case...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Addario Chieco P,Antolino L,Giaccaglia V,Centanini F,Cunsolo GV,Sparagna A,Uccini S,Ziparo V

    更新日期:2014-07-14 00:00:00

  • Serological and molecular study of hepatitis E virus among illegal blood donors.

    abstract:AIM:To investigate the seroprevalence and molecular characteristics of hepatitis E virus (HEV) in the illegal blood donors (IBDs) of central China in the early 1990s. METHODS:A total of 546 blood samples were collected from the IBDs in Maanshan city, a questionnaire was completed by each subject, detailing the age, se...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Cheng XF,Wen YF,Zhu M,Zhan SW,Zheng JX,Dong C,Xiang KX,Xia XB,Wang G,Han LF

    更新日期:2012-03-07 00:00:00

  • Intestinal perforation after combined liver-kidney transplantation for a case of congenital polycystic disease.

    abstract:AIM:To highlight the intestinal perforation (IP), an uncommon and catastrophic complication after combined liver-kidney transplantation. METHODS:Combined liver-kidney transplantation (LKTx) with left kidney excision and a cyst fenestration procedure on the right kidney were performed on a case of 46-year-old female wi...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Peng T,Peng MH,Li LQ,Deng YL,Yang DH,Lu BY,Chen XG,Guo Y,Xiao KY,Chen B,Zhong Q,Wei MY

    更新日期:2004-09-15 00:00:00

  • High concentration of antimitochondrial antibodies predicts progressive primary biliary cirrhosis.

    abstract:AIM:To evaluate the serum concentration of antimitochondrial antibodies (AMAs) as a prognostic indicator of progressive primary biliary cirrhosis (pPBC). METHODS:Serum concentrations of AMA subtypes (anti-M2, anti-M4, and anti-M9), biochemical indices of liver function and Mayo risk factor (MRF) were determined in 30 ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Flisiak R,Pelszynska M,Prokopowicz D,Rogalska M,Grygoruk U

    更新日期:2005-09-28 00:00:00

  • Screening of hepatocyte proteins binding to complete S protein of hepatitis B virus by yeast-two hybrid system.

    abstract:AIM:To investigate the biological function of complete S protein and to look for proteins interacting with complete S protein in hepatocytes. METHODS:We constructed bait plasmid expressing complete S protein of HBV by cloning the gene of complete S protein into pGBKT7, then the recombinant plasmid DNA was transformed ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Bai GQ,Cheng J,Zhang SL,Huang YP,Wang L,Liu Y,Lin SM

    更新日期:2005-07-07 00:00:00

  • Proteomic analysis of blood level of proteins before and after operation in patients with esophageal squamous cell carcinoma at high-incidence area in Henan Province.

    abstract:AIM:To characterize the protein files in blood from same patients with esophageal squamous cell carcinoma (ESCC) before and after operation at the high-incidence area for ESCC in Henan Province, China. METHODS:Two-dimensional electrophoresis, silver staining and ImageMaster 2-DE analysis software were applied to the d...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: An JY,Fan ZM,Zhuang ZH,Qin YR,Gao SS,Li JL,Wang LD

    更新日期:2004-11-15 00:00:00

  • Interaction of major genes predisposing to hepatocellular carcinoma with genes encoding signal transduction pathways influences tumor phenotype and prognosis.

    abstract::Studies on rodents and humans demonstrate an inherited predisposition to hepatocellular carcinoma (HCC). Analysis of the molecular alterations involved in the acquisition of a phenotype resistant or susceptible to hepatocarcinogenesis showed a deregulation of G1 and S phases in HCC of genetically susceptible F344 rats...

    journal_title:World journal of gastroenterology

    pub_type: 社论


    authors: Feo F,Frau M,Pascale RM

    更新日期:2008-11-21 00:00:00

  • Pyogenic liver abscess: an audit of 10 years' experience.

    abstract:AIM:To describe our own experience with pyogenic liver abscesses over the past 10 years and investigate the risk factors associated with failure of initial percutaneous therapy. METHODS:A retrospective study of records of 63 PLA patients presenting between 1998 and 2008 to Australian tertiary referral centre, were rev...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Pang TC,Fung T,Samra J,Hugh TJ,Smith RC

    更新日期:2011-03-28 00:00:00

  • Endoscopic band ligation and endoscopic hemoclip placement for patients with Mallory-Weiss syndrome and active bleeding.

    abstract:AIM:To compare the hemostatic efficacy and safety of two mechanical endoscopic methods: endoscopic band ligation (EBL) and endoscopic hemoclip placement (EHP) in patients with actively bleeding Mallory-Weiss syndrome (MWS). METHODS:A prospective randomized study to compare the efficacy and safety of EHP with EBL was p...

    journal_title:World journal of gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Cho YS,Chae HS,Kim HK,Kim JS,Kim BW,Kim SS,Han SW,Choi KY

    更新日期:2008-04-07 00:00:00